The trans-ancestral genomic architecture of glycemic traits

Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregated genome-wide association studies comprising up to 281,416 individuals without diabetes (30...

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Published in:	Nature genetics Vol. 53; no. 6; pp. 840 - 860
Main Authors:	Marenne, Gaëlle, Horikoshi, Momoko, Chu, Audrey Y., Hong, Jaeyoung, Hottenga, Jouke-Jan, Kaakinen, Marika A., Moreno-Macias, Hortensia, Nolte, Ilja M., Raulerson, Chelsea K., Chen, Brian H., Hai, Yang, He, Jing, Heianza, Yoriko, Huang, Tao, Huerta-Chagoya, Alicia, Jensen, Richard A., Lange, Leslie A., Langefeld, Carl D., Li, Man, Nag, Abhishek, Pistis, Giorgio, Raffield, Laura, Robertson, Neil R., Rueedi, Rico, Ryan, Kathleen, Saxena, Richa, van der Most, Peter J., Wang, Nan, Warren, Helen R., Wilsgaard, Tom, Wong, Andrew, Zafarmand, Mohammad Hadi, Baldassarre, Damiano, Beekman, Marian, Bergman, Richard N., Bornstein, Stefan R., Campbell, Archie, Chang, Yi Cheng, Eiriksdottir, Gudny, Han, Sohee, Hartman, Catharina A., Ichihara, Sahoko, Katsuya, Tomohiro, Khor, Chiea Chuen, Kolcic, Ivana, Kuulasmaa, Teemu, Lemaitre, Rozenn N., Lin, Shih-Yi, Linneberg, Allan, Matsuda, Fumihiko, Moon, Sanghoon, Ohyagi, Yasumasa, Qi, Qibin, Sandow, Kevin, Thuesen, Betina, van Dam, Rob M., Willems van Dijk, Ko, Adair, Linda S., Boehnke, Michael, Bønnelykke, Klaus, Boomsma, D. I., Buchanan, Thomas A., Chambers, John C., Chasman, Daniel I., Chen, Yii-Der Ida, Collins, Francis S., Cucca, Francesco, de Silva, H. Janaka, Ferrucci, Luigi, Florez, Jose C., Franks, Paul W., Grimsgaard, Sameline, Guo, Xiuqing, Huang, Wei, Kato, Norihiro, Koistinen, Heikki A., Kuh, Diana, Kumari, Meena, Launer, Lenore J., Mook-Kanamori, Dennis O., Pedersen, Oluf, Pramstaller, Peter P., Province, Michael A., Psaty, Bruce M., Rosendaal, Frits R., Shu, Xiao-ou, Tai, E. Shyong, Timpson, Nicholas J., Tusie, Teresa, Uusitupa, Matti, Vrijkotte, Tanja G. M., Wei, Wen B., Willemsen, Gonneke, Wong, Tien-Yin, Xiang, Anny H., Yokota, Mitsuhiro, Zeggini, Eleftheria, McCarthy, Mark I., Dupuis, Josée, Parker, Stephen C. J.
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.06.2021 Nature Publishing Group
Subjects:	45/43 631/208 692/699 African Americans Agriculture Alleles Animal Genetics and Genomics Biological effects Biomedical and Life Sciences Biomedicine Blood Glucose - genetics Cancer Research Clinical Medicine Demographic aspects Diabetes Diabetes mellitus (non-insulin dependent) Endocrinology and Diabetes Endokrinologi och diabetes Epigenesis, Genetic Equivalence Europeans Fasting Gene expression Gene Expression Profiling Gene Function Gene mapping Genetic aspects Genome, Human Genome-wide association studies Genome-Wide Association Study Genomes Genomics Glucose Glycated Hemoglobin - metabolism Glycemic index Health aspects Hemoglobin Heterogeneity Hispanic people Human Genetics Humans Insulin Insulin resistance Klinisk medicin Laboratory testing Life Sciences Medical and Health Sciences Medicin och hälsovetenskap Meta-analysis Multifactorial Inheritance - genetics Pathophysiology Physical Chromosome Mapping Quantitative Trait Loci - genetics Quantitative Trait, Heritable White People - genetics Europe
ISSN:	1061-4036, 1546-1718, 1546-1718
Online Access:	Get full text
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