Genetically determined serum urate levels and cardiovascular and other diseases in UK Biobank cohort: A phenome-wide mendelian randomization study

The role of urate in cardiovascular diseases (CVDs) has been extensively investigated in observational studies; however, the extent of any causal effect remains unclear, making it difficult to evaluate its clinical relevance. A phenome-wide association study (PheWAS) together with a Bayesian analysi...

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Vydané v:	PLoS medicine Ročník 16; číslo 10; s. e1002937
Hlavní autori:	Li, Xue, Meng, Xiangrui, He, Yazhou, Spiliopoulou, Athina, Timofeeva, Maria, Wei, Wei-Qi, Gifford, Aliya, Yang, Tian, Varley, Tim, Tzoulaki, Ioanna, Joshi, Peter, Denny, Joshua C., Mckeigue, Paul, Campbell, Harry, Theodoratou, Evropi
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Public Library of Science 18.10.2019 Public Library of Science (PLoS)
Predmet:	Adult Aged Analysis Angina Angina pectoris Arteriosclerosis Arthritis Atherosclerosis Bayes Theorem Bayesian analysis Biological Specimen Banks Biology and Life Sciences Cardiovascular diseases Cardiovascular Diseases - blood Cardiovascular Diseases - complications Cardiovascular Diseases - genetics Cerebral infarction Cerebrovascular diseases Cohort Studies Comorbidity Coronary artery disease Coronary heart disease Diabetes Drug delivery Epidemiology Female Genetic analysis Genetic diversity Genetic Pleiotropy Genetic Predisposition to Disease Genetic variance Genetic Variation Genetics Genome-wide association studies Genome-Wide Association Study Genomes Genomics Gout Health sciences Heart attack Heart diseases Heart failure Humans Hypercholesterolemia Hypertension Informatics Ischemia Male Medical research Medicine and Health Sciences Mendelian Randomization Analysis Metabolic disorders Metabolic syndrome Middle Aged Myocardial infarction Myocardial ischemia Phenomics Phenotype Phenotypes Pleiotropy Polymorphism, Single Nucleotide Public health Randomization Reproducibility of Results Sensitivity and Specificity Social Sciences Software Studies Supervision Systematic review Treatment Outcome Type 2 diabetes United Kingdom Uric acid Uric Acid - blood Vascular diseases United Kingdom United Kingdom > UK United States > US Tennessee Nashville Tennessee
ISSN:	1549-1676, 1549-1277, 1549-1676
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