Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics

Angiotensin-converting enzyme 2 (ACE2) and accessory proteases (TMPRSS2 and CTSL) are needed for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cellular entry, and their expression may shed light on viral tropism and impact across the body. We assessed the cell-type-specific expression...

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Bibliographic Details
Published in:	Nature medicine Vol. 27; no. 3; pp. 546 - 559
Main Authors:	Luecken, Malte D., Sikkema, Lisa, Waghray, Avinash, Heimberg, Graham, Kobayashi, Yoshihiko, Vaishnav, Eeshit Dhaval, Subramanian, Ayshwarya, Smillie, Christopher, Jagadeesh, Karthik A., Duong, Elizabeth Thu, Torlai Triglia, Elena, Ansari, Meshal, Cai, Peiwen, Lin, Brian, Chen, Sijia, Shu, Jian, Haber, Adam L., Chung, Hattie, Montoro, Daniel T., Adams, Taylor, Aliee, Hananeh, Andrusivova, Zaneta, Angelidis, Ilias, Ashenberg, Orr, Bassler, Kevin, Bécavin, Christophe, Benhar, Inbal, Bergenstråhle, Joseph, Bergenstråhle, Ludvig, Braun, Emelie, Bui, Linh T., Chaffin, Mark, Chichelnitskiy, Evgeny, Chiou, Joshua, Conlon, Thomas M., Cuoco, Michael S., Cuomo, Anna S. E., Deprez, Marie, Duclos, Grant, Fischer, David S., Ghazanfar, Shila, Gillich, Astrid, Giotti, Bruno, Gould, Joshua, Guo, Minzhe, Gutierrez, Austin J., Habermann, Arun C., Harvey, Tyler, He, Peng, Hou, Xiaomeng, Hu, Yan, Jaiswal, Alok, Ji, Lu, Jiang, Peiyong, Kapellos, Theodoros S., Kuo, Christin S., Leney-Greene, Michael A., Lim, Kyungtae, Litviňuková, Monika, Ludwig, Leif S., Lukassen, Soeren, Luo, Wendy, Maatz, Henrike, Madissoon, Elo, Mamanova, Lira, Manakongtreecheep, Kasidet, Leroy, Sylvie, Mayr, Christoph H., McAdams, Alexi M., Nabhan, Ahmad N., Nyquist, Sarah K., Penland, Lolita, Poirion, Olivier B., Poli, Sergio, Qi, CanCan, Queen, Rachel, Reichart, Daniel, Rosas, Ivan, Schupp, Jonas C., Shea, Conor V., Shi, Xingyi, Sinha, Rahul, Slowikowski, Kamil, Smith, Neal P., Sountoulidis, Alex, Strunz, Maximilian, Sullivan, Travis B., Sun, Dawei, Talavera-López, Carlos, Tan, Peng, Tantivit, Jessica, Travaglini, Kyle J., Tucker, Nathan R., Vernon, Katherine A., Wadsworth, Marc H., Waldman, Julia, Wang, Xiuting, Yan, Wenjun, Zhao, William, Ziegler, Carly G. K.
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.03.2021 Nature Publishing Group
Subjects:	631/114 631/250 631/326/596/4130 631/337/2019 692/699/255/2514 ACE2 Adult Age Aged Aged, 80 and over Alveolar Epithelial Cells - metabolism Alveolar Epithelial Cells - virology Alveoli Analysis Angiotensin Angiotensin-converting enzyme 2 Angiotensin-Converting Enzyme 2 - genetics Angiotensin-Converting Enzyme 2 - metabolism Biomedical and Life Sciences Biomedicine Cancer Research Cathepsin L - genetics Cathepsin L - metabolism Coronaviridae Coronaviruses COVID-19 COVID-19 - epidemiology COVID-19 - genetics COVID-19 - pathology COVID-19 - virology Crosstalk Cytokines Datasets as Topic - statistics & numerical data Demographic aspects Demographics Demography Disease transmission Epidemics Epithelial cells Female Gene expression Gene Expression Profiling - statistics & numerical data Gene sequencing Genes Genetic aspects Host-Pathogen Interactions - genetics Human tissues Humans Infectious Diseases Interleukin 1 Interleukin 6 Lung - metabolism Lung - virology Lungs Macrophages Male Meta-analysis Metabolic Diseases Middle Aged Molecular Medicine Neurosciences Organ Specificity - genetics Organs Parenchyma Pathogenesis Peptidyl-dipeptidase A Quorum sensing Respiration Respiratory diseases Respiratory System - metabolism Respiratory System - virology Respiratory tract Ribonucleic acid RNA SARS-CoV-2 - physiology Sequence Analysis, RNA - methods Sequence Analysis, RNA - statistics & numerical data Serine Endopeptidases - genetics Serine Endopeptidases - metabolism Severe acute respiratory syndrome coronavirus 2 Sex Single-Cell Analysis - methods Single-Cell Analysis - statistics & numerical data Smoking Transcriptomics Tropism United States Viral diseases Virus Internalization United States
ISSN:	1078-8956, 1546-170X, 1546-170X
Online Access:	Get full text
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