Many LINE1 elements contribute to the transcriptome of human somatic cells

Background While LINE1 (L1) retroelements comprise nearly 20% of the human genome, the majority are thought to have been rendered transcriptionally inactive, due to either mutation or epigenetic suppression. How many L1 elements 'escape' these forms of repression and contribute to the tran...

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Bibliographic Details
Published in:	Genome biology Vol. 10; no. 9; p. R100
Main Authors:	Rangwala, Sanjida H, Zhang, Lili, Kazazian, Haig H
Format:	Journal Article
Language:	English
Published:	London BioMed Central 22.09.2009
Subjects:	Animal Genetics and Genomics Binding Sites - genetics Bioinformatics Biomedical and Life Sciences Cell Line Chromosomes, Human, Pair 1 - genetics Chromosomes, Human, Pair 13 - genetics Chromosomes, Human, Pair 4 - genetics Chromosomes, Human, Pair 6 - genetics DNA, Complementary - chemistry DNA, Complementary - genetics epigenetics Evolutionary Biology Expressed Sequence Tags Gene Expression Profiling Gene Expression Regulation Genome, Human - genetics Human Genetics Humans Life Sciences Long Interspersed Nucleotide Elements - genetics Lymphocytes - cytology Lymphocytes - metabolism Microbial Genetics and Genomics mutation Plant Genetics and Genomics retrotransposons Reverse Transcriptase Polymerase Chain Reaction Sequence Analysis, DNA somatic cells transcription (genetics) Transcription, Genetic transcriptome Sense Promoter Picotiter Plate Cytosine Methylation Additional Data File Lymphoblastoid Cell Line
ISSN:	1474-760X, 1465-6906, 1474-760X, 1465-6914
Online Access:	Get full text
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