Selective mitochondrial DNA degradation following double-strand breaks
Mitochondrial DNA (mtDNA) can undergo double-strand breaks (DSBs), caused by defective replication, or by various endogenous or exogenous sources, such as reactive oxygen species, chemotherapeutic agents or ionizing radiations. MtDNA encodes for proteins involved in ATP production, and maintenance o...
Gespeichert in:
| Veröffentlicht in: | PloS one Jg. 12; H. 4; S. e0176795 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
United States
Public Library of Science
28.04.2017
Public Library of Science (PLoS) |
| Schlagworte: | |
| ISSN: | 1932-6203, 1932-6203 |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Abstract | Mitochondrial DNA (mtDNA) can undergo double-strand breaks (DSBs), caused by defective replication, or by various endogenous or exogenous sources, such as reactive oxygen species, chemotherapeutic agents or ionizing radiations. MtDNA encodes for proteins involved in ATP production, and maintenance of genome integrity following DSBs is thus of crucial importance. However, the mechanisms involved in mtDNA maintenance after DSBs remain unknown. In this study, we investigated the consequences of the production of mtDNA DSBs using a human inducible cell system expressing the restriction enzyme PstI targeted to mitochondria. Using this system, we could not find any support for DSB repair of mtDNA. Instead we observed a loss of the damaged mtDNA molecules and a severe decrease in mtDNA content. We demonstrate that none of the known mitochondrial nucleases are involved in the mtDNA degradation and that the DNA loss is not due to autophagy, mitophagy or apoptosis. Our study suggests that a still uncharacterized pathway for the targeted degradation of damaged mtDNA in a mitophagy/autophagy-independent manner is present in mitochondria, and might provide the main mechanism used by the cells to deal with DSBs. |
|---|---|
| AbstractList | Mitochondrial DNA (mtDNA) can undergo double-strand breaks (DSBs), caused by defective replication, or by various endogenous or exogenous sources, such as reactive oxygen species, chemotherapeutic agents or ionizing radiations. MtDNA encodes for proteins involved in ATP production, and maintenance of genome integrity following DSBs is thus of crucial importance. However, the mechanisms involved in mtDNA maintenance after DSBs remain unknown. In this study, we investigated the consequences of the production of mtDNA DSBs using a human inducible cell system expressing the restriction enzyme PstI targeted to mitochondria. Using this system, we could not find any support for DSB repair of mtDNA. Instead we observed a loss of the damaged mtDNA molecules and a severe decrease in mtDNA content. We demonstrate that none of the known mitochondrial nucle-ases are involved in the mtDNA degradation and that the DNA loss is not due to autophagy, mitophagy or apoptosis. Our study suggests that a still uncharacterized pathway for the targeted degradation of damaged mtDNA in a mitophagy/autophagy-independent manner is present in mitochondria, and might provide the main mechanism used by the cells to deal with DSBs. Mitochondrial DNA (mtDNA) can undergo double-strand breaks (DSBs), caused by defective replication, or by various endogenous or exogenous sources, such as reactive oxygen species, chemotherapeutic agents or ionizing radiations. MtDNA encodes for proteins involved in ATP production, and maintenance of genome integrity following DSBs is thus of crucial importance. However, the mechanisms involved in mtDNA maintenance after DSBs remain unknown. In this study, we investigated the consequences of the production of mtDNA DSBs using a human inducible cell system expressing the restriction enzyme PstI targeted to mitochondria. Using this system, we could not find any support for DSB repair of mtDNA. Instead we observed a loss of the damaged mtDNA molecules and a severe decrease in mtDNA content. We demonstrate that none of the known mitochondrial nucleases are involved in the mtDNA degradation and that the DNA loss is not due to autophagy, mitophagy or apoptosis. Our study suggests that a still uncharacterized pathway for the targeted degradation of damaged mtDNA in a mitophagy/autophagy-independent manner is present in mitochondria, and might provide the main mechanism used by the cells to deal with DSBs. Mitochondrial DNA (mtDNA) can undergo double-strand breaks (DSBs), caused by defective replication, or by various endogenous or exogenous sources, such as reactive oxygen species, chemotherapeutic agents or ionizing radiations. MtDNA encodes for proteins involved in ATP production, and maintenance of genome integrity following DSBs is thus of crucial importance. However, the mechanisms involved in mtDNA maintenance after DSBs remain unknown. In this study, we investigated the consequences of the production of mtDNA DSBs using a human inducible cell system expressing the restriction enzyme PstI targeted to mitochondria. Using this system, we could not find any support for DSB repair of mtDNA. Instead we observed a loss of the damaged mtDNA molecules and a severe decrease in mtDNA content. We demonstrate that none of the known mitochondrial nucleases are involved in the mtDNA degradation and that the DNA loss is not due to autophagy, mitophagy or apoptosis. Our study suggests that a still uncharacterized pathway for the targeted degradation of damaged mtDNA in a mitophagy/autophagy-independent manner is present in mitochondria, and might provide the main mechanism used by the cells to deal with DSBs.Mitochondrial DNA (mtDNA) can undergo double-strand breaks (DSBs), caused by defective replication, or by various endogenous or exogenous sources, such as reactive oxygen species, chemotherapeutic agents or ionizing radiations. MtDNA encodes for proteins involved in ATP production, and maintenance of genome integrity following DSBs is thus of crucial importance. However, the mechanisms involved in mtDNA maintenance after DSBs remain unknown. In this study, we investigated the consequences of the production of mtDNA DSBs using a human inducible cell system expressing the restriction enzyme PstI targeted to mitochondria. Using this system, we could not find any support for DSB repair of mtDNA. Instead we observed a loss of the damaged mtDNA molecules and a severe decrease in mtDNA content. We demonstrate that none of the known mitochondrial nucleases are involved in the mtDNA degradation and that the DNA loss is not due to autophagy, mitophagy or apoptosis. Our study suggests that a still uncharacterized pathway for the targeted degradation of damaged mtDNA in a mitophagy/autophagy-independent manner is present in mitochondria, and might provide the main mechanism used by the cells to deal with DSBs. |
| Audience | Academic |
| Author | Macao, Bertil Farge, Géraldine Ishak, Layal Lachaume, Philippe Falkenberg, Maria Moretton, Amandine Lefebvre, Mathilde Morel, Frédéric Vernet, Patrick Garreau-Balandier, Isabelle |
| AuthorAffiliation | 1 Université Clermont Auvergne, CNRS/IN2P3, Laboratoire de Physique de Clermont, BP 10448, F-63000 Clermont-Ferrand, France 2 Institute of Biomedicine, University of Gothenburg, P.O. Box 440, SE-405 30, Gothenburg, Sweden Instituto de Biologia Molecular de Barcelona, SPAIN |
| AuthorAffiliation_xml | – name: 1 Université Clermont Auvergne, CNRS/IN2P3, Laboratoire de Physique de Clermont, BP 10448, F-63000 Clermont-Ferrand, France – name: 2 Institute of Biomedicine, University of Gothenburg, P.O. Box 440, SE-405 30, Gothenburg, Sweden – name: Instituto de Biologia Molecular de Barcelona, SPAIN |
| Author_xml | – sequence: 1 givenname: Amandine surname: Moretton fullname: Moretton, Amandine – sequence: 2 givenname: Frédéric surname: Morel fullname: Morel, Frédéric – sequence: 3 givenname: Bertil surname: Macao fullname: Macao, Bertil – sequence: 4 givenname: Philippe surname: Lachaume fullname: Lachaume, Philippe – sequence: 5 givenname: Layal surname: Ishak fullname: Ishak, Layal – sequence: 6 givenname: Mathilde surname: Lefebvre fullname: Lefebvre, Mathilde – sequence: 7 givenname: Isabelle surname: Garreau-Balandier fullname: Garreau-Balandier, Isabelle – sequence: 8 givenname: Patrick surname: Vernet fullname: Vernet, Patrick – sequence: 9 givenname: Maria surname: Falkenberg fullname: Falkenberg, Maria – sequence: 10 givenname: Géraldine orcidid: 0000-0003-1054-4274 surname: Farge fullname: Farge, Géraldine |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28453550$$D View this record in MEDLINE/PubMed https://hal.science/hal-01693945$$DView record in HAL https://gup.ub.gu.se/publication/254683$$DView record from Swedish Publication Index (Göteborgs universitet) |
| BookMark | eNqNk1uP0zAQhSO0iL3AP0BQCQmxDy12fEt4QKoWlq1UsRILvFqOPUld3LjESRf-Pe4NNdUKoTwkmnznZObEc56c1L6GJHmO0QgTgd_OfdfUyo2WsTxCWHCRs0fJGc5JOuQpIicHz6fJeQhzhBjJOH-SnKYZZYQxdJZc34ED3doVDBa29Xrma9NY5QYfPo8HBqpGGdVaXw9K75y_t3U1ML4rHAxD26jaDIoG1I_wNHlcKhfg2e5-kXy7_vj16mY4vf00uRpPhzojqB0aIwzmRcawVsALzFWax66ERikFHidAQpuSalQgw7HCCEqMaVQgI4qSKnKRvNz6Lp0PchdBkDjL01xgTrNITLaE8Woul41dqOa39MrKTcE3lVRNa7UDCQwgJaWOoQAVXBVpqVTJ8qJIC54xFL2GW69wD8uu6LlV3VLGUtXJADJllGck8u933XXFAoyGOmbkerL-m9rOZOVXklEUR0-jweXWYHYkuxlP5bqGMM9JTtkKR_bN7mON_9lBaOXCBg3OqRp8t8mEMCoEERF9dYQ-nNyOqlQMx9aljz3qtakc05wIzlDOIjV6gIqXgYXV8SyWNtZ7gsueIDIt_Gor1YUgJ3df_p-9_d5nXx-wM1CunQXvuvVpDX3wxeFf-Zvrfgki8G4L6MaH0EAptW03pz6OZp3ESK43bh-aXG-c3G1cFNMj8d7_n7I_nEQu5A |
| CitedBy_id | crossref_primary_10_1002_2017GH000125 crossref_primary_10_1016_j_bbabio_2022_148554 crossref_primary_10_1083_jcb_202006043 crossref_primary_10_1038_s41434_023_00434_w crossref_primary_10_1242_jcs_248468 crossref_primary_10_3390_antiox10121885 crossref_primary_10_1038_s42255_023_00932_6 crossref_primary_10_1016_j_jgg_2017_11_008 crossref_primary_10_1038_s41392_024_02081_y crossref_primary_10_1038_s41598_025_03671_8 crossref_primary_10_3390_biomedicines10020428 crossref_primary_10_1093_nar_gkaa804 crossref_primary_10_1002_mef2_25 crossref_primary_10_1016_j_tig_2019_01_001 crossref_primary_10_1038_s43586_023_00200_7 crossref_primary_10_1002_iub_1919 crossref_primary_10_1042_BSR20211320 crossref_primary_10_3390_ijms231911391 crossref_primary_10_17816_dent632937 crossref_primary_10_1016_j_addr_2024_115355 crossref_primary_10_1007_s10439_022_03051_7 crossref_primary_10_1042_BCJ20230262 crossref_primary_10_1016_j_arr_2025_102892 crossref_primary_10_3390_genes13050879 crossref_primary_10_1038_d41586_020_01974_6 crossref_primary_10_3390_ijms21041196 crossref_primary_10_1016_j_tig_2017_11_001 crossref_primary_10_1016_j_yexcr_2022_113233 crossref_primary_10_3390_ijms25021015 crossref_primary_10_1016_j_mrfmmm_2018_01_005 crossref_primary_10_1083_jcb_201801168 crossref_primary_10_1093_nar_gkad208 crossref_primary_10_1038_s41586_021_03269_w crossref_primary_10_1186_s12967_022_03685_0 crossref_primary_10_1038_s41467_024_53806_0 crossref_primary_10_1007_s40572_021_00329_1 crossref_primary_10_1002_em_22449 crossref_primary_10_1001_jamanetworkopen_2023_26885 crossref_primary_10_1016_j_biochi_2024_10_013 crossref_primary_10_1038_s41467_018_04131_w crossref_primary_10_1093_genetics_iyae070 crossref_primary_10_1093_humupd_dmab046 crossref_primary_10_1016_j_bbamcr_2022_119233 crossref_primary_10_1093_nar_gky456 crossref_primary_10_3390_ijms241914752 crossref_primary_10_1016_j_tig_2020_08_001 crossref_primary_10_1016_j_trsl_2018_07_013 crossref_primary_10_1016_j_molmed_2020_02_006 crossref_primary_10_1016_j_fct_2019_110916 crossref_primary_10_3390_genes12101604 crossref_primary_10_3390_ijms22147369 crossref_primary_10_3389_fgene_2021_627050 crossref_primary_10_1093_nar_gkae186 crossref_primary_10_3390_ijms23031467 crossref_primary_10_1002_iub_2434 crossref_primary_10_1093_hmg_ddae048 crossref_primary_10_1080_24701394_2018_1472773 crossref_primary_10_3390_pharmaceutics12111083 crossref_primary_10_1038_s41598_018_23690_y crossref_primary_10_1038_s41467_018_04895_1 crossref_primary_10_1016_j_transci_2025_104203 crossref_primary_10_1007_s10517_025_06370_6 crossref_primary_10_1016_j_mito_2018_07_005 crossref_primary_10_1007_s43152_023_00048_9 crossref_primary_10_1002_em_70013 crossref_primary_10_3390_life11030232 crossref_primary_10_1016_j_freeradbiomed_2018_06_041 crossref_primary_10_1016_j_molcel_2023_09_026 crossref_primary_10_3390_cells13060473 crossref_primary_10_1016_j_jbc_2024_107128 crossref_primary_10_1093_nar_gkac690 crossref_primary_10_1146_annurev_biochem_052621_092014 crossref_primary_10_1007_s10555_018_9772_7 crossref_primary_10_3390_pharmaceutics15020570 crossref_primary_10_1002_jimd_12324 crossref_primary_10_1089_ars_2021_0091 crossref_primary_10_1002_cbic_202400935 crossref_primary_10_1038_s41581_020_00369_0 crossref_primary_10_3390_ijms241612715 crossref_primary_10_1016_j_dnarep_2021_103134 crossref_primary_10_1038_s42003_019_0326_5 crossref_primary_10_1016_j_cell_2025_02_009 crossref_primary_10_3390_biom12111630 crossref_primary_10_1007_s13238_017_0499_y crossref_primary_10_1016_j_stem_2022_09_008 crossref_primary_10_1073_pnas_1911252116 crossref_primary_10_3390_life11020076 crossref_primary_10_1016_j_jcyt_2023_10_004 crossref_primary_10_3389_fcell_2022_984245 crossref_primary_10_3390_genes9040175 |
| Cites_doi | 10.3109/19401736.2014.905829 10.2741/4375 10.1074/jbc.M110.215715 10.1128/JVI.02306-13 10.1016/j.mito.2014.03.007 10.1038/ng.f.94 10.1093/nar/28.19.3793 10.1093/nar/gku1032 10.1016/j.molcel.2016.12.014 10.1016/j.ab.2004.07.011 10.1091/mbc.E15-05-0260 10.1128/MCB.24.22.9823-9834.2004 10.1371/journal.pgen.1005664 10.1089/ars.2013.5432 10.1093/hmg/ddi082 10.1038/gt.2008.11 10.1016/j.bbrc.2013.06.048 10.1007/s10495-005-0410-9 10.1016/j.dnarep.2015.07.003 10.1038/nchembio.2102 10.1098/rstb.2013.0442 10.1093/hmg/ddu336 10.1101/cshperspect.a012641 10.1093/nar/gkp348 10.1093/hmg/ddh109 10.1093/nar/gkw931 10.1093/nar/gkn124 10.1073/pnas.0603445103 10.1128/MCB.00457-08 10.1002/pros.23126 10.1038/nrm3439 10.1016/j.molcel.2008.09.024 10.1093/nar/gkt029 10.1016/j.bbagen.2013.10.040 10.1186/s13062-015-0057-6 10.1089/dna.2014.2772 10.1080/15548627.2016.1226734 10.1016/j.dnarep.2013.04.023 10.1038/ng.2501 10.1073/pnas.0914569107 10.1038/emm.2014.122 10.1007/s00335-016-9651-x 10.1038/nrg3275 10.1083/jcb.200809125 10.1093/hmg/10.26.3093 10.1093/brain/aww081 10.1093/nar/gks532 10.1074/jbc.M211730200 10.1016/j.mrfmmm.2007.07.007 10.1016/j.dnarep.2012.06.002 |
| ContentType | Journal Article |
| Copyright | COPYRIGHT 2017 Public Library of Science 2017 Moretton et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Distributed under a Creative Commons Attribution 4.0 International License 2017 Moretton et al 2017 Moretton et al |
| Copyright_xml | – notice: COPYRIGHT 2017 Public Library of Science – notice: 2017 Moretton et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: Distributed under a Creative Commons Attribution 4.0 International License – notice: 2017 Moretton et al 2017 Moretton et al |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM IOV ISR 3V. 7QG 7QL 7QO 7RV 7SN 7SS 7T5 7TG 7TM 7U9 7X2 7X7 7XB 88E 8AO 8C1 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABJCF ABUWG AEUYN AFKRA ARAPS ATCPS AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU D1I DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. KB. KB0 KL. L6V LK8 M0K M0S M1P M7N M7P M7S NAPCQ P5Z P62 P64 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS PTHSS PYCSY RC3 7X8 1XC VOOES 5PM ADTPV AOWAS F1U DOA |
| DOI | 10.1371/journal.pone.0176795 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Gale In Context: Opposing Viewpoints Gale In Context: Science ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Biotechnology Research Abstracts ProQuest Nursing and Allied Health Journals - PSU access expires 11/30/25. Ecology Abstracts Entomology Abstracts (Full archive) Immunology Abstracts Meteorological & Geoastrophysical Abstracts Nucleic Acids Abstracts Virology and AIDS Abstracts Agricultural Science Collection ProQuest Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Materials Science & Engineering Collection ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland Advanced Technologies & Computer Science Collection Agricultural & Environmental Science Collection ProQuest Central Essentials Biological Science Collection ProQuest Central Technology collection Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Materials Science Collection ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Materials Science Database Nursing & Allied Health Database (Alumni Edition) Meteorological & Geoastrophysical Abstracts - Academic ProQuest Engineering Collection Biological Sciences Agricultural Science Database ProQuest Health & Medical Collection Medical Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Engineering Database Nursing & Allied Health Premium Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Environmental Science Database Materials Science Collection ProQuest Central Premium ProQuest One Academic Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China Engineering Collection Environmental Science Collection Genetics Abstracts MEDLINE - Academic Hyper Article en Ligne (HAL) Hyper Article en Ligne (HAL) (Open Access) PubMed Central (Full Participant titles) SwePub SwePub Articles SWEPUB Göteborgs universitet DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Agricultural Science Database Publicly Available Content Database ProQuest Central Student ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Meteorological & Geoastrophysical Abstracts Natural Science Collection Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) Engineering Collection Advanced Technologies & Aerospace Collection Engineering Database Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Agricultural Science Collection ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Meteorological & Geoastrophysical Abstracts - Academic ProQuest One Academic (New) Technology Collection Technology Research Database ProQuest One Academic Middle East (New) Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts ProQuest Engineering Collection Biotechnology Research Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts Materials Science Database ProQuest Materials Science Collection ProQuest Public Health ProQuest Nursing & Allied Health Source ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library Animal Behavior Abstracts Materials Science & Engineering Collection Immunology Abstracts ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | Agricultural Science Database MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Sciences (General) |
| DocumentTitleAlternate | Selective mtDNA degradation following double-strand breaks |
| EISSN | 1932-6203 |
| ExternalDocumentID | 1892971648 oai_doaj_org_article_e5ee23fc386e476ab2faaf59bb2b6850 oai_gup_ub_gu_se_254683 PMC5409072 oai:HAL:hal-01693945v1 A493765095 28453550 10_1371_journal_pone_0176795 |
| Genre | Journal Article |
| GrantInformation_xml | – fundername: ; – fundername: ; grantid: ANR-11-LABX-0063 – fundername: ; grantid: 2013-3621 – fundername: ; grantid: CAN 2016/816 |
| GroupedDBID | --- 123 29O 2WC 53G 5VS 7RV 7X2 7X7 7XC 88E 8AO 8C1 8CJ 8FE 8FG 8FH 8FI 8FJ A8Z AAFWJ AAUCC AAWOE AAYXX ABDBF ABIVO ABJCF ABUWG ACCTH ACGFO ACIHN ACIWK ACPRK ACUHS ADBBV ADRAZ AEAQA AENEX AEUYN AFFHD AFKRA AFPKN AFRAH AHMBA ALMA_UNASSIGNED_HOLDINGS AOIJS APEBS ARAPS ATCPS BAIFH BAWUL BBNVY BBTPI BCNDV BENPR BGLVJ BHPHI BKEYQ BPHCQ BVXVI BWKFM CCPQU CITATION CS3 D1I D1J D1K DIK DU5 E3Z EAP EAS EBD EMOBN ESX EX3 F5P FPL FYUFA GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE IAO IEA IGS IHR IHW INH INR IOV IPY ISE ISR ITC K6- KB. KQ8 L6V LK5 LK8 M0K M1P M48 M7P M7R M7S M~E NAPCQ O5R O5S OK1 OVT P2P P62 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PPXIY PQGLB PQQKQ PROAC PSQYO PTHSS PV9 PYCSY RNS RPM RZL SV3 TR2 UKHRP WOQ WOW ~02 ~KM 3V. ALIPV BBORY CGR CUY CVF ECM EIF IPNFZ NPM RIG 7QG 7QL 7QO 7SN 7SS 7T5 7TG 7TM 7U9 7XB 8FD 8FK AZQEC C1K DWQXO ESTFP FR3 GNUQQ H94 K9. KL. M7N P64 PKEHL PQEST PQUKI PRINS RC3 7X8 PUEGO 1XC VOOES 5PM ADTPV AOWAS F1U - 02 AAPBV ABPTK ADACO BBAFP KM |
| ID | FETCH-LOGICAL-c830t-dd7d16b851cae6b16a290057c024e667907cdf4c0b0d61a10ef11416b0d7bf4a3 |
| IEDL.DBID | DOA |
| ISICitedReferencesCount | 108 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000400383900057&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1932-6203 |
| IngestDate | Fri Nov 26 17:12:38 EST 2021 Tue Oct 14 19:06:55 EDT 2025 Tue Nov 04 16:26:22 EST 2025 Tue Nov 04 02:01:03 EST 2025 Tue Oct 14 20:25:37 EDT 2025 Fri Sep 05 14:15:01 EDT 2025 Tue Oct 07 07:38:41 EDT 2025 Sat Nov 29 13:00:06 EST 2025 Sat Nov 29 09:53:20 EST 2025 Wed Nov 26 09:51:38 EST 2025 Wed Nov 26 09:24:12 EST 2025 Thu May 22 21:19:25 EDT 2025 Wed Feb 19 02:32:32 EST 2025 Tue Nov 18 22:17:47 EST 2025 Sat Nov 29 03:25:49 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 4 |
| Keywords | Autophagic cell death Nucleases DNA replication Mitochondria Small interfering RNAs Mitochondrial DNA DNA repair Apoptosis |
| Language | English |
| License | Distributed under a Creative Commons Attribution 4.0 International License: http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Creative Commons Attribution License |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c830t-dd7d16b851cae6b16a290057c024e667907cdf4c0b0d61a10ef11416b0d7bf4a3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Competing Interests: The authors have declared that no competing interests exist. Conceptualization: FM PL PV MF GF.Data curation: GF.Formal analysis: AM.Funding acquisition: GF PV.Investigation: AM FM BM LI ML IGB GF.Methodology: AM GF.Project administration: GF.Resources: PV MF.Supervision: GF.Validation: GF FM.Visualization: AM GF.Writing – original draft: AM GF.Writing – review & editing: FM PV MF PL BM. |
| ORCID | 0000-0003-1054-4274 |
| OpenAccessLink | https://doaj.org/article/e5ee23fc386e476ab2faaf59bb2b6850 |
| PMID | 28453550 |
| PQID | 1892971648 |
| PQPubID | 1436336 |
| PageCount | e0176795 |
| ParticipantIDs | plos_journals_1892971648 doaj_primary_oai_doaj_org_article_e5ee23fc386e476ab2faaf59bb2b6850 swepub_primary_oai_gup_ub_gu_se_254683 pubmedcentral_primary_oai_pubmedcentral_nih_gov_5409072 hal_primary_oai_HAL_hal_01693945v1 proquest_miscellaneous_1893547737 proquest_journals_1892971648 gale_infotracmisc_A493765095 gale_infotracacademiconefile_A493765095 gale_incontextgauss_ISR_A493765095 gale_incontextgauss_IOV_A493765095 gale_healthsolutions_A493765095 pubmed_primary_28453550 crossref_citationtrail_10_1371_journal_pone_0176795 crossref_primary_10_1371_journal_pone_0176795 |
| PublicationCentury | 2000 |
| PublicationDate | 2017-04-28 |
| PublicationDateYYYYMMDD | 2017-04-28 |
| PublicationDate_xml | – month: 04 year: 2017 text: 2017-04-28 day: 28 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: San Francisco – name: San Francisco, CA USA |
| PublicationTitle | PloS one |
| PublicationTitleAlternate | PLoS One |
| PublicationYear | 2017 |
| Publisher | Public Library of Science Public Library of Science (PLoS) |
| Publisher_xml | – name: Public Library of Science – name: Public Library of Science (PLoS) |
| References | IN Shokolenko (ref17) 2013; 12 Y Chen (ref28) 2014; 21 S Wisnovsky (ref10) 2016; 12 D Narendra (ref42) 2008; 183 C Kornblum (ref55) 2013; 45 M Alexeyev (ref45) 2008; 15 BV Houten (ref29) 2016; 21 G Coffey (ref11) 2000; 28 ML Meyer-Ficca (ref43) 2004; 334 TJ Nicholls (ref24) 2014; 23 M Jazayeri (ref50) 2003; 278 AS Bess (ref47) 2012; 40 A Kukat (ref32) 2008; 36 L Zheng (ref26) 2008; 32 JL Lin (ref53) 2016 DF Suen (ref48) 2010; 107 L Milani (ref5) 2015; 10 PA Gammage (ref35) 2016 L Kazak (ref12) 2012; 13 AM Furda (ref16) 2012; 11 IN Shokolenko (ref18) 2014; 27 KJ Krishnan (ref15) 2008; 40 T Kanki (ref37) 2004; 24 SR Bacman (ref30) 2014 DD Zhdanov (ref21) 2015; 34 H Nightingale (ref34) 2016; 139 RJ Szczesny (ref25) 2013; 41 P Liu (ref27) 2008; 28 S Srivastava (ref36) 2005; 14 KJ Huang (ref52) 2006; 103 AW Tann (ref20) 2011; 286 JP Uhler (ref23) 2015; 34 M Kalinowska (ref51) 2005; 10 JP McCrow (ref2) 2015; 76 MY Cha (ref3) 2015; 47 KB Busch (ref39) 2014; 369 S Srivastava (ref31) 2001; 10 EA Schon (ref33) 2012; 13 F Bruni (ref19) 2016 A Stein (ref8) 2015; 11 F Morel (ref9) 2008; 637 A Herbst (ref4) 2016 AF Phillips (ref44) 2017; 65 M Tanaka (ref46) 2002; 9 MI Ekstrand (ref38) 2004; 13 TJ Chen (ref41) 2013; 437 SK Tadi (ref14) 2015; 27 AB Robertson (ref22) 2014; 42 A Malena (ref49) 2016; 12 C Liang (ref1) 2014; 1840 M Muftuoglu (ref7) 2014; 17 BA Duguay (ref54) 2013; 87 M Alexeyev (ref6) 2013; 5 A Diot (ref40) 2016; 27 SR Bacman (ref13) 2009; 37 |
| References_xml | – volume: 27 start-page: 490 issue: 1 year: 2014 ident: ref18 article-title: The “fast” and the “slow” modes of mitochondrial DNA degradation publication-title: Mitochondrial DNA doi: 10.3109/19401736.2014.905829 – volume: 21 start-page: 42 issue: 1 year: 2016 ident: ref29 article-title: Mitochondrial DNA damage induced autophagy cell death and disease publication-title: Frontiers in Bioscience doi: 10.2741/4375 – volume: 286 start-page: 31975 issue: 37 year: 2011 ident: ref20 article-title: Apoptosis Induced by Persistent Single-strand Breaks in Mitochondrial Genome: CRITICAL ROLE OF EXOG (5'-EXO/ENDONUCLEASE) IN THEIR REPAIR publication-title: Journal of Biological Chemistry doi: 10.1074/jbc.M110.215715 – volume: 87 start-page: 11787 issue: 21 year: 2013 ident: ref54 article-title: Mitochondrial nucleases ENDOG and EXOG participate in mitochondrial DNA depletion initiated by herpes simplex virus 1 UL12.5 publication-title: Journal of virology doi: 10.1128/JVI.02306-13 – volume: 17 start-page: 164 year: 2014 ident: ref7 article-title: Formation and repair of oxidative damage in the mitochondrial DNA publication-title: Mitochondrion doi: 10.1016/j.mito.2014.03.007 – volume: 40 start-page: 275 issue: 3 year: 2008 ident: ref15 article-title: What causes mitochondrial DNA deletions in human cells? publication-title: Nature Genetics doi: 10.1038/ng.f.94 – start-page: gkw676 year: 2016 ident: ref35 article-title: Near-complete elimination of mutant mtDNA by iterative or dynamic dose-controlled treatment with mtZFNs publication-title: Nucleic Acids Res – volume: 28 start-page: 3793 issue: 19 year: 2000 ident: ref11 article-title: An alternate form of Ku80 is required for DNA end-binding activity in mammalian mitochondria publication-title: Nucleic Acids Research doi: 10.1093/nar/28.19.3793 – volume: 42 start-page: 13280 issue: 21 year: 2014 ident: ref22 article-title: Endonuclease G preferentially cleaves 5-hydroxymethylcytosine-modified DNA creating a substrate for recombination publication-title: Nucleic Acids Research doi: 10.1093/nar/gku1032 – volume: 65 start-page: 527 issue: 3 year: 2017 ident: ref44 article-title: Single-Molecule Analysis of mtDNA Replication Uncovers the Basis of the Common Deletion publication-title: Molecular Cell doi: 10.1016/j.molcel.2016.12.014 – volume: 334 start-page: 9 issue: 1 year: 2004 ident: ref43 article-title: Comparative analysis of inducible expression systems in transient transfection studies publication-title: Analytical biochemistry doi: 10.1016/j.ab.2004.07.011 – volume: 27 start-page: 223 issue: 2 year: 2015 ident: ref14 article-title: Microhomology-mediated end joining is the principal mediator of double-strand break repair during mitochondrial DNA lesions publication-title: Molecular Biology of the Cell doi: 10.1091/mbc.E15-05-0260 – volume: 24 start-page: 9823 issue: 22 year: 2004 ident: ref37 article-title: Architectural Role of Mitochondrial Transcription Factor A in Maintenance of Human Mitochondrial DNA publication-title: Molecular and Cellular Biology doi: 10.1128/MCB.24.22.9823-9834.2004 – volume: 11 start-page: e1005664 issue: 11 year: 2015 ident: ref8 article-title: Members of the RAD52 Epistasis Group Contribute to Mitochondrial Homologous Recombination and Double-Strand Break Repair in Saccharomyces cerevisiae publication-title: PLoS Genet doi: 10.1371/journal.pgen.1005664 – volume: 21 start-page: 1949 issue: 14 year: 2014 ident: ref28 article-title: Mitochondrial Genome Linearization Is a Causative Factor for Cardiomyopathy in Mice and Drosophila publication-title: Antioxidants & Redox Signaling doi: 10.1089/ars.2013.5432 – volume: 14 start-page: 893 issue: 7 year: 2005 ident: ref36 article-title: Double-strand breaks of mouse muscle mtDNA promote large deletions similar to multiple mtDNA deletions in humans publication-title: Human Molecular Genetics doi: 10.1093/hmg/ddi082 – volume: 15 start-page: 516 issue: 7 year: 2008 ident: ref45 article-title: Selective elimination of mutant mitochondrial genomes as therapeutic strategy for the treatment of NARP and MILS syndromes publication-title: Gene therapy doi: 10.1038/gt.2008.11 – volume: 437 start-page: 108 issue: 1 year: 2013 ident: ref41 article-title: CDK-associated Cullin 1 promotes cell proliferation with activation of ERK1/2 in human lung cancer A549 cells publication-title: Biochemical and biophysical research communications doi: 10.1016/j.bbrc.2013.06.048 – volume: 10 start-page: 821 issue: 4 year: 2005 ident: ref51 article-title: Regulation of the human apoptotic DNase/RNase endonuclease G: involvement of Hsp70 and ATP publication-title: Apoptosis doi: 10.1007/s10495-005-0410-9 – volume: 9 start-page: 534 issue: 6 year: 2002 ident: ref46 article-title: Gene therapy for mitochondrial disease by delivering restriction endonucleaseSmaI into mitochondria publication-title: Journal of biomedical science – volume: 34 start-page: 28 year: 2015 ident: ref23 article-title: Primer removal during mammalian mitochondrial DNA replication publication-title: DNA Repair doi: 10.1016/j.dnarep.2015.07.003 – volume: 12 start-page: 567 issue: 7 year: 2016 ident: ref10 article-title: Mitochondrial DNA repair and replication proteins revealed by targeted chemical probes publication-title: Nature Chemical Biology doi: 10.1038/nchembio.2102 – volume: 369 start-page: 20130442 issue: 1646 year: 2014 ident: ref39 article-title: Quality matters: how does mitochondrial network dynamics and quality control impact on mtDNA integrity? publication-title: Philosophical Transactions of the Royal Society B: Biological Sciences doi: 10.1098/rstb.2013.0442 – volume: 23 start-page: 6147 issue: 23 year: 2014 ident: ref24 article-title: Linear mtDNA fragments and unusual mtDNA rearrangements associated with pathological deficiency of MGME1 exonuclease publication-title: Human Molecular Genetics doi: 10.1093/hmg/ddu336 – volume: 5 start-page: a012641 issue: 5 year: 2013 ident: ref6 article-title: The Maintenance of Mitochondrial DNA Integrity–Critical Analysis and Update publication-title: Cold Spring Harbor Perspectives in Biology doi: 10.1101/cshperspect.a012641 – year: 2016 ident: ref19 article-title: Human mitochondrial nucleases publication-title: The FEBS Journal – volume: 37 start-page: 4218 issue: 13 year: 2009 ident: ref13 article-title: Intra- and inter-molecular recombination of mitochondrial DNA after in vivo induction of multiple double-strand breaks publication-title: Nucleic Acids Research doi: 10.1093/nar/gkp348 – volume: 13 start-page: 935 issue: 9 year: 2004 ident: ref38 article-title: Mitochondrial transcription factor A regulates mtDNA copy number in mammals publication-title: Human Molecular Genetics doi: 10.1093/hmg/ddh109 – start-page: gkw931 year: 2016 ident: ref53 article-title: Crystal structure of endonuclease G in complex with DNA reveals how it nonspecifically degrades DNA as a homodimer publication-title: Nucleic Acids Research doi: 10.1093/nar/gkw931 – volume: 36 start-page: e44 issue: 7 year: 2008 ident: ref32 article-title: Generation of rho0 cells utilizing a mitochondrially targeted restriction endonuclease and comparative analyses publication-title: Nucleic Acids Research doi: 10.1093/nar/gkn124 – volume: 103 start-page: 8995 issue: 24 year: 2006 ident: ref52 article-title: Endonuclease G: a role for the enzyme in recombination and cellular proliferation publication-title: Proceedings of the National Academy of Sciences doi: 10.1073/pnas.0603445103 – volume: 28 start-page: 4975 issue: 16 year: 2008 ident: ref27 article-title: Removal of Oxidative DNA Damage via FEN1-Dependent Long-Patch Base Excision Repair in Human Cell Mitochondria publication-title: Molecular and Cellular Biology doi: 10.1128/MCB.00457-08 – volume: 76 start-page: 349 issue: 4 year: 2015 ident: ref2 article-title: Spectrum of mitochondrial genomic variation and associated clinical presentation of prostate cancer in South African men publication-title: The Prostate doi: 10.1002/pros.23126 – volume: 13 start-page: 659 issue: 10 year: 2012 ident: ref12 article-title: Minimizing the damage: repair pathways keep mitochondrial DNA intact publication-title: Nature Reviews Molecular Cell Biology doi: 10.1038/nrm3439 – volume: 32 start-page: 325 issue: 3 year: 2008 ident: ref26 article-title: Human DNA2 Is a Mitochondrial Nuclease/Helicase for Efficient Processing of DNA Replication and Repair Intermediates publication-title: Molecular Cell doi: 10.1016/j.molcel.2008.09.024 – volume: 41 start-page: 3144 issue: 5 year: 2013 ident: ref25 article-title: Identification of a novel human mitochondrial endo-/exonuclease Ddk1/c20orf72 necessary for maintenance of proper 7S DNA levels publication-title: Nucleic Acids Research doi: 10.1093/nar/gkt029 – volume: 1840 start-page: 1360 issue: 4 year: 2014 ident: ref1 article-title: The broadening spectrum of mitochondrial disease: Shifts in the diagnostic paradigm publication-title: Biochimica et Biophysica Acta (BBA)—General Subjects doi: 10.1016/j.bbagen.2013.10.040 – volume: 10 issue: 1 year: 2015 ident: ref5 article-title: Mitochondrial activity in gametes and transmission of viable mtDNA publication-title: Biology Direct doi: 10.1186/s13062-015-0057-6 – start-page: 373 year: 2014 ident: ref30 article-title: Methods in Enzymology – volume: 34 start-page: 316 issue: 5 year: 2015 ident: ref21 article-title: Regulation of Apoptotic Endonucleases by EndoG publication-title: DNA and Cell Biology doi: 10.1089/dna.2014.2772 – volume: 12 start-page: 2098 issue: 11 year: 2016 ident: ref49 article-title: Mitochondrial quality control: Cell-type-dependent responses to pathological mutant mitochondrial DNA publication-title: Autophagy doi: 10.1080/15548627.2016.1226734 – volume: 12 start-page: 488 issue: 7 year: 2013 ident: ref17 article-title: Persistent damage induces mitochondrial DNA degradation publication-title: DNA Repair doi: 10.1016/j.dnarep.2013.04.023 – volume: 45 start-page: 214 issue: 2 year: 2013 ident: ref55 article-title: Loss-of-function mutations in MGME1 impair mtDNA replication and cause multisystemic mitochondrial disease publication-title: Nature genetics doi: 10.1038/ng.2501 – year: 2016 ident: ref4 article-title: Latent mitochondrial DNA deletion mutations drive muscle fiber loss at old age publication-title: Aging Cell – volume: 107 start-page: 11835 issue: 26 year: 2010 ident: ref48 article-title: Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells publication-title: Proceedings of the National Academy of Sciences doi: 10.1073/pnas.0914569107 – volume: 47 start-page: e150 issue: 3 year: 2015 ident: ref3 article-title: The role of mitochondrial DNA mutation on neurodegenerative diseases publication-title: Experimental & molecular medicine doi: 10.1038/emm.2014.122 – volume: 27 start-page: 381 issue: 7-8 year: 2016 ident: ref40 article-title: Mitophagy plays a central role in mitochondrial ageing publication-title: Mammalian Genome doi: 10.1007/s00335-016-9651-x – volume: 13 start-page: 878 issue: 12 year: 2012 ident: ref33 article-title: Human mitochondrial DNA: roles of inherited and somatic mutations publication-title: Nat Rev Genet doi: 10.1038/nrg3275 – volume: 183 start-page: 795 issue: 5 year: 2008 ident: ref42 article-title: Parkin is recruited selectively to impaired mitochondria and promotes their autophagy publication-title: The Journal of cell biology doi: 10.1083/jcb.200809125 – volume: 10 start-page: 3093 issue: 26 year: 2001 ident: ref31 article-title: Manipulating mitochondrial DNA heteroplasmy by a mitochondrially targeted restriction endonuclease publication-title: Human Molecular Genetics doi: 10.1093/hmg/10.26.3093 – volume: 139 start-page: 1633 issue: 6 year: 2016 ident: ref34 article-title: Emerging therapies for mitochondrial disorders publication-title: Brain doi: 10.1093/brain/aww081 – volume: 40 start-page: 7916 issue: 16 year: 2012 ident: ref47 article-title: Mitochondrial dynamics and autophagy aid in removal of persistent mitochondrial DNA damage in Caenorhabditis elegans publication-title: Nucleic acids research doi: 10.1093/nar/gks532 – volume: 278 start-page: 9823 issue: 11 year: 2003 ident: ref50 article-title: Inducible Expression of a Dominant Negative DNA Polymerase-γ Depletes Mitochondrial DNA and Produces a ρ0 Phenotype publication-title: Journal of Biological Chemistry doi: 10.1074/jbc.M211730200 – volume: 637 start-page: 111 issue: 1-2 year: 2008 ident: ref9 article-title: Bleomycin-induced double-strand breaks in mitochondrial DNA of Drosophila cells are repaired publication-title: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis doi: 10.1016/j.mrfmmm.2007.07.007 – volume: 11 start-page: 684 issue: 8 year: 2012 ident: ref16 article-title: Oxidants and not alkylating agents induce rapid mtDNA loss and mitochondrial dysfunction publication-title: DNA Repair doi: 10.1016/j.dnarep.2012.06.002 |
| SSID | ssj0053866 |
| Score | 2.5499656 |
| Snippet | Mitochondrial DNA (mtDNA) can undergo double-strand breaks (DSBs), caused by defective replication, or by various endogenous or exogenous sources, such as... Mitochondrial DNA ( mtDNA) can undergo double-strand breaks (DSBs), caused by defective replication, or by various endogenous or exogenous sources, such as... |
| SourceID | plos doaj swepub pubmedcentral hal proquest gale pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | e0176795 |
| SubjectTerms | Aging Animal models Apoptosis Autophagy Base excision repair Biochemistry Biochemistry, Molecular Biology Biology and life sciences Biomedical materials Biotechnology Blotting, Southern Blotting, Western Cell activation Cell death Cell lines Cell proliferation cells Clinical Medicine Clonal deletion Copy number Crystal structure Cullin Cyclin-dependent kinase Cyclooxygenase 1 - genetics damage Degradation Deoxyribonuclease Deoxyribonucleic acid Depletion disease DNA DNA Breaks, Double-Stranded DNA damage DNA Repair DNA, Mitochondrial DNA-directed DNA polymerase Endonuclease Endonucleases - metabolism Enzymes Exonucleases - metabolism expression Flow Cytometry Gene expression Gene therapy Genetics Genomes Genomics HEK293 Cells Homology Humans inducible Ionizing radiation Kinetics Klinisk medicin Lesions Life Sciences Lung cancer Maintenance Mammals Mathematical analysis Millet Mitochondria Mitochondria - metabolism Mitochondrial DNA mtdna replication Mutation Neurodegenerative diseases Nuclease Nuclei Nucleic acids Organelles Oxidative phosphorylation Oxygen Proteins Quality control Reaction kinetics Reactive oxygen species Real-Time Polymerase Chain Reaction recombination removal repair Replication Sequence Analysis targeted restriction-endonuclease transcription factor-a Transfection Viability Viruses |
| SummonAdditionalLinks | – databaseName: ProQuest Nursing and Allied Health Journals - PSU access expires 11/30/25. dbid: 7RV link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3db9MwELdY4YEXYHytMCAgBOwhWxIndvKEykc1pKmgDaq9Wf5KO1GS0jTj3-cuccMiJkDi1T7H9vnufHZ8vyPkeRLI3AQy8TnGfsRxZH1JufKjnGeYAknmTYT39IhPJunpafbJXbhV7lnlxiY2htqUGu_ID8IUNnJ07tPXy-8-Zo3Cv6suhcYWuRqibwzyzI-nG0sMusyYC5ejPDxwq7O_LAu7D5LIOGaVuLAdNaj9nW3emuPTyMFyUVaXuZ-_v6LsYY02-9P45v_O7Ba54TxTb9SK0ja5YovbZNvpfuW9cgDVe3fI-KRJngN20vsGBgEMaGFQjr13k5FnEH2iTdTk5SBk5Q_YHD1T1mphfbxXKYwHx3D5tbpLvozff3576Lt8DL5OabD2jeEmZAp8NC0tUyGTUYbBrBr2ecuAmwHXJo91oALDQhkGNofTFrQIDFd5LOk9MiiA9zvEi7VNLA2jPGUqNhnNUpYpzXSoqWRWBkNCN8sitAMrx5wZC9H8geNwaGm5InAxhVvMIfG7VssWrOMv9G9wxTtahNpuCsrVTDjNFTBQG9FcgzDZmDOpolzKPMmUihRLExjqE5QX0catdgZDjGLw_BCfELp51lAg3EaB73lmsq4q8eHj9B-ITo57RC8dUV4CO7R0MRQwJ4Tx6lHu9ijBaOh-b3NkxoWJH46OBJY18DxZnJyHQ7KDwr9hXSV-SSp8fiPLl1c_7aqxZ3zIV9iybmhoEnNO-ZDcb_WnGwV4Sgm4v8BR3tOs3jD7NcXZvIFEh3MHSF80JC9aHew1mdVLAUWzWlRWYP6HlD748_gfkusRum9B7EfpLhmsV7V9RK7p8_VZtXrcGJmfEhKHXA priority: 102 providerName: ProQuest – databaseName: Public Library of Science (PLoS) Journals Open Access dbid: FPL link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3db9MwELdY4YEXYHwtMCAgBOwhI4kTO3ksH9WQqjIxmPZm-bOdKEm1NOPf5y5JA4FNwKt9ru3z3fmu8f2OkOdpKJ0JZRpwzP1IktgGknIVxI7nWAJJuibD-3jKZ7Ps5CQ__Bko_vYFn_LodcfT_VVZ2H2QH8bzdItcjSljGGxNDqcbywu6y1iXHnfZyMH106D097Z4a4FPIUerZVld5G7--WpygC3a3EeTm_-7k1vkRud5-uNWVLbJFVvcJtudblf-qw6Aeu8OmRw1xXHADvrfQOHBQBYG5dR_Nxv7BtEl2kJMvgMhKr_D5eebslZLG-D_JoXxIcyWX6u75Mvk_ee3B0FXbyHQGQ3XgTHcREyBD6alZSpiMs4xWVXDPW6B2xBHa-MSHarQsEhGoXUQTcGI0HDlEknvkVEBe9shfqJtamkUu4ypxOQ0z1iuNNORppJZGXqEbo5B6A6MHGtiLEXzhY1DUNJyRSCzRMcsjwT9qFULxvEX-jd4wj0tQmk3DXAqotNMAQu1MXUahMcmnEkVOyldmisVK5alsNQnKB-izUvtDYIYJ-DZIf4gTPOsoUA4jQLf68xlXVXiw8fjfyA6-jQgetkRuRLYoWWXIwF7QpiuAeXugBKMgh7OtkBm_LLxg_FUYFsDv5Mn6XnkkR0U9g3rKhFl4CxjAJ3Bz28U4OLup303zowP9Qpb1g0NTRPOKffI_VZf-lWAJ5SCewsc5QNNGixz2FOcLhrIc4grQPpij7xodW4wZF6vBDTNa1FZgfUdMvrg8q09JNdjdM3CJIizXTJan9X2Ebmmz9en1dnjxqD8ANJMdYc priority: 102 providerName: Public Library of Science |
| Title | Selective mitochondrial DNA degradation following double-strand breaks |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/28453550 https://www.proquest.com/docview/1892971648 https://www.proquest.com/docview/1893547737 https://hal.science/hal-01693945 https://pubmed.ncbi.nlm.nih.gov/PMC5409072 https://gup.ub.gu.se/publication/254683 https://doaj.org/article/e5ee23fc386e476ab2faaf59bb2b6850 http://dx.doi.org/10.1371/journal.pone.0176795 |
| Volume | 12 |
| WOSCitedRecordID | wos000400383900057&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: DOA dateStart: 20060101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M~E dateStart: 20060101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Advanced Technologies & Aerospace Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: P5Z dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/hightechjournals providerName: ProQuest – providerCode: PRVPQU databaseName: Agriculture Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M0K dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/agriculturejournals providerName: ProQuest – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M7P dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Engineering Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M7S dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com providerName: ProQuest – providerCode: PRVPQU databaseName: Environmental Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: PATMY dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/environmentalscience providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 7X7 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Materials Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: KB. dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/materialsscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Nursing & Allied Health Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 7RV dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/nahs providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: BENPR dateStart: 20061201 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Public Health Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 8C1 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: PIMPY dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVATS databaseName: Public Library of Science (PLoS) Journals Open Access customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: FPL dateStart: 20060101 isFulltext: true titleUrlDefault: http://www.plos.org/publications/ providerName: Public Library of Science |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3Nb9MwFLdY4cAFMb5WGCUgxMchXRIndnJsx6pN60rUQtVxsRzHaSdKWi3t-Pd5z0mrRkwaBy7vYD838fuw30vt3yPkfeDILHVkYHO8--H7nrYl5YntZTzCEkgyMze8x30-GISTSRTvlPrCM2ElPHApuCMdaO3RTNGQaZ8zmXiZlFkQJYmXsLDM1h0ebZKpcg0GL2asuihHuXtU6aW9XOS6DTbIONaT2NmIDF7_dlXem-GhyMZyvihuCzz_Pj9ZQxk1O1PvMXlUhZRWp5zKPrmn8ydkv3LawvpUIUt_fkp6I1P1BhY46xd4Mqx8eYoGaH0ZdKwUYSPKCktWBtax-A27mpUu1slc2_hBJE8tyJ_lz-IZ-d47-XZ8aleFFGwVUmdlpylPXZZAcKWkZonLpBfhLVQFG7RmIAyHqzTzlZM4KXOl6-gM0iQY4aQ8yXxJn5NGDqI7IJavQCHU9bKQJX4a0ShkUaKYchWVTEunSehGqkJVKONY7GIuzF9nHLKNUioCdSEqXTSJvR21LFE27uDvosK2vIiRbRrAckRlOeIuy2mSN6huUV443Xq66PgQsiGwIDzmneFAnIwcD-JM5booxNnX8T8wjYY1po8VU7YAcShZXX6AOSH-Vo3zsMYJ3q7qT5uhMHYmftrpC2wzuDqRH9y4TXKAtrsRXSHcEKJgzIxD-PmNPd_e_XbbjU_GE3i5XqwNDw18zilvkhel-W_fAkKcAOJWkCivOUbtNes9-dXMYJlDwgDW5zXJh9KFakOm66WApulaFFpg4YaQvvwfmn9FHnoYnTm-7YWHpLG6XuvX5IG6WV0V1y2yx4djpBNuaAg0PHZb5H73ZBAPW2alAdqL-0DPu22gF845Uh4bOgIaBz9gRHx2EV_-Adfnht8 |
| linkProvider | Directory of Open Access Journals |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9NAEF61AQkuQHk1UKhBPA9u_dy1DwgFSpSoIVS0VBWXZV9OKoId4qQVf4rfyIwfAYsKuPTAdXd2vTue19o73xDyKHREoh0R2gxzP4LAM7bwmbS9hMVYAkkkRYb34YANh9HRUby3Qr7XuTB4rbK2iYWh1pnCb-TbbgSOHIP76OX0q41Vo_Dval1CoxSLXfPtFI5s-Yv-Drzfx57XfXPwumdXVQVsFfnO3NaaaZdKiDSUMFS6VHgxpmQq8FaGUganRaWTQDnS0dQVrmMSODPACEczmQTCh3lXyQXYloNatBd-rC0_2A5Kq_Q8n7nblTRsTbPUbIHkw9xhw_0VVQKWvmB1jFcxW9NJlp8V7v5-a7OBbVr4w-7V_42T18iVKvK2OqWqrJEVk14na5Vty61nFQD38xuku18UBwI_YH0BgwcOItWop9bOsGNpRNcoC1FZCShRdgrO39LZQk6Mjd-NUm1JiMQ_5zfJh3PZzy3SSuFdrxMrUCY0vuslEZWBjv04orFUVLnKF9QIp038Wgy4qsDYsSbIhBd_GBkcykqucBQeXglPm9jLUdMSjOQv9K9Qwpa0CCVeNGSzEa8sE4eFGs9PFAivCRgV0kuESMJYSk_SKISlbqJ88jIvd2kQeSeAyBbxF-ExDwsKhBNJ8b7SSCzynPffHf4D0f77BtHTiijJgB1KVDkisCeEKWtQbjQowSiq5tPGyIxfNt7rDDi2FfBDcRCeuG2yjspWsy7nPzUDpq915-zuB8tufDJeVExNtiho_DBgzGdtcrvU1-UqIBIMIbwHjrKGJjeW2exJj8cF5Ducq0D6vDZ5Uup8Y8hoMeXQNFrw3HCsbxH5d_68_k1yqXfwdsAH_eHuXXLZw1DVCWwv2iCt-Wxh7pGL6mR-nM_uFwbOIp_O2w78APUF5BA |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1R3JbtNAdNQGhLgAZWugUINYD268ztgHhAIlatQoVBSqisswa1JR7FA3rfg1vo73vAQsKuDSA9eZN-OZ57fabyHkUewJqz0RuwxzP6IoMK4ImXQDy1JsgSRsmeG9N2LjcbK_n-4ske9NLgyGVTYysRTUOlf4jbznJ6DI0bhPerYOi9jZHLycfXWxgxT-aW3aaVQksm2-nYL7VrwYbsK7fhwEgzfvX2-5dYcBVyWhd-xqzbRPJVgdShgqfSqCFNMzFWguQykDz1FpGylPepr6wveMBf8BVniaSRuJEPZdJhcY-JgYTrgTf2y0AMgRSutUvZD5vZoyNmZ5ZjaAC2DvuKUKy44BC72wPMWwzM7sMC_OMn1_j-Bs1TktdePg6v-M1WvkSm2RO_2KhVbIksmuk5Va5hXOs7ow9_MbZLBbNg0C_eB8AUEIiiPTyL_O5rjvaKy6UTWociwwV34KRoGj87k8NC5-T8q0I8FC_1zcJB_O5T63SCeD975KnEiZ2IR-YBMqI52GaUJTqajyVSioEV6XhA1JcFUXacdeIYe8_PPIwFmrsMKRkHhNSF3iLlbNqiIlf4F_hdS2gMUS4-VAfjThtcTicFAThFYBIZuIUSEDK4SNUykDSZMYjrqOtMqrfN2FoOT9CCxerMsIj3lYQmCZkQxJayLmRcGHb_f-AWj3XQvoaQ1kc0CHEnXuCNwJy5e1INdakCAsVftpU0TGLxff6o84jpVlidIoPvG7ZBUZr0FdwX9yCWzf8NHZ0w8W0_hkDGDMTD4vYcI4YixkXXK74t3FKcBCjMHsB4yyFle3jtmeyQ6mZSl48LeA-oIueVLxf2vJZD7jMDSZ88Jw7HuRhHf-fP51cgnYn4-G4-275HKAFqwXuUGyRjrHR3Nzj1xUJ8cHxdH9UtY55NN5i4Ef1Drs2g |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Selective+mitochondrial+DNA+degradation+following+double-strand+breaks&rft.jtitle=PloS+one&rft.au=Moretton%2C+Amandine&rft.au=Morel%2C+Fr%C3%A9d%C3%A9ric&rft.au=Macao%2C+Bertil&rft.au=Lachaume%2C+Philippe&rft.date=2017-04-28&rft.issn=1932-6203&rft.eissn=1932-6203&rft.volume=12&rft.issue=4&rft.spage=e0176795&rft_id=info:doi/10.1371%2Fjournal.pone.0176795&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1932-6203&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1932-6203&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1932-6203&client=summon |