Differential Requirements for the RAD51 Paralogs in Genome Repair and Maintenance in Human Cells

Deficiency in several of the classical human RAD51 paralogs [RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3] is associated with cancer predisposition and Fanconi anemia. To investigate their functions, isogenic disruption mutants for each were generated in non-transformed MCF10A mammary epithelial cells an...

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Veröffentlicht in:	PLoS genetics Jg. 15; H. 10; S. e1008355
Hauptverfasser:	Garcin, Edwige B., Gon, Stéphanie, Sullivan, Meghan R., Brunette, Gregory J., Cian, Anne De, Concordet, Jean-Paul, Giovannangeli, Carine, Dirks, Wilhelm G., Eberth, Sonja, Bernstein, Kara A., Prakash, Rohit, Jasin, Maria, Modesti, Mauro
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Public Library of Science 04.10.2019 Public Library of Science (PLoS)
Schlagworte:	Anemia Biochemistry, Molecular Biology Biology and Life Sciences Cancer Cell culture Cell Nucleus - genetics Cells (Biology) Chemoresistance Chemotherapy Chromatids - genetics Cloning CRISPR Deoxyribonucleic acid Developmental biology DNA DNA Damage - genetics DNA repair DNA Repair - genetics DNA-Binding Proteins - genetics Epithelial cells Fanconi syndrome Fanconi's anemia Funding Genes Genome, Human - genetics Genomes Genomics HEK293 Cells Homologous Recombination - genetics Humans Ionizing radiation Life Sciences Mammary gland Medical equipment industry Medical research Medicine and Health Sciences Microorganisms Mitomycin Mitomycin C Molecular biology Museums Mutation Olaparib Phenotypes Physical Sciences Rad51 Recombinase - genetics Recombination Research and Analysis Methods Supervision United States New York Pittsburgh Pennsylvania France United States > US Germany Pennsylvania Polymerase chain reaction Cell disruption Cloning Guide RNA Plasmid construction Genetic loci Complement system Analysis of variance
ISSN:	1553-7404, 1553-7390, 1553-7404
Online-Zugang:	Volltext
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