Histone H4 lysine 16 acetylation regulates cellular lifespan

Cells undergoing developmental processes are characterized by persistent non-genetic alterations in chromatin, termed epigenetic changes, represented by distinct patterns of DNA methylation and histone post-translational modifications. Sirtuins, a group of conserved NAD+-dependent deacetylases or AD...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	Nature (London) Ročník 459; číslo 7248; s. 802 - 807
Hlavní autori:	Dang, Weiwei, Steffen, Kristan K, Perry, Rocco, Dorsey, Jean A, Johnson, F. Brad, Shilatifard, Ali, Kaeberlein, Matt, Kennedy, Brian K, Berger, Shelley L
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London Nature Publishing Group UK 11.06.2009 Nature Publishing Group
Predmet:	Acetylation Acetyltransferases Acetyltransferases - metabolism Adenosine diphosphate Ageing, cell death Aging antagonists & inhibitors Apoptosis Binding sites Biological and medical sciences Causes of Cell Division Cell physiology Cells Changes chemistry Chromatin Chromatin - genetics Chromatin - metabolism cytology deficiency Epistasis, Genetic Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Fungal Gene Silencing Genetics Health aspects Histone Acetyltransferases Histone Deacetylase Inhibitors Histone Deacetylases Histone Deacetylases - deficiency Histone Deacetylases - metabolism histones Histones - chemistry Histones - genetics Histones - metabolism Humanities and Social Sciences Life span lysine Lysine - metabolism metabolism Methylation Molecular and cellular biology multidisciplinary Mutant Proteins Mutant Proteins - genetics Mutant Proteins - metabolism Mutation Physiological aspects Post-translational modification Proteins Ribosomal DNA Saccharomyces cerevisiae Saccharomyces cerevisiae - cytology Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins Saccharomyces cerevisiae Proteins - metabolism Science Science (multidisciplinary) senescence Silent Information Regulator Proteins, Saccharomyces cerevisiae Silent Information Regulator Proteins, Saccharomyces cerevisiae - antagonists & inhibitors Silent Information Regulator Proteins, Saccharomyces cerevisiae - deficiency Silent Information Regulator Proteins, Saccharomyces cerevisiae - metabolism Sirtuin 2 Sirtuins Sirtuins - antagonists & inhibitors Sirtuins - deficiency Sirtuins - metabolism Studies Telomere Telomere - genetics Telomere - metabolism transcription (genetics) Transcription, Genetic Yeasts United States Ascomycota Chromatin Yeast Longevity Fungi Histone H4 Gene silencing Regulation(control) Lysine Cell component Epigenetics Acetylation Saccharomyces cerevisiae
ISSN:	0028-0836, 1476-4687, 1476-4687
On-line prístup:	Získať plný text
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Popis
Shrnutí:	Cells undergoing developmental processes are characterized by persistent non-genetic alterations in chromatin, termed epigenetic changes, represented by distinct patterns of DNA methylation and histone post-translational modifications. Sirtuins, a group of conserved NAD+-dependent deacetylases or ADP-ribosyltransferases, promote longevity in diverse organisms; however, their molecular mechanisms in ageing regulation remain poorly understood. Yeast Sir2, the first member of the family to be found, establishes and maintains chromatin silencing by removing histone H4 lysine 16 acetylation and bringing in other silencing proteins. Here we report an age-associated decrease in Sir2 protein abundance accompanied by an increase in H4 lysine 16 acetylation and loss of histones at specific subtelomeric regions in replicatively old yeast cells, which results in compromised transcriptional silencing at these loci. Antagonizing activities of Sir2 and Sas2, a histone acetyltransferase, regulate the replicative lifespan through histone H4 lysine 16 at subtelomeric regions. This pathway, distinct from existing ageing models for yeast, may represent an evolutionarily conserved function of sirtuins in regulation of replicative ageing by maintenance of intact telomeric chromatin.
Bibliografia:	http://dx.doi.org/10.1038/nature08085 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Author Contributions Project planning was performed by W.D., F.B.J., A.S., B.K.K., S.L.B; experimental work by W.D., K.K.S., R.P., J.D.; data analysis by W.D.,K.K.S., F.B.J., M.K.,B.K.K.,S.L.B.; manuscript composition by W.D., F.B.J., M.K., B.K.K., and S.L.B.
ISSN:	0028-0836 1476-4687 1476-4687
DOI:	10.1038/nature08085