The age and genomic integrity of neurons after cortical stroke in humans

In this study, the authors use measures of carbon-14 in neuronal DNA from human stroke patient cortical tissue samples to show that, unlike previous studies done in rodents, they do not find any evidence of increased neurogenesis after an ischemic injury. In addition, DNA damage assays suggest that...

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Vydáno v:Nature neuroscience Ročník 17; číslo 6; s. 801 - 803
Hlavní autoři: Huttner, Hagen B, Bergmann, Olaf, Salehpour, Mehran, Rácz, Attila, Tatarishvili, Jemal, Lindgren, Emma, Csonka, Tamás, Csiba, László, Hortobágyi, Tibor, Méhes, Gábor, Englund, Elisabet, Solnestam, Beata Werne, Zdunek, Sofia, Scharenberg, Christian, Ström, Lena, Ståhl, Patrik, Sigurgeirsson, Benjamin, Dahl, Andreas, Schwab, Stefan, Possnert, Göran, Bernard, Samuel, Kokaia, Zaal, Lindvall, Olle, Lundeberg, Joakim, Frisén, Jonas
Médium: Journal Article
Jazyk:angličtina
Vydáno: New York Nature Publishing Group US 01.06.2014
Nature Publishing Group
Témata:
13/31
13/51
45/23
45/91
631/378/368/2431
Aged
Aged, 80 and over
Analysis
Animal Genetics and Genomics
Basic Medicine
Behavioral Sciences
Biological Techniques
Biomedicine
bomb peak
brief-communication
cell regeneration
Cellular Senescence - physiology
Chromosomes
cortical stroke
DNA
DNA Fragmentation
DNA repair
DNA Repair - physiology
Dynamical Systems
Female
Genetic aspects
Genomes
Hospitals
Humans
Ischemia
Male
Mathematics
Medical and Health Sciences
Medicin och hälsovetenskap
Medicinska och farmaceutiska grundvetenskaper
Middle Aged
Neocortex - pathology
Neocortex - physiology
Neurobiology
Neurogenesis
Neurons
Neurons - pathology
Neurons - physiology
Neurosciences
Neurovetenskaper
Physiological aspects
Stroke
Stroke (Disease)
Stroke - genetics
Stroke - pathology
Hungary
Sweden
Germany
ISSN:1097-6256, 1546-1726, 1546-1726
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Abstract In this study, the authors use measures of carbon-14 in neuronal DNA from human stroke patient cortical tissue samples to show that, unlike previous studies done in rodents, they do not find any evidence of increased neurogenesis after an ischemic injury. In addition, DNA damage assays suggest that there is no increase in DNA rearrangement after this insult. It has been unclear whether ischemic stroke induces neurogenesis or neuronal DNA rearrangements in the human neocortex. Using immunohistochemistry; transcriptome, genome and ploidy analyses; and determination of nuclear bomb test–derived 14 C concentration in neuronal DNA, we found neither to be the case. A large proportion of cortical neurons displayed DNA fragmentation and DNA repair a short time after stroke, whereas neurons at chronic stages after stroke showed DNA integrity, demonstrating the relevance of an intact genome for survival.
AbstractList It has been unclear whether ischemic stroke induces neurogenesis or neuronal DNA rearrangements in the human neocortex. Using immunohistochemistry; transcriptome, genome and ploidy analyses; and determination of nuclear bomb test-derived (14)C concentration in neuronal DNA, we found neither to be the case. A large proportion of cortical neurons displayed DNA fragmentation and DNA repair a short time after stroke, whereas neurons at chronic stages after stroke showed DNA integrity, demonstrating the relevance of an intact genome for survival.
It has been unclear whether ischemic stroke induces neurogenesis or neuronal DNA rearrangements in the human neocortex. Using immunohistochemistry; transcriptome, genome and ploidy analyses; and determination of nuclear bomb test-derived [sup.14]C concentration in neuronal DNA, we found neither to be the case. A large proportion of cortical neurons displayed DNA fragmentation and DNA repair a short time after stroke, whereas neurons at chronic stages after stroke showed DNA integrity, demonstrating the relevance of an intact genome for survival.
It has been unclear whether ischemic stroke induces neurogenesis or neuronal DNA rearrangements in the human neocortex. Using immunohistochemistry; transcriptome, genome and ploidy analyses; and determination of nuclear bomb test-derived C-14 concentration in neuronal DNA, we found neither to be the case. A large proportion of cortical neurons displayed DNA fragmentation and DNA repair a short time after stroke, whereas neurons at chronic stages after stroke showed DNA integrity, demonstrating the relevance of an intact genome for survival.
In this study, the authors use measures of carbon-14 in neuronal DNA from human stroke patient cortical tissue samples to show that, unlike previous studies done in rodents, they do not find any evidence of increased neurogenesis after an ischemic injury. In addition, DNA damage assays suggest that there is no increase in DNA rearrangement after this insult. It has been unclear whether ischemic stroke induces neurogenesis or neuronal DNA rearrangements in the human neocortex. Using immunohistochemistry; transcriptome, genome and ploidy analyses; and determination of nuclear bomb test–derived 14 C concentration in neuronal DNA, we found neither to be the case. A large proportion of cortical neurons displayed DNA fragmentation and DNA repair a short time after stroke, whereas neurons at chronic stages after stroke showed DNA integrity, demonstrating the relevance of an intact genome for survival.
It has been unclear whether ischemic stroke induces neurogenesis or neuronal DNA rearrangements in the human neocortex. Using immunohistochemistry; transcriptome, genome and ploidy analyses; and determination of nuclear bomb test-derived super(14)C concentration in neuronal DNA, we found neither to be the case. A large proportion of cortical neurons displayed DNA fragmentation and DNA repair a short time after stroke, whereas neurons at chronic stages after stroke showed DNA integrity, demonstrating the relevance of an intact genome for survival.
It has been unclear whether ischemic stroke induces neurogenesis or neuronal DNA rearrangements in the human neocortex. Using immunohistochemistry; transcriptome, genome and ploidy analyses; and determination of nuclear bomb test-derived (14)C concentration in neuronal DNA, we found neither to be the case. A large proportion of cortical neurons displayed DNA fragmentation and DNA repair a short time after stroke, whereas neurons at chronic stages after stroke showed DNA integrity, demonstrating the relevance of an intact genome for survival.It has been unclear whether ischemic stroke induces neurogenesis or neuronal DNA rearrangements in the human neocortex. Using immunohistochemistry; transcriptome, genome and ploidy analyses; and determination of nuclear bomb test-derived (14)C concentration in neuronal DNA, we found neither to be the case. A large proportion of cortical neurons displayed DNA fragmentation and DNA repair a short time after stroke, whereas neurons at chronic stages after stroke showed DNA integrity, demonstrating the relevance of an intact genome for survival.
Audience Academic
Author Ström, Lena
Huttner, Hagen B
Lindvall, Olle
Salehpour, Mehran
Sigurgeirsson, Benjamin
Bergmann, Olaf
Rácz, Attila
Solnestam, Beata Werne
Schwab, Stefan
Hortobágyi, Tibor
Ståhl, Patrik
Tatarishvili, Jemal
Possnert, Göran
Dahl, Andreas
Csonka, Tamás
Méhes, Gábor
Scharenberg, Christian
Lindgren, Emma
Frisén, Jonas
Kokaia, Zaal
Englund, Elisabet
Csiba, László
Bernard, Samuel
Zdunek, Sofia
Lundeberg, Joakim
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  organization: Department of Cell and Molecular Biology, Karolinska Institute
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  organization: Department of Physics and Astronomy, Ion Physics, Uppsala University
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  organization: Department of Cell and Molecular Biology, Karolinska Institute
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  organization: Department of Gene Technology, Royal Institute of Technology, SciLifeLab
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  organization: Deep Sequencing Group, SFB655, Biotechnology Center, TU-Dresden
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Cites_doi 10.1093/bioinformatics/btp324
10.1385/1-59259-973-7:275
10.1186/1471-2105-10-80
10.1038/nn.2473
10.1016/j.nimb.2012.08.054
10.1016/S0167-4943(01)00223-0
10.1093/bioinformatics/btp120
10.1089/ars.2010.3451
10.1371/journal.pone.0025760
10.1016/j.neuron.2012.03.030
10.1016/j.cell.2005.04.028
10.1161/STROKEAHA.111.627802
10.1073/pnas.0603512103
10.1038/sj.jcbfm.9600180
10.1016/j.expneurol.2010.08.006
10.1126/science.1164680
10.1016/j.cell.2013.05.002
10.1073/pnas.0605177103
10.1093/bioinformatics/btr310
10.1161/01.STR.0000252156.65953.a9
10.1016/j.cell.2011.12.013
10.1016/j.nimb.2007.01.172
10.1038/nn.3356
10.1371/journal.pone.0019119
10.1016/j.nimb.2004.04.057
10.1016/S0168-583X(96)00676-3
ContentType Journal Article
Copyright Springer Nature America, Inc. 2014
COPYRIGHT 2014 Nature Publishing Group
Copyright Nature Publishing Group Jun 2014
Distributed under a Creative Commons Attribution 4.0 International License
Copyright_xml – notice: Springer Nature America, Inc. 2014
– notice: COPYRIGHT 2014 Nature Publishing Group
– notice: Copyright Nature Publishing Group Jun 2014
– notice: Distributed under a Creative Commons Attribution 4.0 International License
CorporateAuthor Tumor microenvironment
Institutionen för kliniska vetenskaper, Lund
Lunds universitet
Profile areas and other strong research environments
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StemTherapy: National Initiative on Stem Cells for Regenerative Therapy
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References OhiraKNat. Neurosci.2010131731791:CAS:528:DC%2BD1MXhs1SktbrP10.1038/nn.2473
BergmannONeuron2012746346391:CAS:528:DC%2BC38Xns1Wktrc%3D10.1016/j.neuron.2012.03.030
SpaldingKLBhardwajRDBuchholzBADruidHFrisenJCell20051221331431:CAS:528:DC%2BD2MXmsFeiuro%3D10.1016/j.cell.2005.04.028
LiPAntioxid. Redox Signal.201114190519181:CAS:528:DC%2BC3MXkvVSqs7Y%3D10.1089/ars.2010.3451
LiWJ. Cereb. Blood Flow Metab.20062618119810.1038/sj.jcbfm.9600180
BorgströmELundinSLundebergJPLoS ONE20116e1911910.1371/journal.pone.0019119
SpaldingKLCell2013153121912271:CAS:528:DC%2BC3sXptFOlt7c%3D10.1016/j.cell.2013.05.002
BrownTASouthonJRNucl. Instrum. Methods Phys. Res. B19971232082131:CAS:528:DyaK2sXhslyjs78%3D10.1016/S0168-583X(96)00676-3
KreuzbergMExp. Neurol.201022690991:CAS:528:DC%2BC3cXht12ktrrM10.1016/j.expneurol.2010.08.006
OsmanAMPorrittMJNilssonMKuhnHGStroke2011423559356510.1161/STROKEAHA.111.627802
SpeitGHartmannAMethods Mol. Biol.20063142752861:CAS:528:DC%2BD2MXhtFyltrfK10.1385/1-59259-973-7:275
SuberbielleENat. Neurosci.2013166136211:CAS:528:DC%2BC3sXksVOnu7k%3D10.1038/nn.3356
KlempinFKronenbergGCheungGKettenmannHKempermannGPLoS ONE20116e257601:CAS:528:DC%2BC3MXhsVSgtrzE10.1371/journal.pone.0025760
LekerRRStroke20073815316110.1161/01.STR.0000252156.65953.a9
GeHBioinformatics201127192219281:CAS:528:DC%2BC3MXoslyisrY%3D10.1093/bioinformatics/btr310
LiHDurbinRBioinformatics200925175417601:CAS:528:DC%2BD1MXot1Cjtbo%3D10.1093/bioinformatics/btp324
HuaQZoppiUWilliamsASmithANucl. Instrum. Methods Phys. Res. B.2004223–22428429210.1016/j.nimb.2004.04.057
TrapnellCPachterLSalzbergSLBioinformatics200925110511111:CAS:528:DC%2BD1MXltFWisrk%3D10.1093/bioinformatics/btp120
SalehpourMHakanssonKPossnertGNucl. Instrum. Methods Phys. Res. B.2013294971031:CAS:528:DC%2BC38XhslKgtbfK10.1016/j.nimb.2012.08.054
SantosGMSouthonJRGriffinSBeaupreSRDruffelERMNucl. Instrum. Methods Phys. Res. B.20072592933021:CAS:528:DC%2BD2sXlsFGqtro%3D10.1016/j.nimb.2007.01.172
BhardwajRDProc. Natl. Acad. Sci. USA200610312564125681:CAS:528:DC%2BD28Xos1Krsrc%3D10.1073/pnas.0605177103
JinKProc. Natl. Acad. Sci. USA200610313198132021:CAS:528:DC%2BD28Xptlels70%3D10.1073/pnas.0603512103
XieCTammiMTBMC Bioinformatics2009108010.1186/1471-2105-10-80
BergmannOScience2009324981021:CAS:528:DC%2BD1MXjvVajsbc%3D10.1126/science.1164680
RauschTCell201214859711:CAS:528:DC%2BC38XhtFKgtrg%3D10.1016/j.cell.2011.12.013
BenavidesSHMonserratAJFarinaSPortaEAArch. Gerontol. Geriatr.2002342192311:CAS:528:DC%2BD38XitFWntLg%3D10.1016/S0167-4943(01)00223-0
F Klempin (BFnn3706_CR14) 2011; 6
T Rausch (BFnn3706_CR9) 2012; 148
M Salehpour (BFnn3706_CR18) 2013; 294
Q Hua (BFnn3706_CR19) 2004; 223–224
TA Brown (BFnn3706_CR13) 1997; 123
RR Leker (BFnn3706_CR5) 2007; 38
AM Osman (BFnn3706_CR16) 2011; 42
P Li (BFnn3706_CR7) 2011; 14
KL Spalding (BFnn3706_CR11) 2013; 153
H Li (BFnn3706_CR25) 2009; 25
H Ge (BFnn3706_CR24) 2011; 27
GM Santos (BFnn3706_CR20) 2007; 259
C Trapnell (BFnn3706_CR23) 2009; 25
KL Spalding (BFnn3706_CR1) 2005; 122
SH Benavides (BFnn3706_CR15) 2002; 34
W Li (BFnn3706_CR6) 2006; 26
E Suberbielle (BFnn3706_CR8) 2013; 16
E Borgström (BFnn3706_CR22) 2011; 6
G Speit (BFnn3706_CR21) 2006; 314
M Kreuzberg (BFnn3706_CR4) 2010; 226
K Ohira (BFnn3706_CR17) 2010; 13
C Xie (BFnn3706_CR26) 2009; 10
K Jin (BFnn3706_CR3) 2006; 103
O Bergmann (BFnn3706_CR10) 2009; 324
O Bergmann (BFnn3706_CR12) 2012; 74
RD Bhardwaj (BFnn3706_CR2) 2006; 103
21589638 - PLoS One. 2011 Apr 27;6(4):e19119
21593131 - Bioinformatics. 2011 Jul 15;27(14):1922-8
16009139 - Cell. 2005 Jul 15;122(1):133-43
19451168 - Bioinformatics. 2009 Jul 15;25(14):1754-60
16901981 - Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12564-8
23525040 - Nat Neurosci. 2013 May;16(5):613-21
20037576 - Nat Neurosci. 2010 Feb;13(2):173-9
20713052 - Exp Neurol. 2010 Nov;226(1):90-9
16924107 - Proc Natl Acad Sci U S A. 2006 Aug 29;103(35):13198-202
20677909 - Antioxid Redox Signal. 2011 May 15;14(10):1905-18
19342590 - Science. 2009 Apr 3;324(5923):98-102
22265402 - Cell. 2012 Jan 20;148(1-2):59-71
16673888 - Methods Mol Biol. 2006;314:275-86
22022443 - PLoS One. 2011;6(10):e25760
21980195 - Stroke. 2011 Dec;42(12):3559-65
22632721 - Neuron. 2012 May 24;74(4):634-9
19289445 - Bioinformatics. 2009 May 1;25(9):1105-11
17122419 - Stroke. 2007 Jan;38(1):153-61
14764325 - Arch Gerontol Geriatr. 2002 May-Jun;34(3):219-31
19267900 - BMC Bioinformatics. 2009 Mar 06;10:80
16001017 - J Cereb Blood Flow Metab. 2006 Feb;26(2):181-98
23746839 - Cell. 2013 Jun 6;153(6):1219-27
References_xml – reference: SuberbielleENat. Neurosci.2013166136211:CAS:528:DC%2BC3sXksVOnu7k%3D10.1038/nn.3356
– reference: XieCTammiMTBMC Bioinformatics2009108010.1186/1471-2105-10-80
– reference: LiWJ. Cereb. Blood Flow Metab.20062618119810.1038/sj.jcbfm.9600180
– reference: SalehpourMHakanssonKPossnertGNucl. Instrum. Methods Phys. Res. B.2013294971031:CAS:528:DC%2BC38XhslKgtbfK10.1016/j.nimb.2012.08.054
– reference: SpaldingKLCell2013153121912271:CAS:528:DC%2BC3sXptFOlt7c%3D10.1016/j.cell.2013.05.002
– reference: RauschTCell201214859711:CAS:528:DC%2BC38XhtFKgtrg%3D10.1016/j.cell.2011.12.013
– reference: KlempinFKronenbergGCheungGKettenmannHKempermannGPLoS ONE20116e257601:CAS:528:DC%2BC3MXhsVSgtrzE10.1371/journal.pone.0025760
– reference: LiHDurbinRBioinformatics200925175417601:CAS:528:DC%2BD1MXot1Cjtbo%3D10.1093/bioinformatics/btp324
– reference: JinKProc. Natl. Acad. Sci. USA200610313198132021:CAS:528:DC%2BD28Xptlels70%3D10.1073/pnas.0603512103
– reference: SpaldingKLBhardwajRDBuchholzBADruidHFrisenJCell20051221331431:CAS:528:DC%2BD2MXmsFeiuro%3D10.1016/j.cell.2005.04.028
– reference: OhiraKNat. Neurosci.2010131731791:CAS:528:DC%2BD1MXhs1SktbrP10.1038/nn.2473
– reference: BorgströmELundinSLundebergJPLoS ONE20116e1911910.1371/journal.pone.0019119
– reference: BenavidesSHMonserratAJFarinaSPortaEAArch. Gerontol. Geriatr.2002342192311:CAS:528:DC%2BD38XitFWntLg%3D10.1016/S0167-4943(01)00223-0
– reference: SantosGMSouthonJRGriffinSBeaupreSRDruffelERMNucl. Instrum. Methods Phys. Res. B.20072592933021:CAS:528:DC%2BD2sXlsFGqtro%3D10.1016/j.nimb.2007.01.172
– reference: LekerRRStroke20073815316110.1161/01.STR.0000252156.65953.a9
– reference: KreuzbergMExp. Neurol.201022690991:CAS:528:DC%2BC3cXht12ktrrM10.1016/j.expneurol.2010.08.006
– reference: BergmannOScience2009324981021:CAS:528:DC%2BD1MXjvVajsbc%3D10.1126/science.1164680
– reference: TrapnellCPachterLSalzbergSLBioinformatics200925110511111:CAS:528:DC%2BD1MXltFWisrk%3D10.1093/bioinformatics/btp120
– reference: BrownTASouthonJRNucl. Instrum. Methods Phys. Res. B19971232082131:CAS:528:DyaK2sXhslyjs78%3D10.1016/S0168-583X(96)00676-3
– reference: HuaQZoppiUWilliamsASmithANucl. Instrum. Methods Phys. Res. B.2004223–22428429210.1016/j.nimb.2004.04.057
– reference: GeHBioinformatics201127192219281:CAS:528:DC%2BC3MXoslyisrY%3D10.1093/bioinformatics/btr310
– reference: OsmanAMPorrittMJNilssonMKuhnHGStroke2011423559356510.1161/STROKEAHA.111.627802
– reference: BhardwajRDProc. Natl. Acad. Sci. USA200610312564125681:CAS:528:DC%2BD28Xos1Krsrc%3D10.1073/pnas.0605177103
– reference: LiPAntioxid. Redox Signal.201114190519181:CAS:528:DC%2BC3MXkvVSqs7Y%3D10.1089/ars.2010.3451
– reference: SpeitGHartmannAMethods Mol. Biol.20063142752861:CAS:528:DC%2BD2MXhtFyltrfK10.1385/1-59259-973-7:275
– reference: BergmannONeuron2012746346391:CAS:528:DC%2BC38Xns1Wktrc%3D10.1016/j.neuron.2012.03.030
– volume: 25
  start-page: 1754
  year: 2009
  ident: BFnn3706_CR25
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btp324
– volume: 314
  start-page: 275
  year: 2006
  ident: BFnn3706_CR21
  publication-title: Methods Mol. Biol.
  doi: 10.1385/1-59259-973-7:275
– volume: 10
  start-page: 80
  year: 2009
  ident: BFnn3706_CR26
  publication-title: BMC Bioinformatics
  doi: 10.1186/1471-2105-10-80
– volume: 13
  start-page: 173
  year: 2010
  ident: BFnn3706_CR17
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.2473
– volume: 294
  start-page: 97
  year: 2013
  ident: BFnn3706_CR18
  publication-title: Nucl. Instrum. Methods Phys. Res. B.
  doi: 10.1016/j.nimb.2012.08.054
– volume: 34
  start-page: 219
  year: 2002
  ident: BFnn3706_CR15
  publication-title: Arch. Gerontol. Geriatr.
  doi: 10.1016/S0167-4943(01)00223-0
– volume: 25
  start-page: 1105
  year: 2009
  ident: BFnn3706_CR23
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btp120
– volume: 14
  start-page: 1905
  year: 2011
  ident: BFnn3706_CR7
  publication-title: Antioxid. Redox Signal.
  doi: 10.1089/ars.2010.3451
– volume: 6
  start-page: e25760
  year: 2011
  ident: BFnn3706_CR14
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0025760
– volume: 74
  start-page: 634
  year: 2012
  ident: BFnn3706_CR12
  publication-title: Neuron
  doi: 10.1016/j.neuron.2012.03.030
– volume: 122
  start-page: 133
  year: 2005
  ident: BFnn3706_CR1
  publication-title: Cell
  doi: 10.1016/j.cell.2005.04.028
– volume: 42
  start-page: 3559
  year: 2011
  ident: BFnn3706_CR16
  publication-title: Stroke
  doi: 10.1161/STROKEAHA.111.627802
– volume: 103
  start-page: 13198
  year: 2006
  ident: BFnn3706_CR3
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0603512103
– volume: 26
  start-page: 181
  year: 2006
  ident: BFnn3706_CR6
  publication-title: J. Cereb. Blood Flow Metab.
  doi: 10.1038/sj.jcbfm.9600180
– volume: 226
  start-page: 90
  year: 2010
  ident: BFnn3706_CR4
  publication-title: Exp. Neurol.
  doi: 10.1016/j.expneurol.2010.08.006
– volume: 324
  start-page: 98
  year: 2009
  ident: BFnn3706_CR10
  publication-title: Science
  doi: 10.1126/science.1164680
– volume: 153
  start-page: 1219
  year: 2013
  ident: BFnn3706_CR11
  publication-title: Cell
  doi: 10.1016/j.cell.2013.05.002
– volume: 103
  start-page: 12564
  year: 2006
  ident: BFnn3706_CR2
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0605177103
– volume: 27
  start-page: 1922
  year: 2011
  ident: BFnn3706_CR24
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btr310
– volume: 38
  start-page: 153
  year: 2007
  ident: BFnn3706_CR5
  publication-title: Stroke
  doi: 10.1161/01.STR.0000252156.65953.a9
– volume: 148
  start-page: 59
  year: 2012
  ident: BFnn3706_CR9
  publication-title: Cell
  doi: 10.1016/j.cell.2011.12.013
– volume: 259
  start-page: 293
  year: 2007
  ident: BFnn3706_CR20
  publication-title: Nucl. Instrum. Methods Phys. Res. B.
  doi: 10.1016/j.nimb.2007.01.172
– volume: 16
  start-page: 613
  year: 2013
  ident: BFnn3706_CR8
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.3356
– volume: 6
  start-page: e19119
  year: 2011
  ident: BFnn3706_CR22
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0019119
– volume: 223–224
  start-page: 284
  year: 2004
  ident: BFnn3706_CR19
  publication-title: Nucl. Instrum. Methods Phys. Res. B.
  doi: 10.1016/j.nimb.2004.04.057
– volume: 123
  start-page: 208
  year: 1997
  ident: BFnn3706_CR13
  publication-title: Nucl. Instrum. Methods Phys. Res. B
  doi: 10.1016/S0168-583X(96)00676-3
– reference: 23525040 - Nat Neurosci. 2013 May;16(5):613-21
– reference: 21980195 - Stroke. 2011 Dec;42(12):3559-65
– reference: 16001017 - J Cereb Blood Flow Metab. 2006 Feb;26(2):181-98
– reference: 21593131 - Bioinformatics. 2011 Jul 15;27(14):1922-8
– reference: 16924107 - Proc Natl Acad Sci U S A. 2006 Aug 29;103(35):13198-202
– reference: 19267900 - BMC Bioinformatics. 2009 Mar 06;10:80
– reference: 17122419 - Stroke. 2007 Jan;38(1):153-61
– reference: 20713052 - Exp Neurol. 2010 Nov;226(1):90-9
– reference: 19342590 - Science. 2009 Apr 3;324(5923):98-102
– reference: 21589638 - PLoS One. 2011 Apr 27;6(4):e19119
– reference: 14764325 - Arch Gerontol Geriatr. 2002 May-Jun;34(3):219-31
– reference: 16673888 - Methods Mol Biol. 2006;314:275-86
– reference: 20677909 - Antioxid Redox Signal. 2011 May 15;14(10):1905-18
– reference: 23746839 - Cell. 2013 Jun 6;153(6):1219-27
– reference: 20037576 - Nat Neurosci. 2010 Feb;13(2):173-9
– reference: 19289445 - Bioinformatics. 2009 May 1;25(9):1105-11
– reference: 16009139 - Cell. 2005 Jul 15;122(1):133-43
– reference: 22632721 - Neuron. 2012 May 24;74(4):634-9
– reference: 22265402 - Cell. 2012 Jan 20;148(1-2):59-71
– reference: 22022443 - PLoS One. 2011;6(10):e25760
– reference: 19451168 - Bioinformatics. 2009 Jul 15;25(14):1754-60
– reference: 16901981 - Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12564-8
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Snippet In this study, the authors use measures of carbon-14 in neuronal DNA from human stroke patient cortical tissue samples to show that, unlike previous studies...
It has been unclear whether ischemic stroke induces neurogenesis or neuronal DNA rearrangements in the human neocortex. Using immunohistochemistry;...
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SubjectTerms 13/31
13/51
45/23
45/91
631/378/368/2431
Aged
Aged, 80 and over
Analysis
Animal Genetics and Genomics
Basic Medicine
Behavioral Sciences
Biological Techniques
Biomedicine
bomb peak
brief-communication
cell regeneration
Cellular Senescence - physiology
Chromosomes
cortical stroke
DNA
DNA Fragmentation
DNA repair
DNA Repair - physiology
Dynamical Systems
Female
Genetic aspects
Genomes
Hospitals
Humans
Ischemia
Male
Mathematics
Medical and Health Sciences
Medicin och hälsovetenskap
Medicinska och farmaceutiska grundvetenskaper
Middle Aged
Neocortex - pathology
Neocortex - physiology
Neurobiology
Neurogenesis
Neurons
Neurons - pathology
Neurons - physiology
Neurosciences
Neurovetenskaper
Physiological aspects
Stroke
Stroke (Disease)
Stroke - genetics
Stroke - pathology
Title The age and genomic integrity of neurons after cortical stroke in humans
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Volume 17
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