Directional dominance on stature and cognition in diverse human populations

An analysis of 16 health-related quantitative traits in approximately 350,000 individuals reveals statistically significant associations between genome-wide homozygosity and four complex traits (height, lung function, cognitive ability and educational attainment); in each case increased homozygosity...

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Published in:	Nature (London) Vol. 523; no. 7561; pp. 459 - 462
Main Authors:	Esko, Tonu, Nutile, Teresa, Jackson, Anne U., Schurmann, Claudia, Stančáková, Alena, Zhao, Wei, Enroth, Stefan, Guo, Xiuqing, Chasman, Daniel I., Rietveld, Cornelius A., Pattaro, Cristian, Vuckovic, Dragana, Bouchard, Claude, Benton, Miles C., Drong, Alexander, Yengo, Loic, Bielak, Lawrence F., Zhi, Degui, Mägi, Reedik, Karaderi, Tugce, Liu, Tian, van der Laan, Sander W., Asselbergs, Folkert W., Barr, R. Graham, Baumeister, Sebastian E., Benjamin, Daniel J., Boerwinkle, Eric, Chanock, Stephen J., Gillham-Nasenya, Irina, Gottesman, Omri, Grodstein, Francine, Gu, Charles, Huang, Jinyan, Ingelsson, Erik, Johansson, Åsa, Jukema, J. Wouter, Kähönen, Mika, Koellinger, Philipp, Kooner, Manraj K., Lahti, Jari, Lu, Yingchang, Lundqvist, Annamari, Männistö, Satu, Matchan, Angela, Mathias, Rasika A., Meitinger, Thomas, Morrison, Alanna, Nadukuru, Rajiv, Nelis, Mari, Nieminen, Markku S., Patarcic, Inga, Peyser, Patricia A., Prokopenko, Inga, Rose, Lynda M., Sala, Cinzia, Sarin, Antti-Pekka, Schmidt, Helena, Sennblad, Bengt, Seshadri, Sudha, Smith, Blair H., Smith, Jennifer A., Southam, Lorraine, Stathopoulou, Maria G., Strawbridge, Rona J., Taylor, Kent D., Tuomilehto, Jaakko, Vaidya, Dhananjay, Vasankari, Tuula, Vedantam, Sailaja, Vuoksimaa, Eero, Whitfield, John B., Willemsen, Gonneke, Zaza, Gianluigi, Melbye, Mads, Bisgaard, Hans, Cooper, Richard S., Froguel, Philippe, Pasterkamp, Gerard, Ferrucci, Luigi, Scott, Robert A., Morris, Andrew D., Deloukas, Panos, Lindgren, Cecilia M., Timpson, Nicholas J., Munroe, Patricia B., Gambaro, Giovanni, Morris, Andrew P., Eriksson, Johan G., Martin, Nicholas G., Hunt, Steven C., Kaprio, Jaakko, Becker, Diane M., Bharadwaj, Dwaipayan, Boehnke, Michael, Metspalu, Andres, Dupuis, Josée, Vollenweider, Peter, Rotter, Jerome I., Weir, David R., Chambers, John C.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 23.07.2015 Nature Publishing Group
Subjects:	45 45/43 631/181/2474 631/208/729/743 631/208/730 Biological Evolution Blood pressure Blood Pressure - genetics Body Height - genetics Cholesterol, LDL - genetics Cognition Cognition & reasoning Cognitive ability Cohort Studies Disease Educational attainment Educational Status Female Forced Expiratory Volume - genetics Genetic research Genome, Human - genetics Genomes Genomics Homozygosity Homozygote Human populations Humanities and Social Sciences Humans Inbreeding letter Lung Volume Measurements Male multidisciplinary Offspring Phenotype Public health Risk factors Science Studies
ISSN:	0028-0836, 1476-4687, 1476-4687
Online Access:	Get full text
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