Harnessing the Power of CAR-NK Cells: A Promising Off-the-Shelf Therapeutic Strategy for CD38-Positive Malignancies

CD38 is highly expressed on multiple myeloma (MM) cells and has been successfully targeted by different target therapy methods. This molecule is a critical prognostic marker in both diffuse large B-cell lymphoma and chronic lymphocytic leukemia. We have designed and generated an anti-CD38 CAR-NK cel...

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Bibliographic Details
Published in:	Iranian journal of immunology Vol. 20; no. 4; pp. 410 - 426
Main Authors:	Asadi, Maryam, Kiani, Razie, Razban, Vahid, Faraji, Seyed Nooreddin, Ahmadi, Amirhossein, Fallahi, Jafar, Ramezani, Amin, Erfani, Nasrollah
Format:	Journal Article
Language:	English
Published:	Iran Shiraz Institute for Cancer Research 01.12.2023 Shiraz University of Medical Sciences
Subjects:	Annexin V Antigens Apoptosis B-cell lymphoma car nk cell cd38 CD38 antigen Cell Line, Tumor Chimeric antigen receptors Chronic lymphocytic leukemia Cytotoxicity, Immunologic Flow cytometry Granzymes - metabolism Humans Immunotherapy, Adoptive - methods Killer Cells, Natural Leukemia, Lymphocytic, Chronic, B-Cell Lymphatic leukemia Lymphocytes B Malignancy Multiple myeloma Natural killer cells Perforin Perforin - metabolism Receptors, Chimeric Antigen - genetics Receptors, Chimeric Antigen - metabolism γ-Interferon CD38 Malignancy CAR NK Cell Multiple Myeloma
ISSN:	1735-1383, 1735-367X, 1735-367X
Online Access:	Get full text
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