Relation between high levels of myeloperoxidase in the culprit artery and microvascular obstruction, infarct size and reverse remodeling in ST-elevation myocardial infarction
To better understand the role of myeloperoxidases (MPO) in microvascular obstruction (MO) phenomenon and infarct size (IS) using cardiac magnetic resonance (CMR) data in patients with acute myocardial infarction (AMI). 40 consecutive patients classified according to the median level of MPO in the cu...
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| Vydáno v: | PLOS ONE Ročník 12; číslo 7; s. e0179929 |
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| Hlavní autoři: | , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
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United States
Public Library of Science (PLoS)
13.07.2017
Public Library of Science |
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| ISSN: | 1932-6203, 1932-6203 |
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| Abstract | To better understand the role of myeloperoxidases (MPO) in microvascular obstruction (MO) phenomenon and infarct size (IS) using cardiac magnetic resonance (CMR) data in patients with acute myocardial infarction (AMI).
40 consecutive patients classified according to the median level of MPO in the culprit artery. A CMR study was performed during the week following AMI and at 6 months, with late gadolinium enhancement sequences.
Persistent MO was observed in the same proportion (50 vs. 65%, p = 0.728) between the low vs. high MPO group levels. However, the extent of the microvascular obstruction was significantly greater in the high-MPO group (6 (0-9) vs.16.5 (0-31), p = 0.027), together with a greater infarct size, and a trend towards a lower left ventricular ejection fraction (LVEF) (p = 0.054) at one week. CMR data at 6 months showed that reverse systolic remodeling was two fold more present in the low-MPO group (p = 0.058). Interestingly, the extent of MO (8.5 (6.5-31) vs. 4.1 (3-11.55), p = 0.042) and IS remained significantly greater (24.5 (9.75-35) vs. 7.5 (2.5-18.75), p = 0.022) in the high-MPO group. Moreover, MPO in the culprit artery appeared to correlate positively with MPO in non-culprit arteries and serum, and with troponin levels and peak CK.
This patient-based study revealed in patients after AMI that high MPO levels in the culprit artery were associated with more severe microvascular obstruction and greater IS. These findings may provide new insights pathophysiology explanation for the adverse prognostic impact of MO. |
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| AbstractList | To better understand the role of myeloperoxidases (MPO) in microvascular obstruction (MO) phenomenon and infarct size (IS) using cardiac magnetic resonance (CMR) data in patients with acute myocardial infarction (AMI).
40 consecutive patients classified according to the median level of MPO in the culprit artery. A CMR study was performed during the week following AMI and at 6 months, with late gadolinium enhancement sequences.
Persistent MO was observed in the same proportion (50 vs. 65%, p = 0.728) between the low vs. high MPO group levels. However, the extent of the microvascular obstruction was significantly greater in the high-MPO group (6 (0-9) vs.16.5 (0-31), p = 0.027), together with a greater infarct size, and a trend towards a lower left ventricular ejection fraction (LVEF) (p = 0.054) at one week. CMR data at 6 months showed that reverse systolic remodeling was two fold more present in the low-MPO group (p = 0.058). Interestingly, the extent of MO (8.5 (6.5-31) vs. 4.1 (3-11.55), p = 0.042) and IS remained significantly greater (24.5 (9.75-35) vs. 7.5 (2.5-18.75), p = 0.022) in the high-MPO group. Moreover, MPO in the culprit artery appeared to correlate positively with MPO in non-culprit arteries and serum, and with troponin levels and peak CK.
This patient-based study revealed in patients after AMI that high MPO levels in the culprit artery were associated with more severe microvascular obstruction and greater IS. These findings may provide new insights pathophysiology explanation for the adverse prognostic impact of MO. Main objective To better understand the role of myeloperoxidases (MPO) in microvascular obstruction (MO) phenomenon and infarct size (IS) using cardiac magnetic resonance (CMR) data in patients with acute myocardial infarction (AMI). Method 40 consecutive patients classified according to the median level of MPO in the culprit artery. A CMR study was performed during the week following AMI and at 6 months, with late gadolinium enhancement sequences. Results Persistent MO was observed in the same proportion (50 vs. 65%, p = 0.728) between the low vs. high MPO group levels. However, the extent of the microvascular obstruction was significantly greater in the high-MPO group (6 (0–9) vs.16.5 (0–31), p = 0.027), together with a greater infarct size, and a trend towards a lower left ventricular ejection fraction (LVEF) (p = 0.054) at one week. CMR data at 6 months showed that reverse systolic remodeling was two fold more present in the low-MPO group (p = 0.058). Interestingly, the extent of MO (8.5 (6.5–31) vs. 4.1 (3–11.55), p = 0.042) and IS remained significantly greater (24.5 (9.75–35) vs. 7.5 (2.5–18.75), p = 0.022) in the high-MPO group. Moreover, MPO in the culprit artery appeared to correlate positively with MPO in non-culprit arteries and serum, and with troponin levels and peak CK. Conclusion This patient-based study revealed in patients after AMI that high MPO levels in the culprit artery were associated with more severe microvascular obstruction and greater IS. These findings may provide new insights pathophysiology explanation for the adverse prognostic impact of MO. To better understand the role of myeloperoxidases (MPO) in microvascular obstruction (MO) phenomenon and infarct size (IS) using cardiac magnetic resonance (CMR) data in patients with acute myocardial infarction (AMI).40 consecutive patients classified according to the median level of MPO in the culprit artery. A CMR study was performed during the week following AMI and at 6 months, with late gadolinium enhancement sequences.Persistent MO was observed in the same proportion (50 vs. 65%, p = 0.728) between the low vs. high MPO group levels. However, the extent of the microvascular obstruction was significantly greater in the high-MPO group (6 (0-9) vs.16.5 (0-31), p = 0.027), together with a greater infarct size, and a trend towards a lower left ventricular ejection fraction (LVEF) (p = 0.054) at one week. CMR data at 6 months showed that reverse systolic remodeling was two fold more present in the low-MPO group (p = 0.058). Interestingly, the extent of MO (8.5 (6.5-31) vs. 4.1 (3-11.55), p = 0.042) and IS remained significantly greater (24.5 (9.75-35) vs. 7.5 (2.5-18.75), p = 0.022) in the high-MPO group. Moreover, MPO in the culprit artery appeared to correlate positively with MPO in non-culprit arteries and serum, and with troponin levels and peak CK.This patient-based study revealed in patients after AMI that high MPO levels in the culprit artery were associated with more severe microvascular obstruction and greater IS. These findings may provide new insights pathophysiology explanation for the adverse prognostic impact of MO. Main objective To better understand the role of myeloperoxidases (MPO) in microvascular obstruction (MO) phenomenon and infarct size (IS) using cardiac magnetic resonance (CMR) data in patients with acute myocardial infarction (AMI). Method 40 consecutive patients classified according to the median level of MPO in the culprit artery. A CMR study was performed during the week following AMI and at 6 months, with late gadolinium enhancement sequences. Results Persistent MO was observed in the same proportion (50 vs. 65%, p = 0.728) between the low vs. high MPO group levels. However, the extent of the microvascular obstruction was significantly greater in the high-MPO group (6 (0-9) vs.16.5 (0-31), p = 0.027), together with a greater infarct size, and a trend towards a lower left ventricular ejection fraction (LVEF) (p = 0.054) at one week. CMR data at 6 months showed that reverse systolic remodeling was two fold more present in the low-MPO group (p = 0.058). Interestingly, the extent of MO (8.5 (6.5-31) vs. 4.1 (3-11.55), p = 0.042) and IS remained significantly greater (24.5 (9.75-35) vs. 7.5 (2.5-18.75), p = 0.022) in the high-MPO group. Moreover, MPO in the culprit artery appeared to correlate positively with MPO in non-culprit arteries and serum, and with troponin levels and peak CK. Conclusion This patient-based study revealed in patients after AMI that high MPO levels in the culprit artery were associated with more severe microvascular obstruction and greater IS. These findings may provide new insights pathophysiology explanation for the adverse prognostic impact of MO. To better understand the role of myeloperoxidases (MPO) in microvascular obstruction (MO) phenomenon and infarct size (IS) using cardiac magnetic resonance (CMR) data in patients with acute myocardial infarction (AMI).MAIN OBJECTIVETo better understand the role of myeloperoxidases (MPO) in microvascular obstruction (MO) phenomenon and infarct size (IS) using cardiac magnetic resonance (CMR) data in patients with acute myocardial infarction (AMI).40 consecutive patients classified according to the median level of MPO in the culprit artery. A CMR study was performed during the week following AMI and at 6 months, with late gadolinium enhancement sequences.METHOD40 consecutive patients classified according to the median level of MPO in the culprit artery. A CMR study was performed during the week following AMI and at 6 months, with late gadolinium enhancement sequences.Persistent MO was observed in the same proportion (50 vs. 65%, p = 0.728) between the low vs. high MPO group levels. However, the extent of the microvascular obstruction was significantly greater in the high-MPO group (6 (0-9) vs.16.5 (0-31), p = 0.027), together with a greater infarct size, and a trend towards a lower left ventricular ejection fraction (LVEF) (p = 0.054) at one week. CMR data at 6 months showed that reverse systolic remodeling was two fold more present in the low-MPO group (p = 0.058). Interestingly, the extent of MO (8.5 (6.5-31) vs. 4.1 (3-11.55), p = 0.042) and IS remained significantly greater (24.5 (9.75-35) vs. 7.5 (2.5-18.75), p = 0.022) in the high-MPO group. Moreover, MPO in the culprit artery appeared to correlate positively with MPO in non-culprit arteries and serum, and with troponin levels and peak CK.RESULTSPersistent MO was observed in the same proportion (50 vs. 65%, p = 0.728) between the low vs. high MPO group levels. However, the extent of the microvascular obstruction was significantly greater in the high-MPO group (6 (0-9) vs.16.5 (0-31), p = 0.027), together with a greater infarct size, and a trend towards a lower left ventricular ejection fraction (LVEF) (p = 0.054) at one week. CMR data at 6 months showed that reverse systolic remodeling was two fold more present in the low-MPO group (p = 0.058). Interestingly, the extent of MO (8.5 (6.5-31) vs. 4.1 (3-11.55), p = 0.042) and IS remained significantly greater (24.5 (9.75-35) vs. 7.5 (2.5-18.75), p = 0.022) in the high-MPO group. Moreover, MPO in the culprit artery appeared to correlate positively with MPO in non-culprit arteries and serum, and with troponin levels and peak CK.This patient-based study revealed in patients after AMI that high MPO levels in the culprit artery were associated with more severe microvascular obstruction and greater IS. These findings may provide new insights pathophysiology explanation for the adverse prognostic impact of MO.CONCLUSIONThis patient-based study revealed in patients after AMI that high MPO levels in the culprit artery were associated with more severe microvascular obstruction and greater IS. These findings may provide new insights pathophysiology explanation for the adverse prognostic impact of MO. Main objective 40 consecutive patients classified according to the median level of MPO in the culprit artery. A CMR study was performed during the week following AMI and at 6 months, with late gadolinium enhancement sequences. Persistent MO was observed in the same proportion (50 vs. 65%, p = 0.728) between the low vs. high MPO group levels. However, the extent of the microvascular obstruction was significantly greater in the high-MPO group (6 (0-9) vs.16.5 (0-31), p = 0.027), together with a greater infarct size, and a trend towards a lower left ventricular ejection fraction (LVEF) (p = 0.054) at one week. CMR data at 6 months showed that reverse systolic remodeling was two fold more present in the low-MPO group (p = 0.058). Interestingly, the extent of MO (8.5 (6.5-31) vs. 4.1 (3-11.55), p = 0.042) and IS remained significantly greater (24.5 (9.75-35) vs. 7.5 (2.5-18.75), p = 0.022) in the high-MPO group. Moreover, MPO in the culprit artery appeared to correlate positively with MPO in non-culprit arteries and serum, and with troponin levels and peak CK. This patient-based study revealed in patients after AMI that high MPO levels in the culprit artery were associated with more severe microvascular obstruction and greater IS. These findings may provide new insights pathophysiology explanation for the adverse prognostic impact of MO. |
| Audience | Academic |
| Author | Cochet, Alexandre Stamboul, Karim Cottin, Yves Maillot, Nicolas Bugiardini, Raffaele Rochette, Luc Lorgis, Luc Vergely, Catherine Zeller, Marianne Guenancia, Charles Fichot, Marie Leclercq, Thibault Porot, Guillaume |
| AuthorAffiliation | 3 Laboratory of Cerebro-Vascular Pathophysiology and epidemiology (PEC2), University of Burgundy, Dijon, France.University of Burgundy, Dijon, France 2 MRI Unit and LE2I UMR CNRS 6306, University Hospital, Dijon, France 1 Department of Cardiology, University Hospital, Bd de Lattre de Tassigny, Dijon Cedex, France University of Bologna, ITALY |
| AuthorAffiliation_xml | – name: 3 Laboratory of Cerebro-Vascular Pathophysiology and epidemiology (PEC2), University of Burgundy, Dijon, France.University of Burgundy, Dijon, France – name: 2 MRI Unit and LE2I UMR CNRS 6306, University Hospital, Dijon, France – name: 1 Department of Cardiology, University Hospital, Bd de Lattre de Tassigny, Dijon Cedex, France – name: University of Bologna, ITALY |
| Author_xml | – sequence: 1 fullname: Stamboul, Karim – sequence: 2 fullname: Zeller, Marianne – sequence: 3 fullname: Rochette, Luc – sequence: 4 fullname: Cottin, Yves – sequence: 5 fullname: Cochet, Alexandre – sequence: 6 fullname: Leclercq, Thibault – sequence: 7 fullname: Porot, Guillaume – sequence: 8 orcidid: 0000-0002-3554-7714 fullname: Guenancia, Charles – sequence: 9 fullname: Fichot, Marie – sequence: 10 fullname: Maillot, Nicolas – sequence: 11 orcidid: 0000-0003-4009-776x fullname: Vergely, Catherine – sequence: 12 fullname: Lorgis, Luc – sequence: 13 fullname: Bugiardini, Raffaele |
| BackLink | https://cir.nii.ac.jp/crid/1871428068002141824$$DView record in CiNii https://www.ncbi.nlm.nih.gov/pubmed/28704420$$D View this record in MEDLINE/PubMed https://ube.hal.science/hal-03431609$$DView record in HAL |
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| ContentType | Journal Article |
| Contributor | Service de Cardiologie [CHU de Dijon] ; Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon) Conseil Régional de Bourgogne Service de radiologie et d'Imagerie médicale diagnostique et thérapeutique (CHU de Dijon) ; Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon) Laboratoire Electronique, Informatique et Image [UMR6306] (Le2i) ; Université de Bourgogne (UB)-École Nationale Supérieure d'Arts et Métiers (ENSAM) ; Arts et Métiers Sciences et Technologies ; HESAM Université (HESAM)-HESAM Université (HESAM)-Arts et Métiers Sciences et Technologies ; HESAM Université (HESAM)-HESAM Université (HESAM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS) Fédération Francaise de Cardiologie (FFC) Union Régionale des Caisses d'Assurance Maladie de Bourgogne (URCAM) Université de Bourgogne (UB) Association de Cardiologie de Bourgog |
| Contributor_xml | – sequence: 1 fullname: Université de Bourgogne (UB) – sequence: 2 fullname: Service de Cardiologie [CHU de Dijon] ; Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon) – sequence: 3 fullname: Physiopathologie et épidémiologie cérébro-cardiovasculaire [Dijon] (PEC2) ; Université de Bourgogne (UB)-Université Bourgogne Franche-Comté [COMUE] (UBFC) – sequence: 4 fullname: Laboratoire Electronique, Informatique et Image [UMR6306] (Le2i) ; Université de Bourgogne (UB)-École Nationale Supérieure d'Arts et Métiers (ENSAM) ; Arts et Métiers Sciences et Technologies ; HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Arts et Métiers Sciences et Technologies ; HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS) – sequence: 5 fullname: Service de radiologie et d'Imagerie médicale diagnostique et thérapeutique (CHU de Dijon) ; Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon) – sequence: 6 fullname: University Hospital of Dijon – sequence: 7 fullname: Faculty of Medicine of Dijon – sequence: 8 fullname: Association de Cardiologie de Bourgogne – sequence: 9 fullname: Union Régionale des Caisses d'Assurance Maladie de Bourgogne (URCAM) – sequence: 10 fullname: Agence Régionale de Santé (ARS) de Bourgogne – sequence: 11 fullname: Conseil Régional de Bourgogne – sequence: 12 fullname: Fédération Francaise de Cardiologie (FFC) – sequence: 13 fullname: Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon) – sequence: 14 fullname: Laboratoire Electronique, Informatique et Image [UMR6306] (Le2i) ; Université de Bourgogne (UB)-École Nationale Supérieure d'Arts et Métiers (ENSAM) ; Arts et Métiers Sciences et Technologies ; HESAM Université (HESAM)-HESAM Université (HESAM)-Arts et Métiers Sciences et Technologies ; HESAM Université (HESAM)-HESAM Université (HESAM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS) – sequence: 15 fullname: Vergely, Catherine |
| Copyright | COPYRIGHT 2017 Public Library of Science 2017 Stamboul et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Distributed under a Creative Commons Attribution 4.0 International License 2017 Stamboul et al 2017 Stamboul et al |
| Copyright_xml | – notice: COPYRIGHT 2017 Public Library of Science – notice: 2017 Stamboul et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: Distributed under a Creative Commons Attribution 4.0 International License – notice: 2017 Stamboul et al 2017 Stamboul et al |
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| DOI | 10.1371/journal.pone.0179929 |
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| DocumentTitleAlternate | Relationship between MPO and infarct size in STEMI patients |
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| Keywords | Acute Coronary Syndromes Disease Leukocyte Mortality Definition Long-Term Dimethylarginine No-Reflow |
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| License | Distributed under a Creative Commons Attribution 4.0 International License: http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Creative Commons Attribution License |
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| Snippet | To better understand the role of myeloperoxidases (MPO) in microvascular obstruction (MO) phenomenon and infarct size (IS) using cardiac magnetic resonance... Main objective To better understand the role of myeloperoxidases (MPO) in microvascular obstruction (MO) phenomenon and infarct size (IS) using cardiac... Main objective 40 consecutive patients classified according to the median level of MPO in the culprit artery. A CMR study was performed during the week... Main objective To better understand the role of myeloperoxidases (MPO) in microvascular obstruction (MO) phenomenon and infarct size (IS) using cardiac... |
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| SubjectTerms | [SDV.IB]Life Sciences [q-bio]/Bioengineering [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system Acute Coronary Syndromes Acute Coronary Syndromes, No-Reflow, Long-Term, Leukocyte, Dimethylarginine, Definition, Mortality, Disease Aged Arteries Arteries - enzymology Arteries - pathology Biology and Life Sciences Calcium-binding protein Cardiac patients Cardiology Cardiology and cardiovascular system Cardiovascular disease Definition Dimethylarginine Disease Epidemiology Female Gadolinium Health aspects Heart Heart attack Heart attacks Heart diseases Human health and pathology Humans Hypertension Infarction Ischemia Laboratories Leukocyte Life Sciences Long-Term Magnetic resonance Magnetic resonance imaging Magnetic Resonance Imaging, Cine Magnetic Resonance Imaging, Cine - methods Male Medicine Medicine and Health Sciences Microcirculation Microvasculature Middle Aged Mortality Myocardial infarction Neutrophils Nitric oxide NMR No-Reflow Nuclear magnetic resonance Patients Peroxidase Peroxidase - metabolism Plasma Prognosis Q R Remodeling Research Article Resonance Science ST Elevation Myocardial Infarction ST Elevation Myocardial Infarction - blood ST Elevation Myocardial Infarction - enzymology ST Elevation Myocardial Infarction - pathology Stroke Volume Troponin Ventricle Ventricular Function, Left Ventricular Remodeling |
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| Title | Relation between high levels of myeloperoxidase in the culprit artery and microvascular obstruction, infarct size and reverse remodeling in ST-elevation myocardial infarction |
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