Role of Brain-Derived Neurotrophic Factor in Beneficial Effects of Repetitive Transcranial Magnetic Stimulation for Upper Limb Hemiparesis after Stroke

Repetitive transcranial magnetic stimulation (rTMS) can improve upper limb hemiparesis after stroke but the mechanism underlying its efficacy remains elusive. rTMS seems to alter brain-derived neurotrophic factor (BDNF) and such effect is influenced by BDNF gene polymorphism. To investigate the mole...

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Vydáno v:PloS one Ročník 11; číslo 3; s. e0152241
Hlavní autoři: Niimi, Masachika, Hashimoto, Kenji, Kakuda, Wataru, Miyano, Satoshi, Momosaki, Ryo, Ishima, Tamaki, Abo, Masahiro
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Public Library of Science 23.03.2016
Public Library of Science (PLoS)
Témata:
Aged
Arm
Biology and Life Sciences
Biomarkers
Bipolar disorder
Brain
Brain research
Brain-derived neurotrophic factor
Brain-Derived Neurotrophic Factor - blood
Brain-Derived Neurotrophic Factor - genetics
Brain-Derived Neurotrophic Factor - physiology
Brain-Derived Neurotrophic Factor/blood/genetics/physiology
Care and treatment
Case-Control Studies
Complications and side effects
Female
Gelatinase B
Gene polymorphism
Health aspects
Hemiplegia
Human health sciences
Human subjects
Humans
Magnetic brain stimulation
Magnetic fields
Male
Matrix metalloproteinase
Matrix Metalloproteinase 9 - blood
Medicine
Medicine and Health Sciences
Mental depression
Mental health
Metalloproteinase
Middle Aged
Muscles
Neurologie
Neurology
Neurosciences
Paresis
Paresis - etiology
Paresis - physiopathology
Paresis - rehabilitation
Paresis - therapy
Paresis/etiology/physiopathology/rehabilitation/therapy
Patients
Physical Sciences
Polymorphism
Polymorphism, Genetic - genetics
Polymorphism, Genetic - physiology
Polymorphism, Genetic/genetics/physiology
Protein Precursors - blood
Rehabilitation
Research and Analysis Methods
Risk factors
Sciences de la santé humaine
Serum levels
Stroke
Stroke - complications
Studies
Therapy
Transcranial Direct Current Stimulation
Transcranial magnetic stimulation
ISSN:1932-6203, 1932-6203
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Shrnutí:Repetitive transcranial magnetic stimulation (rTMS) can improve upper limb hemiparesis after stroke but the mechanism underlying its efficacy remains elusive. rTMS seems to alter brain-derived neurotrophic factor (BDNF) and such effect is influenced by BDNF gene polymorphism. To investigate the molecular effects of rTMS on serum levels of BDNF, its precursor proBDNF and matrix metalloproteinase-9 (MMP-9) in poststroke patients with upper limb hemiparesis. Poststroke patients with upper limb hemiparesis were studied. Sixty-two patients underwent rehabilitation plus rTMS combination therapy and 33 patients underwent rehabilitation monotherapy without rTMS for 14 days at our hospital. One Hz rTMS was applied over the motor representation of the first dorsal interosseous muscle on the non-lesional hemisphere. Fugl-Meyer Assessment and Wolf Motor Function (WMFT) were used to evaluate motor function on the affected upper limb before and after intervention. Blood samples were collected for analysis of BDNF polymorphism and measurement of BDNF, proBDNF and MMP-9 levels. Two-week combination therapy increased BDNF and MMP-9 serum levels, but not serum proBDNF. Serum BDNF and MMP-9 levels did not correlate with motor function improvement, though baseline serum proBDNF levels correlated negatively and significantly with improvement in WMFT (ρ = -0.422, p = 0.002). The outcome of rTMS therapy was not altered by BDNF gene polymorphism. The combination therapy of rehabilitation plus low-frequency rTMS seems to improve motor function in the affected limb, by activating BDNF processing. BDNF and its precursor proBDNF could be potentially suitable biomarkers for poststroke motor recovery.
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scopus-id:2-s2.0-84962032564
Conceived and designed the experiments: MN KH MA. Performed the experiments: MN SM TI. Analyzed the data: MN KH RM. Contributed reagents/materials/analysis tools: MN RM. Wrote the paper: MN KH WK RM.
Competing Interests: The authors have declared that no competing interests exist.
These authors also contributed equally to this work.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0152241