Prognostic Value of the Metabolic Response on Serial 18 F-FDG PET/CT in Pancreatic Cancer

The prognostic value of serial F-fluorodeoxyglucose positron emission tomography/ computed tomography ( F-FDG PET/CT) for patients with borderline resectable or locally advanced pancreatic cancer who undergo conversion surgery or continue chemotherapy without surgery has not been well-established. A...

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Veröffentlicht in:Gut and liver Jg. 19; H. 3; S. 462 - 472
Hauptverfasser: Ahn, Jinwoo, Song, Yoo Sung, Kim, Bomi, Yang, Soomin, Jung, Kwangrok, Lee, Jong-Chan, Kim, Jaihwan, Hwang, Jin-Hyeok
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Korea (South) 거트앤리버 소화기연관학회협의회 15.05.2025
Schlagworte:
Adult
Aged
Carcinoma, Pancreatic Ductal - diagnostic imaging
Carcinoma, Pancreatic Ductal - metabolism
Carcinoma, Pancreatic Ductal - mortality
Carcinoma, Pancreatic Ductal - therapy
Female
Fluorodeoxyglucose F18
Humans
Male
Middle Aged
Pancreatic Neoplasms - diagnostic imaging
Pancreatic Neoplasms - metabolism
Pancreatic Neoplasms - mortality
Pancreatic Neoplasms - pathology
Pancreatic Neoplasms - surgery
Pancreatic Neoplasms - therapy
Positron Emission Tomography Computed Tomography - methods
Prognosis
Radiopharmaceuticals
Retrospective Studies
내과학
Pancreatic neoplasms
Positron emission tomography computed tomography
Prognosis
ISSN:1976-2283, 2005-1212
Online-Zugang:Volltext
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Zusammenfassung:The prognostic value of serial F-fluorodeoxyglucose positron emission tomography/ computed tomography ( F-FDG PET/CT) for patients with borderline resectable or locally advanced pancreatic cancer who undergo conversion surgery or continue chemotherapy without surgery has not been well-established. A retrospective analysis of patients with pancreatic ductal adenocarcinoma was conducted at Seoul National University Bundang Hospital between March 2013 and February 2022. Patients underwent PET/CT at baseline and subsequent radiologic evaluations following chemotherapy. Changes in the maximum standardized uptake value (SUVmax), mean standardized uptake value (SUVmean), metabolic tumor volume, and total lesion glycolysis were analyzed. Based on their treatment regimens, patients were stratified into the conversion surgery group or nonconversion surgery group. Survival outcomes and various clinical factors were assessed. Among 121 patients, 52 underwent conversion surgery, and 69 continued to receive chemotherapy without surgery. A significant reduction in the SUVmax was correlated with prolonged recurrence-free survival and overall survival in the conversion surgery group. Confirmation of a pathologic response indicated a significant association between reductions in the SUVmax and positive outcomes. Reductions in the metabolic tumor volume and total lesion glycolysis were associated with improved progression-free survival and overall survival in the nonconversion surgery group. Serial PET/CT scans demonstrated prognostic value in pancreatic ductal adenocarcinoma patients, revealing distinct correlations in the conversion surgery group and nonconversion surgery group.
ISSN:1976-2283
2005-1212
DOI:10.5009/gnl240458