Biomarker Profiling by Nuclear Magnetic Resonance Spectroscopy for the Prediction of All-Cause Mortality: An Observational Study of 17,345 Persons

Early identification of ambulatory persons at high short-term risk of death could benefit targeted prevention. To identify biomarkers for all-cause mortality and enhance risk prediction, we conducted high-throughput profiling of blood specimens in two large population-based cohorts. 106 candidate bi...

Full description

Saved in:

Bibliographic Details
Published in:	PLoS medicine Vol. 11; no. 2; p. e1001606
Main Authors:	Fischer, Krista, Kettunen, Johannes, Würtz, Peter, Haller, Toomas, Havulinna, Aki S., Kangas, Antti J., Soininen, Pasi, Esko, Tõnu, Tammesoo, Mari-Liis, Mägi, Reedik, Smit, Steven, Palotie, Aarno, Ripatti, Samuli, Salomaa, Veikko, Ala-Korpela, Mika, Perola, Markus, Metspalu, Andres
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01.02.2014 Public Library of Science (PLoS)
Subjects:	Adolescent Adult Aged Aged, 80 and over Biological markers Biological Specimen Banks Biology Biomarkers - blood Cause of Death Cholesterol Citric Acid - blood Estonia - epidemiology Female Finland Finland - epidemiology Health risk assessment High-Throughput Screening Assays - methods Humans Kaplan-Meier Estimate Lipoproteins, LDL - blood Magnetic Resonance Spectroscopy Male Medicine Middle Aged Mortality NMR Nuclear magnetic resonance Nuclear magnetic resonance spectroscopy Orosomucoid - analysis Particle Size Physiological aspects Predictive Value of Tests Prognosis Proportional Hazards Models Reproducibility of Results Risk Assessment Risk Factors Serum Albumin - analysis Serum Albumin, Human Studies Time Factors United Kingdom United States Young Adult Finland Estonia United States United Kingdom
ISSN:	1549-1676, 1549-1277, 1549-1676
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!