LMNA R482L mutation causes impairments in C2C12 myoblasts subpopulations, alterations in metabolic reprogramming during differentiation, and oxidative stress

LMNA mutations causing classical familial partial lipodystrophy of Dunnigan type (FPLD2) usually affect residue R482. FPLD is a severe metabolic disorder that often leads to cardiovascular and skeletal muscle complications. How LMNA mutations affect the functional properties of skeletal muscles is s...

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Bibliographic Details
Published in:	Scientific reports Vol. 15; no. 1; pp. 5358 - 22
Main Authors:	Ivanova, Oksana A., Predeus, Alexander V., Sorokina, Margarita Y., Ignatieva, Elena V., Bobkov, Danila E., Sukhareva, Kseniia S., Kostareva, Anna A., Dmitrieva, Renata I.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 13.02.2025 Nature Publishing Group Nature Portfolio
Subjects:	631/337/2019 631/532/1360 631/532/2439 631/80/304 692/617/375/374 Animals Autophagy Autophagy - genetics Carbohydrate metabolism Carbohydrates Cell Differentiation - genetics Cell Line Connective tissues Gene expression Glutathione Humanities and Social Sciences Lamin Type A - genetics Lamin Type A - metabolism Lipodystrophy Lipodystrophy, Familial Partial - genetics Lipodystrophy, Familial Partial - metabolism Lipodystrophy, Familial Partial - pathology Metabolic disorders Metabolic Reprogramming Metabolism Mice Mice, Transgenic multidisciplinary Muscle Fibers, Skeletal - metabolism Muscles Musculoskeletal system Mutation Myoblasts Myoblasts - cytology Myoblasts - metabolism Myoblasts - pathology Myotubes Oxidative stress Oxidative Stress - genetics Phenotypes Reactive oxygen species Reactive Oxygen Species - metabolism Science Science (multidisciplinary) Skeletal muscle Subpopulations Transgenic mice
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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