Prostaglandin-dependent modulation of dopaminergic neurotransmission elicits inflammation-induced aversion in mice

Systemic inflammation causes malaise and general feelings of discomfort. This fundamental aspect of the sickness response reduces the quality of life for people suffering from chronic inflammatory diseases and is a nuisance during mild infections like common colds or the flu. To investigate how infl...

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Bibliographic Details
Published in:	The Journal of clinical investigation Vol. 126; no. 2; pp. 695 - 705
Main Authors:	Fritz, Michael, Klawonn, Anna M., Nilsson, Anna, Singh, Anand Kumar, Zajdel, Joanna, Björk Wilhelms, Daniel, Lazarus, Michael, Löfberg, Andreas, Jaarola, Maarit, Örtegren Kugelberg, Unn, Billiar, Timothy R., Hackam, David J., Sodhi, Chhinder P., Breyer, Matthew D., Jakobsson, Johan, Schwaninger, Markus, Schütz, Günther, Rodriguez Parkitna, Jan, Saper, Clifford B., Blomqvist, Anders, Engblom, David
Format:	Journal Article
Language:	English
Published:	United States American Society for Clinical Investigation 01.02.2016
Subjects:	Animals Basic Medicine Biomedical research Brain - metabolism Brain - pathology Brain Diseases - genetics Brain Diseases - metabolism Brain Diseases - pathology Brain research Cell Line Councils Cyclooxygenase 1 - genetics Cyclooxygenase 1 - metabolism Dinoprostone - genetics Dinoprostone - metabolism Dopaminergic mechanisms Dopaminergic Neurons - metabolism Dopaminergic Neurons - pathology Endothelium Endothelium, Vascular - metabolism Endothelium, Vascular - pathology Experiments Health aspects Inflammation Inflammation - genetics Inflammation - metabolism Inflammation - pathology Medical and Health Sciences Medicin och hälsovetenskap Medicinska och farmaceutiska grundvetenskaper Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Knockout Neural transmission Neurosciences Neurovetenskaper Physiological aspects Properties Prostaglandins Receptors, Dopamine D1 - genetics Receptors, Dopamine D1 - metabolism Rodents Social research Synaptic Transmission
ISSN:	0021-9738, 1558-8238, 1558-8238
Online Access:	Get full text
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