The Progression of Liver Fibrosis Is Related with Overexpression of the miR-199 and 200 Families

Chronic hepatitis C (CH) can develop into liver cirrhosis (LC) and hepatocellular carcinoma (HCC). Liver fibrosis and HCC development are strongly correlated, but there is no effective treatment against fibrosis because the critical mechanism of progression of liver fibrosis is not fully understood....

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Bibliographic Details
Published in:	PloS one Vol. 6; no. 1; p. e16081
Main Authors:	Murakami, Yoshiki, Toyoda, Hidenori, Tanaka, Masami, Kuroda, Masahiko, Harada, Yoshinori, Matsuda, Fumihiko, Tajima, Atsushi, Kosaka, Nobuyoshi, Ochiya, Takahiro, Shimotohno, Kunitada
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 24.01.2011 Public Library of Science (PLoS)
Subjects:	Aberration Animals Antiviral agents Bile Biological activity Biology Biopsy Carbon tetrachloride Cirrhosis Comparative analysis Correlation Development and progression Diagnostic software Diagnostic systems Disease Progression Fats and oils Fibrosis Gene Expression Gene Expression Regulation Genes Hepatic Stellate Cells - pathology Hepatitis Hepatitis C Hepatitis C virus Hepatocellular carcinoma Humans Interferon Kinases Liver Liver cancer Liver cirrhosis Liver Cirrhosis - genetics Liver Cirrhosis - pathology Medicine Mice MicroRNA MicroRNAs - analysis miRNA Molecular modelling Oils & fats Olive oil Quality RNA, Neoplasm - analysis Rodents Severity of Illness Index Stellate cells Therapeutic applications Up-Regulation Viral infections Japan
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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