Fragment Length of Circulating Tumor DNA

Malignant tumors shed DNA into the circulation. The transient half-life of circulating tumor DNA (ctDNA) may afford the opportunity to diagnose, monitor recurrence, and evaluate response to therapy solely through a non-invasive blood draw. However, detecting ctDNA against the normally occurring back...

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Bibliographic Details
Published in:	PLoS genetics Vol. 12; no. 7; p. e1006162
Main Authors:	Underhill, Hunter R., Kitzman, Jacob O., Hellwig, Sabine, Welker, Noah C., Daza, Riza, Baker, Daniel N., Gligorich, Keith M., Rostomily, Robert C., Bronner, Mary P., Shendure, Jay
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01.07.2016 Public Library of Science (PLoS)
Subjects:	Alleles Animals Biology and life sciences Biomarkers, Tumor - blood Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Cell Line, Tumor Deoxyribonucleic acid DNA DNA sequencing DNA, Neoplasm - blood DNA, Neoplasm - genetics Experiments Genes Genetic aspects Glioblastoma - blood Glioblastoma - genetics Hep G2 Cells Humans Liver Neoplasms - genetics Liver Neoplasms - metabolism Lung cancer Lung Neoplasms - genetics Lung Neoplasms - metabolism Magnetic Resonance Imaging Male Medicine and Health Sciences Melanoma Melanoma - genetics Melanoma - metabolism Metastasis Methods Mutation Neoplasm Transplantation Proto-Oncogene Proteins B-raf - genetics Rats Research and Analysis Methods Studies Tumors
ISSN:	1553-7404, 1553-7390, 1553-7404
Online Access:	Get full text
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