Testosterone, Sex Hormone-Binding Globulin and the Metabolic Syndrome in Men: An Individual Participant Data Meta-Analysis of Observational Studies
Low total testosterone (TT) and sex hormone-binding globulin (SHBG) concentrations have been associated with the metabolic syndrome (MetS) in men, but the reported strength of association varies considerably. We aimed to investigate whether associations differ across specific subgroups (according to...
Uloženo v:
| Vydáno v: | PloS one Ročník 9; číslo 7; s. e100409 |
|---|---|
| Hlavní autoři: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
United States
Public Library of Science
14.07.2014
Public Library of Science (PLoS) |
| Témata: | |
| ISSN: | 1932-6203, 1932-6203 |
| On-line přístup: | Získat plný text |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | Low total testosterone (TT) and sex hormone-binding globulin (SHBG) concentrations have been associated with the metabolic syndrome (MetS) in men, but the reported strength of association varies considerably.
We aimed to investigate whether associations differ across specific subgroups (according to age and body mass index (BMI)) and individual MetS components.
Two previously published meta-analyses including an updated systematic search in PubMed and EMBASE.
Cross-sectional or prospective observational studies with data on TT and/or SHBG concentrations in combination with MetS in men.
We conducted an individual participant data meta-analysis of 20 observational studies. Mixed effects models were used to assess cross-sectional and prospective associations of TT, SHBG and free testosterone (FT) with MetS and its individual components. Multivariable adjusted odds ratios (ORs) and hazard ratios (HRs) were calculated and effect modification by age and BMI was studied.
Men with low concentrations of TT, SHBG or FT were more likely to have prevalent MetS (ORs per quartile decrease were 1.69 (95% CI 1.60-1.77), 1.73 (95% CI 1.62-1.85) and 1.46 (95% CI 1.36-1.57) for TT, SHBG and FT, respectively) and incident MetS (HRs per quartile decrease were 1.25 (95% CI 1.16-1.36), 1.44 (95% 1.30-1.60) and 1.14 (95% 1.01-1.28) for TT, SHBG and FT, respectively). Overall, the magnitude of associations was largest in non-overweight men and varied across individual components: stronger associations were observed with hypertriglyceridemia, abdominal obesity and hyperglycaemia and associations were weakest for hypertension.
Associations of testosterone and SHBG with MetS vary according to BMI and individual MetS components. These findings provide further insights into the pathophysiological mechanisms linking low testosterone and SHBG concentrations to cardiometabolic risk. |
|---|---|
| AbstractList | Background Low total testosterone (TT) and sex hormone-binding globulin (SHBG) concentrations have been associated with the metabolic syndrome (MetS) in men, but the reported strength of association varies considerably. Objectives We aimed to investigate whether associations differ across specific subgroups (according to age and body mass index (BMI)) and individual MetS components. Data sources Two previously published meta-analyses including an updated systematic search in PubMed and EMBASE. Study Eligibility Criteria Cross-sectional or prospective observational studies with data on TT and/or SHBG concentrations in combination with MetS in men. Methods We conducted an individual participant data meta-analysis of 20 observational studies. Mixed effects models were used to assess cross-sectional and prospective associations of TT, SHBG and free testosterone (FT) with MetS and its individual components. Multivariable adjusted odds ratios (ORs) and hazard ratios (HRs) were calculated and effect modification by age and BMI was studied. Results Men with low concentrations of TT, SHBG or FT were more likely to have prevalent MetS (ORs per quartile decrease were 1.69 (95% CI 1.60-1.77), 1.73 (95% CI 1.62-1.85) and 1.46 (95% CI 1.36-1.57) for TT, SHBG and FT, respectively) and incident MetS (HRs per quartile decrease were 1.25 (95% CI 1.16-1.36), 1.44 (95% 1.30-1.60) and 1.14 (95% 1.01-1.28) for TT, SHBG and FT, respectively). Overall, the magnitude of associations was largest in non-overweight men and varied across individual components: stronger associations were observed with hypertriglyceridemia, abdominal obesity and hyperglycaemia and associations were weakest for hypertension. Conclusions Associations of testosterone and SHBG with MetS vary according to BMI and individual MetS components. These findings provide further insights into the pathophysiological mechanisms linking low testosterone and SHBG concentrations to cardiometabolic risk. Low total testosterone (TT) and sex hormone-binding globulin (SHBG) concentrations have been associated with the metabolic syndrome (MetS) in men, but the reported strength of association varies considerably. We aimed to investigate whether associations differ across specific subgroups (according to age and body mass index (BMI)) and individual MetS components. Two previously published meta-analyses including an updated systematic search in PubMed and EMBASE. We conducted an individual participant data meta-analysis of 20 observational studies. Mixed effects models were used to assess cross-sectional and prospective associations of TT, SHBG and free testosterone (FT) with MetS and its individual components. Multivariable adjusted odds ratios (ORs) and hazard ratios (HRs) were calculated and effect modification by age and BMI was studied. Men with low concentrations of TT, SHBG or FT were more likely to have prevalent MetS (ORs per quartile decrease were 1.69 (95% CI 1.60-1.77), 1.73 (95% CI 1.62-1.85) and 1.46 (95% CI 1.36-1.57) for TT, SHBG and FT, respectively) and incident MetS (HRs per quartile decrease were 1.25 (95% CI 1.16-1.36), 1.44 (95% 1.30-1.60) and 1.14 (95% 1.01-1.28) for TT, SHBG and FT, respectively). Overall, the magnitude of associations was largest in non-overweight men and varied across individual components: stronger associations were observed with hypertriglyceridemia, abdominal obesity and hyperglycaemia and associations were weakest for hypertension. Associations of testosterone and SHBG with MetS vary according to BMI and individual MetS components. These findings provide further insights into the pathophysiological mechanisms linking low testosterone and SHBG concentrations to cardiometabolic risk. Low total testosterone (TT) and sex hormone-binding globulin (SHBG) concentrations have been associated with the metabolic syndrome (MetS) in men, but the reported strength of association varies considerably.BACKGROUNDLow total testosterone (TT) and sex hormone-binding globulin (SHBG) concentrations have been associated with the metabolic syndrome (MetS) in men, but the reported strength of association varies considerably.We aimed to investigate whether associations differ across specific subgroups (according to age and body mass index (BMI)) and individual MetS components.OBJECTIVESWe aimed to investigate whether associations differ across specific subgroups (according to age and body mass index (BMI)) and individual MetS components.Two previously published meta-analyses including an updated systematic search in PubMed and EMBASE.DATA SOURCESTwo previously published meta-analyses including an updated systematic search in PubMed and EMBASE.Cross-sectional or prospective observational studies with data on TT and/or SHBG concentrations in combination with MetS in men.STUDY ELIGIBILITY CRITERIACross-sectional or prospective observational studies with data on TT and/or SHBG concentrations in combination with MetS in men.We conducted an individual participant data meta-analysis of 20 observational studies. Mixed effects models were used to assess cross-sectional and prospective associations of TT, SHBG and free testosterone (FT) with MetS and its individual components. Multivariable adjusted odds ratios (ORs) and hazard ratios (HRs) were calculated and effect modification by age and BMI was studied.METHODSWe conducted an individual participant data meta-analysis of 20 observational studies. Mixed effects models were used to assess cross-sectional and prospective associations of TT, SHBG and free testosterone (FT) with MetS and its individual components. Multivariable adjusted odds ratios (ORs) and hazard ratios (HRs) were calculated and effect modification by age and BMI was studied.Men with low concentrations of TT, SHBG or FT were more likely to have prevalent MetS (ORs per quartile decrease were 1.69 (95% CI 1.60-1.77), 1.73 (95% CI 1.62-1.85) and 1.46 (95% CI 1.36-1.57) for TT, SHBG and FT, respectively) and incident MetS (HRs per quartile decrease were 1.25 (95% CI 1.16-1.36), 1.44 (95% 1.30-1.60) and 1.14 (95% 1.01-1.28) for TT, SHBG and FT, respectively). Overall, the magnitude of associations was largest in non-overweight men and varied across individual components: stronger associations were observed with hypertriglyceridemia, abdominal obesity and hyperglycaemia and associations were weakest for hypertension.RESULTSMen with low concentrations of TT, SHBG or FT were more likely to have prevalent MetS (ORs per quartile decrease were 1.69 (95% CI 1.60-1.77), 1.73 (95% CI 1.62-1.85) and 1.46 (95% CI 1.36-1.57) for TT, SHBG and FT, respectively) and incident MetS (HRs per quartile decrease were 1.25 (95% CI 1.16-1.36), 1.44 (95% 1.30-1.60) and 1.14 (95% 1.01-1.28) for TT, SHBG and FT, respectively). Overall, the magnitude of associations was largest in non-overweight men and varied across individual components: stronger associations were observed with hypertriglyceridemia, abdominal obesity and hyperglycaemia and associations were weakest for hypertension.Associations of testosterone and SHBG with MetS vary according to BMI and individual MetS components. These findings provide further insights into the pathophysiological mechanisms linking low testosterone and SHBG concentrations to cardiometabolic risk.CONCLUSIONSAssociations of testosterone and SHBG with MetS vary according to BMI and individual MetS components. These findings provide further insights into the pathophysiological mechanisms linking low testosterone and SHBG concentrations to cardiometabolic risk. Low total testosterone (TT) and sex hormone-binding globulin (SHBG) concentrations have been associated with the metabolic syndrome (MetS) in men, but the reported strength of association varies considerably. We aimed to investigate whether associations differ across specific subgroups (according to age and body mass index (BMI)) and individual MetS components. Two previously published meta-analyses including an updated systematic search in PubMed and EMBASE. Cross-sectional or prospective observational studies with data on TT and/or SHBG concentrations in combination with MetS in men. We conducted an individual participant data meta-analysis of 20 observational studies. Mixed effects models were used to assess cross-sectional and prospective associations of TT, SHBG and free testosterone (FT) with MetS and its individual components. Multivariable adjusted odds ratios (ORs) and hazard ratios (HRs) were calculated and effect modification by age and BMI was studied. Men with low concentrations of TT, SHBG or FT were more likely to have prevalent MetS (ORs per quartile decrease were 1.69 (95% CI 1.60-1.77), 1.73 (95% CI 1.62-1.85) and 1.46 (95% CI 1.36-1.57) for TT, SHBG and FT, respectively) and incident MetS (HRs per quartile decrease were 1.25 (95% CI 1.16-1.36), 1.44 (95% 1.30-1.60) and 1.14 (95% 1.01-1.28) for TT, SHBG and FT, respectively). Overall, the magnitude of associations was largest in non-overweight men and varied across individual components: stronger associations were observed with hypertriglyceridemia, abdominal obesity and hyperglycaemia and associations were weakest for hypertension. Associations of testosterone and SHBG with MetS vary according to BMI and individual MetS components. These findings provide further insights into the pathophysiological mechanisms linking low testosterone and SHBG concentrations to cardiometabolic risk. Background Low total testosterone (TT) and sex hormone-binding globulin (SHBG) concentrations have been associated with the metabolic syndrome (MetS) in men, but the reported strength of association varies considerably. Objectives We aimed to investigate whether associations differ across specific subgroups (according to age and body mass index (BMI)) and individual MetS components. Data sources Two previously published meta-analyses including an updated systematic search in PubMed and EMBASE. Study Eligibility Criteria Cross-sectional or prospective observational studies with data on TT and/or SHBG concentrations in combination with MetS in men. Methods We conducted an individual participant data meta-analysis of 20 observational studies. Mixed effects models were used to assess cross-sectional and prospective associations of TT, SHBG and free testosterone (FT) with MetS and its individual components. Multivariable adjusted odds ratios (ORs) and hazard ratios (HRs) were calculated and effect modification by age and BMI was studied. Results Men with low concentrations of TT, SHBG or FT were more likely to have prevalent MetS (ORs per quartile decrease were 1.69 (95% CI 1.60-1.77), 1.73 (95% CI 1.62-1.85) and 1.46 (95% CI 1.36-1.57) for TT, SHBG and FT, respectively) and incident MetS (HRs per quartile decrease were 1.25 (95% CI 1.16-1.36), 1.44 (95% 1.30-1.60) and 1.14 (95% 1.01-1.28) for TT, SHBG and FT, respectively). Overall, the magnitude of associations was largest in non-overweight men and varied across individual components: stronger associations were observed with hypertriglyceridemia, abdominal obesity and hyperglycaemia and associations were weakest for hypertension. Conclusions Associations of testosterone and SHBG with MetS vary according to BMI and individual MetS components. These findings provide further insights into the pathophysiological mechanisms linking low testosterone and SHBG concentrations to cardiometabolic risk. |
| Audience | Academic |
| Author | Akishita, Masahiro Tuomainen, Tomi-Pekka Völzke, Henry Tong, Peter C. Y. Kauhanen, Jussi Corona, Giovanni Goncharov, Nicolai P. Undén, Anna-Lena Brand, Judith S. Onat, Altan Kumanov, Philip Wallaschofski, Henri Ferrucci, Luigi Bouchard, Claude Salonen, Jukka T. van der Schouw, Yvonne T. Haring, Robin Chen, Richard Y. T. Schneider, Harald J. Almeida, Osvaldo P. Klotsche, Jens Rovers, Maroeska M. Maggio, Marcello Chubb, S. A. Paul Hautanen, Aarno Yeap, Bu B. Wittchen, Hans-Ulrich Gietema, Jourik A. Gannagé-Yared, Marie-Hélène |
| AuthorAffiliation | 19 Clinical Center of Endocrinology and Gerontology, Medical University, Sofia, Bulgaria 5 Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland 13 Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan 7 Andrology and Sexual Medicine Unit Department of Clinical Physiopathology, University of Florence, Florence, Italy University of Padova, Italy 23 MAS-Metabolic Analytical Services Oy, Helsinki, Finland 22 Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany 16 Center for Family and Community Medicine, Stockholm, Sweden 24 Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, United States of America 11 Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong, Hong Kong 21 Institute of Clinical Psychology, Center of Clinical Epidemiology and Longitudinal Studies, University of Dresden, Dresden, Germany 2 Departments of EBH |
| AuthorAffiliation_xml | – name: 11 Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong, Hong Kong – name: 9 Department of Internal Medicine and Biomedical Sciences, University of Parma, Parma, Italy – name: 6 Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany – name: 5 Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland – name: 13 Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan – name: University of Padova, Italy – name: 21 Institute of Clinical Psychology, Center of Clinical Epidemiology and Longitudinal Studies, University of Dresden, Dresden, Germany – name: 10 Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, United States of America – name: 15 Department of Endocrinology, Saint-Joseph University, Beirut, Lebanon – name: 17 Department of Clinical Chemistry, University of Helsinki, Helsinki, Finland – name: 3 School of Medicine and Pharmacology, University of Western Australia, Perth, Australia – name: 4 Medizinische Klinik Innenstadt der Universität München, München, Germany – name: 7 Andrology and Sexual Medicine Unit Department of Clinical Physiopathology, University of Florence, Florence, Italy – name: 12 Department of Endocrinology, Changing General Hospital, Singapore, Singapore – name: 16 Center for Family and Community Medicine, Stockholm, Sweden – name: 20 School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, Australia – name: 19 Clinical Center of Endocrinology and Gerontology, Medical University, Sofia, Bulgaria – name: 8 Department of Cardiology, Istanbul University, Istanbul, Turkey – name: 14 Department of Medical Oncology, University Medical Center Groningen, Groningen, Netherlands – name: 1 Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands – name: 23 MAS-Metabolic Analytical Services Oy, Helsinki, Finland – name: 18 Endocrinology Research Center, Moscow, Russia – name: 22 Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany – name: 24 Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, United States of America – name: 2 Departments of EBH and operating rooms, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands |
| Author_xml | – sequence: 1 givenname: Judith S. surname: Brand fullname: Brand, Judith S. – sequence: 2 givenname: Maroeska M. surname: Rovers fullname: Rovers, Maroeska M. – sequence: 3 givenname: Bu B. surname: Yeap fullname: Yeap, Bu B. – sequence: 4 givenname: Harald J. surname: Schneider fullname: Schneider, Harald J. – sequence: 5 givenname: Tomi-Pekka surname: Tuomainen fullname: Tuomainen, Tomi-Pekka – sequence: 6 givenname: Robin surname: Haring fullname: Haring, Robin – sequence: 7 givenname: Giovanni surname: Corona fullname: Corona, Giovanni – sequence: 8 givenname: Altan surname: Onat fullname: Onat, Altan – sequence: 9 givenname: Marcello surname: Maggio fullname: Maggio, Marcello – sequence: 10 givenname: Claude surname: Bouchard fullname: Bouchard, Claude – sequence: 11 givenname: Peter C. Y. surname: Tong fullname: Tong, Peter C. Y. – sequence: 12 givenname: Richard Y. T. surname: Chen fullname: Chen, Richard Y. T. – sequence: 13 givenname: Masahiro surname: Akishita fullname: Akishita, Masahiro – sequence: 14 givenname: Jourik A. surname: Gietema fullname: Gietema, Jourik A. – sequence: 15 givenname: Marie-Hélène surname: Gannagé-Yared fullname: Gannagé-Yared, Marie-Hélène – sequence: 16 givenname: Anna-Lena surname: Undén fullname: Undén, Anna-Lena – sequence: 17 givenname: Aarno surname: Hautanen fullname: Hautanen, Aarno – sequence: 18 givenname: Nicolai P. surname: Goncharov fullname: Goncharov, Nicolai P. – sequence: 19 givenname: Philip surname: Kumanov fullname: Kumanov, Philip – sequence: 20 givenname: S. A. Paul surname: Chubb fullname: Chubb, S. A. Paul – sequence: 21 givenname: Osvaldo P. surname: Almeida fullname: Almeida, Osvaldo P. – sequence: 22 givenname: Hans-Ulrich surname: Wittchen fullname: Wittchen, Hans-Ulrich – sequence: 23 givenname: Jens surname: Klotsche fullname: Klotsche, Jens – sequence: 24 givenname: Henri surname: Wallaschofski fullname: Wallaschofski, Henri – sequence: 25 givenname: Henry surname: Völzke fullname: Völzke, Henry – sequence: 26 givenname: Jussi surname: Kauhanen fullname: Kauhanen, Jussi – sequence: 27 givenname: Jukka T. surname: Salonen fullname: Salonen, Jukka T. – sequence: 28 givenname: Luigi surname: Ferrucci fullname: Ferrucci, Luigi – sequence: 29 givenname: Yvonne T. surname: van der Schouw fullname: van der Schouw, Yvonne T. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25019163$$D View this record in MEDLINE/PubMed http://kipublications.ki.se/Default.aspx?queryparsed=id:129476431$$DView record from Swedish Publication Index (Karolinska Institutet) |
| BookMark | eNqNk21v0zAQxyMEYg_wDRBYQkIg0WI7z3uBVAZslTYN0cFby3EurYdrl9gZ2-fgC3NtM7RME0J5Eef8-__jO9_tRQ-tsxBFzxgdszhn7y5c11ppxisMjymjNKHlg2iXlTEfZZzGD2-td6I97y8oTeMiyx5HOzylrGRZvBv9PgcfnA_Qos1bMoMrcuzaJX6MPmhbazsnR8ZVndGWSFuTsAByCkFWzmhFZte2bt0SCO6egj0gE0umqLrUdScN-SLboJVeSRvIRxnkRjma4KmvvfbENeSs8tBeyqAdBsksdLUG_yR61Ejj4Wn_3o--ff50fng8Ojk7mh5OTkYqL7MwSmmVxEoBz5KMFRBDlXJoWKxiluesKRugMi4YSzmvmayShBYq41wWNUoyWcX70Yut78o4L_p6esHSJKWU53mOxHRL1E5eiFWrl7K9Fk5qsQm4di42KRoQaVE1rGZQAFcJS5kscs7jrKJQpiVLGvQabb38L1h11cCtD_3AFTrhhdEC-ff96bpqCbUCG1ppBrLhjtULMXeXAvsgSyhFg9e9Qet-dnjNYqm9AmOkBddt80w4TbEP9qOXd9D7q9FTc4kJa9s4_K9am4pJwoo0jWmeIDW-h8KnhqVW2FiNxvhA8GYgQCbAVZjLznsxnX39f_bs-5B9dYtdgDRh4Z3p1s3mh-Dz25X-W-KbKUHgYAuo1nnfQiOUDpumxdS0EYyK9UjeFE2sR1L0I4ni5I74xv-fsj-g0jq6 |
| CitedBy_id | crossref_primary_10_17656_jsmc_10371 crossref_primary_10_1007_s11930_017_0132_3 crossref_primary_10_1016_j_ctim_2015_12_001 crossref_primary_10_1111_andr_310 crossref_primary_10_1371_journal_pone_0183369 crossref_primary_10_5694_mja16_00393 crossref_primary_10_1111_liv_13735 crossref_primary_10_1136_bmjopen_2020_048013 crossref_primary_10_1016_j_beem_2025_102004 crossref_primary_10_1097_PSY_0000000000001293 crossref_primary_10_1210_clinem_dgad175 crossref_primary_10_1007_s11154_022_09728_7 crossref_primary_10_25122_jml_2022_0203 crossref_primary_10_1016_j_urolonc_2014_11_010 crossref_primary_10_1111_andr_12979 crossref_primary_10_1097_MED_0000000000000886 crossref_primary_10_3389_fendo_2024_1365283 crossref_primary_10_1210_endrev_bnaf013 crossref_primary_10_1016_j_metabol_2018_03_024 crossref_primary_10_1155_2018_4926789 crossref_primary_10_1111_cen_13530 crossref_primary_10_2217_bmm_2016_0359 crossref_primary_10_1016_j_sxmr_2019_01_002 crossref_primary_10_1111_cen_13372 crossref_primary_10_1136_bcr_2017_220416 crossref_primary_10_3390_reports5010005 crossref_primary_10_1002_cam4_6918 crossref_primary_10_1371_journal_pone_0302403 crossref_primary_10_5534_wjmh_180032 crossref_primary_10_1096_fj_201800612R crossref_primary_10_1155_2017_4547658 crossref_primary_10_1530_EC_18_0480 crossref_primary_10_3389_fendo_2019_00345 crossref_primary_10_1016_j_euf_2017_05_007 crossref_primary_10_1093_jsxmed_qdaf170 crossref_primary_10_4158_EP161543_OR crossref_primary_10_1111_cen_13407 crossref_primary_10_1016_j_jdiacomp_2016_10_011 crossref_primary_10_1007_s42000_021_00345_8 crossref_primary_10_1111_cen_13888 crossref_primary_10_1007_s12265_019_09939_5 crossref_primary_10_1007_s40615_023_01762_8 crossref_primary_10_1111_and_12736 crossref_primary_10_1111_andr_12581 crossref_primary_10_1080_00325481_2017_1261608 crossref_primary_10_1016_j_diabres_2016_09_022 crossref_primary_10_3389_fpsyt_2022_847310 crossref_primary_10_1111_cen_13390 crossref_primary_10_1038_s41598_017_02367_y crossref_primary_10_1111_cen_14122 crossref_primary_10_1136_bmjopen_2019_034777 crossref_primary_10_1007_s12020_019_01978_x crossref_primary_10_1038_s41443_021_00516_6 crossref_primary_10_1111_dom_13601 crossref_primary_10_1016_j_sxmr_2019_06_006 crossref_primary_10_1111_cen_12738 crossref_primary_10_1016_j_jsbmb_2019_105496 crossref_primary_10_1136_bmjopen_2017_020293 crossref_primary_10_1038_nrendo_2015_112 crossref_primary_10_14814_phy2_15127 crossref_primary_10_1186_s12967_024_06040_7 crossref_primary_10_1016_j_ejca_2015_11_009 crossref_primary_10_1177_20420188221106879 crossref_primary_10_1016_j_jsxm_2018_09_012 crossref_primary_10_1080_09168451_2018_1490172 crossref_primary_10_1016_j_jsbmb_2017_06_007 crossref_primary_10_1111_bju_13621 crossref_primary_10_1007_s00432_023_04778_z crossref_primary_10_1007_s12020_024_04019_4 crossref_primary_10_1111_jsm_12952 crossref_primary_10_1210_clinem_dgae317 crossref_primary_10_1016_j_eururo_2015_12_005 crossref_primary_10_1016_j_xfnr_2023_03_001 crossref_primary_10_1097_MOU_0000000000000421 crossref_primary_10_1080_00325481_2020_1805917 crossref_primary_10_1111_andr_12568 crossref_primary_10_1016_j_exger_2017_08_016 crossref_primary_10_1155_2024_6166698 crossref_primary_10_1186_s12902_015_0034_1 crossref_primary_10_3389_fendo_2023_1277393 crossref_primary_10_1016_j_physbeh_2020_112826 crossref_primary_10_1210_er_2018_00178 crossref_primary_10_2147_DMSO_S293259 crossref_primary_10_1016_j_hfc_2019_02_007 crossref_primary_10_1111_nyas_15211 crossref_primary_10_1530_EJE_14_1103 crossref_primary_10_2147_DMSO_S483344 crossref_primary_10_5534_wjmh_190030 crossref_primary_10_2147_DMSO_S332028 crossref_primary_10_3390_ijms22179425 crossref_primary_10_1111_andr_12654 crossref_primary_10_1007_s40618_023_02136_x crossref_primary_10_1177_1756287215612961 crossref_primary_10_3389_fendo_2020_00428 crossref_primary_10_1186_s13098_021_00643_6 crossref_primary_10_1016_j_ejca_2017_07_006 crossref_primary_10_1530_EJE_16_0834 crossref_primary_10_3389_fendo_2024_1384603 crossref_primary_10_1111_cen_15189 crossref_primary_10_1210_jc_2015_2460 crossref_primary_10_1007_s40746_021_00226_7 crossref_primary_10_1097_MED_0000000000000161 crossref_primary_10_1007_s40618_016_0480_2 crossref_primary_10_1097_HJH_0000000000001812 crossref_primary_10_1177_1756287217742837 crossref_primary_10_1111_andr_12705 crossref_primary_10_1080_13685538_2018_1501015 crossref_primary_10_1097_JIM_0000000000000203 crossref_primary_10_1371_journal_pone_0189042 crossref_primary_10_1002_dmrr_3133 crossref_primary_10_1016_j_mce_2015_06_031 crossref_primary_10_1371_journal_pone_0265629 crossref_primary_10_3389_fphys_2025_1504778 crossref_primary_10_1097_MOU_0000000000000440 crossref_primary_10_1002_gps_5040 crossref_primary_10_1111_cen_14682 crossref_primary_10_1373_clinchem_2015_245969 crossref_primary_10_1038_s41598_019_50855_0 crossref_primary_10_1016_j_numecd_2021_05_022 crossref_primary_10_1097_HJH_0000000000003506 crossref_primary_10_3389_fendo_2024_1394383 crossref_primary_10_3389_fendo_2014_00217 crossref_primary_10_1111_cen_13905 crossref_primary_10_1097_MD_0000000000011779 crossref_primary_10_1016_j_mce_2022_111556 crossref_primary_10_1016_j_amjms_2025_08_004 crossref_primary_10_1093_ejendo_lvae166 crossref_primary_10_1007_s00394_018_1707_0 crossref_primary_10_1016_j_beem_2015_06_005 crossref_primary_10_1016_S2213_8587_24_00199_2 crossref_primary_10_1038_s41598_017_03078_0 crossref_primary_10_3389_fcvm_2022_998056 crossref_primary_10_1155_2017_4375253 crossref_primary_10_5534_wjmh_2017_35_2_65 crossref_primary_10_3389_fendo_2020_00582 crossref_primary_10_1097_MED_0000000000000582 crossref_primary_10_1111_nyas_15188 crossref_primary_10_3389_fcvm_2022_869251 crossref_primary_10_1186_s12986_021_00580_1 crossref_primary_10_1038_srep19844 crossref_primary_10_1111_cen_13501 crossref_primary_10_1155_2017_4257875 crossref_primary_10_3389_fendo_2023_1187212 |
| Cites_doi | 10.1111/j.1743-6109.2007.00529.x 10.1161/CIRCULATIONAHA.109.192644 10.1038/sj.ijo.0801837 10.2337/diabetes.51.4.1016 10.1111/j.1462-8902.2004.00335.x 10.1373/49.8.1381 10.1016/j.metabol.2007.05.020 10.1530/eje.0.1490601 10.2337/diacare.29.03.06.dc05-1755 10.1210/jc.2008-0054 10.1530/EJE-07-0893 10.2337/dc11-0888 10.3109/13685538.2010.487550 10.1210/jc.2007-2707 10.1007/s00198-008-0591-5 10.1200/JCO.2005.02.176 10.1530/EJE-13-0222 10.1093/hmg/ddp522 10.1210/jc.2006-2764 10.1111/j.1365-2265.2005.02306.x 10.1093/biomet/76.3.425 10.2337/dc09-1788 10.1530/eje.0.1450001 10.1210/jc.2006-1864 10.1080/13685530802204629 10.1530/eje.1.02175 10.1016/j.jacc.2006.09.032 10.2337/db09-0031 10.1210/jc.2003-031287 10.1111/j.1365-2265.2008.03370.x 10.1111/j.1463-1326.2005.00532.x 10.1093/ije/dyq158 10.1111/j.1439-0272.2006.00743.x 10.1111/j.1743-6109.2010.01991.x 10.2337/diacare.27.5.1036 10.1111/j.1743-6109.2008.00856.x 10.1210/jc.2004-2190 10.1111/j.1532-5415.2006.00963.x 10.1210/jc.2005-0228 10.1038/sj.ijo.0801467 10.2337/dc10-2109 10.2337/dc10-0879 10.1210/jcem.84.10.6079 10.1038/sj.ijo.0801281 10.1046/j.1463-1326.2003.00250.x 10.1210/jc.2004-1158 10.1056/NEJMoa0804381 10.1530/EJE-11-1051 10.1038/oby.2003.98 10.1210/jc.2005-1326 10.1210/jc.2003-030680 10.1038/hr.2010.43 10.1185/030079905X38187 10.2337/dc08-0423 |
| ContentType | Journal Article |
| Copyright | COPYRIGHT 2014 Public Library of Science 2014 Brand et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2014 Brand et al 2014 Brand et al |
| Copyright_xml | – notice: COPYRIGHT 2014 Public Library of Science – notice: 2014 Brand et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2014 Brand et al 2014 Brand et al |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM IOV ISR 3V. 7QG 7QL 7QO 7RV 7SN 7SS 7T5 7TG 7TM 7U9 7X2 7X7 7XB 88E 8AO 8C1 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABJCF ABUWG AEUYN AFKRA ARAPS ATCPS AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU D1I DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. KB. KB0 KL. L6V LK8 M0K M0S M1P M7N M7P M7S NAPCQ P5Z P62 P64 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS PTHSS PYCSY RC3 7X8 5PM ADTPV AOWAS D8T ZZAVC DOA |
| DOI | 10.1371/journal.pone.0100409 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Gale In Context: Opposing Viewpoints In Context: Science ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Biotechnology Research Abstracts Nursing & Allied Health Database Ecology Abstracts Entomology Abstracts (Full archive) Immunology Abstracts Meteorological & Geoastrophysical Abstracts Nucleic Acids Abstracts Virology and AIDS Abstracts Agricultural Science Collection Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Materials Science & Engineering Collection ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland Advanced Technologies & Computer Science Collection Agricultural & Environmental Science Collection ProQuest Central Essentials Biological Science Collection ProQuest Central Technology Collection Natural Science Collection Environmental Sciences and Pollution Management ProQuest One ProQuest Materials Science Collection ProQuest Central Korea Engineering Research Database Proquest Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Materials Science Database Nursing & Allied Health Database (Alumni Edition) Meteorological & Geoastrophysical Abstracts - Academic ProQuest Engineering Collection ProQuest Biological Science Collection Agriculture Science Database ProQuest Health & Medical Collection Medical Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Engineering Database Nursing & Allied Health Premium Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Environmental Science Database Materials Science Collection ProQuest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China Engineering Collection Environmental Science Collection Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) SwePub SwePub Articles SWEPUB Freely available online SwePub Articles full text DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Agricultural Science Database Publicly Available Content Database ProQuest Central Student ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Meteorological & Geoastrophysical Abstracts Natural Science Collection Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) Engineering Collection Advanced Technologies & Aerospace Collection Engineering Database Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Agricultural Science Collection ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Meteorological & Geoastrophysical Abstracts - Academic ProQuest One Academic (New) Technology Collection Technology Research Database ProQuest One Academic Middle East (New) Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts ProQuest Engineering Collection Biotechnology Research Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts Materials Science Database ProQuest Materials Science Collection ProQuest Public Health ProQuest Nursing & Allied Health Source ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library Animal Behavior Abstracts Materials Science & Engineering Collection Immunology Abstracts ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | Agricultural Science Database MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Sciences (General) |
| DocumentTitleAlternate | Testosterone, SHBG and Metabolic Syndrome in Men |
| EISSN | 1932-6203 |
| ExternalDocumentID | 1545002777 oai_doaj_org_article_58bf1d1e8e2c4151a872236b0e95914f oai_swepub_ki_se_520308 PMC4096400 3372472661 A418553074 25019163 10_1371_journal_pone_0100409 |
| Genre | Meta-Analysis Journal Article |
| GeographicLocations | Istanbul Turkey Perth Western Australia Australia Singapore United States--US Netherlands Turkey China Finland Louisiana Hong Kong China Italy Australia Germany |
| GeographicLocations_xml | – name: Singapore – name: Netherlands – name: Italy – name: China – name: Louisiana – name: Perth Western Australia Australia – name: United States--US – name: Turkey – name: Germany – name: Hong Kong China – name: Australia – name: Finland – name: Istanbul Turkey |
| GroupedDBID | --- 123 29O 2WC 53G 5VS 7RV 7X2 7X7 7XC 88E 8AO 8C1 8CJ 8FE 8FG 8FH 8FI 8FJ A8Z AAFWJ AAUCC AAWOE AAYXX ABDBF ABIVO ABJCF ABUWG ACCTH ACGFO ACIHN ACIWK ACPRK ACUHS ADBBV ADRAZ AEAQA AENEX AEUYN AFFHD AFKRA AFPKN AFRAH AHMBA ALMA_UNASSIGNED_HOLDINGS AOIJS APEBS ARAPS ATCPS BAWUL BBNVY BCNDV BENPR BGLVJ BHPHI BKEYQ BPHCQ BVXVI BWKFM CCPQU CITATION CS3 D1I D1J D1K DIK DU5 E3Z EAP EAS EBD EMOBN ESX EX3 F5P FPL FYUFA GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE IAO IEA IGS IHR IHW INH INR IOV IPY ISE ISR ITC K6- KB. KQ8 L6V LK5 LK8 M0K M1P M48 M7P M7R M7S M~E NAPCQ O5R O5S OK1 OVT P2P P62 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PPXIY PQGLB PQQKQ PROAC PSQYO PTHSS PYCSY RNS RPM SV3 TR2 UKHRP WOQ WOW ~02 ~KM ALIPV CGR CUY CVF ECM EIF IPNFZ NPM PV9 RIG RZL BBORY 3V. 7QG 7QL 7QO 7SN 7SS 7T5 7TG 7TM 7U9 7XB 8FD 8FK AZQEC C1K DWQXO ESTFP FR3 GNUQQ H94 K9. KL. M7N P64 PKEHL PQEST PQUKI PRINS RC3 7X8 PUEGO 5PM ADTPV AOWAS BAIFH BBTPI D8T ZZAVC AAPBV ABPTK |
| ID | FETCH-LOGICAL-c796t-50b43cce264618e3eb52ef13c31771f9fe0a3811522d1ab4408c622a8de266ab3 |
| IEDL.DBID | FPL |
| ISICitedReferencesCount | 175 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000339618600006&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1932-6203 |
| IngestDate | Sun Oct 01 00:11:39 EDT 2023 Fri Oct 03 12:44:52 EDT 2025 Tue Nov 25 03:37:58 EST 2025 Tue Nov 04 01:58:50 EST 2025 Wed Oct 01 13:58:12 EDT 2025 Tue Oct 07 07:47:49 EDT 2025 Sat Nov 29 13:01:02 EST 2025 Sat Nov 29 10:11:03 EST 2025 Wed Nov 26 10:28:26 EST 2025 Wed Nov 26 09:33:56 EST 2025 Thu May 22 21:22:17 EDT 2025 Mon Jul 21 05:51:01 EDT 2025 Tue Nov 18 22:25:58 EST 2025 Sat Nov 29 04:18:49 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 7 |
| Language | English |
| License | This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. Creative Commons Attribution License |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c796t-50b43cce264618e3eb52ef13c31771f9fe0a3811522d1ab4408c622a8de266ab3 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 content type line 14 ObjectType-Feature-3 ObjectType-Evidence Based Healthcare-1 ObjectType-Article-1 ObjectType-Feature-2 content type line 23 Deceased. Conceived and designed the experiments: JSB MMR YTvdS. Performed the experiments: BBY HJS TPT RH GC AO MM CB PCYT RYTC MA JAG MHGY ALU AH NPG PK SAPC OPA HUW JK HW HV JK JTS LF. Analyzed the data: JSB. Contributed reagents/materials/analysis tools: BBY HJS TPT RH GC AO MM CB PCYT RYTC MA JAG MHGY ALU AH NPG PK SAPC OPA HUW JK HW HV JK JTS LF. Wrote the paper: JSB MMR YTvdS. Competing Interests: The authors have the following interests: Prof. Jukka T. Salonen is currently employed by MAS-Metabolic Analytical Services Oy. This employment commenced after the completion of this study. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials. |
| OpenAccessLink | http://dx.doi.org/10.1371/journal.pone.0100409 |
| PMID | 25019163 |
| PQID | 1545002777 |
| PQPubID | 1436336 |
| ParticipantIDs | plos_journals_1545002777 doaj_primary_oai_doaj_org_article_58bf1d1e8e2c4151a872236b0e95914f swepub_primary_oai_swepub_ki_se_520308 pubmedcentral_primary_oai_pubmedcentral_nih_gov_4096400 proquest_miscellaneous_1545420516 proquest_journals_1545002777 gale_infotracmisc_A418553074 gale_infotracacademiconefile_A418553074 gale_incontextgauss_ISR_A418553074 gale_incontextgauss_IOV_A418553074 gale_healthsolutions_A418553074 pubmed_primary_25019163 crossref_citationtrail_10_1371_journal_pone_0100409 crossref_primary_10_1371_journal_pone_0100409 |
| PublicationCentury | 2000 |
| PublicationDate | 2014-07-14 |
| PublicationDateYYYYMMDD | 2014-07-14 |
| PublicationDate_xml | – month: 07 year: 2014 text: 2014-07-14 day: 14 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: San Francisco – name: San Francisco, USA |
| PublicationTitle | PloS one |
| PublicationTitleAlternate | PLoS One |
| PublicationYear | 2014 |
| Publisher | Public Library of Science Public Library of Science (PLoS) |
| Publisher_xml | – name: Public Library of Science – name: Public Library of Science (PLoS) |
| References | S Soderberg (ref57) 2001; 25 PJ Anderson (ref54) 2001; 25 A Vermeulen (ref22) 1999; 84 R Robeva (ref34) 2006; 38 J Taieb (ref43) 2003; 49 I Gabriely (ref58) 2002; 51 IT Huhtaniemi (ref41) 2012; 166 HU Wittchen (ref21) 2005; 21 AL Unden (ref36) 2005; 63 R Haring (ref12) 2009; 58 S Lappalainen (ref56) 2008; 93 S Khosla (ref42) 2008; 19 J Kaukua (ref49) 2003; 11 NP Goncharov (ref30) 2008; 11 J Lidfeldt (ref24) 2003; 5 ref45 A Mozumdar (ref2) 2011; 34 C Li (ref7) 2010; 33 M Akishita (ref26) 2010; 33 HJ Schneider (ref20) 2009; 70 J Tierney (ref25) 1989; 76 SA Chubb (ref8) 2008; 158 C Wang (ref44) 2004; 89 R Haring (ref46) 2013; 169 PC Tong (ref37) 2005; 90 S Bhasin (ref55) 2011; 34 N Pitteloud (ref50) 2005; 90 M Muller (ref10) 2005; 90 RY Chen (ref31) 2006; 8 S Lim (ref3) 2011; 34 ES Ford (ref6) 2008; 31 O Ukkola (ref38) 2001; 145 G Corona (ref16) 2007; 4 ref1 G Corona (ref18) 2011; 8 MH Emmelot-Vonk (ref29) 2008; 299 V Kupelian (ref9) 2008; 93 EL Ding (ref52) 2009; 361 JR Perry (ref53) 2010; 19 A Rodriguez (ref13) 2007; 92 A Hautanen (ref39) 2000; 24 KG Alberti (ref23) 2009; 120 RY Chen (ref27) 2010; 13 AM Isidori (ref51) 1999; 84 AS Gami (ref5) 2007; 49 KK Miller (ref47) 2004; 89 W Rosner (ref40) 2007; 92 V Kupelian (ref14) 2006; 91 JS Brand (ref17) 2011; 40 C Lorenzo (ref4) 2006; 29 M Maggio (ref33) 2006; 54 J Nuver (ref35) 2005; 23 MH Gannage-Yared (ref32) 2006; 155 A Onat (ref19) 2007; 56 L Niskanen (ref48) 2004; 6 DE Laaksonen (ref15) 2004; 27 DE Laaksonen (ref11) 2003; 149 G Corona (ref28) 2008; 5 |
| References_xml | – volume: 4 start-page: 1038 year: 2007 ident: ref16 article-title: NCEP-ATPIII-defined metabolic syndrome, type 2 diabetes mellitus, and prevalence of hypogonadism in male patients with sexual dysfunction publication-title: J Sex Med doi: 10.1111/j.1743-6109.2007.00529.x – ident: ref1 – volume: 120 start-page: 1640 year: 2009 ident: ref23 article-title: Harmonizing the metabolic syndrome: A joint interim statement of the international diabetes federation task force on epidemiology and prevention; national heart, lung, and blood institute; american heart association; world heart federation; international atherosclerosis society; and international association for the study of obesity publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.109.192644 – volume: 25 start-page: 1782 year: 2001 ident: ref54 article-title: Factor analysis of the metabolic syndrome: Obesity vs insulin resistance as the central abnormality publication-title: Int J Obes Relat Metab Disord doi: 10.1038/sj.ijo.0801837 – volume: 51 start-page: 1016 year: 2002 ident: ref58 article-title: Leptin resistance during aging is independent of fat mass publication-title: Diabetes doi: 10.2337/diabetes.51.4.1016 – volume: 6 start-page: 208 year: 2004 ident: ref48 article-title: Changes in sex hormone-binding globulin and testosterone during weight loss and weight maintenance in abdominally obese men with the metabolic syndrome publication-title: Diabetes Obes Metab doi: 10.1111/j.1462-8902.2004.00335.x – volume: 49 start-page: 1381 year: 2003 ident: ref43 article-title: Testosterone measured by 10 immunoassays and by isotope-dilution gas chromatography-mass spectrometry in sera from 116 men, women, and children publication-title: Clin Chem doi: 10.1373/49.8.1381 – volume: 56 start-page: 1356 year: 2007 ident: ref19 article-title: Serum sex hormone-binding globulin, a determinant of cardiometabolic disorders independent of abdominal obesity and insulin resistance in elderly men and women publication-title: Metabolism doi: 10.1016/j.metabol.2007.05.020 – volume: 149 start-page: 601 year: 2003 ident: ref11 article-title: Sex hormones, inflammation and the metabolic syndrome: A population-based study publication-title: Eur J Endocrinol doi: 10.1530/eje.0.1490601 – volume: 29 start-page: 625 year: 2006 ident: ref4 article-title: Trend in the prevalence of the metabolic syndrome and its impact on cardiovascular disease incidence: The san antonio heart study publication-title: Diabetes Care doi: 10.2337/diacare.29.03.06.dc05-1755 – volume: 93 start-page: 3403 year: 2008 ident: ref9 article-title: Inverse association of testosterone and the metabolic syndrome in men is consistent across race and ethnic groups publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2008-0054 – volume: 158 start-page: 785 year: 2008 ident: ref8 article-title: Lower sex hormone-binding globulin is more strongly associated with metabolic syndrome than lower total testosterone in older men: The health in men study publication-title: Eur J Endocrinol doi: 10.1530/EJE-07-0893 – volume: 34 start-page: 2464 year: 2011 ident: ref55 article-title: Sex hormone-binding globulin, but not testosterone, is associated prospectively and independently with incident metabolic syndrome in men: The framingham heart study publication-title: Diabetes Care doi: 10.2337/dc11-0888 – volume: 13 start-page: 233 year: 2010 ident: ref27 article-title: Self-referred older asian males in a men's health clinic: The inter-relationships between androgens, metabolic parameters and quality of life measures publication-title: Aging Male doi: 10.3109/13685538.2010.487550 – volume: 93 start-page: 1304 year: 2008 ident: ref56 article-title: Androgen receptor gene CAG repeat polymorphism and X-chromosome inactivation in children with premature adrenarche publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2007-2707 – volume: 19 start-page: 1465 year: 2008 ident: ref42 article-title: Comparison of sex steroid measurements in men by immunoassay versus mass spectroscopy and relationships with cortical and trabecular volumetric bone mineral density publication-title: Osteoporos Int doi: 10.1007/s00198-008-0591-5 – volume: 23 start-page: 3718 year: 2005 ident: ref35 article-title: The metabolic syndrome and disturbances in hormone levels in long-term survivors of disseminated testicular cancer publication-title: J Clin Oncol doi: 10.1200/JCO.2005.02.176 – volume: 169 start-page: 463 year: 2013 ident: ref46 article-title: Testosterone and cardiometabolic risk in the general population - the impact of measurement method on risk associations: A comparative study between immunoassay and mass spectrometry publication-title: Eur J Endocrinol doi: 10.1530/EJE-13-0222 – volume: 19 start-page: 535 year: 2010 ident: ref53 article-title: Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes publication-title: Hum Mol Genet doi: 10.1093/hmg/ddp522 – volume: 92 start-page: 3568 year: 2007 ident: ref13 article-title: Aging, androgens, and the metabolic syndrome in a longitudinal study of aging publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2006-2764 – volume: 63 start-page: 94 year: 2005 ident: ref36 article-title: Gender differences in the relation of insulin-like growth factor binding protein-1 to cardiovascular risk factors: A population-based study publication-title: Clin Endocrinol (Oxf) doi: 10.1111/j.1365-2265.2005.02306.x – volume: 76 start-page: 425 year: 1989 ident: ref25 article-title: Approximate marginal densities of nonlinear functions publication-title: Biometrika doi: 10.1093/biomet/76.3.425 – volume: 33 start-page: 1618 year: 2010 ident: ref7 article-title: Association of testosterone and sex hormone-binding globulin with metabolic syndrome and insulin resistance in men publication-title: Diabetes Care doi: 10.2337/dc09-1788 – volume: 145 start-page: 1 year: 2001 ident: ref38 article-title: Age, body mass index, race and other determinants of steroid hormone variability: The HERITAGE family study publication-title: Eur J Endocrinol doi: 10.1530/eje.0.1450001 – volume: 92 start-page: 405 year: 2007 ident: ref40 article-title: Position statement: Utility, limitations, and pitfalls in measuring testosterone: An endocrine society position statement publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2006-1864 – volume: 11 start-page: 118 year: 2008 ident: ref30 article-title: Three definitions of metabolic syndrome applied to a sample of young obese men and their relation with plasma testosterone publication-title: Aging Male doi: 10.1080/13685530802204629 – volume: 155 start-page: 167 year: 2006 ident: ref32 article-title: Serum adiponectin and leptin levels in relation to the metabolic syndrome, androgenic profile and somatotropic axis in healthy non-diabetic elderly men publication-title: Eur J Endocrinol doi: 10.1530/eje.1.02175 – volume: 299 start-page: 39 year: 2008 ident: ref29 article-title: Effect of testosterone supplementation on functional mobility, cognition, and other parameters in older men: A randomized controlled trial publication-title: JAMA – volume: 49 start-page: 403 year: 2007 ident: ref5 article-title: Metabolic syndrome and risk of incident cardiovascular events and death: A systematic review and meta-analysis of longitudinal studies publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2006.09.032 – volume: 58 start-page: 2027 year: 2009 ident: ref12 article-title: Prediction of metabolic syndrome by low serum testosterone levels in men: Results from the study of health in pomerania publication-title: Diabetes doi: 10.2337/db09-0031 – volume: 89 start-page: 534 year: 2004 ident: ref44 article-title: Measurement of total serum testosterone in adult men: Comparison of current laboratory methods versus liquid chromatography-tandem mass spectrometry publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2003-031287 – volume: 84 start-page: 3673 year: 1999 ident: ref51 article-title: Leptin and androgens in male obesity: Evidence for leptin contribution to reduced androgen levels publication-title: J Clin Endocrinol Metab – ident: ref45 – volume: 70 start-page: 446 year: 2009 ident: ref20 article-title: Prevalence of low male testosterone levels in primary care in germany: Cross-sectional results from the DETECT study publication-title: Clin Endocrinol (Oxf) doi: 10.1111/j.1365-2265.2008.03370.x – volume: 8 start-page: 429 year: 2006 ident: ref31 article-title: Relative androgen deficiency in relation to obesity and metabolic status in older men publication-title: Diabetes Obes Metab doi: 10.1111/j.1463-1326.2005.00532.x – volume: 40 start-page: 189 year: 2011 ident: ref17 article-title: Testosterone, sex hormone-binding globulin and the metabolic syndrome: A systematic review and meta-analysis of observational studies publication-title: Int J Epidemiol doi: 10.1093/ije/dyq158 – volume: 38 start-page: 216 year: 2006 ident: ref34 article-title: Low testosterone levels and unimpaired melatonin secretion in young males with metabolic syndrome publication-title: Andrologia doi: 10.1111/j.1439-0272.2006.00743.x – volume: 8 start-page: 272 year: 2011 ident: ref18 article-title: Testosterone and metabolic syndrome: A meta-analysis study publication-title: J Sex Med doi: 10.1111/j.1743-6109.2010.01991.x – volume: 27 start-page: 1036 year: 2004 ident: ref15 article-title: Testosterone and sex hormone-binding globulin predict the metabolic syndrome and diabetes in middle-aged men publication-title: Diabetes Care doi: 10.2337/diacare.27.5.1036 – volume: 5 start-page: 2454 year: 2008 ident: ref28 article-title: Low levels of androgens in men with erectile dysfunction and obesity publication-title: J Sex Med doi: 10.1111/j.1743-6109.2008.00856.x – volume: 90 start-page: 2636 year: 2005 ident: ref50 article-title: Increasing insulin resistance is associated with a decrease in leydig cell testosterone secretion in men publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2004-2190 – volume: 54 start-page: 1832 year: 2006 ident: ref33 article-title: Association between hormones and metabolic syndrome in older italian men publication-title: J Am Geriatr Soc doi: 10.1111/j.1532-5415.2006.00963.x – volume: 90 start-page: 6418 year: 2005 ident: ref37 article-title: Association of testosterone, insulin-like growth factor-I, and C-reactive protein with metabolic syndrome in chinese middle-aged men with a family history of type 2 diabetes publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2005-0228 – volume: 25 start-page: 98 year: 2001 ident: ref57 article-title: A strong association between biologically active testosterone and leptin in non-obese men and women is lost with increasing (central) adiposity publication-title: Int J Obes Relat Metab Disord doi: 10.1038/sj.ijo.0801467 – volume: 34 start-page: 1323 year: 2011 ident: ref3 article-title: Increasing prevalence of metabolic syndrome in korea: The korean national health and nutrition examination survey for 1998–2007 publication-title: Diabetes Care doi: 10.2337/dc10-2109 – volume: 34 start-page: 216 year: 2011 ident: ref2 article-title: Persistent increase of prevalence of metabolic syndrome among U.S. adults: NHANES III to NHANES 1999–2006 publication-title: Diabetes Care doi: 10.2337/dc10-0879 – volume: 84 start-page: 3666 year: 1999 ident: ref22 article-title: A critical evaluation of simple methods for the estimation of free testosterone in serum publication-title: J Clin Endocrinol Metab doi: 10.1210/jcem.84.10.6079 – volume: 24 start-page: S64 year: 2000 ident: ref39 article-title: Synthesis and regulation of sex hormone-binding globulin in obesity publication-title: Int J Obes Relat Metab Disord doi: 10.1038/sj.ijo.0801281 – volume: 5 start-page: 106 year: 2003 ident: ref24 article-title: Socio-demographic and psychosocial factors are associated with features of the metabolic syndrome. the women's health in the lund area (WHILA) study publication-title: Diabetes Obes Metab doi: 10.1046/j.1463-1326.2003.00250.x – volume: 90 start-page: 2618 year: 2005 ident: ref10 article-title: Endogenous sex hormones and metabolic syndrome in aging men publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2004-1158 – volume: 361 start-page: 1152 year: 2009 ident: ref52 article-title: Sex hormone-binding globulin and risk of type 2 diabetes in women and men publication-title: N Engl J Med doi: 10.1056/NEJMoa0804381 – volume: 166 start-page: 983 year: 2012 ident: ref41 article-title: Comparison of serum testosterone and estradiol measurements in 3174 european men using platform immunoassay and mass spectrometry; relevance for the diagnostics in aging men publication-title: Eur J Endocrinol doi: 10.1530/EJE-11-1051 – volume: 11 start-page: 689 year: 2003 ident: ref49 article-title: Sex hormones and sexual function in obese men losing weight publication-title: Obes Res doi: 10.1038/oby.2003.98 – volume: 91 start-page: 843 year: 2006 ident: ref14 article-title: Low sex hormone-binding globulin, total testosterone, and symptomatic androgen deficiency are associated with development of the metabolic syndrome in nonobese men publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2005-1326 – volume: 89 start-page: 525 year: 2004 ident: ref47 article-title: Measurement of free testosterone in normal women and women with androgen deficiency: Comparison of methods publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2003-030680 – volume: 33 start-page: 587 year: 2010 ident: ref26 article-title: Association of low testosterone with metabolic syndrome and its components in middle-aged japanese men publication-title: Hypertens Res doi: 10.1038/hr.2010.43 – volume: 21 start-page: 619 year: 2005 ident: ref21 article-title: Cardiovascular risk factors in primary care: Methods and baseline prevalence rates—the DETECT program publication-title: Curr Med Res Opin doi: 10.1185/030079905X38187 – volume: 31 start-page: 1898 year: 2008 ident: ref6 article-title: Metabolic syndrome and incident diabetes: Current state of the evidence publication-title: Diabetes Care doi: 10.2337/dc08-0423 |
| SSID | ssj0053866 |
| Score | 2.5354593 |
| SecondaryResourceType | review_article |
| Snippet | Low total testosterone (TT) and sex hormone-binding globulin (SHBG) concentrations have been associated with the metabolic syndrome (MetS) in men, but the... Background Low total testosterone (TT) and sex hormone-binding globulin (SHBG) concentrations have been associated with the metabolic syndrome (MetS) in men,... BACKGROUND:Low total testosterone (TT) and sex hormone-binding globulin (SHBG) concentrations have been associated with the metabolic syndrome (MetS) in men,... Background Low total testosterone (TT) and sex hormone-binding globulin (SHBG) concentrations have been associated with the metabolic syndrome (MetS) in men,... |
| SourceID | plos doaj swepub pubmedcentral proquest gale pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | e100409 |
| SubjectTerms | Adult Age Factors Aged Aged, 80 and over Alcohol use Analysis Androgens Binding Biology and Life Sciences Body mass Body Mass Index Body size Body weight Cross-Sectional Studies Data analysis Data processing Epidemiology Globulins Health risks Hormones Humans Hyperglycemia Hypertension Hypertriglyceridemia Low concentrations Male Medical research Medicine and Health Sciences Men Meta-analysis Metabolic disorders Metabolic syndrome Metabolic Syndrome - epidemiology Middle Aged Obesity Observational studies Observational Studies as Topic Odds Ratio Overweight Physical Sciences Prospective Studies Research and Analysis Methods Sex Sex Hormone-Binding Globulin - analysis Subgroups Testosterone Testosterone - blood Upgrading Young Adult |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELbQigMXRHk1pQWDEA-JtHHi2Am3gqhAQgVBQb1ZtuPQVbfJqski_gd_mJnYGzWiUjlw243Hq3hmPPPZO_5MyFPH6pJbDhMpES6GDG1iXZUyNgAGdMHqKtfDrSUf5eFhcXxcfr5w1RfWhHl6YK-4vbwwNauYK1xqIdkwXUjIaMIkrsxLxmuMvoks14spH4NhFgsRDsplku0Fu-wu28btJkiShgWIFxLRwNc_RuXZctF2l0HOvysnJ_yiQ046uEVuBjBJ9_0gNsg119wmG2G6dvRF4JR-eYf8PsIbZJAUAd7tFe3cL3oCaBW-4NIY8xdFahAsS6e6qSjAQnrmevCQxdzSNa0BhdYz17wGETofT3LRpQ612U1PseJ06BnrQHdC25q2Ztz8BfnO1y7eJd8O3h29fR-H-xhiK0vRx3lieGatAwwlWOEyZ_LU1SyzgEEk2Lx2iQYAAIggrZg2eJe1FWmqiwq6CG2ye2TWwMA2CRWsci6rqyrhmifcGJbximW6KA0AKCYikq2No2wgK8c7MxZq-AdOwqLFq1ihSVUwaUTisdfSk3VcIf8G7T7KItX28AAcUAUHVFc5YEQeodcof251DBhqH2mBcgihPCJPBgmk22iwnueHXnWd-vDp-z8Iff0yEXoehOoW1GF1OEMBY0Iar4nk9kQSgoadNG-ij6-10ilE0rhFISX0XPv95c2Px2b8UazRa1y78jI8hSAP1rvvp8moWQDaDBYiWUTkZAJNVD9taeYnA9s52ElAoonIMz_VJl3Co1P4BJZKkXxp638Y9QG5AciY4yY-49tk1p-v3A65bn_28-784RBr_gAglYbJ priority: 102 providerName: Directory of Open Access Journals – databaseName: Nursing & Allied Health Database dbid: 7RV link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1bb9MwFLag8MALMG4LDDAIcZHIFieOk_CCOmDaJHbRuk17i2zH2apVSWlSxP_gD3NO4gQiJkDirY2Pq9o-l8_O8XcIeWFYnnDNwZA8YVyI0MqVWRK5CsCAjFmehbKpWvI52tuLT0-TA3vgVtm0ys4nNo46KzWekW9gqMc9VBS9n39xsWoUvl21JTSukmsMsTHoc3R40nlisGUh7HW5IGIbdnXW52Vh1j2kSsM0xF_CUcPa3_vm0XxWVpcBz9_zJwcso01k2rr1v2O6TW5aTErHrRKtkCumuENWrNVX9LWlpn5zl3w_wkI0yK0Ag3tLJ-Yb3QbQC1_czWlzP4Zi-gZmt1NZZBTQJd01NSjabKrpxLIjUGjdNcU7Oi7oTn8hjB5Im-Jd1PSjrGXT0-1YU2iZ033VnyGDvE2BvEeOtz4dfdh2bVkHV0eJqN3QUzzQ2gAUEyw2gVGhb3IWaIAyEahObjwJOAKAhZ8xqbAktha-L-MMugipgvtkVMDAVgkVLDMmyLPM45J7XCkW8IwFMk4U4DAmHBJ0q5tqy3mOpTdmafMiL4K9TzvFKepEanXCIW7fa95yfvxFfhMVp5dFxu7mQbk4S60DSMNY5SxjJja-BtDEZBwBMhPKM0mYMJ475CmqXdpef-39TjpGdqEQPDF3yPNGAlk7CkwLOpPLqkp39k_-QWhyOBB6ZYXyEqZDS3sVA8aEbGADybWBJPgePWheRSPpZqVKf2o09Ox0_vLmZ30z_iim-hWmXLYy3IdYAav3oLWzfmYBrzPYzwQOiQYWOJj6YUsxPW9I02GdBMQrh7xsbXXQxT66gE-wUj5yOD388_9_RG4AdOZ4ys_4GhnVi6V5TK7rr_W0Wjxp3NAP6MaTtA priority: 102 providerName: ProQuest |
| Title | Testosterone, Sex Hormone-Binding Globulin and the Metabolic Syndrome in Men: An Individual Participant Data Meta-Analysis of Observational Studies |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/25019163 https://www.proquest.com/docview/1545002777 https://www.proquest.com/docview/1545420516 https://pubmed.ncbi.nlm.nih.gov/PMC4096400 http://kipublications.ki.se/Default.aspx?queryparsed=id:129476431 https://doaj.org/article/58bf1d1e8e2c4151a872236b0e95914f http://dx.doi.org/10.1371/journal.pone.0100409 |
| Volume | 9 |
| WOSCitedRecordID | wos000339618600006&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: DOA dateStart: 20060101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M~E dateStart: 20060101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Advanced Technologies & Aerospace Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: P5Z dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/hightechjournals providerName: ProQuest – providerCode: PRVPQU databaseName: Agricultural Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M0K dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/agriculturejournals providerName: ProQuest – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M7P dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Engineering Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M7S dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com providerName: ProQuest – providerCode: PRVPQU databaseName: Environmental Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: PATMY dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/environmentalscience providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 7X7 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Materials Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: KB. dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/materialsscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Nursing & Allied Health Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 7RV dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/nahs providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: BENPR dateStart: 20061201 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Public Health Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 8C1 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: PIMPY dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVATS databaseName: Public Library of Science (PLoS) Journals Open Access customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: FPL dateStart: 20060101 isFulltext: true titleUrlDefault: http://www.plos.org/publications/ providerName: Public Library of Science |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3db9MwELeg44EXYHwtMIpBiA-JlDgfdsJbO1at2tpF6zYVXiIncaCiSqu1Rfwf_MPcOW5QYBPwcmrju0g---yfnfPPhLxQrIj8zIdAcriyYYZObZlHwk4BDMiQFXkg9a0lR2I0CieTKP61UPztC74n2Dvj085iXqqOgwRneF5vy_U4x8VWPz7ajLwQu5yb43FXWTamH83SX4_FrcVsvrwMaP6ZL9lgFdUzUf_2_9bhDrllMCftVp1km1xT5V2ybaJ6SV8b6uk398iPU7xoBrkT4BVv6Vh9pwcAauGP3Zvq8y8U0zMwe53KMqeAHulQraAjzaYZHRv2AwqlQ1W-p92SDuoDXzSWJoW7XNEPciW1pb1hRaHzgh6n9R4x6JsUx_vkrL9_undgm2sb7ExEfGUHTup7WaYAanEWKk-lgasK5mUAVQR0jUI5EnACAAc3ZzLFK68z7royzMGEy9R7QFolVGyHUM5ypbwizx1f-o6fpszzc-bJMEoBZzFuEW_TmklmOM3xao1Zoj_UCVjbVC5O0POJ8bxF7NpqUXF6_EW_hx2l1kVGbv0AmjgxAZ4EYVqwnKlQuRmAIiZDAciLp46Kgoj5hUWeYjdLquOt9biSdJE9KICR1rfIc62BrBwlpv18luvlMhkcn_-D0vikofTKKBVzcEcmzVELqBOyfTU0dxuaMLZkjeIdDIqNV5YJAm7cyRACLDeBcnnxs7oYX4qpfKWarysd34W5AFrvYRVXtWcBjzNYr3gWEY2Ia7i-WVJOv2hSdGgnDvORRV5WsdkwMY--wi9oKRc5mh5dXbXH5CbAYh938Jm_S1qri7V6Qm5k31bT5UWbXBcn5ygnQssQZLjH2mSrtz-KT9p6V6etByaQh70OyKFziFLEWo5BxsEnsIgHw_jjT2JFjmY |
| linkProvider | Public Library of Science |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1bb9MwFLZGQYIXYNxWGMwgYCCRLU6cGxJCHWNqtXaraEETL8FxnFFRJaVpufwO_ge_kXMSJxAxAS974K2Nj6Pk-Fzj4-8Qcl-xJOCSgyKZrjLAQ0eGiAPPiCAYED5LYkcUXUv63sGBf3QUDFfI9-osDJZVVjaxMNRxJvEb-Ta6esyhPO_57KOBXaNwd7VqoVGKxb76-hlStvxZbxfW94Fl7b0cv-gauquAIb3AXRiOGXFbSgWRgMt8ZavIsVTCbAme1IMnT5QpwI2BX7NiJiLsyCxdyxJ-DFNcEdlw3zPkLOeWiVo0dN5Wlh9sh-vq43m2x7a1NGzNslRtmQjNhmWPv7i_oktA7Qtas2mWnxTo_l6v2UA1LTzh3qX_jYeXyUUdc9NOqSSrZEWlV8iqtmo5faShtx9fJd_G2GgHsSOAmU_oSH2hXQjq4Y-xMynO_1AsT8HqfSrSmEL0TAdqAYo0nUg60ugPFEYHKn1KOynt1Qfe6FDoEvZ0QXfFQhQzjQoVhmYJPYzqb-RAr0s8r5HXp8Kc66SVwoutEeqyWCk7iWOTC27yKGI2j5kt_CCCOJO5bWJX0hRKjemOrUWmYbFR6UFuV7I4RBkMtQy2iVHPmpWYJn-h30FBrWkRkby4kM2PQ23gQsePEhYz5StLQlDIhO9B5OlGpgqcgPGkTTZQzMPyeG9tV8MOoic54Gl4m9wrKBCVJMWyp2OxzPOwd_jmH4hGrxpEm5ooyYAdUuijJvBOiHbWoFxvUIJtlY3hNVTKiit5-FODYGalYycP362H8aZYypiqbFnSgO1wcPVulHpdcxbyEQb5mt0mXkPjG6xvjqST9wUoPKyTC_64TR6WtqExRV_6AL9gpSzEqLr55-ffIOe740E_7PcO9m-RC5AmcNzRYHydtBbzpbpNzslPi0k-v1OYQErenba9-AEW7O-B |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9NAEF6VgBAXoLxqKHRBQEHCjddvIyGUEqJGbdOIFFRxMev1ukREdogdHr-Df8OvY8ZeGywq4NIDt8Q7a3ln52nPfkPIfcmSwBY2KJLhSh08dKTzOPD0CIIB7rMkdnjZtWTPG438o6NgvEK-12dhsKyytomloY4zge_Iu-jqMYfyvG6iyiLG_cHz-UcdO0jhl9a6nUYlIrvy62dI3_Jnwz7s9QPTHLw8fLGjqw4DuvACt9AdI7ItISREBS7zpSUjx5QJswR4VQ9WkUiDg0sDH2fGjEfYnVm4psn9GKa4PLLgvmfIWQ9yTCwnHDtvay8AdsR11VE9y2NdJRlb8yyVWwbCtGEJ5C-usOwY0PiFznyW5ScFvb_XbrYQTkuvOLj0P_PzMrmoYnHaq5RnlazI9ApZVdYup48UJPfjq-TbITbgQUwJYOwTOpFf6A4E-_BH356W54Iolq1gVT_laUwhqqb7sgAFm00FnShUCAqj-zJ9SnspHTYH4eiYq9L2tKB9XvBypl6jxdAsoQdR8-4c6FXp5zXy-lSYc510UljYGqEui6W0kjg2bG4bdhQxy46Zxf0ggviTuRqxaskKhcJ6x5Yjs7D8gOlBzlexOER5DJU8akRvZs0rrJO_0G-j0Da0iFReXsgWx6EyfKHjRwmLmfSlKSBYZNz3ICJ1I0MGTsDsRCMbKPJhdey3sbdhD1GVHPBAtkbulRSIVpKinB7zZZ6Hw4M3_0A0edUi2lRESQbsEFwdQYE1IQpai3K9RQk2V7SG11BBa67k4U9tgpm1vp08fLcZxptiiWMqs2VFY5vgI2H3blQ63nAW8hQGeZylEa-l_S3Wt0fS6fsSLB72yQU_rZGHlZ1oTVGXPsAv2CkTsatu_vn5N8h5MBPh3nC0e4tcgOzBxg8dzF4nnWKxlLfJOfGpmOaLO6U1pOTdaZuLHzHP-Es |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Testosterone%2C+Sex+Hormone-Binding+Globulin+and+the+Metabolic+Syndrome+in+Men%3A+An+Individual+Participant+Data+Meta-Analysis+of+Observational+Studies&rft.jtitle=PloS+one&rft.au=Brand%2C+Judith+S&rft.au=Rovers%2C+Maroeska+M&rft.au=Yeap%2C+Bu+B&rft.au=Schneider%2C+Harald+J&rft.date=2014-07-14&rft.pub=Public+Library+of+Science&rft.issn=1932-6203&rft.eissn=1932-6203&rft.volume=9&rft.issue=7&rft_id=info:doi/10.1371%2Fjournal.pone.0100409&rft.externalDocID=A418553074 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1932-6203&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1932-6203&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1932-6203&client=summon |