Polyclonal origins of human premalignant colorectal lesions

Cancer is generally thought to be caused by expansion of a single mutant cell . However, analyses of early colorectal cancer lesions suggest that tumors may instead originate from multiple, genetically distinct cell populations . Detecting polyclonal tumor initiation is challenging in patients, as i...

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Vydané v:	Nature (London)
Hlavní autori:	Van Egeren, Debra, Schenck, Ryan O., Khan, Aziz, Horning, Aaron M., Mo, Shanlan, Weiß, Clemens L., Esplin, Edward D., Becker, Winston R., Wu, Si, Hanson, Casey, Barapour, Nasim, Jiang, Lihua, Contrepois, Kévin, Lee, Hayan, Nevins, Stephanie A., Guha, Tuhin K., Zhang, Hao, He, Zhen, Ma, Zhicheng, Monte, Emma, Karathanos, Thomas V., Laquindanum, Rozelle, Mills, Meredith A., Chaib, Hassan, Chiu, Roxanne, Jian, Ruiqi, Chan, Joanne, Ellenberger, Mathew, Bahmani, Bahareh, Michael, Basil, Weimer, Annika K., Esplin, D. Glen, Lancaster, Samuel, Shen, Jeanne, Ladabaum, Uri, Longacre, Teri A., Kundaje, Anshul, Greenleaf, William J., Hu, Zheng, Ford, James M., Snyder, Michael P., Curtis, Christina
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England 25.11.2025
ISSN:	0028-0836, 1476-4687, 1476-4687
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