Integrated Metagenomics/Metaproteomics Reveals Human Host-Microbiota Signatures of Crohn's Disease

Crohn's disease (CD) is an inflammatory bowel disease of complex etiology, although dysbiosis of the gut microbiota has been implicated in chronic immune-mediated inflammation associated with CD. Here we combined shotgun metagenomic and metaproteomic approaches to identify potential functional...

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Veröffentlicht in:	PloS one Jg. 7; H. 11; S. e49138
Hauptverfasser:	Erickson, Alison R., Cantarel, Brandi L., Lamendella, Regina, Darzi, Youssef, Mongodin, Emmanuel F., Pan, Chongle, Shah, Manesh, Halfvarson, Jonas, Tysk, Curt, Henrissat, Bernard, Raes, Jeroen, Verberkmoes, Nathan C., Fraser, Claire M., Hettich, Robert L., Jansson, Janet K.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Public Library of Science 28.11.2012 Public Library of Science (PLoS)
Schlagworte:	Acids Acquired immune deficiency syndrome AIDS Bacteria Bacteria - genetics Bacteria - metabolism Bioengineering Bioindicators Bioinformatics Biology Biomarkers Carbohydrate metabolism Carbohydrates Cluster Analysis Colon Crohn Disease - metabolism Crohn Disease - microbiology Crohn's Disease Crohns disease Development and progression Diagnostic systems Dysbacteriosis Earth science Etiology Female Gastroenterology Gastrointestinal diseases Gastrointestinal Tract - metabolism Gastrointestinal Tract - microbiology Genomes Humans Ileum Ileum - metabolism Ileum - microbiology Ileum - pathology Inflammation Inflammatory bowel disease Inflammatory bowel diseases Internal medicine Intestinal microflora Intestinal Mucosa - metabolism Intestinal Mucosa - microbiology Intestinal Mucosa - pathology Intestine Laboratories Male Mass spectrometry Medicin Medicine Metabolic Networks and Pathways Metabolism Metagenome Metagenomics Microbiota Microbiota (Symbiotic organisms) Proteins Proteome Proteomics Scientific imaging Shotguns Signatures Studies Target recognition Twins, Monozygotic California Belgium United States > US Maryland Tennessee Baltimore Maryland
ISSN:	1932-6203, 1932-6203
Online-Zugang:	Volltext
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