Genome-wide association meta-analysis identifies pleiotropic risk loci for aerodigestive squamous cell cancers

Squamous cell carcinomas (SqCC) of the aerodigestive tract have similar etiological risk factors. Although genetic risk variants for individual cancers have been identified, an agnostic, genome-wide search for shared genetic susceptibility has not been performed. To identify novel and pleotropic SqC...

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Vydané v:	PLoS genetics Ročník 17; číslo 3; s. e1009254
Hlavní autori:	Lesseur, Corina, Ferreiro-Iglesias, Aida, McKay, James D., Bossé, Yohan, Johansson, Mattias, Gaborieau, Valerie, Landi, Maria Teresa, Christiani, David C., Caporaso, Neil C., Bojesen, Stig E., Amos, Christopher I., Shete, Sanjay, Liu, Geoffrey, Rennert, Gadi, Albanes, Demetrius, Aldrich, Melinda C., Tardon, Adonina, Chen, Chu, Triantafillos, Liloglou, Field, John K., Teare, Marion Dawn, Kiemeney, Lambertus A., Diergaarde, Brenda, Ferris, Robert L., Zienolddiny, Shanbeh, Lam, Stephen, Olshan, Andrew F., Weissler, Mark C., Lacko, Martin, Risch, Angela, Bickeböller, Heike, Ness, Andy R., Thomas, Steve, Le Marchand, Loic, Schabath, Matthew B., Wünsch-Filho, Victor, Tajara, Eloiza H., Andrew, Angeline S., Clifford, Gary M., Lazarus, Philip, Grankvist, Kjell, Johansson, Mikael, Arnold, Susanne, Melander, Olle, Brunnström, Hans, Boccia, Stefania, Cadoni, Gabriella, Timens, Wim, Obeidat, Ma’en, Xiao, Xiangjun, Houlston, Richard S., Hung, Rayjean J., Brennan, Paul
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Public Library of Science 05.03.2021 Public Library of Science (PLoS)
Predmet:	Alleles Association analysis Biology and Life Sciences Biomarkers, Tumor Breast Cancer and Oncology Cancer och onkologi Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Clinical Medicine Copy number Correlation analysis Datasets Deoxyribonucleic acid Digestive system cancer Digestive System Neoplasms - genetics Digestive System Neoplasms - metabolism Digestive System Neoplasms - pathology DNA DNA methylation Esophageal cancer Esophagus Gene expression Gene loci Genetic analysis Genetic aspects Genetic Loci Genetic Predisposition to Disease Genome-wide association studies Genome-Wide Association Study Genomes Genomic analysis Genotype Head & neck cancer Head and neck cancer Human papillomavirus Humans Klinisk medicin Larynx Lung cancer Lung carcinoma Medical and Health Sciences Medicin och hälsovetenskap Medicine and Health Sciences Meta-analysis Mutation Odds Ratio Ovarian cancer Pharynx Physical Sciences Prostate cancer Research and Analysis Methods Risk factors Signal Transduction Solid tumors Squamous cell carcinoma Tobacco smoking Tumors France
ISSN:	1553-7404, 1553-7390, 1553-7404
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