Polyclonal origins of human premalignant colorectal lesions

Cancer is generally thought to be caused by expansion of a single mutant cell . However, analyses of early colorectal cancer lesions suggest that tumors may instead originate from multiple, genetically distinct cell populations . Detecting polyclonal tumor initiation is challenging in patients, as i...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Nature (London)
Hauptverfasser:	Van Egeren, Debra, Schenck, Ryan O., Khan, Aziz, Horning, Aaron M., Mo, Shanlan, Weiß, Clemens L., Esplin, Edward D., Becker, Winston R., Wu, Si, Hanson, Casey, Barapour, Nasim, Jiang, Lihua, Contrepois, Kévin, Lee, Hayan, Nevins, Stephanie A., Guha, Tuhin K., Zhang, Hao, He, Zhen, Ma, Zhicheng, Monte, Emma, Karathanos, Thomas V., Laquindanum, Rozelle, Mills, Meredith A., Chaib, Hassan, Chiu, Roxanne, Jian, Ruiqi, Chan, Joanne, Ellenberger, Mathew, Bahmani, Bahareh, Michael, Basil, Weimer, Annika K., Esplin, D. Glen, Lancaster, Samuel, Shen, Jeanne, Ladabaum, Uri, Longacre, Teri A., Kundaje, Anshul, Greenleaf, William J., Hu, Zheng, Ford, James M., Snyder, Michael P., Curtis, Christina
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England 25.11.2025
ISSN:	0028-0836, 1476-4687, 1476-4687
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!