Well-differentiated papillary mesothelial tumor of the fallopian tube: A case report
Well-differentiated papillary mesothelial tumor (WDPMT) is a rare mesothelial neoplasm that typically arises in the peritoneum of women of reproductive age and generally follows an indolent course, although occasional recurrence or malignant transformation has been reported. WDPMT of the fallopian t...
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| Veröffentlicht in: | Current problems in cancer. Case reports Jg. 20; S. 100398 |
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01.12.2025
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| Abstract | Well-differentiated papillary mesothelial tumor (WDPMT) is a rare mesothelial neoplasm that typically arises in the peritoneum of women of reproductive age and generally follows an indolent course, although occasional recurrence or malignant transformation has been reported. WDPMT of the fallopian tube is extremely uncommon. We report the case of a 46-year-old woman with long-standing menorrhagia who underwent total abdominal hysterectomy with bilateral salpingectomy for uterine leiomyomas, during which a solitary 5-mm nodule was incidentally identified on the left fallopian tube. Histological examination showed fibrovascular cores lined by cuboidal mesothelial cells with minimal atypia and no stromal invasion, while immunohistochemistry revealed WT1 and calretinin positivity, estrogen receptor and progesterone receptor negativity, weak focal PAX8 staining, and retained nuclear expression of BRCA1-associated protein 1 (BAP1) and methylthioadenosine phosphorylase (MTAP). These findings supported a diagnosis of WDPMT. This case adds to the limited literature on fallopian tube WDPMT and highlights the importance of recognizing this rare entity and considering long-term follow-up, given its generally indolent but occasionally unpredictable behavior. |
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| AbstractList | Well-differentiated papillary mesothelial tumor (WDPMT) is a rare mesothelial neoplasm that typically arises in the peritoneum of women of reproductive age and generally follows an indolent course, although occasional recurrence or malignant transformation has been reported. WDPMT of the fallopian tube is extremely uncommon. We report the case of a 46-year-old woman with long-standing menorrhagia who underwent total abdominal hysterectomy with bilateral salpingectomy for uterine leiomyomas, during which a solitary 5-mm nodule was incidentally identified on the left fallopian tube. Histological examination showed fibrovascular cores lined by cuboidal mesothelial cells with minimal atypia and no stromal invasion, while immunohistochemistry revealed WT1 and calretinin positivity, estrogen receptor and progesterone receptor negativity, weak focal PAX8 staining, and retained nuclear expression of BRCA1-associated protein 1 (BAP1) and methylthioadenosine phosphorylase (MTAP). These findings supported a diagnosis of WDPMT. This case adds to the limited literature on fallopian tube WDPMT and highlights the importance of recognizing this rare entity and considering long-term follow-up, given its generally indolent but occasionally unpredictable behavior. AbstractWell-differentiated papillary mesothelial tumor (WDPMT) is a rare mesothelial neoplasm that typically arises in the peritoneum of women of reproductive age and generally follows an indolent course, although occasional recurrence or malignant transformation has been reported. WDPMT of the fallopian tube is extremely uncommon. We report the case of a 46-year-old woman with long-standing menorrhagia who underwent total abdominal hysterectomy with bilateral salpingectomy for uterine leiomyomas, during which a solitary 5-mm nodule was incidentally identified on the left fallopian tube. Histological examination showed fibrovascular cores lined by cuboidal mesothelial cells with minimal atypia and no stromal invasion, while immunohistochemistry revealed WT1 and calretinin positivity, estrogen receptor and progesterone receptor negativity, weak focal PAX8 staining, and retained nuclear expression of BRCA1-associated protein 1 (BAP1) and methylthioadenosine phosphorylase (MTAP). These findings supported a diagnosis of WDPMT. This case adds to the limited literature on fallopian tube WDPMT and highlights the importance of recognizing this rare entity and considering long-term follow-up, given its generally indolent but occasionally unpredictable behavior. |
| ArticleNumber | 100398 |
| Author | Kotani, Hideko Kaneko, Hisae Kitazawa, Sohei Tasaka, Mie |
| Author_xml | – sequence: 1 givenname: Hideko surname: Kotani fullname: Kotani, Hideko organization: Department of Obstetrics and Gynecology, Uwajima City Hospital, Uwajima, Ehime, Japan – sequence: 2 givenname: Sohei surname: Kitazawa fullname: Kitazawa, Sohei email: kitazawa@m.ehime-u.ac.jp organization: Department of Molecular Pathology, Ehime University Graduate School of Medicine, Toon, Ehime, Japan – sequence: 3 givenname: Hisae surname: Kaneko fullname: Kaneko, Hisae organization: Department of Obstetrics and Gynecology, Matsuyama Madonna Hospital, Matsuyama, Ehime, Japan – sequence: 4 givenname: Mie surname: Tasaka fullname: Tasaka, Mie organization: Department of Obstetrics and Gynecology, Matsuyama Madonna Hospital, Matsuyama, Ehime, Japan |
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| Keywords | mesothelial tumor peritoneum mesothelioma fallopian tube Well-differentiated papillary mesothelial tumor |
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| References_xml | – volume: 35 start-page: 1327 year: 2022 end-page: 1333 ident: bib0008 article-title: Well differentiated papillary mesothelial tumor: a new name and new problems publication-title: Mod Pathol – volume: 65 start-page: 292 year: 1990 end-page: 296 ident: bib0002 article-title: Well-differentiated papillary mesothelioma of the peritoneum. A clinicopathologic study of 22 cases publication-title: Cancer – volume: 52 start-page: 211 year: 2024 end-page: 216 ident: bib0010 article-title: Investigation of MTAP and BAP1 staining loss and P16/CDKN2A deletion in pleural cytology specimens and its role in the diagnosis of mesothelioma publication-title: Diagn Cytopathol – volume: 191 start-page: 814 year: 2008 end-page: 825 ident: bib0007 article-title: Peritoneal mesotheliomas: clinicopathologic features, CT findings, and differential diagnosis publication-title: AJR Am J Roentgenol – volume: 4 year: 2020 ident: bib0001 article-title: WHO Classification of Tumours Series publication-title: Female Genital Tumours – volume: 49 year: 2021 ident: bib0005 article-title: Peritoneal well-differentiated papillary mesothelioma associated with infertility in a 37-year-old woman publication-title: J Int Med Res – volume: 17 start-page: 608 year: 2022 end-page: 622 ident: bib0009 article-title: The 2021 WHO Classification of Tumors of the Pleura: Advances Since the 2015 Classification publication-title: J Thorac Oncol – volume: 38 start-page: 990 year: 2014 end-page: 998 ident: bib0006 article-title: Well-differentiated papillary mesothelioma with invasive foci publication-title: Am J Surg Pathol – volume: 32 start-page: 88 year: 2019 end-page: 99 ident: bib0012 article-title: Well-differentiated papillary mesothelioma of the peritoneum is genetically defined by mutually exclusive TRAF7 and CDC42 mutations publication-title: Mod Pathol – volume: 36 start-page: 117 year: 2012 end-page: 127 ident: bib0003 article-title: Well-differentiated papillary mesothelioma of the female peritoneum: a clinicopathologic study of 26 cases publication-title: Am J Surg Pathol – volume: 38 start-page: 43 year: 2019 end-page: 50 ident: bib0004 article-title: Well-differentiated papillary mesothelioma: A 17-year single institution experience with a series of 75 cases publication-title: Ann Diagn Pathol – volume: 56 start-page: 662 year: 2024 end-page: 670 ident: bib0011 article-title: The significance of BAP1 and MTAP/CDKN2A expression in well-differentiated papillary mesothelial tumour: a series of 21 cases and a review of the literature publication-title: Pathology |
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| SubjectTerms | Fallopian tube Hematology, Oncology, and Palliative Medicine Mesothelial tumor Mesothelioma Peritoneum Well-differentiated papillary mesothelial tumor |
| Title | Well-differentiated papillary mesothelial tumor of the fallopian tube: A case report |
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