Regulation of ERBB2 by oestrogen receptor–PAX2 determines response to tamoxifen

Tamoxifen resistance mechanism Tamoxifen is commonly used for breast cancer therapy, but a proportion of patients become resistant to the treatment, and their cancer is more likely to return. A study of the relationship between the oestrogen receptor and ERBB2/HER-2 pathways in breast cancer throws...

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Bibliographic Details
Published in:	Nature Vol. 456; no. 7222; pp. 663 - 666
Main Authors:	Hurtado, Antoni, Holmes, Kelly A., Geistlinger, Timothy R., Hutcheson, Iain R., Nicholson, Robert I., Brown, Myles, Jiang, Jie, Howat, William J., Ali, Simak, Carroll, Jason S.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 04.12.2008 Nature Publishing Group
Subjects:	Antineoplastic agents Binding sites Biological and medical sciences Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - pathology Cancer Care and treatment Cell growth Cell Line Cell Line, Tumor Cells Chromatin Immunoprecipitation Competition Dosage and administration Drug Resistance, Neoplasm - genetics Drug therapy Estrogen Estrogens - metabolism Gene Expression Regulation, Neoplastic - drug effects Gene Silencing General aspects Genes, erbB-2 - genetics Genetic aspects Gynecology. Andrology. Obstetrics Health aspects Histone Acetyltransferases Humanities and Social Sciences Humans letter Mammary gland diseases Medical sciences multidisciplinary Nuclear Receptor Coactivator 3 Oncogenes Oncology, Experimental PAX2 Transcription Factor - deficiency PAX2 Transcription Factor - genetics PAX2 Transcription Factor - metabolism Pharmacology. Drug treatments Physiological aspects Proteins Receptor, ErbB-2 - genetics Receptors Receptors, Estrogen - metabolism Regression analysis Regulatory Sequences, Nucleic Acid - genetics Repressor Proteins - metabolism RNA polymerase Science Tamoxifen Tamoxifen - metabolism Tamoxifen - pharmacology Trans-Activators Tumors United Kingdom United States Antineoplastic agent Human Estrogen receptor Treatment resistance Breast disease Antiestrogen erbB2 Gene Breast cancer Antihormone Malignant tumor Tamoxifene Mammary gland diseases Selective estrogen receptor modulator Cancerology C-Onc gene Established cell line Genetics Non steroid compound Protooncogene Cancer Hormonal receptor
ISSN:	0028-0836, 1476-4687, 1476-4687, 1476-4679
Online Access:	Get full text
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