Significantly Reduced Genoprevalence of Vaccine-Type HPV-16/18 Infections among Vaccinated Compared to Non-Vaccinated Young Women 5.5 Years after a Bivalent HPV-16/18 Vaccine (Cervarix®) Pilot Project in Uganda

The objective of this study was to determine the prevalence and some predictors for vaccine and non-vaccine types of HPV infections among bivalent HPV vaccinated and non-vaccinated young women in Uganda. This was a comparative cross sectional study 5.5 years after a bivalent HPV 16/18 vaccination (C...

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Vydáno v:	PloS one Ročník 11; číslo 8; s. e0160099
Hlavní autoři:	Kumakech, Edward, Berggren, Vanja, Wabinga, Henry, Lillsunde-Larsson, Gabriella, Helenius, Gisela, Kaliff, Malin, Karlsson, Mats, Kirimunda, Samuel, Musubika, Caroline, Andersson, Sören
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Public Library of Science 02.08.2016 Public Library of Science (PLoS)
Témata:	Adolescent Biology and Life Sciences Body mass Care and treatment Causes of CD4 antigen CD8 antigen Clinical Laboratory Medicine Clinical Medicine Coinfection Comparative analysis Cross-Sectional Studies Female Genetic aspects Genotype Genotyping Girls Health aspects Health risks Health Sciences HIV Infections - epidemiology HIV Infections - microbiology Human immunodeficiency virus Human papillomavirus Human papillomavirus 16 Human papillomavirus 16 - drug effects Human papillomavirus 16 - genetics Human papillomavirus 16 - immunology Human papillomavirus 18 - drug effects Human papillomavirus 18 - genetics Human papillomavirus 18 - immunology Humans Hälsovetenskap Immunization Immunization Programs - organization & administration Infections Klinisk laboratoriemedicin Klinisk medicin Lentivirus Lymphocytes Mass Vaccination Medical and Health Sciences Medicin och hälsovetenskap Medicine and Health Sciences Papillomaviridae Papillomavirus infections Papillomavirus Infections - epidemiology Papillomavirus Infections - immunology Papillomavirus Infections - prevention & control Papillomavirus Vaccines - administration & dosage People and Places Pilot Projects Prevalence Retroviridae Risk analysis Risk factors Sexual partners Sexually transmitted diseases STD Strains (organisms) Syphilis Syphilis - epidemiology Syphilis - microbiology Treponema pallidum Uganda - epidemiology Urban areas Vaccination Vaccines Womens health Young Adult Uganda Sweden Belgium United Kingdom > UK Africa England Kampala Uganda Germany
ISSN:	1932-6203, 1932-6203
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Shrnutí:	The objective of this study was to determine the prevalence and some predictors for vaccine and non-vaccine types of HPV infections among bivalent HPV vaccinated and non-vaccinated young women in Uganda. This was a comparative cross sectional study 5.5 years after a bivalent HPV 16/18 vaccination (Cervarix®, GlaxoSmithKline, Belgium) pilot project in western Uganda. Cervical swabs were collected between July 2014-August 2014 and analyzed with a HPV genotyping test, CLART® HPV2 assay (Genomica, Madrid Spain) which is based on PCR followed by microarray for determination of genotype. Blood samples were also tested for HIV and syphilis infections as well as CD4 and CD8 lymphocyte levels. The age range of the participants was 15-24 years and mean age was 18.6(SD 1.4). Vaccine-type HPV-16/18 strains were significantly less prevalent among vaccinated women compared to non-vaccinated women (0.5% vs 5.6%, p 0.006, OR 95% CI 0.08(0.01-0.64). At type-specific level, significant difference was observed for HPV16 only. Other STIs (HIV/syphilis) were important risk factors for HPV infections including both vaccine types and non-vaccine types. In addition, for non-vaccine HPV types, living in an urban area, having a low BMI, low CD4 count and having had a high number of life time sexual partners were also significant risk factors. Our data concurs with the existing literature from other parts of the world regarding the effectiveness of bivalent HPV-16/18 vaccine in reducing the prevalence of HPV infections particularly vaccine HPV- 16/18 strains among vaccinated women. This study reinforces the recommendation to vaccinate young girls before sexual debut and integrate other STI particularly HIV and syphilis interventions into HPV vaccination packages.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Competing Interests: The authors have declared that no competing interests exist. Conceived and designed the experiments: EK VB SA HW GLL GH.Performed the experiments: EK GLL GH M. Kaliff M. Karlsson SK CM.Analyzed the data: EK SA GLL VB HW.Contributed reagents/materials/analysis tools: GLL GH M. Kaliff M. Karlsson SK CM HW.Wrote the paper: EK SA GLL VB SK CM HW.
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0160099