Meta-Analysis of Genome-Wide Association Studies Identifies Six New Loci for Serum Calcium Concentrations

Calcium is vital to the normal functioning of multiple organ systems and its serum concentration is tightly regulated. Apart from CASR, the genes associated with serum calcium are largely unknown. We conducted a genome-wide association meta-analysis of 39,400 individuals from 17 population-based coh...

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Vydáno v:	PLoS genetics Ročník 9; číslo 9; s. e1003796
Hlavní autoři:	O'Seaghdha, Conall M., Wu, Hongsheng, Yang, Qiong, Kapur, Karen, Guessous, Idris, Zuber, Annie Mercier, Köttgen, Anna, Stoudmann, Candice, Teumer, Alexander, Kutalik, Zoltán, Mangino, Massimo, Dehghan, Abbas, Zhang, Weihua, Eiriksdottir, Gudny, Li, Guo, Tanaka, Toshiko, Portas, Laura, Lopez, Lorna M., Hayward, Caroline, Lohman, Kurt, Matsuda, Koichi, Padmanabhan, Sandosh, Firsov, Dmitri, Sorice, Rossella, Ulivi, Sheila, Brockhaus, A. Catharina, Kleber, Marcus E., Mahajan, Anubha, Ernst, Florian D., Gudnason, Vilmundur, Launer, Lenore J., Mace, Aurelien, Boerwinckle, Eric, Arking, Dan E., Tanikawa, Chizu, Nakamura, Yusuke, Brown, Morris J., Gaspoz, Jean-Michel, Theler, Jean-Marc, Siscovick, David S., Psaty, Bruce M., Bergmann, Sven, Vollenweider, Peter, Vitart, Veronique, Wright, Alan F., Zemunik, Tatijana, Boban, Mladen, Kolcic, Ivana, Navarro, Pau, Brown, Edward M., Estrada, Karol, Ding, Jingzhong, Harris, Tamara B., Bandinelli, Stefania, Hernandez, Dena, Singleton, Andrew B., Girotto, Giorgia, Ruggiero, Daniela, d'Adamo, Adamo Pio, Robino, Antonietta, Meitinger, Thomas, Meisinger, Christa, Davies, Gail, Starr, John M., Chambers, John C., Boehm, Bernhard O., Winkelmann, Bernhard R., Huang, Jie, Murgia, Federico, Wild, Sarah H., Campbell, Harry, Morris, Andrew P., Franco, Oscar H., Hofman, Albert, Uitterlinden, Andre G., Rivadeneira, Fernando, Völker, Uwe, Hannemann, Anke, Biffar, Reiner, Hoffmann, Wolfgang, Shin, So–Youn, Lescuyer, Pierre, Henry, Hughes, Schurmann, Claudia, Munroe, Patricia B., Gasparini, Paolo, Pirastu, Nicola, Ciullo, Marina, Gieger, Christian, März, Winfried, Lind, Lars, Spector, Tim D., Smith, Albert V., Rudan, Igor, Wilson, James F., Polasek, Ozren, Deary, Ian J., Pirastu, Mario, Ferrucci, Luigi, Liu, Yongmei
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Public Library of Science 01.09.2013 Public Library of Science (PLoS)
Témata:	Animals Bone and Bones - metabolism Bone density Bone Density - genetics Calcium Calcium - blood Calcium, Dietary Experiments Gene expression Gene Expression Regulation Genetic aspects Genome-wide association studies Genome-Wide Association Study Genomes Homeostasis Homeostasis - genetics Humans Kidney - metabolism Kinases Meta-analysis Mice Ontology Physiological aspects Polymorphism, Single Nucleotide Population White People - genetics United States
ISSN:	1553-7404, 1553-7390, 1553-7404
On-line přístup:	Získat plný text
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