Immunoexpression of C4 Binding Protein in Oral Leukoplakia and Oral Squamous Cell Carcinoma
The immune evasion of dysplastic cells plays an important role in suppressing the immune response and progression of malignancy. The role of the complement inhibitors in the development of oral epithelial dysplastic lesions and squamous cell carcinoma (SCC) is still unclear. This study aimed to asse...
Saved in:
| Published in: | Iranian journal of immunology Vol. 18; no. 2; pp. 95 - 102 |
|---|---|
| Main Authors: | , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Iran
Shiraz Institute for Cancer Research
01.06.2021
Shiraz University of Medical Sciences |
| Subjects: | |
| ISSN: | 1735-1383, 1735-367X, 1735-367X |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | The immune evasion of dysplastic cells plays an important role in suppressing the immune response and progression of malignancy. The role of the complement inhibitors in the development of oral epithelial dysplastic lesions and squamous cell carcinoma (SCC) is still unclear.
This study aimed to assess the expression of C4 binding protein (C4BP) as a complement inhibitor in oral squamous cell carcinoma and leukoplakia.
In this study, 94 samples were classified into four groups: leukoplakia with mild to moderate dysplasia, leukoplakia with severe dysplasia or carcinoma in situ, early invasive SCC, and invasive SCC. The expression of C4BP marker was evaluated by immunohistochemistry (IHC) and real-time PCR. The results were analyzed by the Kruskal-Wallis, Bonferroni adjusted Dunn's multiple comparison, and one-way ANOVA tests.
The results of IHC revealed the expression patterns of C4BP in oral dysplasia and SCC, and indicated that the C4BP expression was not significantly different between different histopathological grades in epithelial cells and vessels (P=0.157 and P=0.123, respectively) but, it was significantly different in fibroblasts and lymphocytes (P=0.017 and P=0.043, respectively). The real-time PCR showed a significant correlation between the dysplasia grade and expression of C4BP (P<0.05).
According to the results, C4BP is expressed in the cancerous tissue by the tumor cells and their surrounding stroma. In addition, upregulation of the C4BP gene as an inhibitor of the complement system is a possible strategy adopted by the tumor cells to evade the immune system. |
|---|---|
| AbstractList | Background: The immune evasion of dysplastic cells plays an important role in suppressing the immune response and progression of malignancy. The role of the complement inhibitors in the development of oral epithelial dysplastic lesions and squamous cell carcinoma (SCC) is still unclear. Objective: This study aimed to assess the expression of C4 binding protein (C4BP) as a complement inhibitor in oral squamous cell carcinoma and leukoplakia. Methods: In this study, 94 samples were classified into four groups: leukoplakia with mild to moderate dysplasia, leukoplakia with severe dysplasia or carcinoma in situ, early invasive SCC, and invasive SCC. The expression of C4BP marker was evaluated by immunohistochemistry (IHC) and real-time PCR. The results were analyzed by the Kruskal-Wallis, Bonferroni adjusted Dunn’s multiple comparison, and one-way ANOVA tests. Results: The results of IHC revealed the expression patterns of C4BP in oral dysplasia and SCC, and indicated that the C4BP expression was not significantly different between different histopathological grades in epithelial cells and vessels (P=0.157 and P=0.123, respectively) but, it was significantly different in fibroblasts and lymphocytes (P=0.017 and P=0.043, respectively). The real-time PCR showed a significant correlation between the dysplasia grade and expression of C4BP (p <0.05). Conclusion: According to the results, C4BP is expressed in the cancerous tissue by the tumor cells and their surrounding stroma. In addition, upregulation of the C4BP gene as an inhibitor of the complement system is a possible strategy adopted by the tumor cells to evade the immune system. The immune evasion of dysplastic cells plays an important role in suppressing the immune response and progression of malignancy. The role of the complement inhibitors in the development of oral epithelial dysplastic lesions and squamous cell carcinoma (SCC) is still unclear.BACKGROUNDThe immune evasion of dysplastic cells plays an important role in suppressing the immune response and progression of malignancy. The role of the complement inhibitors in the development of oral epithelial dysplastic lesions and squamous cell carcinoma (SCC) is still unclear.This study aimed to assess the expression of C4 binding protein (C4BP) as a complement inhibitor in oral squamous cell carcinoma and leukoplakia.OBJECTIVEThis study aimed to assess the expression of C4 binding protein (C4BP) as a complement inhibitor in oral squamous cell carcinoma and leukoplakia.In this study, 94 samples were classified into four groups: leukoplakia with mild to moderate dysplasia, leukoplakia with severe dysplasia or carcinoma in situ, early invasive SCC, and invasive SCC. The expression of C4BP marker was evaluated by immunohistochemistry (IHC) and real-time PCR. The results were analyzed by the Kruskal-Wallis, Bonferroni adjusted Dunn's multiple comparison, and one-way ANOVA tests.METHODSIn this study, 94 samples were classified into four groups: leukoplakia with mild to moderate dysplasia, leukoplakia with severe dysplasia or carcinoma in situ, early invasive SCC, and invasive SCC. The expression of C4BP marker was evaluated by immunohistochemistry (IHC) and real-time PCR. The results were analyzed by the Kruskal-Wallis, Bonferroni adjusted Dunn's multiple comparison, and one-way ANOVA tests.The results of IHC revealed the expression patterns of C4BP in oral dysplasia and SCC, and indicated that the C4BP expression was not significantly different between different histopathological grades in epithelial cells and vessels (P=0.157 and P=0.123, respectively) but, it was significantly different in fibroblasts and lymphocytes (P=0.017 and P=0.043, respectively). The real-time PCR showed a significant correlation between the dysplasia grade and expression of C4BP (P<0.05).RESULTSThe results of IHC revealed the expression patterns of C4BP in oral dysplasia and SCC, and indicated that the C4BP expression was not significantly different between different histopathological grades in epithelial cells and vessels (P=0.157 and P=0.123, respectively) but, it was significantly different in fibroblasts and lymphocytes (P=0.017 and P=0.043, respectively). The real-time PCR showed a significant correlation between the dysplasia grade and expression of C4BP (P<0.05).According to the results, C4BP is expressed in the cancerous tissue by the tumor cells and their surrounding stroma. In addition, upregulation of the C4BP gene as an inhibitor of the complement system is a possible strategy adopted by the tumor cells to evade the immune system.CONCLUSIONAccording to the results, C4BP is expressed in the cancerous tissue by the tumor cells and their surrounding stroma. In addition, upregulation of the C4BP gene as an inhibitor of the complement system is a possible strategy adopted by the tumor cells to evade the immune system. The immune evasion of dysplastic cells plays an important role in suppressing the immune response and progression of malignancy. The role of the complement inhibitors in the development of oral epithelial dysplastic lesions and squamous cell carcinoma (SCC) is still unclear. This study aimed to assess the expression of C4 binding protein (C4BP) as a complement inhibitor in oral squamous cell carcinoma and leukoplakia. In this study, 94 samples were classified into four groups: leukoplakia with mild to moderate dysplasia, leukoplakia with severe dysplasia or carcinoma in situ, early invasive SCC, and invasive SCC. The expression of C4BP marker was evaluated by immunohistochemistry (IHC) and real-time PCR. The results were analyzed by the Kruskal-Wallis, Bonferroni adjusted Dunn's multiple comparison, and one-way ANOVA tests. The results of IHC revealed the expression patterns of C4BP in oral dysplasia and SCC, and indicated that the C4BP expression was not significantly different between different histopathological grades in epithelial cells and vessels (P=0.157 and P=0.123, respectively) but, it was significantly different in fibroblasts and lymphocytes (P=0.017 and P=0.043, respectively). The real-time PCR showed a significant correlation between the dysplasia grade and expression of C4BP (P<0.05). According to the results, C4BP is expressed in the cancerous tissue by the tumor cells and their surrounding stroma. In addition, upregulation of the C4BP gene as an inhibitor of the complement system is a possible strategy adopted by the tumor cells to evade the immune system. |
| Author | Mirzaei, Seyed Abbas Namdari, Mahshid Mashhadiabbas, Fatemeh Alizadeh, Akram Fayazi-Boroujeni, Masoume |
| Author_xml | – sequence: 1 givenname: Fatemeh surname: Mashhadiabbas fullname: Mashhadiabbas, Fatemeh organization: Oral and Maxillofacial Pathology Department, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran – sequence: 2 givenname: Masoume surname: Fayazi-Boroujeni fullname: Fayazi-Boroujeni, Masoume – sequence: 3 givenname: Akram surname: Alizadeh fullname: Alizadeh, Akram – sequence: 4 givenname: Mahshid surname: Namdari fullname: Namdari, Mahshid – sequence: 5 givenname: Seyed Abbas surname: Mirzaei fullname: Mirzaei, Seyed Abbas |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34190690$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kU-LFDEQxYOsuH_0G4gEvHiZsZJ0J52jNro7MLCCCoKHpjqpXjLbncymp0G_vXFn9OBBKKji8eNRj3fJzmKKxNhLAWspQVVvwy6sJUixbgwosRamkU_YhTCqXiltvp2dbqEadc4u53kHoDUIeMbOVSUsaAsX7PtmmpaY6Mc-0zyHFHkaeFvx9yH6EO_4p5wOFCIvc5tx5Fta7tN-xPuAHKM_ip8fFpzSMvOWxpG3mF2IacLn7OmA40wvTvuKff344Ut7s9reXm_ad9uVV0odVlob5wbfAFqERjvyg0OtyXvvDEonBEGDpPTj_0ZghdIP1DsvQMvBqiu2Ofr6hLtun8OE-WeXMHSPQsp3HeZDcCN1UvS1pt44jX0FivriViNaJ2xVC-iL15uj1z6nh4XmQzeF2ZVYGKkk7GRdaWtqI2RBX_-D7tKSY0nayaYCXdu69PQ_SqvGmt_9FOrViVr6ifzfEH-KUr8A-AiWig |
| ContentType | Journal Article |
| Copyright | Copyright Shiraz Institute for Cancer Research Spring 2021 Copyright Shiraz Institute for Cancer Research 2021 |
| Copyright_xml | – notice: Copyright Shiraz Institute for Cancer Research Spring 2021 – notice: Copyright Shiraz Institute for Cancer Research 2021 |
| DBID | CGR CUY CVF ECM EIF NPM 3V. 7T5 7U9 7X7 7XB 88E 8FE 8FH 8FI 8FJ 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU CWDGH DWQXO FYUFA GHDGH GNUQQ H94 HCIFZ K9. LK8 M0S M1P M7N M7P PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS 7X8 DOA |
| DOI | 10.22034/iji.2021.87031.1782 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Immunology Abstracts Virology and AIDS Abstracts ProQuest Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Database (Proquest) ProQuest Central Natural Science Collection ProQuest One Community College Middle East & Africa Database ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database ProQuest Central Premium ProQuest One Academic ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic DOAJ Directory of Open Access Journals |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Central China ProQuest Central ProQuest One Applied & Life Sciences ProQuest Health & Medical Research Collection Health Research Premium Collection Middle East & Africa Database Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Algology Mycology and Protozoology Abstracts (Microbiology C) Health & Medical Research Collection Biological Science Collection AIDS and Cancer Research Abstracts ProQuest Central (New) ProQuest Medical Library (Alumni) Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition Immunology Abstracts ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | ProQuest Central Student MEDLINE - Academic ProQuest Central Student MEDLINE |
| Database_xml | – sequence: 1 dbid: DOA name: Directory of Open Access Journals (DOAJ) url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 1735-367X |
| EndPage | 102 |
| ExternalDocumentID | oai_doaj_org_article_21b56eb7c6ab403eb1a45aa9c194510b 34190690 |
| Genre | Journal Article |
| GroupedDBID | --- 53G 5GY 7X7 88E 8FE 8FH 8FI 8FJ 8R4 8R5 ABUWG ACPRK ADBBV AENEX AFKRA AFRAH AHMBA ALIPV ALMA_UNASSIGNED_HOLDINGS BAWUL BBNVY BCNDV BENPR BHPHI BPHCQ BVXVI CCPQU CGR CUY CVF CWDGH DIK EBD ECM EIF EMOBN EOJEC F5P FRP FYUFA GROUPED_DOAJ HCIFZ HMCUK LK8 M1P M7P NPM OBODZ OK1 PHGZT PQQKQ PROAC PSQYO Q2X RNS SV3 UKHRP W2D 3V. 7T5 7U9 7XB 8FK AFFHD AZQEC DWQXO GNUQQ H94 K9. M7N PHGZM PJZUB PKEHL PPXIY PQEST PQGLB PQUKI PRINS 7X8 PUEGO |
| ID | FETCH-LOGICAL-d333t-667ccfd80a9a086cedfca66edddc7a2c11e08ae360066071a4a2dfebcd1062f93 |
| IEDL.DBID | DOA |
| ISICitedReferencesCount | 0 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000714028400001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1735-1383 1735-367X |
| IngestDate | Fri Oct 03 12:42:43 EDT 2025 Fri Sep 05 11:28:41 EDT 2025 Sat Nov 29 14:27:37 EST 2025 Sat Nov 29 14:28:11 EST 2025 Thu Apr 03 06:49:09 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-d333t-667ccfd80a9a086cedfca66edddc7a2c11e08ae360066071a4a2dfebcd1062f93 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| OpenAccessLink | https://doaj.org/article/21b56eb7c6ab403eb1a45aa9c194510b |
| PMID | 34190690 |
| PQID | 2638971383 |
| PQPubID | 105770 |
| PageCount | 8 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_21b56eb7c6ab403eb1a45aa9c194510b proquest_miscellaneous_2546975712 proquest_journals_2840659520 proquest_journals_2638971383 pubmed_primary_34190690 |
| PublicationCentury | 2000 |
| PublicationDate | 2021-06-01 |
| PublicationDateYYYYMMDD | 2021-06-01 |
| PublicationDate_xml | – month: 06 year: 2021 text: 2021-06-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | Iran |
| PublicationPlace_xml | – name: Iran – name: Shiraz |
| PublicationTitle | Iranian journal of immunology |
| PublicationTitleAlternate | Iran J Immunol |
| PublicationYear | 2021 |
| Publisher | Shiraz Institute for Cancer Research Shiraz University of Medical Sciences |
| Publisher_xml | – name: Shiraz Institute for Cancer Research – name: Shiraz University of Medical Sciences |
| SSID | ssj0066010 |
| Score | 2.180949 |
| Snippet | The immune evasion of dysplastic cells plays an important role in suppressing the immune response and progression of malignancy. The role of the complement... Background: The immune evasion of dysplastic cells plays an important role in suppressing the immune response and progression of malignancy. The role of the... Background:The immune evasion of dysplastic cells plays an important role in suppressing the immune response and progression of malignancy. The role of the... |
| SourceID | doaj proquest pubmed |
| SourceType | Open Website Aggregation Database Index Database |
| StartPage | 95 |
| SubjectTerms | Adult Aged Aged, 80 and over Cancer carcinoma in situ complement c4b binding protein, head and neck squamous cell carcinoma Complement C4b-Binding Protein - analysis Complement C4b-Binding Protein - genetics Complement C4b-Binding Protein - physiology Complement component C4 Complement inhibitors Complement system Dysplasia Epithelial cells Female Fibroblasts Head & neck cancer Humans Immune response Immunohistochemistry Invasiveness Kruskal-Wallis test Leukokeratosis Leukoplakia, Oral - immunology Leukoplakia, Oral - pathology Lymphocytes Male Malignancy Middle Aged Mouth Neoplasms - immunology Mouth Neoplasms - pathology Oral cancer Oral carcinoma Oral squamous cell carcinoma Squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck - immunology Squamous Cell Carcinoma of Head and Neck - pathology Stroma Tumor cells Tumors |
| SummonAdditionalLinks | – databaseName: Biological Science Database dbid: M7P link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwEB5BAakXyrtLCzIS17TxI3ZyQnRFBRIqKwFSJQ7R-BEUWJLtPlD593icbLkULkg5RLaUWGN7Zj575huAl85SgqX0mXcRrioe4Q7SWzR9IRowYbnFVGzCnJ2V5-fVbDxwW41hlVudmBS17x2dkR8LMq0RUZXy1eIio6pRdLs6ltC4CbeIJUGm0L3ZVhNrAhspIVIWxLUnh9Q5IXKpjttvbUSHgh-VxOB-xE2i4qOQtL_7msnmnO7972jvwd3R22Svh-VxH26E7gHcGepP_noIX95RdkgfLsdo2I71DZsqdtKmXBc2IxKHtmPx-bCM33kfNt_7xTw6nciw80Pjx4sN0vkBm4b5nE2pNlHX_8BH8Pn0zafp22ystpB5KeU609o41_gyxwojznHBNw61Dt57Z1A4zkNeYpA6CdZwVCh8E6zzEVWKppKPYafru7APrLB5IBKh3LjooMgCC49opNOqbITyYQInJOh6MRBq1ERxnRr65dd63DG14LbQwRqn0apcRpuCqkCsHK9UVCR2Aodb0dfjvlvVf-R-fXeEs0SgKPIJvLjqjhuKbkmwC1FYNRUIqExhuJjAk2H2rwZK5HdE7fz03_8-gF1aWkNE2SHsrJeb8Axuu5_rdrV8ntbobwOS7dQ priority: 102 providerName: ProQuest |
| Title | Immunoexpression of C4 Binding Protein in Oral Leukoplakia and Oral Squamous Cell Carcinoma |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/34190690 https://www.proquest.com/docview/2638971383 https://www.proquest.com/docview/2840659520 https://www.proquest.com/docview/2546975712 https://doaj.org/article/21b56eb7c6ab403eb1a45aa9c194510b |
| Volume | 18 |
| WOSCitedRecordID | wos000714028400001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: Directory of Open Access Journals (DOAJ) customDbUrl: eissn: 1735-367X dateEnd: 20231231 omitProxy: false ssIdentifier: ssj0066010 issn: 1735-1383 databaseCode: DOA dateStart: 20040101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVPQU databaseName: Biological Sciences customDbUrl: eissn: 1735-367X dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0066010 issn: 1735-1383 databaseCode: M7P dateStart: 20080301 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1735-367X dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0066010 issn: 1735-1383 databaseCode: 7X7 dateStart: 20080301 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Middle East & Africa Database customDbUrl: eissn: 1735-367X dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0066010 issn: 1735-1383 databaseCode: CWDGH dateStart: 20080301 isFulltext: true titleUrlDefault: https://search.proquest.com/middleeastafrica providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1735-367X dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0066010 issn: 1735-1383 databaseCode: BENPR dateStart: 20080301 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3di9QwEB_0VPBF_Hb1XCL4undt0ibto7vcoSDr4gcs-FAmH4Wea3vu7Yr-984kvcMHxRehlJJAm85MkvmRmd8AvHSWEyyVn3lHcLXICe4gP9HWF2gDkza3GItNmOWyWq_r1W-lvjgmLNEDJ8Edy9yWOljjNNoiU7S0YFEi1o7QN9mT5dWXvJ5LMJXWYM0wI6ZCqpJZ9lRKmpMyU8Vxd9YRLpT5UcXc7Ue5iSR8_OG_e5lxtzm9C3dGN1G8SsO7B9dCfx9upcKRPx_A5zec1jGEH2MYay-GViwKMe9ikopYMftC1wu63m3pPW_D_stwviFvEQX2PjV--LZHBv5iETYbseCiQv3wFR_Cp9OTj4vXs7FMwswrpXYzrY1zra8yrJEAigu-dah18N47g9LlecgqDEpHuRiSH0rfBus8wUHZ1uoRHPRDH56AKG0WmP0nM448C1Vi6RGNcrqoWln4MIE5y6k5T0wYDXNTxwbSWDNqrPmXxiZweCnlZpwwF41kz8mwqv7cTTiUmQ9lNoEXV900E_h4A_tAwmqY2b82pcnlBB4n5V0NlFnrmJP56f_4gWdwm-0nBYwdwsFuuw_P4ab7vusutlO4btYm3qsp3JifLFfvp9E4pxxXuvoFuI3kQw |
| linkProvider | Directory of Open Access Journals |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9RADLaqFgSX8oYtBQYJjmmTmSSTHBCiC1VXXZZKFGklDsGZmaDANtnuA-if4jdiJ9nlAtx6QMohykh5jB3b34z9GeCZybnAUlnPGoKrYUBwB_mMXJ8jBybzIMem2YQejZLxOD3ZgJ-rWhhOq1zZxMZQ29rwGvm-ZNdKiCpRL6fnHneN4t3VVQuNVi2O3cV3gmzzF4PXJN_nUh6-Oe0feV1XAc8qpRZeHGtjCpv4mCLF88bZwmAcO2ut0ShNEDg_Qadi9sbkgDFEaQuXG0voSRZMvkQmf4vsuOYUMj1eA7yYwU1TgKki5vZTbamelL4K98svJaFRGewlzBi_F-iG-o9T4P4e2zY-7vDG_zY7N2G7i6bFq1b9b8GGq27D1ba_5sUd-Djg6pfa_eiyfStRF6IfioOyqeURJ0xSUVaCjnczus_QLb_W0wkF1Siwsu3F9-dL5PUR0XeTiehz76WqPsO78OFSvuwebFZ15R6AiHLfMUmSrw0FYCrCyCJqZeIwKWRoXQ8OWLDZtCUMyZjCu7lQzz5nnUXIZJBHscu1iTEPfUU-E8MIMTVBGpKhzHuwuxJ11tmVefZbzn8eJrjOBJHS78HT9TAZDN4FwsrRZGXcACHVkQ5kD-632rZ-USb3Y-rqnX8_-wlcOzp9O8yGg9HxQ7jOat1mz-3C5mK2dI_givm2KOezx83_IeDTZavcL16ZTiA |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwELaq8hAX3o-FAkaCY7qJ7djJASG6ZcWqZVkJkCpxSCe2gwJLst0H0L_Gr2Mmj3IBbj0g5RDZUh72eL4Ze-Ybxp7anBIspQucRXdVRejuAN0h9HkEMJFHOTTFJsx0mhwdpbMt9rPPhaGwyl4nNora1Zb2yIeCoBU9qkQOiy4sYrY_frE4CaiCFJ209uU0WhE58Kff0X1bPZ_s41w_E2L86v3oddBVGAiclHIdaG2sLVwSQgpo21vvCgtae-ecNSBsFPkwAS81ITOCMSgQrvC5dehJiYKImFD9XzBKN0rhjZn1KKDJ0WmSMWVMPH-yTdsTIpRqWH4u0TMV0W5C7PG7kWloACkc7u92boN342v_80hdZ1c7K5u_bJfFDbblq5vsUlt38_QW-zihrJja_-iigCteF3yk-F7Z5PjwGZFXlBXH6-0Sn3PoN1_qxRyNbeBQubbx3ckGaN-Ej_x8zkdUk6mqv8Jt9uFc_uwO267qyt9jPM5DT-RJobFomMkYYgdgpNUqKYRyfsD2aJKzRUskkhG1d9NQLz9lnabIRJTH2ufGashVKBFLQcUAqY1ShQo0H7CdftqzTt-sst9z_ududOOJOFKEA_bkrBsVCZ0OQeVxsDIqjJCa2ERiwO62knf2oUT6R5TW9__97sfsMkpadjiZHjxgV0jC26C6Hba9Xm78Q3bRfluXq-WjZqlwdnzeEvcLvzlW7w |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Immunoexpression+of+C4+Binding+Protein+in+Oral+Leukoplakia+and+Oral+Squamous+Cell+Carcinoma&rft.jtitle=Iranian+journal+of+immunology&rft.au=Fatemeh+Mashhadi-Abbas&rft.au=Masoume+Fayazi_Boroujeni&rft.au=Akram+Alizadeh&rft.au=Mahshid+Namdari&rft.date=2021-06-01&rft.pub=Shiraz+University+of+Medical+Sciences&rft.issn=1735-1383&rft.eissn=1735-367X&rft.volume=18&rft.issue=2&rft.spage=95&rft.epage=102&rft_id=info:doi/10.22034%2Fiji.2021.87031.1782&rft.externalDBID=DOA&rft.externalDocID=oai_doaj_org_article_21b56eb7c6ab403eb1a45aa9c194510b |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1735-1383&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1735-1383&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1735-1383&client=summon |