Genetic architecture of subcortical brain structures in 38,851 individuals
Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus, using genome-wide association analyses in al...
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| Vydané v: | Nature genetics Ročník 51; číslo 11; s. 1624 - 1636 |
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| Médium: | Journal Article |
| Jazyk: | English |
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New York
Nature Publishing Group US
01.11.2019
Nature Publishing Group |
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| ISSN: | 1061-4036, 1546-1718, 1546-1718 |
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| Abstract | Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus, using genome-wide association analyses in almost 40,000 individuals from CHARGE, ENIGMA and UK Biobank. We show that variability in subcortical volumes is heritable, and identify 48 significantly associated loci (40 novel at the time of analysis). Annotation of these loci by utilizing gene expression, methylation and neuropathological data identified 199 genes putatively implicated in neurodevelopment, synaptic signaling, axonal transport, apoptosis, inflammation/infection and susceptibility to neurological disorders. This set of genes is significantly enriched for
Drosophila
orthologs associated with neurodevelopmental phenotypes, suggesting evolutionarily conserved mechanisms. Our findings uncover novel biology and potential drug targets underlying brain development and disease.
Genome-wide analysis identifies variants associated with the volume of seven different subcortical brain regions defined by magnetic resonance imaging. Implicated genes are involved in neurodevelopmental and synaptic signaling pathways. |
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| AbstractList | Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus, using genome-wide association analyses in almost 40,000 individuals from CHARGE, ENIGMA and UK Biobank. We show that variability in subcortical volumes is heritable, and identify 48 significantly associated loci (40 novel at the time of analysis). Annotation of these loci by utilizing gene expression, methylation and neuropathological data identified 199 genes putatively implicated in neurodevelopment, synaptic signaling, axonal transport, apoptosis, inflammation/infection and susceptibility to neurological disorders. This set of genes is significantly enriched for Drosophila orthologs associated with neurodevelopmental phenotypes, suggesting evolutionarily conserved mechanisms. Our findings uncover novel biology and potential drug targets underlying brain development and disease. Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus, using genome-wide association analyses in almost 40,000 individuals from CHARGE, ENIGMA and UK Biobank. We show that variability in subcortical volumes is heritable, and identify 48 significantly associated loci (40 novel at the time of analysis). Annotation of these loci by utilizing gene expression, methylation and neuropathological data identified 199 genes putatively implicated in neurodevelopment, synaptic signaling, axonal transport, apoptosis, inflammation/infection and susceptibility to neurological disorders. This set of genes is significantly enriched for Drosophila orthologs associated with neurodevelopmental phenotypes, suggesting evolutionarily conserved mechanisms. Our findings uncover novel biology and potential drug targets underlying brain development and disease. Genome-wide analysis identifies variants associated with the volume of seven different subcortical brain regions defined by magnetic resonance imaging. Implicated genes are involved in neurodevelopmental and synaptic signaling pathways. Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus, using genome-wide association analyses in almost 40,000 individuals from CHARGE, ENIGMA and UK Biobank. We show that variability in subcortical volumes is heritable, and identify 48 significantly associated loci (40 novel at the time of analysis). Annotation of these loci by utilizing gene expression, methylation and neuropathological data identified 199 genes putatively implicated in neurodevelopment, synaptic signaling, axonal transport, apoptosis, inflammation/infection and susceptibility to neurological disorders. This set of genes is significantly enriched for Drosophila orthologs associated with neurodevelopmental phenotypes, suggesting evolutionarily conserved mechanisms. Our findings uncover novel biology and potential drug targets underlying brain development and disease.Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus, using genome-wide association analyses in almost 40,000 individuals from CHARGE, ENIGMA and UK Biobank. We show that variability in subcortical volumes is heritable, and identify 48 significantly associated loci (40 novel at the time of analysis). Annotation of these loci by utilizing gene expression, methylation and neuropathological data identified 199 genes putatively implicated in neurodevelopment, synaptic signaling, axonal transport, apoptosis, inflammation/infection and susceptibility to neurological disorders. This set of genes is significantly enriched for Drosophila orthologs associated with neurodevelopmental phenotypes, suggesting evolutionarily conserved mechanisms. Our findings uncover novel biology and potential drug targets underlying brain development and disease. Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus, using genome-wide association analyses in almost 40,000 individuals from CHARGE, ENIGMA and UK Biobank. We show that variability in subcortical volumes is heritable, and identify 48 significantly associated loci (40 novel at the time of analysis). Annotation of these loci by utilizing gene expression, methylation and neuropathological data identified 199 genes putatively implicated in neurodevelopment, synaptic signaling, axonal transport, apoptosis, inflammation/infection and susceptibility to neurological disorders. This set of genes is significantly enriched for Drosophila orthologs associated with neurodevelopmental phenotypes, suggesting evolutionarily conserved mechanisms. Our findings uncover novel biology and potential drug targets underlying brain development and disease. Genome-wide analysis identifies variants associated with the volume of seven different subcortical brain regions defined by magnetic resonance imaging. Implicated genes are involved in neurodevelopmental and synaptic signaling pathways. |
| Audience | Academic |
| Author | Meyer-Lindenberg, Andreas Holsboer, Florian Zwiers, Marcel P. Huentelman, Matthew Heslenfeld, Dirk J. Lawrie, Stephen M. Psaty, Bruce M. Jack, Clifford R. Saremi, Arvin Bernard, Manon Ehrlich, Stefan Boks, Marco P. Smoller, Jordan W. Pütz, Benno Green, Robert C Sachdev, Perminder S. Fornage, Myriam Amin, Najaf Eicher, John D. Stein, Dan J. Stevens, Allison White, Tonya Milaneschi, Yuri Fleischman, Debra A. Mattheisen, Manuel Hofer, Edith Toga, Arthur W. Walter, Henrik Athanasiu, Lavinia Groenewold, Nynke A. Martin, Nicholas G. Carmichael, Owen Hegenscheid, Katrin Chen, Qiang Goldman, Aaron L. Hansell, Narelle K. Beiser, Alexa S. Doan, Nhat Trung Gollub, Randy L. Luciano, Michelle Davey Smith, George Kwok, John B. J. Lee, Tom V. Tordesillas-Gutierrez, Diana Ikram, M. Kamran Hoekstra, Pieter J. van Eijk, Kristel R. Marquand, Andre F. Veltman, Dick J. Thompson, Paul M. Soininen, Hilkka Bulayeva, Kazima B. Nho, Kwangsik McMahon, Katie L. Lin, Honghuang Andersson, Micael Westlye, Lars T. Schumann, Gunter Klein, Marieke Bralten, Janita Schmidt, Reinh |
| AuthorAffiliation | 9 Cell Circuits Program, Broad Institute, Cambridge, MA, USA 212 Department of Radiology, Mayo Clinic, Rochester, MN, USA 89 German Center for Neurodegenerative Diseases, Greifswald, Germany 105 Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA 193 Center for Neurobehavioral Genetics, University of California, Los Angeles, Los Angeles, CA, USA 201 Kaiser Permanent Washington Health Research Institute, Seattle, WA, USA 88 Department of Psychiatry, University Medicine Greifswald, Greifswald, Germany 184 Clinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine, CA, USA 8 Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA 6 Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, the Netherlands 34 MRC-SGDP Centre, In |
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Hans, Roskilde, Denmark – name: 63 Department of Psychiatry, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, the Netherlands – name: 129 Pennington Biomedical Research Center, Baton Rouge, LA, USA – name: 216 Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine, CA, USA – name: 101 Academic Unit for Psychiatry of Old Age, University of Melbourne, Melbourne, Victoria, Australia – name: 158 Clinical Neuropsychology Section, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands – name: 249 Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC-Sophia Children’s Hospital, Rotterdam, the Netherlands – name: 223 Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA – name: 15 University of Bordeaux, Inserm, Bordeaux Population Health Research Center, Team VINTAGE, UMR 1219, Bordeaux, France – name: 33 Division of Intramural Research, Population Sciences Branch, National Heart, Lung and 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University of Texas Health Science Center at Houston, Houston, TX, USA – name: 197 Imaging of Dementia and Aging Laboratory, Department of Neurology, University of California, Davis, Davis, CA, USA – name: 142 Department of Cognitive Sciences, University of California, San Diego, San Diego, CA, USA – name: 163 Institut Pasteur de Lille, Lille, France – name: 7 Department of Clinical Genetics, Erasmus MC, Rotterdam, the Netherlands – name: 23 Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria – name: 84 Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany – name: 205 Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA – name: 43 Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN, USA – name: 242 Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, 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M. organization: Clinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, University of California, Irvine, Center for the Neurobiology of Learning and Memory, University of California, Irvine – sequence: 156 givenname: Norman surname: Delanty fullname: Delanty, Norman organization: The Royal College of Surgeons in Ireland, Neurology Division, Beaumont Hospital – sequence: 159 givenname: Elena surname: Shumskaya fullname: Shumskaya, Elena organization: Department of Human Genetics, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Donders Centre for Cognitive Neuroimaging, Radboud University – sequence: 164 givenname: Bruce M. surname: Psaty fullname: Psaty, Bruce M. organization: Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Kaiser Permanent Washington Health Research Institute, Department of Epidemiology, University of Washington, Department of Health Services, University of Washington – sequence: 165 givenname: Mark E. surname: Bastin fullname: Bastin, Mark E. organization: Brain Research Imaging Centre, University of Edinburgh, Centre for Clinical Brain Sciences, University of Edinburgh – sequence: 168 givenname: Simone surname: Reppermund fullname: Reppermund, Simone organization: Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Department of Developmental Disability Neuropsychiatry, School of Psychiatry, UNSW Medicine – sequence: 174 givenname: Marjolein M. 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J. organization: Department of Human Genetics, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Radboud University – sequence: 178 givenname: Anbupalam surname: Thalamuthu fullname: Thalamuthu, Anbupalam organization: Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales – sequence: 188 givenname: Evan surname: Fletcher fullname: Fletcher, Evan organization: Imaging of Dementia and Aging Laboratory, Department of Neurology, University of California, Davis – sequence: 190 givenname: Oliver surname: Gruber fullname: Gruber, Oliver organization: Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University – sequence: 193 givenname: Lenore J. surname: Launer fullname: Launer, Lenore J. organization: Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health – sequence: 194 givenname: Lars surname: Nyberg fullname: Nyberg, Lars organization: Department of Integrative Medical Biology, Umeå University, Umeå Centre for Functional Brain Imaging (UFBI), Umeå University, Radiation Sciences, Umeå University – sequence: 201 givenname: Vidar M. surname: Steen fullname: Steen, Vidar M. organization: NORMENT, Department of Clinical Science, University of Bergen, Dr Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital – sequence: 203 givenname: Nynke A. surname: Groenewold fullname: Groenewold, Nynke A. organization: Department of Psychiatry and Mental Health, University of Cape Town – sequence: 204 givenname: Wiro J. surname: Niessen fullname: Niessen, Wiro J. organization: Department of Radiology and Nuclear Medicine, Erasmus MC, Department of Medical Informatics, Erasmus MC, Imaging Physics, Faculty of Applied Sciences, Delft University of Technology – sequence: 207 givenname: William T. surname: Longstreth fullname: Longstreth, William T. organization: Department of Epidemiology, University of Washington, Department of Neurology, University of Washington – sequence: 208 givenname: M. Kamran surname: Ikram fullname: Ikram, M. Kamran organization: Department of Epidemiology, Erasmus MC, Department of Neurology, Erasmus MC – sequence: 211 givenname: Jessika E. surname: Sussmann fullname: Sussmann, Jessika E. organization: Division of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh – sequence: 216 givenname: Ole A. orcidid: 0000-0002-4461-3568 surname: Andreassen fullname: Andreassen, Ole A. organization: CoE NORMENT, Division of Mental Health and Addiction, Oslo University Hospital, CoE NORMENT, Institute of Clinical Medicine, University of Oslo – sequence: 220 givenname: Jessica A. orcidid: 0000-0003-0076-8434 surname: Turner fullname: Turner, Jessica A. organization: The Mind Research Network and LBERI, Tri-institutional Center for Translational Research in Neuroimaging and Data Science, Georgia State University, Department of Psychology, Georgia State University – sequence: 221 givenname: Zdenka surname: Pausova fullname: Pausova, Zdenka organization: Hospital for Sick Children, University of Toronto – sequence: 222 givenname: Gunter orcidid: 0000-0002-7740-6469 surname: Schumann fullname: Schumann, Gunter organization: MRC-SGDP Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London – sequence: 224 givenname: Srdjan orcidid: 0000-0002-8140-8061 surname: Djurovic fullname: Djurovic, Srdjan organization: NORMENT, Department of Clinical Science, University of Bergen, Department of Medical Genetics, Oslo University Hospital – sequence: 225 givenname: Ian J. surname: Deary fullname: Deary, Ian J. organization: Department of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh – sequence: 227 givenname: Bertram surname: Müller-Myhsok fullname: Müller-Myhsok, Bertram organization: Max Planck Institute of Psychiatry, Munich Cluster for Systems Neurology (SyNergy), Institute of Translational Medicine, University of Liverpool – sequence: 232 givenname: Joshua W. orcidid: 0000-0002-3976-5073 surname: Cheung fullname: Cheung, Joshua W. organization: Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California – sequence: 234 givenname: Jean-Luc surname: Martinot fullname: Martinot, Jean-Luc organization: INSERM, Research Unit 1000 ‘Neuroimaging and Psychiatry’, Paris Saclay University and Paris Descartes University—DIGITEO Labs – sequence: 235 givenname: Marcel P. surname: Zwiers fullname: Zwiers, Marcel P. organization: Donders Institute for Brain, Cognition and Behaviour, Radboud University, Donders Centre for Cognitive Neuroimaging, Radboud University – sequence: 239 givenname: Ryota surname: Kanai fullname: Kanai, Ryota organization: Department of Neuroinformatics, Araya, Institute of Cognitive Neuroscience, University College London, School of Psychology, University of Sussex – sequence: 242 givenname: Sanjay M. surname: Sisodiya fullname: Sisodiya, Sanjay M. organization: UCL Queen Square Institute of Neurology, Chalfont Centre for Epilepsy – sequence: 243 givenname: Tonya surname: White fullname: White, Tonya organization: Department of Radiology and Nuclear Medicine, Erasmus MC, Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC-Sophia Children’s Hospital – sequence: 247 givenname: Henry surname: Völzke fullname: Völzke, Henry organization: Institute for Community Medicine, University Medicine Greifswald, German Center for Cardiovascular Research (partner site Greifswald) – sequence: 250 givenname: Markus M. surname: Nöthen fullname: Nöthen, Markus M. organization: Institute of Human Genetics, University of Bonn, Department of Genomics, Life and Brain Center, University of Bonn – sequence: 251 givenname: Roel A. surname: Ophoff fullname: Ophoff, Roel A. organization: Center for Neurobehavioral Genetics, University of California, Los Angeles, Department of Psychiatry, Erasmus Medical Center – sequence: 254 givenname: Perminder S. orcidid: 0000-0002-9595-3220 surname: Sachdev fullname: Sachdev, Perminder S. organization: Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Neuropsychiatric Institute, Prince of Wales Hospital – sequence: 256 givenname: Neeltje E. M. surname: van Haren fullname: van Haren, Neeltje E. M. organization: Department of Psychiatry, UMC Brain Center, University Medical Center Utrecht, Utrecht University, Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC-Sophia Children’s Hospital – sequence: 257 givenname: Simon E. orcidid: 0000-0002-3132-1996 surname: Fisher fullname: Fisher, Simon E. organization: Donders Institute for Brain, Cognition and Behaviour, Radboud University, Language and Genetics Department, Max Planck Institute for Psycholinguistics – sequence: 258 givenname: Alexa S. surname: Beiser fullname: Beiser, Alexa S. organization: The Framingham Heart Study, Department of Neurology, Boston University School of Medicine, Department of Biostatistics, Boston University School of Public Health – sequence: 261 givenname: Karen A. surname: Mather fullname: Mather, Karen A. organization: Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Neuroscience Research Australia – sequence: 262 givenname: Nina orcidid: 0000-0002-6931-269X surname: Romanczuk-Seiferth fullname: Romanczuk-Seiferth, Nina organization: Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin – sequence: 263 givenname: Catharina A. surname: Hartman fullname: Hartman, Catharina A. organization: University Medical Center Groningen, Department of Psychiatry, University of Groningen – sequence: 268 givenname: Pieter J. surname: Hoekstra fullname: Hoekstra, Pieter J. organization: University Medical Center Groningen, Department of Psychiatry, University of Groningen – sequence: 269 givenname: Paul A. surname: Nyquist fullname: Nyquist, Paul A. organization: GeneSTAR Research Program, Department of Medicine, Johns Hopkins University School of Medicine – sequence: 270 givenname: Barbara orcidid: 0000-0003-4375-6572 surname: Franke fullname: Franke, Barbara organization: Department of Human Genetics, Radboud University Medical Center, Department of Psychiatry, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Radboud University – sequence: 272 givenname: Hans J. orcidid: 0000-0003-3684-4208 surname: Grabe fullname: Grabe, Hans J. organization: Department of Psychiatry, University Medicine Greifswald, German Center for Neurodegenerative Diseases – sequence: 273 givenname: Andrew D. surname: Johnson fullname: Johnson, Andrew D. organization: Division of Intramural Research, Population Sciences Branch, National Heart, Lung and Blood Institute – sequence: 274 givenname: Christopher surname: Chen fullname: Chen, Christopher organization: Department of Pharmacology, National University of Singapore, Memory Aging and Cognition Center, National University Health System – sequence: 277 givenname: Myriam surname: Fornage fullname: Fornage, Myriam organization: The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Human Genetics Center, University of Texas Health Science Center at Houston – sequence: 282 givenname: Arno surname: Villringer fullname: Villringer, Arno organization: Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Faculty of Medicine, CRC 1052 ‘Obesity Mechanisms’, University of Leipzig |
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| ContentType | Journal Article |
| Copyright | The Author(s), under exclusive licence to Springer Nature America, Inc. 2019 COPYRIGHT 2019 Nature Publishing Group Copyright Nature Publishing Group Nov 2019 licence_http://creativecommons.org/publicdomain/zero |
| Copyright_xml | – notice: The Author(s), under exclusive licence to Springer Nature America, Inc. 2019 – notice: COPYRIGHT 2019 Nature Publishing Group – notice: Copyright Nature Publishing Group Nov 2019 – notice: licence_http://creativecommons.org/publicdomain/zero |
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| DOI | 10.1038/s41588-019-0511-y |
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| ISSN | 1061-4036 1546-1718 |
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| Issue | 11 |
| Keywords | VINTAGE HEALTHY |
| Language | English |
| License | licence_http://creativecommons.org/publicdomain/zero/: http://creativecommons.org/publicdomain/zero Reprints and permissions information is available at www.nature.com/reprints. |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 PMCID: PMC7055269 C.L.S. drafted the manuscript with contributions from H.H.H.A., D.P.H., C.C.W., T.V.L., A.A.-V., S.Ehrlich., A.K.H., M.W.V., D.J., T.G.M.v.E., C.D.W., M.J.W., S.E.F., K.A.M., P.J.H., B.F., H.J.G., A.D.J., O.L.L., S.Debette, S.E.M., J.M.S., P.M.T., S.S. and M.A.I. M.S., N.J., L.R.Y., T.V.L., G.C., L.A., M.E.R., A.d.B., I.K., M.A., S.A., S.E., R.R.-S., A.K.H., H.J.J., A.Stevens., J.B., M.W.V., A.V.W., K.W., N.A., S.H., A.L.G., P.H.L., S.G., S.L.H., D.K., L.Schmaal, S.M.L., I.A., E.W., D.T.-G., J.C.I., L.N.V., R.B., F.C., D.J., O.C., U.K.H., B.S.A., C.-Y.C., A.A.A., M.P.B., A.F.M., S.K.M., P.A., A.J.Schork., D.C.M.L., T.Y.W., L.Shen, P.G.S., E.J.C.d.G., M.T., K.R.v.E., N.J.A.v.d.W., A.M.M., J.S.R., N.R., W.H., M.C.V.H., J.B.J.K., L.M.O.L., A.Hofman, G.H., M.E.B., S.R., J.-J.H., A.Simmons, N.H., P.R.S., T.W.M., P.Maillard, O.Gruber, N.A.G., J.E.S., H.Lemaître, B.M.-M., D.v.R., I.J.D., R.M.B., I.M., R.K., H.v.B., M.J.W., D.v.‘t.E., M.M.N., S.E.F., A.S.B., K.A.M., N.R.-S., D.J.H., H.J.G., C.M.v.D., J.M.W., C.DeCarli, P.L.D.J. and V.G. contributed to the preparation of data. C.L.S., H.H.H.A., D.P.H., M.J.K., J.L.S., M.S., M.Sargurupremraj, N.J., G.V.R., A.V.S., J.C.B., X.J., M.Luciano., E.H., A.Teumer, S.J.v.d.L., J.Y., L.R.Y., S.L., K.J.Y., G.C., M.E.R., N.J.A., H.J.J., A.V.W., S.H., N.M.S., S.G., D.T.G., J.S., C.-Y.C., L.M.O.L., Q.Y., A.Thalamuthu, I.O.F., D.v.‘t.E., C.Depondt and P.L.D.J. performed the statistical analyses. C.L.S., H.H.H.A., C.C.W., M.J.K., T.V.L., S.L., Y.H., K.J.Y., J.D.E., Q.Y. and A.D.J. carried out the downstream analyses. All authors reviewed the manuscript for intellectual content. Author contributions |
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| Title | Genetic architecture of subcortical brain structures in 38,851 individuals |
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