Polyclonal origins of human premalignant colorectal lesions

Cancer is generally thought to be caused by expansion of a single mutant cell . However, analyses of early colorectal cancer lesions suggest that tumors may instead originate from multiple, genetically distinct cell populations . Detecting polyclonal tumor initiation is challenging in patients, as i...

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Bibliographic Details

Published in:	Nature (London)
Main Authors:	Van Egeren, Debra, Schenck, Ryan O., Khan, Aziz, Horning, Aaron M., Mo, Shanlan, Weiß, Clemens L., Esplin, Edward D., Becker, Winston R., Wu, Si, Hanson, Casey, Barapour, Nasim, Jiang, Lihua, Contrepois, Kévin, Lee, Hayan, Nevins, Stephanie A., Guha, Tuhin K., Zhang, Hao, He, Zhen, Ma, Zhicheng, Monte, Emma, Karathanos, Thomas V., Laquindanum, Rozelle, Mills, Meredith A., Chaib, Hassan, Chiu, Roxanne, Jian, Ruiqi, Chan, Joanne, Ellenberger, Mathew, Bahmani, Bahareh, Michael, Basil, Weimer, Annika K., Esplin, D. Glen, Lancaster, Samuel, Shen, Jeanne, Ladabaum, Uri, Longacre, Teri A., Kundaje, Anshul, Greenleaf, William J., Hu, Zheng, Ford, James M., Snyder, Michael P., Curtis, Christina
Format:	Journal Article
Language:	English
Published:	England 25.11.2025
ISSN:	0028-0836, 1476-4687, 1476-4687
Online Access:	Get full text
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