Genetic studies of body mass index yield new insights for obesity biology

Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individual...

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Vydáno v:	Nature (London) Ročník 518; číslo 7538; s. 197 - 206
Hlavní autoři:	Croteau-Chonka, Damien C., Wood, Andrew R., Absher, Devin, Bragg-Gresham, Jennifer L., Buyske, Steven, Feitosa, Mary F., Mangino, Massimo, Mateo Leach, Irene, Palmer, Cameron D., Pasko, Dorota, Ju Sung, Yun, Teumer, Alexander, van der Laan, Sander W., Ärnlöv, Johan, Berne, Christian, Bonnycastle, Lori L., Bruinenberg, Marcel, Ida Chen, Yii-Der, de Craen, Anton J. M., Delgado, Graciela, Fraser, Ross M., Grönberg, Henrik, Gusto, Gaëlle, Hassinen, Maija, Jeff, Janina M., Kinnunen, Leena, Kratzer, Wolfgang, Lee, Nanette R., Lichtner, Peter, Lind, Lars, Sin Lo, Ken, Lorbeer, Roberto, Mahajan, Anubha, Milani, Lili, Monda, Keri L., Nolte, Ilja M., Pilz, Stefan, Rettig, Rainer, Ripke, Stephan, Sanna, Serena, Schumacher, Fredrick R., Scott, William R., Smolonska, Joanna, Stirrups, Kathleen, Stringham, Heather M., Uh, Hae-Won, Vandenput, Liesbeth, Warren, Helen R., Brennan, Eoin P., Drong, Alexander W., Min, Josine L., Okada, Yukinori, Takahashi, Atsushi, Tanaka, Toshihiro, Westra, Harm-Jan, Campbell, Harry, den Ruijter, Hester M., Erbel, Raimund, Farrall, Martin, Franco, Oscar H., Gejman, Pablo V., Gieger, Christian, Gottesman, Omri, Hingorani, Aroon D., Hyppönen, Elina, Jarvelin, Marjo-Riitta, Jöckel, Karl-Heinz, Johansen, Berit, Kooperberg, Charles, Langenberg, Claudia, Postma, Dirkje S., Price, Jackie F., Rao, D. C., Rioux, John D., Schunkert, Heribert, Shuldiner, Alan R., Strauch, Konstantin, Tremblay, Angelo, Adair, Linda S., de Bakker, Paul I. W., Ferrucci, Luigi, Hveem, Kristian, März, Winfried, Munroe, Patricia B., Njølstad, Inger, Palmer, Colin N. A., Pedersen, Nancy L., Pérusse, Louis, Saaristo, Timo E., Saleheen, Danish, Sattar, Naveed, Eline Slagboom, P., Tuomilehto, Jaakko, Deloukas, Panos, Stefansson, Kari, van Duijn, Cornelia M., Willer, Cristen J., Ingelsson, Erik, Hirschhorn, Joel N., Loos, Ruth J. F.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 12.02.2015 Nature Publishing Group
Témata:	631/208/205/2138 Adipogenesis - genetics Adiposity - genetics Age Factors Biology Body Mass Index Central nervous system Clinical Medicine Diabetes Endocrinology and Diabetes Endokrinologi och diabetes Energy Metabolism - genetics Europe - ethnology Female Folkhälsovetenskap, global hälsa och socialmedicin Gene expression Genetic aspects Genetic Predisposition to Disease - genetics Genetic research Genetics Genome-Wide Association Study Genomes Genomics Glutamic Acid - metabolism Health and Welfare Health aspects Humanities and Social Sciences Humans Hälsa och välfärd Insulin - metabolism Insulin Secretion Klinisk medicin Male Medical and Health Sciences Medical Genetics and Genomics Medicin och hälsovetenskap Medicinsk genetik och genomik Meta-analysis Metabolic disorders multidisciplinary Obesity Obesity - genetics Obesity - metabolism Polymorphism, Single Nucleotide - genetics Public Health, Global Health and Social Medicine Quantitative Trait Loci - genetics Racial Groups - genetics Science Studies Synapses - metabolism Systematic review Europe phenotype disease course body mass gene linkage disequilibrium genetic association heredity gene frequency genetic variability insulin release copy number variation quantitative trait locus nonhuman priority journal receiver operating characteristic human energy metabolism gene expression obesity
ISSN:	0028-0836, 1476-4687, 1476-4687
On-line přístup:	Získat plný text
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