Large-scale genome-wide meta-analysis of polycystic ovary syndrome suggests shared genetic architecture for different diagnosis criteria

Polycystic ovary syndrome (PCOS) is a disorder characterized by hyperandrogenism, ovulatory dysfunction and polycystic ovarian morphology. Affected women frequently have metabolic disturbances including insulin resistance and dysregulation of glucose homeostasis. PCOS is diagnosed with two different...

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Bibliographic Details
Published in:	PLoS genetics Vol. 14; no. 12; p. e1007813
Main Authors:	Day, Felix, Karaderi, Tugce, Jones, Michelle R., Meun, Cindy, He, Chunyan, Drong, Alex, Kraft, Peter, Lin, Nan, Huang, Hongyan, Broer, Linda, Magi, Reedik, Saxena, Richa, Laisk, Triin, Urbanek, Margrit, Hayes, M. Geoffrey, Thorleifsson, Gudmar, Fernandez-Tajes, Juan, Mahajan, Anubha, Mullin, Benjamin H., Stuckey, Bronwyn G. A., Spector, Timothy D., Wilson, Scott G., Goodarzi, Mark O., Davis, Lea, Obermayer-Pietsch, Barbara, Uitterlinden, André G., Anttila, Verneri, Neale, Benjamin M., Jarvelin, Marjo-Riitta, Fauser, Bart, Kowalska, Irina, Visser, Jenny A., Andersen, Marianne, Ong, Ken, Stener-Victorin, Elisabet, Ehrmann, David, Legro, Richard S., Salumets, Andres, McCarthy, Mark I., Morin-Papunen, Laure, Thorsteinsdottir, Unnur, Stefansson, Kari, Styrkarsdottir, Unnur, Perry, John R. B., Dunaif, Andrea, Laven, Joop, Franks, Steve, Lindgren, Cecilia M., Welt, Corrine K.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 19.12.2018 Public Library of Science (PLoS)
Subjects:	Asian People - genetics Bioinformatics Biology and Life Sciences Body mass index Cardiovascular disease Case-Control Studies Clinical medicine Cohort Studies Coronary artery Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diagnosis Endocrinology Epidemiology Fasting Female Funding Gene loci Genetic analysis Genetic aspects Genetic Predisposition to Disease Genetics Genome-wide association studies Genome-Wide Association Study Genomes Genomics Gonadotropins Gynecology Heart diseases Homeostasis Hospitals Humans Insulin Internal medicine Laboratory testing Linkage analysis Linkage disequilibrium Medicine Medicine and Health Sciences Menopause Mental disorders Meta-analysis Metabolism Mutation Obstetrics Pharmacology Phenotype Phenotypes Physical Sciences Pituitary (anterior) Polycystic ovary syndrome Polycystic Ovary Syndrome - diagnosis Polycystic Ovary Syndrome - genetics Public health Research and Analysis Methods Schizophrenia Supervision Testosterone White People - genetics Los Angeles California Netherlands United States > US Illinois Massachusetts Kentucky California Chicago Illinois Australia Western Australia Australia Estonia
ISSN:	1553-7404, 1553-7390, 1553-7404
Online Access:	Get full text
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