Mitochondrial heteroplasmic shifts reveal a positive selection of breast cancer

Background Breast cancer is, despite screening, not always detected early enough and is together with other tumor types known to shed genetic information in circulation. Unlike single-copy nuclear DNA, mitochondrial DNA (mtDNA) copies range from 100s to 10,000s per cell, thus providing a potentially...

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Vydáno v:	Journal of Translational Medicine Ročník 21; číslo 1; s. 1 - 14
Hlavní autoři:	Li, Yanni, Sundquist, Kristina, Vats, Sakshi, Hong, Mun-Gwan, Wang, Xiao, Chen, Yilun, Hedelius, Anna, Saal, Lao H., Sundquist, Jan, Memon, Ashfaque A.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Springer Science and Business Media LLC 05.10.2023 BioMed Central BioMed Central Ltd Springer Nature B.V BMC
Témata:	Analysis Basic Medicine Bioinformatics Biomedical and Life Sciences Biomedicine Biopsy Breast cancer Breast Neoplasms Cancer Cancer and Oncology Cancer och onkologi Case-Control Studies Cellular Metabolism Therapy Clinical Medicine ddPCR validation Development and progression Diagnosis DNA, Mitochondrial Exercise Female Gene mutations Genetic aspects Genetic testing Genomes Germ-Line Mutation Health aspects Health surveys Heteroplasmic mutation Heteroplasmy Humans Klinisk medicin Mammography Medical and Health Sciences Medical diagnosis Medical Genetics and Genomics (including Gene Therapy) Medical prognosis Medicin och hälsovetenskap Medicine Medicine/Public Health Medicinsk genetik och genomik (Här ingår: Genterapi) Medicinska och farmaceutiska grundvetenskaper Middle Aged Mitochondrial DNA Mortality mtDNA Mutation Natural selection Oncology, Experimental Plasma Positive selection Prevention R Risk factors Sequencing Womens health Sweden United States > US Germany Breast cancer ddPCR validation mtDNA Sequencing Heteroplasmic mutation
ISSN:	1479-5876, 1479-5876
On-line přístup:	Získat plný text
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