Occurrence of Anti-Drug Antibodies against Interferon-Beta and Natalizumab in Multiple Sclerosis: A Collaborative Cohort Analysis

Immunogenicity of biopharmaceutical products in multiple sclerosis is a frequent side effect which has a multifactorial etiology. Here we study associations between anti-drug antibody (ADA) occurrence and demographic and clinical factors. Retrospective data from routine ADA test laboratories in Swed...

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Bibliographic Details
Published in:	PloS one Vol. 11; no. 11; p. e0162752
Main Authors:	Bachelet, Delphine, Hässler, Signe, Mbogning, Cyprien, Link, Jenny, Ryner, Malin, Ramanujam, Ryan, Auer, Michael, Hyldgaard Jensen, Poul Erik, Koch-Henriksen, Nils, Warnke, Clemens, Ingenhoven, Kathleen, Buck, Dorothea, Grummel, Verena, Lawton, Andy, Donnellan, Naoimh, Hincelin-Mery, Agnès, Sikkema, Dan, Pallardy, Marc, Kieseier, Bernd, Hemmer, Bernard, Hartung, Hans Peter, Soelberg Sorensen, Per, Deisenhammer, Florian, Dönnes, Pierre, Davidson, Julie, Fogdell-Hahn, Anna, Broët, Philippe
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 02.11.2016 Public Library of Science (PLoS)
Subjects:	Adult Aged Antibodies Antibodies - blood Antibodies - immunology Antibodies, Anti-Idiotypic - blood Antibodies, Anti-Idiotypic - immunology Backup software Biological response modifiers Biology and Life Sciences Biomarkers Biopharmaceuticals Care and treatment Cohort analysis Cohort Studies Collaboration Consortia Databases, Factual Demographics Development and progression Etiology Europe - epidemiology Female Humans Immunogenicity Immunoglobulins Immunology Immunotherapy Interferon Interferon-beta - adverse effects Interferon-beta - immunology Interferon-beta - therapeutic use Laboratories Male Medicine and Health Sciences Middle Aged Monoclonal antibodies Multiple sclerosis Multiple Sclerosis - complications Multiple Sclerosis - drug therapy Multiple Sclerosis - epidemiology Multiple Sclerosis - mortality Natalizumab Natalizumab - adverse effects Natalizumab - immunology Natalizumab - therapeutic use Neurology Neurosciences Patient Outcome Assessment Patients People and Places Pharmaceuticals Population Surveillance Proportional Hazards Models Regression analysis Research and Analysis Methods Risk Factors Side effects Systematic review Vitamin D β-Interferon
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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