Directional dominance on stature and cognition in diverse human populations
An analysis of 16 health-related quantitative traits in approximately 350,000 individuals reveals statistically significant associations between genome-wide homozygosity and four complex traits (height, lung function, cognitive ability and educational attainment); in each case increased homozygosity...
Gespeichert in:
| Veröffentlicht in: | Nature (London) Jg. 523; H. 7561; S. 459 - 462 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
London
Nature Publishing Group UK
23.07.2015
Nature Publishing Group |
| Schlagworte: | |
| ISSN: | 0028-0836, 1476-4687, 1476-4687 |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Abstract | An analysis of 16 health-related quantitative traits in approximately 350,000 individuals reveals statistically significant associations between genome-wide homozygosity and four complex traits (height, lung function, cognitive ability and educational attainment); in each case increased homozygosity associates with a decreased trait value, but no evidence was seen of an influence on blood pressure, cholesterol, or ten other cardio-metabolic traits.
Parental relatedness link to height and intelligence
This consortium meta-analysis of 102 cohorts and more than 350,000 individuals investigates the effects of homozygosity on traits of public health importance by observing contiguous homozygous segments (runs of homozygosity, ROH), which are inferred to be homozygous along their complete length. Focusing on 16 health-related quantitative traits, the authors find statistically significant associations between summed runs of homozygosity and four complex traits: height, forced expiratory lung volume in a second, general cognitive ability and educational attainment. In each case increased homozygosity associates with decreased trait value. No evidence was seen of an influence of genome-wide homozygosity on blood pressure and low density lipoprotein cholesterol, or ten other cardio-metabolic traits.
Homozygosity has long been associated with rare, often devastating, Mendelian disorders
1
, and Darwin was one of the first to recognize that inbreeding reduces evolutionary fitness
2
. However, the effect of the more distant parental relatedness that is common in modern human populations is less well understood. Genomic data now allow us to investigate the effects of homozygosity on traits of public health importance by observing contiguous homozygous segments (runs of homozygosity), which are inferred to be homozygous along their complete length. Given the low levels of genome-wide homozygosity prevalent in most human populations, information is required on very large numbers of people to provide sufficient power
3
,
4
. Here we use runs of homozygosity to study 16 health-related quantitative traits in 354,224 individuals from 102 cohorts, and find statistically significant associations between summed runs of homozygosity and four complex traits: height, forced expiratory lung volume in one second, general cognitive ability and educational attainment (
P
< 1 × 10
−300
, 2.1 × 10
−6
, 2.5 × 10
−10
and 1.8 × 10
−10
, respectively). In each case, increased homozygosity was associated with decreased trait value, equivalent to the offspring of first cousins being 1.2 cm shorter and having 10 months’ less education. Similar effect sizes were found across four continental groups and populations with different degrees of genome-wide homozygosity, providing evidence that homozygosity, rather than confounding, directly contributes to phenotypic variance. Contrary to earlier reports in substantially smaller samples
5
,
6
, no evidence was seen of an influence of genome-wide homozygosity on blood pressure and low density lipoprotein cholesterol, or ten other cardio-metabolic traits. Since directional dominance is predicted for traits under directional evolutionary selection
7
, this study provides evidence that increased stature and cognitive function have been positively selected in human evolution, whereas many important risk factors for late-onset complex diseases may not have been. |
|---|---|
| AbstractList | Homozygosity has long been associated with rare, often devastating, Mendelian disorders, and Darwin was one of the first to recognize that inbreeding reduces evolutionary fitness. However, the effect of the more distant parental relatedness that is common in modern human populations is less well understood. Genomic data now allow us to investigate the effects of homozygosity on traits of public health importance by observing contiguous homozygous segments (runs of homozygosity), which are inferred to be homozygous along their complete length. Given the low levels of genome-wide homozygosity prevalent in most human populations, information is required on very large numbers of people to provide sufficient power. Here we use runs of homozygosity to study 16 health-related quantitative traits in 354,224 individuals from 102 cohorts, and find statistically significant associations between summed runs of homozygosity and four complex traits: height, forced expiratory lung volume in one second, general cognitive ability and educational attainment (P < 1 × 10(-300), 2.1 × 10(-6), 2.5 × 10(-10) and 1.8 × 10(-10), respectively). In each case, increased homozygosity was associated with decreased trait value, equivalent to the offspring of first cousins being 1.2 cm shorter and having 10 months' less education. Similar effect sizes were found across four continental groups and populations with different degrees of genome-wide homozygosity, providing evidence that homozygosity, rather than confounding, directly contributes to phenotypic variance. Contrary to earlier reports in substantially smaller samples, no evidence was seen of an influence of genome-wide homozygosity on blood pressure and low density lipoprotein cholesterol, or ten other cardio-metabolic traits. Since directional dominance is predicted for traits under directional evolutionary selection, this study provides evidence that increased stature and cognitive function have been positively selected in human evolution, whereas many important risk factors for late-onset complex diseases may not have been. An analysis of 16 health-related quantitative traits in approximately 350,000 individuals reveals statistically significant associations between genome-wide homozygosity and four complex traits (height, lung function, cognitive ability and educational attainment); in each case increased homozygosity associates with a decreased trait value, but no evidence was seen of an influence on blood pressure, cholesterol, or ten other cardio-metabolic traits. Parental relatedness link to height and intelligence This consortium meta-analysis of 102 cohorts and more than 350,000 individuals investigates the effects of homozygosity on traits of public health importance by observing contiguous homozygous segments (runs of homozygosity, ROH), which are inferred to be homozygous along their complete length. Focusing on 16 health-related quantitative traits, the authors find statistically significant associations between summed runs of homozygosity and four complex traits: height, forced expiratory lung volume in a second, general cognitive ability and educational attainment. In each case increased homozygosity associates with decreased trait value. No evidence was seen of an influence of genome-wide homozygosity on blood pressure and low density lipoprotein cholesterol, or ten other cardio-metabolic traits. Homozygosity has long been associated with rare, often devastating, Mendelian disorders 1 , and Darwin was one of the first to recognize that inbreeding reduces evolutionary fitness 2 . However, the effect of the more distant parental relatedness that is common in modern human populations is less well understood. Genomic data now allow us to investigate the effects of homozygosity on traits of public health importance by observing contiguous homozygous segments (runs of homozygosity), which are inferred to be homozygous along their complete length. Given the low levels of genome-wide homozygosity prevalent in most human populations, information is required on very large numbers of people to provide sufficient power 3 , 4 . Here we use runs of homozygosity to study 16 health-related quantitative traits in 354,224 individuals from 102 cohorts, and find statistically significant associations between summed runs of homozygosity and four complex traits: height, forced expiratory lung volume in one second, general cognitive ability and educational attainment ( P < 1 × 10 −300 , 2.1 × 10 −6 , 2.5 × 10 −10 and 1.8 × 10 −10 , respectively). In each case, increased homozygosity was associated with decreased trait value, equivalent to the offspring of first cousins being 1.2 cm shorter and having 10 months’ less education. Similar effect sizes were found across four continental groups and populations with different degrees of genome-wide homozygosity, providing evidence that homozygosity, rather than confounding, directly contributes to phenotypic variance. Contrary to earlier reports in substantially smaller samples 5 , 6 , no evidence was seen of an influence of genome-wide homozygosity on blood pressure and low density lipoprotein cholesterol, or ten other cardio-metabolic traits. Since directional dominance is predicted for traits under directional evolutionary selection 7 , this study provides evidence that increased stature and cognitive function have been positively selected in human evolution, whereas many important risk factors for late-onset complex diseases may not have been. Homozygosity has long been associated with rare, often devastating, Mendelian disorders, and Darwin was one of the first to recognize that inbreeding reduces evolutionary fitness. However, the effect of the more distant parental relatedness that is common in modern human populations is less well understood. Genomic data now allow us to investigate the effects of homozygosity on traits of public health importance by observing contiguous homozygous segments (runs of homozygosity), which are inferred to be homozygous along their complete length. Given the low levels of genome-wide homozygosity prevalent in most human populations, information is required on very large numbers of people to provide sufficient power. Here we use runs of homozygosity to study 16 health-related quantitative traits in 354,224 individuals from 102 cohorts, and find statistically significant associations between summed runs of homozygosity and four complex traits: height, forced expiratory lung volume in one second, general cognitive ability and educational attainment (P < 1 × 10(-300), 2.1 × 10(-6), 2.5 × 10(-10) and 1.8 × 10(-10), respectively). In each case, increased homozygosity was associated with decreased trait value, equivalent to the offspring of first cousins being 1.2 cm shorter and having 10 months' less education. Similar effect sizes were found across four continental groups and populations with different degrees of genome-wide homozygosity, providing evidence that homozygosity, rather than confounding, directly contributes to phenotypic variance. Contrary to earlier reports in substantially smaller samples, no evidence was seen of an influence of genome-wide homozygosity on blood pressure and low density lipoprotein cholesterol, or ten other cardio-metabolic traits. Since directional dominance is predicted for traits under directional evolutionary selection, this study provides evidence that increased stature and cognitive function have been positively selected in human evolution, whereas many important risk factors for late-onset complex diseases may not have been. Homozygosity has long been associated with rare, often devastating, Mendelian disorders, and Darwin was one of the first to recognize that inbreeding reduces evolutionary fitness. However, the effect of the more distant parental relatedness that is common in modern human populations is less well understood. Genomic data now allow us to investigate the effects of homozygosity on traits of public health importance by observing contiguous homozygous segments (runs of homozygosity), which are inferred to be homozygous along their complete length. Given the low levels of genome-wide homozygosity prevalent in most human populations, information is required on very large numbers of people to provide sufficient power. Here we use runs of homozygosity to study 16 health-related quantitative traits in 354,224 individuals from 102 cohorts, and find statistically significant associations between summed runs of homozygosity and four complex traits: height, forced expiratory lung volume in one second, general cognitive ability and educational attainment (P < 1 × 10(-300), 2.1 × 10(-6), 2.5 × 10(-10) and 1.8 × 10(-10), respectively). In each case, increased homozygosity was associated with decreased trait value, equivalent to the offspring of first cousins being 1.2 cm shorter and having 10 months' less education. Similar effect sizes were found across four continental groups and populations with different degrees of genome-wide homozygosity, providing evidence that homozygosity, rather than confounding, directly contributes to phenotypic variance. Contrary to earlier reports in substantially smaller samples, no evidence was seen of an influence of genome-wide homozygosity on blood pressure and low density lipoprotein cholesterol, or ten other cardio-metabolic traits. Since directional dominance is predicted for traits under directional evolutionary selection, this study provides evidence that increased stature and cognitive function have been positively selected in human evolution, whereas many important risk factors for late-onset complex diseases may not have been. Homozygosity has long been associated with rare, often devastating, Mendelian disorders(1), and Darwin was one of the first to recognize that inbreeding reduces evolutionary fitness(2). However, the effect of the more distant parental relatedness that is common in modern human populations is less well understood. Genomic data now allow us to investigate the effects of homozygosity on traits of public health importance by observing contiguous homozygous segments (runs of homozygosity), which are inferred to be homozygous along their complete length. Given the low levels of genome-wide homozygosity prevalent in most human populations, information is required on very large numbers of people to provide sufficient power(3,4). Here we use runs of homozygosity to study 16 health-related quantitative traits in 354,224 individuals from 102 cohorts, and find statistically significant associations between summed runs of homozygosity and four complex traits: height, forced expiratory lung volume in one second, general cognitive ability and educational attainment (P < 1 x 10(-300), 2.1 x 10(-6), 2.5 x 10(-10) and 1.8 x 10(-10), respectively). In each case, increased homozygosity was associated with decreased trait value, equivalent to the offspring of first cousins being 1.2 cm shorter and having 10 months' less education. Similar effect sizes were found across four continental groups and populations with different degrees of genome-wide homozygosity, providing evidence that homozygosity, rather than confounding, directly contributes to phenotypic variance. Contrary to earlier reports in substantially smaller samples(5,6), no evidence was seen of an influence of genome-wide homozygosity on blood pressure and low density lipoprotein cholesterol, or ten other cardio-metabolic traits. Since directional dominance is predicted for traits under directional evolutionary selection(7), this study provides evidence that increased stature and cognitive function have been positively selected in human evolution, whereas many important risk factors for late-onset complex diseases may not have been. Homozygosity has long been associated with rare, often devastating, Mendelian disorders (1), and Darwin was one of the first to recognize that inbreeding reduces evolutionary fitness (2). However, the effect of the more distant parental relatedness that is common in modern human populations is less well understood. Genomic data now allow us to investigate the effects of homozygosity on traits of public health importance by observing contiguous homozygous segments (runs of homozygosity), which are inferred to be homozygous along their complete length. Given the low levels of genome-wide homozygosity prevalent in most human populations, information is required on very large numbers of people to provide sufficient power (3,4). Here we use runs of homozygosity to study 16 health-related quantitative traits in 354,224 individuals from 102 cohorts, and find statistically significant associations between summed runs of homozygosity and four complex traits: height, forced expiratory lung volume in one second, general cognitive ability and educational attainment (P < 1 x [10.sup.-300], 2.1 x [10.sup.-6], 2.5 x [10.sup.-10] and 1.8 x [10.sup.-10], respectively). In each case, increased homozygosity was associated with decreased trait value, equivalent to the offspring of first cousins being 1.2 cm shorter and having 10 months' less education. Similar effect sizes were found across four continental groups and populations with different degrees of genome-wide homozygosity, providing evidence that homozygosity, rather than confounding, directly contributes to phenotypic variance. Contrary to earlier reports in substantially smaller samples (5,6), no evidence was seen of an influence of genome-wide homozygosity on blood pressure and low density lipoprotein cholesterol, or ten other cardio-metabolic traits. Since directional dominance is predicted for traits under directional evolutionary selection (7), this study provides evidence that increased stature and cognitive function have been positively selected in human evolution, whereas many important risk factors for late-onset complex diseases may not have been. Homozygosity has long been associated with rare, often devastating, Mendelian disorders, and Darwin was one of the first to recognize that inbreeding reduces evolutionary fitness. However, the effect of the more distant parental relatedness that is common in modern human populations is less well understood. Genomic data now allow us to investigate the effects of homozygosity on traits of public health importance by observing contiguous homozygous segments (runs of homozygosity), which are inferred to be homozygous along their complete length. Given the low levels of genome-wide homozygosity prevalent in most human populations, information is required on very large numbers of people to provide sufficient power. Here we use runs of homozygosity to study 16 health-related quantitative traits in 354,224 individuals from 102 cohorts, and find statistically significant associations between summed runs of homozygosity and four complex traits: height, forced expiratory lung volume in one second, general cognitive ability and educational attainment (P < 1 × 10^sup -300^, 2.1 × 10^sup -6^,2.5310210 and 1.8 × 10^sup -10^, respectively). In each case, increased homozygosity was associated with decreased trait value, equivalent to the offspring of first cousins being 1.2 cm shorter and having 10 months' less education. Similar effect sizes were found across four continental groups and populations with different degrees of genome-wide homozygosity, providing evidence that homozygosity, rather than confounding, directly contributes to phenotypic variance. Contrary to earlier reports in substantially smaller samples,noevidencewas seen of an influence of genome-wide homozygosity on blood pressure and low density lipoprotein cholesterol, or ten other cardio-metabolic traits. Since directional dominance is predicted for traits under directional evolutionary selection, this study provides evidence that increased stature and cognitive function have been positively selected in human evolution, whereas many important risk factors for late-onset complex diseases may not have been. Homozygosity has long been associated with rare, often devastating, Mendelian disorders1 and Darwin was one of the first to recognise that inbreeding reduces evolutionary fitness2. However, the effect of the more distant parental relatedness common in modern human populations is less well understood. Genomic data now allow us to investigate the effects of homozygosity on traits of public health importance by observing contiguous homozygous segments (runs of homozygosity, ROH), which are inferred to be homozygous along their complete length. Given the low levels of genome-wide homozygosity prevalent in most human populations, information is required on very large numbers of people to provide sufficient power3,4. Here we use ROH to study 16 health-related quantitative traits in 354,224 individuals from 102 cohorts and find statistically significant associations between summed runs of homozygosity (SROH) and four complex traits: height, forced expiratory lung volume in 1 second (FEV1), general cognitive ability (g) and educational attainment (nominal p<1 × 10−300, 2.1 × 10−6, 2.5 × 10−10, 1.8 × 10−10). In each case increased homozygosity was associated with decreased trait value, equivalent to the offspring of first cousins being 1.2 cm shorter and having 10 months less education. Similar effect sizes were found across four continental groups and populations with different degrees of genome-wide homozygosity, providing convincing evidence for the first time that homozygosity, rather than confounding, directly contributes to phenotypic variance. Contrary to earlier reports in substantially smaller samples5,6, no evidence was seen of an influence of genome-wide homozygosity on blood pressure and low density lipoprotein (LDL) cholesterol, or ten other cardio-metabolic traits. Since directional dominance is predicted for traits under directional evolutionary selection7, this study provides evidence that increased stature and cognitive function have been positively selected in human evolution, whereas many important risk factors for late-onset complex diseases may not have been. |
| Audience | Academic |
| Author | O'Connel, Jeffrey R. Fox, Caroline S. Psaty, Bruce M. Morris, Andrew D. Nutile, Teresa Mihailov, Evelin Gandin, Ilaria van Hylckama Vlieg, Astrid Caulfield, Mark J. Allison, Matthew A. Pirastu, Mario Amin, Najaf Kerr, Shona M. Ogunniyi, Adesola Mohlke, Karen L. Shrestha, Smeeta Broeckel, Ulrich Chen, Constance Lindgren, Cecilia M. Jackson, Anne U. Vuoksimaa, Eero Afzal, Uzma Nadukuru, Rajiv van Setten, Jessica Peyser, Patricia A. Hofer, Edith Robino, Antonietta Palmer, Colin N. A. Uitterlinden, Andre G. Chandak, Giriraj R. Esko, Tonu Okada, Yukinori Concas, Maria Pina Huffman, Jennifer E. Kaprio, Jaakko Wang, Zhaoming Knekt, Paul Lind, Penelope A. Martin, Nicholas G. Borecki, Ingrid B. Navarro, Pau Wentworth-Shields, William Stanton, Alice V. Magnusson, Patrik K. E. Ruggiero, Daniela Samani, Nilesh J. Berndt, Sonja I. Zhu, Xiaofeng Matchan, Angela Campbell, Harry Shuldiner, Alan R. Bakker, Stephan J. L. Hysi, Pirro G. Ware, Erin B. Cooper, Richard S. Mei, Hao Hemani, Gibran Tönjes, Anke Jukema, J. Wouter van der Laan, Sander W. Hakonarson, Hako |
| AuthorAffiliation | 86 Copenhagen Prospective Studies on Asthma in Childhood, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark 196 Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospital , The Capital Region, Copenhagen, 2000, Denmark 72 Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, P.O. box 30.001, 9700 RB, Groningen, The Netherlands 210 National Institute for Health and Welfare (THL), P.O.Box 30, Mannerheimintie 166, Helsinki, FI-00271, Finland 25 Immunology, Genetics & Pathology, Uppsala University, Husargatan 3, Box 815, Uppsala, SE-751 08, Sweden 99 University of Groningen, University Medical Center Groningen, Department of Internal Medicine, Hanzeplein 1, Groningen, 9700RB, The Netherlands 32 Department of Medical Genetics, University of Lausanne, Rue du Bugnon 27, Lausanne, 1005, Switzerland 195 Department of Medicine, University of Leipzig, Leipzig, Germany 9 Institute of Genetics and Biophysics “A. |
| AuthorAffiliation_xml | – name: 26 MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, EH4 2XU, Edinburgh, UK – name: 198 Department of Psychiatry, University Medical Center Groningen, University of Groningen, P.O. box 30.001, Groningen, 9700 RB, The Netherlands – name: 92 Department of Epidemiology Research, Statens Serum Institut, Artillerivej 5, Copenhagen, 2300, Denmark – name: 34 Genomic Research on Complex Diseases (GRC) Group, CSIR-Centre for Cellular and Molecular Biology, Habshiguda, Uppal Road, Hyderabad, 500007, India – name: 68 Dipartimento di Scienze della Vita e della Riproduzione, University of Verona, Strada Le Grazie 15, Verona, 37134, Italy – name: 138 Folkhälsan Reasearch Centre, PB 63, Helsinki, FI-00014 University of Helsinki, Finland – name: 156 Pulmonary Center and Department of Medicine, Boston University School of Medicine, 72 E Concord St, Boston, 02118, MA, USA – name: 179 Centre for Vascular Prevention, Danube-University Krems, 3500 Krems, Austria – name: 197 Department of Epidemiology, University of Alabama at Birmingham, 1665 University Blvd, Birmingham, 35294, AL, USA – name: 217 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, Stockholm, SE-171 77, Sweden – name: 48 Institute for Medical Informatics, Statistics and Documentation, Medical University Graz, Auenbruggerplatz2, Graz, A-8036, Austria – name: 131 Department of Clinical Physiology, University of Tampere and Tampere University Hospital, P.O. Box 2000, Tampere, 33521, Finland – name: 165 Department Public Health Sciences, University of Virginia School of Medicine, 3232 West Complex, Charlottesville, 22908, USA – name: 141 Transplantation laboratory, Haartman Institute, University of Helsinki, P.O. Box 21, Helsinki, FI-00014, Finland – name: 2 Estonian Genome Center, University of Tartu, Riia 23b, 51010, Tartu, Estonia – name: 214 Research Center of Applied and Preventive Cardiovascular medicine, University of Turku, Turku, 20521, Finland – name: 157 Department of Medicine, University of Ibadan, Ibadan, Nigeria – name: 153 Molecular Epidemiology, QIMR Berghofer Medical Research Institute, 300 Herston Rd, Herston, Brisbane, 4006, Australia – name: 87 The Danish Pediatric Asthma Center, Gentofte Hospital, The Capital Region, Copenhagen, Denmark – name: 213 Department of Clinical Physiology and Nuclear Medicine, University of Turku and Turku University Hospital, Turku, 20521, Finland – name: 21 Department of Epidemiology, University of Michigan, 1415 Washington Heights, 48109, Ann Arbor, MI, USA – name: 114 Cardiology, Geneva University Hospitals, Rue Gabrielle-Perret-Gentil, 4, Genève 14, 1211, Switzerland – name: 8 Department of Medical Sciences, University of Trieste, Strada di Fiume 447 - Osp. di Cattinara, Trieste, 34149, Italy – name: 17 Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyoku, Tokyo, 113-8510, Japan – name: 10 Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, 48109, MI, USA – name: 225 Geriatric Research and Education Clinical Center, Veterans Administration Medical Center, 685 W Baltimore MSTF, Baltimore, 21201, USA – name: 136 Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, 70210, Finland – name: 200 Dipartimento di Scienze Mediche, Catholic University of the Sacred Heart, Via G. Moscati 31/34, Roma, 00168, Italy – name: 71 Department of Biostatistics, University of Alabama at Birmingham, 1665 University Blvd, Birmingham, 35294, AL, USA – name: 77 Center for Lifespan Psychology, Max Planck Institute for Human Development, Lentzeallee 94, Berlin, 14195, Germany – name: 63 MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK – name: 6 Unit of Public Health Genomics, National Institute for Health and Welfare, P.O. Box 104, Helsinki, FI-00251, Finland – name: 115 Robertson Centre, University of Glasgow, Boyd Orr Building, Glasgow, G12 8QQ, Scotland – name: 137 Institute of Behavioural Sciences, University of Helsinki, P.O. Box 9, FI-00014 University of Helsinki, Helsinki, Finland – name: 5 Department of Genetics, Harvard Medical School, 25 Shattuck St, Boston, 02115, MA, USA – name: 111 Psychology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK – name: 183 Finnish Lung Health Association, Sibeliuksenkatu 11 A 1, Helsinki, FI-00250, Finland – name: 58 Department of Biological Psychology, VU University Amsterdam, Van der Boechorststraat 1, 1081 BT, Amsterdam, Netherlands – name: 85 Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Royal Devon and Exeter Hospital, Barrack Road, Exeter, EX2 5DW, UK – name: 226 BHF centre, University of Glasgow, 126 University Avenue, Glasgow, G12 8TA, Scotland – name: 187 Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, USA – name: 150 Division of General Internal Medicine, Massachusetts General Hospital , 50 Staniford St, Boston, 02114, MA, USA – name: 57 Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, Neuherberg, 85764, Germany – name: 106 McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, 21205, MD, USA – name: 169 University of Dundee, Kirsty Semple Way, Dundee, DD2 4DB, UK – name: 172 UMR INSERM U1122; IGE-PCV “Interactions Gène-Environnement en Physiopathologie Cardio-Vasculaire”, INSERM, University of Lorraine, 30 Rue Lionnois, Nancy, 54000, France – name: 193 Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, 21589, Saudi Arabia – name: 221 Department of Pharmaceutical Sciences , University of Oklahoma Health Sceienecs Center, Oklahoma City , 73104, USA – name: 45 The GeneSTAR Research Program, Division of General Internal Medicine, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, 21287, Maryland, USA – name: 112 Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK – name: 145 Department of Health, Functional Capacity and Welfare, National Institute for Health and Welfare, P.O. Box 30, Helsinki, FI-00271, Finland – name: 230 Imperial College Healthcare NHS Trust, Imperial College London, Praed Street, London, W2 1NY, UK – name: 78 Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Ihnestr. 72, Berlin, 14195, Germany – name: 207 Cardiovascular Genetics Division, University of Utah, 420 Chipeta Way, Room 1160, Salt Lake City, 84117, Utah, USA – name: 27 Department of Gerontology and Geriatrics, Leiden University Medical Center , PO Box 9600, Leiden, Netherlands – name: 167 Institute of Molecular Biology and Biochemistry, Medical University Graz, Harrachgasse 21, Graz, A-8010, Austria – name: 89 Department of Cardiovascular Sciences, University of Leicester, BHF Cardiovascular Research Centre, Glenfield Hospital, Groby Road, Leicester, LE3 9QP, UK – name: 142 National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, RTP, NC, USA – name: 83 Experimental Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Heidelberglaan 100, Utrecht, 3584 CX, The Netherlands – name: 152 Institute of Human Genetics, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, München, 81675, Germany – name: 222 The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, 10029, USA – name: 60 NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK – name: 158 ICAMS, University of Glasgow, 126 University Way, Glasgow, G12 8TA, UK – name: 3 Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children’s Hospital, Cambridge, 02141, MA, USA – name: 59 Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK – name: 209 Department of Psychiatry, Erasmus Medical Center, PO Box 2040, Rotterdam, 3000 CA, The Netherlands – name: 139 Department of Clinical Chemistry, Fimlab Laboratories and School of Medicine University of Tampere, Tampere, 33520, Finland – name: 50 Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, CMM L8:03, Karolinska University Hospital, Solna, Stockholm, 171 76, Sweden – name: 67 Quantitative Genetics, QIMR Berghofer Medical Research Institute, 300 Herston Rd, Herston, Brisbane, 4006, Australia – name: 94 Department of Human Genetics, University of Chicago, 920 E. 58th Street, Chicago, IL, USA – name: 208 Alzheimer Scotland Research Centre, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK – name: 143 Ophthalmology, Massachusetts Eye and Ear, 243 Charles St, Boston, 02114, USA – name: 119 Division of Biostatistics, Washington University, 660 S Euclid, St Louis, 63110, MO, USA – name: 130 Department of Cardiology C5-P , Leiden University Medical Center, PO Box 9600, Leiden, Netherlands – name: 103 Department of Economics and Center for Economic and Social Research, University of Southern California, 314C Dauterive Hall, 635 Downey Way, Los Angeles, CA, 90089, USA – name: 95 Department of Family and Preventive Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, 92093, USA – name: 211 Department of kinesiology, Laval University, 2300 rue de la Terrasse, Quebec, G1V 0A6, Canada – name: 127 Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden – name: 218 Department of Genetics and Biostatistics, Washington University School of Medicine, 4444 Forest Park Boulevard, Saint Louis, 63108, MO, USA – name: 104 Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, 1200 Pressler St., Suite 453E, Houston, Texas, 77030, USA – name: 196 Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospital , The Capital Region, Copenhagen, 2000, Denmark – name: 55 Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, Neuherberg, 85764, Germany – name: 201 Department of Biostatistics, University of Liverpool, Duncan Building, Daulby Stree, Liverpool, L69 3GA, UK – name: 223 Genome Institute of Singapore, 60 Biopolis Street, #02-01 Genome, Singapore, 138672, Singapore – name: 155 HUCH Heart and Lung center, Helsinki University Central Hospital, P.O. Box 340, Helsinki, FI-00029, Finland – name: 101 Institute for Community Medicine, University Medicine Greifswald, W.-Rathenau-Str. 48, Greifswald, 17475, Germany – name: 166 Department of Psychological & Brain Sciences, Indiana University Bloomington, 1101 E. 10th St., Bloomington, IN 47405, USA – name: 11 The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, 10029, USA – name: 190 Translational Gerontology Branch, National institute on Aging, Baltimore, 21225, Maryland, USA – name: 65 Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, GPO Box 2434, Brisbane Qld 4001, Brisbane, Australia – name: 219 Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, 21205, Maryland, USA – name: 51 Channing Division of Network Medicine, Brigham & Women’s Hospital, 181 Longwood, Boston, 02115, USA – name: 202 Department of General Practice and Primary Health Care, University of Helsinki, P.O. Box 20, University of Helsinki, Helsinki, FI-00014, Finland – name: 18 Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan – name: 117 Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ferdinand-Sauerbruch-Str. NK, 17475, Greifswald, Germany – name: 24 Epidemiology, University of North Carolina, 137 E. Franklin St., Suite 306, 27599-8050, Chapel Hill, USA – name: 40 Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Friedrich-Ludwig-Jahn-Str. 15A, Greifswald, 17475, Germany – name: 206 Neuro-Imaging Genetics, QIMR Berghofer Medical Research Institute, 300 Herston Rd, Herston, Brisbane, 4006 Australia – name: 109 College of Medicine, Dentistry and Nursing, Ninewells Hospital and Medical School, College Office, Level 10, Dundee, DD1 9SY, UK – name: 113 Department of Internal Medicine B, University Medicine Greifswald, Ferdinand-Sauerbruch-Str. NK, Greifswald, 17475, Germany |
| Author_xml | – sequence: 2 givenname: Tonu surname: Esko fullname: Esko, Tonu organization: Estonian Genome Center, University of Tartu, Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Program in Medical and Population Genetics, Broad Institute, Department of Genetics, Harvard Medical School – sequence: 6 givenname: Teresa surname: Nutile fullname: Nutile, Teresa organization: Institute of Genetics and Biophysics “A. Buzzati-Traverso” CNR – sequence: 7 givenname: Anne U. surname: Jackson fullname: Jackson, Anne U. organization: Department of Biostatistics and Center for Statistical Genetics, University of Michigan – sequence: 8 givenname: Claudia surname: Schurmann fullname: Schurmann, Claudia organization: The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, The Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai – sequence: 12 givenname: Alena surname: Stančáková fullname: Stančáková, Alena organization: Department of Medicine, University of Eastern Finland – sequence: 14 givenname: Wei surname: Zhao fullname: Zhao, Wei organization: Department of Epidemiology, University of Michigan – sequence: 18 givenname: Stefan surname: Enroth fullname: Enroth, Stefan organization: Department of Immunology, Genetics, and Pathology, Biomedical Center, SciLifeLab Uppsala, Uppsala University – sequence: 21 givenname: Xiuqing surname: Guo fullname: Guo, Xiuqing organization: Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute, Department of Pediatrics, Harbor-UCLA Medical Center – sequence: 22 givenname: Daniel I. surname: Chasman fullname: Chasman, Daniel I. organization: Division of Preventive Medicine, Brigham and Women's Hospital – sequence: 39 givenname: Cornelius A. surname: Rietveld fullname: Rietveld, Cornelius A. organization: Erasmus School of Economics, Erasmus University Rotterdam – sequence: 42 givenname: Cristian surname: Pattaro fullname: Pattaro, Cristian organization: Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), 39100 Bolzano, Italy (affiliated Institute of the University of Lübeck, D-23562 Lübeck, Germany) – sequence: 47 givenname: Dragana surname: Vuckovic fullname: Vuckovic, Dragana organization: Department of Medical Sciences, University of Trieste – sequence: 49 givenname: Claude surname: Bouchard fullname: Bouchard, Claude organization: Pennington Biomedical Research Center – sequence: 53 givenname: Miles C. surname: Benton fullname: Benton, Miles C. organization: Institute of Health and Biomedical Innovation, Queensland University of Technology – sequence: 58 givenname: Alexander surname: Drong fullname: Drong, Alexander organization: Wellcome Trust Centre for Human Genetics, University of Oxford – sequence: 59 givenname: Loic surname: Yengo fullname: Yengo, Loic organization: CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Lille 2 University – sequence: 60 givenname: Lawrence F. surname: Bielak fullname: Bielak, Lawrence F. organization: Department of Epidemiology, University of Michigan – sequence: 61 givenname: Degui surname: Zhi fullname: Zhi, Degui organization: Department of Biostatistics, University of Alabama at Birmingham – sequence: 64 givenname: Reedik surname: Mägi fullname: Mägi, Reedik organization: Estonian Genome Center, University of Tartu – sequence: 66 givenname: Tugce surname: Karaderi fullname: Karaderi, Tugce organization: Wellcome Trust Centre for Human Genetics, University of Oxford – sequence: 68 givenname: Tian surname: Liu fullname: Liu, Tian organization: Center for Lifespan Psychology, Max Planck Institute for Human Development, Vertebrate Genomics, Max Planck Institute for Molecular Genetics – sequence: 73 givenname: Sander W. surname: van der Laan fullname: van der Laan, Sander W. organization: Division Heart and Lungs, Experimental Cardiology, University Medical Center Utrecht – sequence: 87 givenname: Folkert W. surname: Asselbergs fullname: Asselbergs, Folkert W. organization: Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Institute of Cardiovascular Science, faculty of Population Health Sciences, University College London – sequence: 89 givenname: R. Graham surname: Barr fullname: Barr, R. Graham organization: Department of Medicine, Columbia University – sequence: 90 givenname: Sebastian E. surname: Baumeister fullname: Baumeister, Sebastian E. organization: Institute for Community Medicine, University Medicine Greifswald – sequence: 91 givenname: Daniel J. surname: Benjamin fullname: Benjamin, Daniel J. organization: Department of Economics, Cornell University, Department of Economics and Center for Economic and Social Research, University of Southern California – sequence: 93 givenname: Eric surname: Boerwinkle fullname: Boerwinkle, Eric organization: Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston – sequence: 98 givenname: Stephen J. surname: Chanock fullname: Chanock, Stephen J. organization: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health – sequence: 118 givenname: Irina surname: Gillham-Nasenya fullname: Gillham-Nasenya, Irina organization: Department of Twin Research & Genetic Epidemiology, King's College London – sequence: 119 givenname: Omri surname: Gottesman fullname: Gottesman, Omri organization: The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai – sequence: 121 givenname: Francine surname: Grodstein fullname: Grodstein, Francine organization: Nutrition, Harvard School of Public Health – sequence: 122 givenname: Charles surname: Gu fullname: Gu, Charles organization: Division of Biostatistics, Washington University – sequence: 133 givenname: Jinyan surname: Huang fullname: Huang, Jinyan organization: State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital Affiliated with Shanghai Jiao Tong University School of Medicine – sequence: 137 givenname: Erik surname: Ingelsson fullname: Ingelsson, Erik organization: Wellcome Trust Centre for Human Genetics, University of Oxford, Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University – sequence: 139 givenname: Åsa surname: Johansson fullname: Johansson, Åsa organization: Department of Immunology, Genetics, and Pathology, Biomedical Center, SciLifeLab Uppsala, Uppsala University, Uppsala Clinical Research Center, Uppsala University – sequence: 141 givenname: J. Wouter surname: Jukema fullname: Jukema, J. Wouter organization: Department of Cardiology C5-P, Leiden University Medical Center – sequence: 142 givenname: Mika surname: Kähönen fullname: Kähönen, Mika organization: Department of Clinical Physiology, University of Tampere and Tampere University Hospital – sequence: 147 givenname: Philipp surname: Koellinger fullname: Koellinger, Philipp organization: Erasmus School of Economics, Erasmus University Rotterdam – sequence: 149 givenname: Manraj K. surname: Kooner fullname: Kooner, Manraj K. organization: Department of Cardiology, Ealing Hospital NHS Trust – sequence: 152 givenname: Jari surname: Lahti fullname: Lahti, Jari organization: Institute of Behavioural Sciences, University of Helsinki, Folkhälsan Reasearch Centre, PB 63, Helsinki, FI-00014 University of Helsinki – sequence: 164 givenname: Yingchang surname: Lu fullname: Lu, Yingchang organization: The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, The Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai – sequence: 166 givenname: Annamari surname: Lundqvist fullname: Lundqvist, Annamari organization: Department of Health, Functional Capacity and Welfare, National Institute for Health and Welfare – sequence: 167 givenname: Satu surname: Männistö fullname: Männistö, Satu organization: Department of Chronic Disease Prevention, National Institute for Health and Welfare – sequence: 170 givenname: Angela surname: Matchan fullname: Matchan, Angela organization: Human Genetics, Wellcome Trust Sanger Institute, Hinxton – sequence: 171 givenname: Rasika A. surname: Mathias fullname: Mathias, Rasika A. organization: Division of General Internal Medicine, Department of Medicine, The GeneSTAR Research Program, The Johns Hopkins University School of Medicine, Division of Allergy and Clinical Immunology, Department of Medicine, The Johns Hopkins University School of Medicine – sequence: 175 givenname: Thomas surname: Meitinger fullname: Meitinger, Thomas organization: Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Human Genetics, Klinikum rechts der Isar, Technische Universität München – sequence: 182 givenname: Alanna surname: Morrison fullname: Morrison, Alanna organization: Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston – sequence: 184 givenname: Rajiv surname: Nadukuru fullname: Nadukuru, Rajiv organization: The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai – sequence: 186 givenname: Mari surname: Nelis fullname: Nelis, Mari organization: Estonian Genome Center, University of Tartu – sequence: 187 givenname: Markku S. surname: Nieminen fullname: Nieminen, Markku S. organization: HUCH Heart and Lung center, Helsinki University Central Hospital – sequence: 194 givenname: Inga surname: Patarcic fullname: Patarcic, Inga organization: Centre for Global Health and Department of Public Health, School of Medicine, University of Split – sequence: 196 givenname: Patricia A. surname: Peyser fullname: Peyser, Patricia A. organization: Department of Epidemiology, University of Michigan – sequence: 199 givenname: Inga surname: Prokopenko fullname: Prokopenko, Inga organization: Department of Genomics of Common Disease, School of Public Health, Imperial College London – sequence: 205 givenname: Lynda M. surname: Rose fullname: Rose, Lynda M. organization: Division of Preventive Medicine, Brigham and Women's Hospital – sequence: 207 givenname: Cinzia surname: Sala fullname: Sala, Cinzia organization: Division of Genetics and Cell Biology, San Raffaele Scientific Institute – sequence: 210 givenname: Antti-Pekka surname: Sarin fullname: Sarin, Antti-Pekka organization: Unit of Public Health Genomics, National Institute for Health and Welfare, Institute for Molecular Medicine Finland (FIMM), University of Helsinki – sequence: 212 givenname: Helena surname: Schmidt fullname: Schmidt, Helena organization: Institute of Molecular Biology and Biochemistry, Medical University Graz – sequence: 215 givenname: Bengt surname: Sennblad fullname: Sennblad, Bengt organization: Department of Medicine Solna, Atherosclerosis Research Unit, Karolinska Institutet, Science for Life Laboratory, Karolinska Institutet – sequence: 216 givenname: Sudha surname: Seshadri fullname: Seshadri, Sudha organization: National Heart, Lung, and Blood Institute's Framingham Heart Study, Department of Neurology, Boston University School of Medicine – sequence: 219 givenname: Blair H. surname: Smith fullname: Smith, Blair H. organization: University of Dundee – sequence: 220 givenname: Jennifer A. surname: Smith fullname: Smith, Jennifer A. organization: Department of Epidemiology, University of Michigan – sequence: 223 givenname: Lorraine surname: Southam fullname: Southam, Lorraine organization: Wellcome Trust Centre for Human Genetics, University of Oxford, Human Genetics, Wellcome Trust Sanger Institute, Hinxton – sequence: 225 givenname: Maria G. surname: Stathopoulou fullname: Stathopoulou, Maria G. organization: UMR INSERM U1122, IGE-PCV “Interactions Gène-Environnement en Physiopathologie Cardio-Vasculaire”, INSERM, University of Lorraine – sequence: 227 givenname: Rona J. surname: Strawbridge fullname: Strawbridge, Rona J. organization: Department of Medicine Solna, Atherosclerosis Research Unit, Karolinska Institutet – sequence: 231 givenname: Kent D. surname: Taylor fullname: Taylor, Kent D. organization: Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute, Department of Pediatrics, Harbor-UCLA Medical Center – sequence: 236 givenname: Jaakko surname: Tuomilehto fullname: Tuomilehto, Jaakko organization: Diabetes Prevention Unit, National Institute for Health and Welfare, Centre for Vascular Prevention, Danube-University Krems, Diabetes Research Group, King Abdulaziz University – sequence: 238 givenname: Dhananjay surname: Vaidya fullname: Vaidya, Dhananjay organization: Division of General Internal Medicine, Department of Medicine, The GeneSTAR Research Program, The Johns Hopkins University School of Medicine, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health – sequence: 241 givenname: Tuula surname: Vasankari fullname: Vasankari, Tuula organization: Finnish Lung Health Association – sequence: 242 givenname: Sailaja surname: Vedantam fullname: Vedantam, Sailaja organization: Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Program in Medical and Population Genetics, Broad Institute, Department of Genetics, Harvard Medical School – sequence: 245 givenname: Eero surname: Vuoksimaa fullname: Vuoksimaa, Eero organization: Department of Public Health, University of Helsinki, Hjelt Institute – sequence: 249 givenname: John B. surname: Whitfield fullname: Whitfield, John B. organization: Genetic Epidemiology, QIMR Berghofer Medical Research Institute – sequence: 251 givenname: Gonneke surname: Willemsen fullname: Willemsen, Gonneke organization: Department of Biological Psychology, VU University Amsterdam – sequence: 254 givenname: Gianluigi surname: Zaza fullname: Zaza, Gianluigi organization: Department of Medicine, Renal Unit, University of Verona – sequence: 258 givenname: Mads surname: Melbye fullname: Melbye, Mads organization: Department of Epidemiology Research, Statens Serum Institut, Department of Medicine, Stanford University – sequence: 259 givenname: Hans surname: Bisgaard fullname: Bisgaard, Hans organization: COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen – sequence: 263 givenname: Richard S. surname: Cooper fullname: Cooper, Richard S. organization: Department of Public Health Sciences, Stritch School of Medicine, Loyola University Chicago – sequence: 264 givenname: Philippe surname: Froguel fullname: Froguel, Philippe organization: CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Lille 2 University, Department of Genomics of Common Disease, School of Public Health, Imperial College London – sequence: 265 givenname: Gerard surname: Pasterkamp fullname: Pasterkamp, Gerard organization: Division Heart and Lungs, Experimental Cardiology, University Medical Center Utrecht – sequence: 268 givenname: Luigi surname: Ferrucci fullname: Ferrucci, Luigi organization: Translational Gerontology Branch, National institute on Aging – sequence: 269 givenname: Robert A. surname: Scott fullname: Scott, Robert A. organization: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus – sequence: 270 givenname: Andrew D. surname: Morris fullname: Morris, Andrew D. organization: Usher Institute for Population Health Sciences and Informatics, University of Edinburgh – sequence: 273 givenname: Panos surname: Deloukas fullname: Deloukas, Panos organization: William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University – sequence: 277 givenname: Cecilia M. surname: Lindgren fullname: Lindgren, Cecilia M. organization: Program in Medical and Population Genetics, Broad Institute, Wellcome Trust Centre for Human Genetics, University of Oxford – sequence: 278 givenname: Nicholas J. surname: Timpson fullname: Timpson, Nicholas J. organization: MRC Integrative Epidemiology Unit, University of Bristol – sequence: 280 givenname: Patricia B. surname: Munroe fullname: Munroe, Patricia B. organization: Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London – sequence: 287 givenname: Giovanni surname: Gambaro fullname: Gambaro, Giovanni organization: Dipartimento di Scienze Mediche, Catholic University of the Sacred Heart – sequence: 288 givenname: Andrew P. surname: Morris fullname: Morris, Andrew P. organization: Estonian Genome Center, University of Tartu, Wellcome Trust Centre for Human Genetics, University of Oxford, Department of Biostatistics, University of Liverpool – sequence: 289 givenname: Johan G. surname: Eriksson fullname: Eriksson, Johan G. organization: Department of Chronic Disease Prevention, National Institute for Health and Welfare, Department of General Practice and Primary Health Care, University of Helsinki, Vasa Central Hospital, Folkhälsan Reasearch Centre, PB 63, University of Helsinki, Unit of General Practice, Helsinki University Central Hospital – sequence: 291 givenname: Nicholas G. surname: Martin fullname: Martin, Nicholas G. organization: Genetic Epidemiology, QIMR Berghofer Medical Research Institute – sequence: 292 givenname: Steven C. surname: Hunt fullname: Hunt, Steven C. organization: Cardiovascular Genetics Division, University of Utah – sequence: 298 givenname: Jaakko surname: Kaprio fullname: Kaprio, Jaakko organization: Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Department of Public Health, University of Helsinki, Hjelt Institute, National Institute for Health and Welfare (THL) – sequence: 318 givenname: Diane M. surname: Becker fullname: Becker, Diane M. organization: Division of General Internal Medicine, Department of Medicine, The GeneSTAR Research Program, The Johns Hopkins University School of Medicine, Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health – sequence: 319 givenname: Dwaipayan surname: Bharadwaj fullname: Bharadwaj, Dwaipayan organization: Genomics and Molecular Medicine, CSIR-Institute of Genomics & Integrative Biology, School of Biotechnology, Jawaharlal Nehru University – sequence: 321 givenname: Michael surname: Boehnke fullname: Boehnke, Michael organization: Department of Biostatistics and Center for Statistical Genetics, University of Michigan – sequence: 326 givenname: Andres surname: Metspalu fullname: Metspalu, Andres organization: Estonian Genome Center, University of Tartu, Institute of Molecular and Cell Biology, University of Tartu – sequence: 336 givenname: Josée surname: Dupuis fullname: Dupuis, Josée organization: Department of Biostatistics, Boston University School of Public Health, National Heart, Lung, and Blood Institute's Framingham Heart Study – sequence: 340 givenname: Peter surname: Vollenweider fullname: Vollenweider, Peter organization: Department of Internal Medicine, University Hospital – sequence: 343 givenname: Jerome I. surname: Rotter fullname: Rotter, Jerome I. organization: Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute, Department of Pediatrics, Harbor-UCLA Medical Center – sequence: 349 givenname: David R. surname: Weir fullname: Weir, David R. organization: Institute for Social Research, University of Michigan – sequence: 353 givenname: John C. surname: Chambers fullname: Chambers, John C. organization: Department of Epidemiology and Biostatistics, Imperial College London, Department of Cardiology, Ealing Hospital NHS Trust, Imperial College Healthcare NHS Trust, Imperial College London |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26131930$$D View this record in MEDLINE/PubMed https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-258904$$DView record from Swedish Publication Index (Uppsala universitet) https://research.hhs.se/esploro/outputs/journalArticle/Directional-dominance-on-stature-and-cognition/991001480975506056$$DView record from Swedish Publication Index http://kipublications.ki.se/Default.aspx?queryparsed=id:131711856$$DView record from Swedish Publication Index (Karolinska Institutet) |
| BookMark | eNp1k11v0zAUhi00xLbCFfcoYjcgyLATO45vkKqNj0mVkPi6tRznJPVI7S5OBvwbfgu_DGft2ga18kUsn-d9c3zO8Sk6ss4CQk8JPic4zd9Y1fUtEJqR_AE6IZRnMc1yfoROME7yGOdpdoxOvb_GGDPC6SN0nGQkJSLFJ2h2aVrQnXFWNVHpFsYqqyFyNvLdnW-kbBlpV1szQJGxf_-U5hZaD9G8XygbLd2yb9QQ9I_Rw0o1Hp6svxP07f27rxcf49mnD1cX01msuWBdrCuqSkrStEpZgXOKc14SDopkhGBd6KosQoQLYFQIKoqKKV0InIiKJxzCfSYoXvn6n7DsC7lszUK1v6VTRq6PfoQdSEaSlLHAk4P8fO4HkhDGCE1zEYqUYZYFzeuDmkvzfSpdW8u-lwkLGhrwtys8sAsoNdiuVc1INY5YM5e1u5WUhWuHYkzQi7VB62568J1cGK-haZQF13tJMpGL0DY-pHb2H3rt-jY0cE1xkQm-pWrVgDS2cuG_ejCVU5qkmIpEsG0pR1QNFkKSYc4qE45H_PM9vF6aG7kLne-BwiphYfRe15cjQWA6-NXVqvdeXn35PGaf7VZ6U-L7mQ7AqxWgW-d9C9UGIVgOL0buvJjtbGxobbq7cQ45m-aA5n42grOtod1pwB78H9BOJqQ |
| CODEN | NATUAS |
| CitedBy_id | crossref_primary_10_1038_nrg_2017_109 crossref_primary_10_1038_srep30197 crossref_primary_10_1016_j_intell_2016_04_004 crossref_primary_10_1038_s41467_020_19595_y crossref_primary_10_1007_s11892_016_0757_z crossref_primary_10_1016_j_abb_2017_05_001 crossref_primary_10_1126_science_aad9379 crossref_primary_10_1212_WNL_0000000000208075 crossref_primary_10_1016_j_ajhg_2020_05_014 crossref_primary_10_1093_jeb_voaf017 crossref_primary_10_1038_s41467_017_00556_x crossref_primary_10_1093_ije_dyz174 crossref_primary_10_1038_ncomms13311 crossref_primary_10_1038_s41467_019_12283_6 crossref_primary_10_1007_s10519_021_10053_z crossref_primary_10_1016_S0140_6736_21_00534_1 crossref_primary_10_1111_mec_13681 crossref_primary_10_1016_j_rdc_2017_04_009 crossref_primary_10_3390_biology14070833 crossref_primary_10_1111_oik_10674 crossref_primary_10_3389_fgene_2020_629373 crossref_primary_10_1016_j_therap_2016_01_001 crossref_primary_10_1038_s41588_022_01103_1 crossref_primary_10_3389_fpsyg_2023_1009962 crossref_primary_10_1002_jcb_26850 crossref_primary_10_1016_j_ajhg_2018_02_013 crossref_primary_10_3389_fgene_2020_00296 crossref_primary_10_1038_s41598_019_41022_6 crossref_primary_10_1155_2023_1766080 crossref_primary_10_1534_genetics_116_189936 crossref_primary_10_1038_ng_3451 crossref_primary_10_1038_s41598_019_49901_8 crossref_primary_10_3390_cancers12123646 crossref_primary_10_1194_jlr_O072629 crossref_primary_10_1186_s12864_018_4489_0 crossref_primary_10_1016_j_neubiorev_2019_07_016 crossref_primary_10_1038_s41437_024_00736_8 crossref_primary_10_1038_s41467_019_11724_6 crossref_primary_10_1093_molbev_msae094 crossref_primary_10_1007_s12035_015_9662_8 crossref_primary_10_1016_j_neuroimage_2016_01_049 crossref_primary_10_1073_pnas_1621096114 crossref_primary_10_1111_nyas_14859 crossref_primary_10_1038_tp_2016_246 crossref_primary_10_1186_s13073_017_0414_4 crossref_primary_10_1002_ajhb_23210 crossref_primary_10_1155_2020_5478574 crossref_primary_10_3389_fnagi_2016_00217 crossref_primary_10_1093_beheco_arae101 crossref_primary_10_1371_journal_pgen_1010934 crossref_primary_10_1038_mp_2015_120 crossref_primary_10_1186_s12863_016_0402_5 crossref_primary_10_1002_ajpa_24660 crossref_primary_10_3390_ijms24087006 crossref_primary_10_1186_s12982_024_00132_x crossref_primary_10_3390_biomedicines11010138 crossref_primary_10_1007_s10519_022_10113_y crossref_primary_10_1038_s41598_019_53274_3 crossref_primary_10_1002_csc2_21018 crossref_primary_10_1186_s12864_017_4312_3 crossref_primary_10_1007_s00439_019_02045_1 crossref_primary_10_1017_eaa_2017_22 crossref_primary_10_1007_s13410_016_0522_5 crossref_primary_10_1007_s40806_024_00395_2 crossref_primary_10_1016_j_csbj_2020_07_003 crossref_primary_10_1017_S0140525X16000959 crossref_primary_10_1038_s41598_019_57389_5 crossref_primary_10_1371_journal_pone_0196360 crossref_primary_10_1038_s41598_019_47436_6 crossref_primary_10_1016_j_tig_2020_07_006 crossref_primary_10_1038_s10038_025_01331_3 crossref_primary_10_3389_fgene_2019_00888 crossref_primary_10_1038_s41588_018_0215_8 crossref_primary_10_1038_s41437_021_00471_4 crossref_primary_10_1016_j_ajhg_2021_06_005 crossref_primary_10_1017_S0140525X21000893 crossref_primary_10_1038_s41431_025_01799_9 crossref_primary_10_2337_dcS15_3002 crossref_primary_10_1038_s41598_018_27047_3 crossref_primary_10_1186_s12864_022_08351_9 crossref_primary_10_1038_s41431_018_0134_2 crossref_primary_10_1073_pnas_1518046113 crossref_primary_10_1093_hmg_ddab085 crossref_primary_10_7554_eLife_81698 crossref_primary_10_1002_ajhb_24166 crossref_primary_10_1038_s41380_017_0005_1 crossref_primary_10_1038_s41467_021_27394_2 crossref_primary_10_1093_ije_dyw308 crossref_primary_10_1016_j_ajhg_2019_08_011 crossref_primary_10_1038_nn_4404 crossref_primary_10_1016_j_abb_2016_03_019 crossref_primary_10_1371_journal_pone_0226015 crossref_primary_10_1038_srep28496 crossref_primary_10_1016_j_ajhg_2018_03_003 crossref_primary_10_1016_j_gde_2016_08_005 crossref_primary_10_1159_000478897 crossref_primary_10_1007_s10519_021_10047_x crossref_primary_10_1038_s41398_020_01145_1 crossref_primary_10_1038_s42003_022_03291_2 crossref_primary_10_1016_j_evolhumbehav_2024_106596 crossref_primary_10_1016_j_intell_2015_08_008 crossref_primary_10_1371_journal_pgen_1009241 crossref_primary_10_1186_s12864_023_09208_5 crossref_primary_10_1016_j_therap_2015_12_001 crossref_primary_10_3982_ECTA20830 crossref_primary_10_1177_14747049241238623 crossref_primary_10_3389_fgene_2021_808829 crossref_primary_10_1093_hmg_ddaa255 crossref_primary_10_1016_j_ajhg_2018_10_022 crossref_primary_10_1080_15384101_2017_1395533 crossref_primary_10_1016_j_evolhumbehav_2024_106636 crossref_primary_10_3390_life14080929 crossref_primary_10_1371_journal_pone_0182791 |
| Cites_doi | 10.1126/science.1235488 10.1073/pnas.75.8.3906 10.1371/journal.pgen.1002656 10.1038/ng.941 10.1038/nrg2664 10.1038/nature10781 10.1016/S0140-6736(01)41972-6 10.1086/519795 10.1038/ng1726 10.1093/bioinformatics/btm108 10.1371/journal.pgen.1000415 10.32614/RJ-2010-009 10.1038/ng.2385 10.1086/302661 10.1371/journal.pone.0118935 10.1086/279872 10.1093/hmg/ddl473 10.5962/bhl.title.110800 10.1038/nature10423 10.5962/bhl.title.32181 10.1038/nature12818 10.1016/j.intell.2014.02.006 10.1038/ng.3097 10.1371/journal.pgen.1002655 10.1534/genetics.111.130922 10.1007/s10519-014-9644-z 10.1037/0033-2909.101.2.171 10.1371/journal.pgen.1003502 10.1534/genetics.107.075614 10.1159/000362878 10.1038/nature09410 10.1016/S0168-9525(02)00033-1 10.1093/hmg/ddi493 10.1073/pnas.1318945111 10.1038/ng.2797 10.1016/j.ajhg.2008.08.007 10.1371/journal.pone.0013996 10.1038/nature10405 10.1038/nature11632 10.1093/genetics/163.3.1011 |
| ContentType | Journal Article |
| Copyright | Springer Nature Limited 2015 COPYRIGHT 2015 Nature Publishing Group Copyright Nature Publishing Group Jul 23, 2015 |
| Copyright_xml | – notice: Springer Nature Limited 2015 – notice: COPYRIGHT 2015 Nature Publishing Group – notice: Copyright Nature Publishing Group Jul 23, 2015 |
| CorporateAuthor | The BioBank Japan Project |
| CorporateAuthor_xml | – name: The BioBank Japan Project |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7QG 7QL 7QP 7QR 7RV 7SN 7SS 7ST 7T5 7TG 7TK 7TM 7TO 7U9 7X2 7X7 7XB 88A 88E 88G 88I 8AF 8AO 8C1 8FD 8FE 8FG 8FH 8FI 8FJ 8FK 8G5 ABJCF ABUWG AEUYN AFKRA ARAPS ATCPS AZQEC BBNVY BEC BENPR BGLVJ BHPHI BKSAR C1K CCPQU D1I DWQXO FR3 FYUFA GHDGH GNUQQ GUQSH H94 HCIFZ K9. KB. KB0 KL. L6V LK8 M0K M0S M1P M2M M2O M2P M7N M7P M7S MBDVC NAPCQ P5Z P62 P64 PATMY PCBAR PDBOC PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS PSYQQ PTHSS PYCSY Q9U R05 RC3 S0X SOI 7U8 7X8 JXQ 5PM ADTPV AOWAS BTSUP DF2 D8T ZZAVC |
| DOI | 10.1038/nature14618 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Nursing & Allied Health Database Ecology Abstracts Entomology Abstracts (Full archive) Environment Abstracts Immunology Abstracts Meteorological & Geoastrophysical Abstracts Neurosciences Abstracts Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Virology and AIDS Abstracts Agricultural Science Collection Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) Psychology Database (Alumni) Science Database (Alumni Edition) STEM Database ProQuest Pharma Collection Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Research Library (Alumni Edition) ProQuest Materials Science & Engineering Collection ProQuest Central (Alumni) ProQuest One Sustainability (subscription) ProQuest Central UK/Ireland Health Research Premium Collection Agricultural & Environmental Science Collection ProQuest Central Essentials Biological Science Collection eLibrary ProQuest Central Technology collection Natural Science Collection Earth, Atmospheric & Aquatic Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Materials Science Collection ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student Research Library Prep AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Materials Science Database Nursing & Allied Health Database (Alumni Edition) Meteorological & Geoastrophysical Abstracts - Academic ProQuest Engineering Collection ProQuest Biological Science Collection Agricultural Science Database Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) Psychology Database Research Library Science Database (subscription) Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Engineering Database Research Library (Corporate) Nursing & Allied Health Premium Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Environmental Science Database Earth, Atmospheric & Aquatic Science Database Materials Science Collection ProQuest Central Premium ProQuest One Academic ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China ProQuest One Psychology Engineering Collection Environmental Science Collection ProQuest Central Basic University of Michigan Genetics Abstracts SIRS Editorial Environment Abstracts TOXLINE MEDLINE - Academic Toxline PubMed Central (Full Participant titles) SwePub SwePub Articles SwePub Editorial SWEPUB Uppsala universitet SWEPUB Freely available online SwePub Articles full text |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Agricultural Science Database ProQuest One Psychology Research Library Prep ProQuest Central Student Oncogenes and Growth Factors Abstracts ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts elibrary ProQuest AP Science SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Meteorological & Geoastrophysical Abstracts Natural Science Collection Health & Medical Research Collection Biological Science Collection Chemoreception Abstracts ProQuest Central (New) ProQuest Medical Library (Alumni) Engineering Collection Advanced Technologies & Aerospace Collection Engineering Database Virology and AIDS Abstracts ProQuest Science Journals (Alumni Edition) ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Earth, Atmospheric & Aquatic Science Database Agricultural Science Collection ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts Meteorological & Geoastrophysical Abstracts - Academic ProQuest One Academic (New) University of Michigan Technology Collection Technology Research Database ProQuest One Academic Middle East (New) SIRS Editorial Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing Research Library (Alumni Edition) ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Biology Journals (Alumni Edition) ProQuest Central Earth, Atmospheric & Aquatic Science Collection ProQuest Health & Medical Research Collection Genetics Abstracts ProQuest Engineering Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts Materials Science Database ProQuest Research Library ProQuest Materials Science Collection ProQuest Public Health ProQuest Central Basic ProQuest Science Journals ProQuest Nursing & Allied Health Source ProQuest Psychology Journals (Alumni) ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library ProQuest Psychology Journals Animal Behavior Abstracts Materials Science & Engineering Collection Immunology Abstracts Environment Abstracts ProQuest Central (Alumni) TOXLINE MEDLINE - Academic |
| DatabaseTitleList | TOXLINE MEDLINE Agricultural Science Database |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: PATMY name: Environmental Science Database url: http://search.proquest.com/environmentalscience sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Sciences (General) Physics Public Health |
| EISSN | 1476-4687 |
| EndPage | 462 |
| ExternalDocumentID | oai_swepub_ki_se_512355 oai_hhs_se_1155143890006056 oai_DiVA_org_uu_258904 PMC4516141 3758763631 A423049295 26131930 10_1038_nature14618 |
| Genre | Research Support, Non-U.S. Gov't Meta-Analysis Journal Article |
| GrantInformation_xml | – fundername: NICHD NIH HHS grantid: R01 HD056465 – fundername: NIDDK NIH HHS grantid: U01 DK078616 – fundername: Medical Research Council grantid: G0701863 – fundername: NIDCD NIH HHS grantid: R03 DC013373 – fundername: NIDDK NIH HHS grantid: R01 DK072193 – fundername: NIA NIH HHS grantid: U01 AG049505 – fundername: Medical Research Council grantid: MC_UU_12013/1 – fundername: NHGRI NIH HHS grantid: R01 HG002899 – fundername: Chief Scientist Office grantid: CZB/4/710 – fundername: European Research Council grantid: 323195 |
| GroupedDBID | --- --Z -DZ -ET -~X .55 .CO .XZ 00M 07C 0R~ 0WA 123 186 1OL 1VR 29M 2KS 2XV 39C 3V. 4.4 41X 53G 5RE 6TJ 70F 7RV 7X2 7X7 7XC 85S 88A 88E 88I 8AF 8AO 8C1 8CJ 8FE 8FG 8FH 8FI 8FJ 8G5 8R4 8R5 8WZ 97F 97L A6W A7Z A8Z AAEEF AAHBH AAHTB AAIKC AAKAB AAKAS AAMNW AASDW AAYEP AAYZH AAZLF ABAWZ ABDBF ABDQB ABFSI ABIVO ABJCF ABJNI ABLJU ABOCM ABPEJ ABPPZ ABUWG ABWJO ABZEH ACBEA ACBWK ACGFO ACGFS ACGOD ACIWK ACKOT ACMJI ACNCT ACPRK ACUHS ACWUS ADBBV ADFRT ADUKH ADYSU ADZCM AENEX AEUYN AFFNX AFKRA AFLOW AFRAH AFSHS AGAYW AGHSJ AGHTU AGNAY AGSOS AHMBA AHSBF AIDAL AIDUJ ALFFA ALIPV ALMA_UNASSIGNED_HOLDINGS AMTXH APEBS ARAPS ARMCB ARTTT ASPBG ATCPS ATWCN AVWKF AXYYD AZFZN AZQEC B0M BBNVY BCU BDKGC BEC BENPR BGLVJ BHPHI BIN BKEYQ BKKNO BKSAR BLC BPHCQ BVXVI CCPQU CJ0 CS3 D1I D1J D1K DO4 DU5 DWQXO E.- E.L EAD EAP EAS EAZ EBC EBD EBO EBS ECC EE. EJD EMB EMF EMH EMK EMOBN EPL EPS ESE ESN ESX EX3 EXGXG F5P FEDTE FQGFK FSGXE FYUFA GNUQQ GUQSH HCIFZ HG6 HMCUK HVGLF HZ~ I-F IAO ICQ IEA IEP IGS IH2 IHR INH INR IOF IPY ISR ITC K6- KB. KOO L6V L7B LK5 LK8 LSO M0K M0L M1P M2M M2O M2P M7P M7R M7S N9A NAPCQ NEJ NEPJS O9- OBC OES OHH OMK OVD P-O P2P P62 PATMY PCBAR PDBOC PKN PM3 PQQKQ PROAC PSQYO PSYQQ PTHSS PYCSY Q2X R05 RND RNS RNT RNTTT RXW S0X SC5 SHXYY SIXXV SJFOW SJN SNYQT SOJ SV3 TAE TAOOD TBHMF TDRGL TEORI TH9 TN5 TSG TUS TWZ U5U UIG UKHRP UKR UMD UQL VQA VVN WH7 WOW X7M XIH XKW XZL Y6R YAE YCJ YFH YIF YIN YNT YOC YQT YR2 YR5 YXB YZZ Z5M ZCA ZE2 ZKB ~02 ~7V ~88 ~8M ~KM AARCD AAYXX ABFSG ABUFD ACSTC ADXHL AETEA AFANA AFFDN AFFHD ALPWD ATHPR CITATION PHGZM PHGZT PJZUB PPXIY PQGLB ADGHP CGR CUY CVF ECM EIF NPM ACMFV AEIIB PMFND 7QG 7QL 7QP 7QR 7SN 7SS 7ST 7T5 7TG 7TK 7TM 7TO 7U9 7XB 8FD 8FK C1K FR3 H94 K9. KL. M7N MBDVC P64 PKEHL PQEST PQUKI PRINS Q9U RC3 SOI 7U8 7X8 ESTFP JXQ PUEGO 5PM .-4 .GJ .HR 08P 1CY 1VW 354 3EH 3O- 41~ 42X 4R4 663 79B 9M8 AAJYS AAVBQ ABDPE ABEFU ABNNU ACBNA ACBTR ACRPL ACTDY ADNMO ADRHT ADTPV AEZWR AFBBN AFHIU AFHKK AFKWF AGCDD AGGDT AGQPQ AGSTI AHWEU AIXLP AIYXT AJUXI AOWAS BCR BES BKOMP BTSUP DB5 DF2 FA8 FAC J5H L-9 LGEZI LOTEE MVM N4W NADUK NFIDA NXXTH ODYON OHT PEA PV9 QS- R4F RHI SKT TUD UBY UHB USG VOH X7L XOL YJ6 YQI YQJ YV5 YXA YYP YYQ ZCG ZGI ZHY ZY4 ~G0 D8T ZZAVC |
| ID | FETCH-LOGICAL-c795t-cf4ad4133f35b084087d17ea16110cbcfdbf3579e549949bf5acb9029f727e083 |
| IEDL.DBID | M2M |
| ISICitedReferencesCount | 130 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000358378900036&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0028-0836 1476-4687 |
| IngestDate | Tue Nov 25 03:36:30 EST 2025 Tue Nov 04 16:48:06 EST 2025 Tue Nov 04 16:57:00 EST 2025 Tue Nov 04 01:47:12 EST 2025 Thu Oct 02 16:29:43 EDT 2025 Sat Nov 29 14:33:08 EST 2025 Sat Nov 29 13:36:16 EST 2025 Sat Nov 29 11:49:51 EST 2025 Tue Jun 10 15:34:23 EDT 2025 Sun Nov 23 08:50:12 EST 2025 Wed Nov 26 10:28:09 EST 2025 Mon Jul 21 05:58:41 EDT 2025 Sat Nov 29 05:17:53 EST 2025 Tue Nov 18 21:54:05 EST 2025 Fri Feb 21 02:38:05 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 7561 |
| Language | English |
| License | Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms Reprints and permissions information is available at www.nature.com/reprints. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c795t-cf4ad4133f35b084087d17ea16110cbcfdbf3579e549949bf5acb9029f727e083 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Article-2 ObjectType-Feature-1 content type line 23 |
| OpenAccessLink | http://kipublications.ki.se/Default.aspx?queryparsed=id:131711856 |
| PMID | 26131930 |
| PQID | 1698979697 |
| PQPubID | 40569 |
| PageCount | 4 |
| ParticipantIDs | swepub_primary_oai_swepub_ki_se_512355 swepub_primary_oai_hhs_se_1155143890006056 swepub_primary_oai_DiVA_org_uu_258904 pubmedcentral_primary_oai_pubmedcentral_nih_gov_4516141 proquest_miscellaneous_1698961376 proquest_journals_1698979697 gale_infotracmisc_A423049295 gale_infotracgeneralonefile_A423049295 gale_infotraccpiq_423049295 gale_infotracacademiconefile_A423049295 gale_incontextgauss_ISR_A423049295 pubmed_primary_26131930 crossref_primary_10_1038_nature14618 crossref_citationtrail_10_1038_nature14618 springer_journals_10_1038_nature14618 |
| PublicationCentury | 2000 |
| PublicationDate | 2015-07-23 |
| PublicationDateYYYYMMDD | 2015-07-23 |
| PublicationDate_xml | – month: 07 year: 2015 text: 2015-07-23 day: 23 |
| PublicationDecade | 2010 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: England |
| PublicationSubtitle | International weekly journal of science |
| PublicationTitle | Nature (London) |
| PublicationTitleAbbrev | Nature |
| PublicationTitleAlternate | Nature |
| PublicationYear | 2015 |
| Publisher | Nature Publishing Group UK Nature Publishing Group |
| Publisher_xml | – name: Nature Publishing Group UK – name: Nature Publishing Group |
| References | McQuillan (CR3) 2008; 83 Lango Allen (CR34) 2010; 467 Nalls (CR22) 2009; 5 Gibson, Morton, Collins (CR11) 2006; 15 Wright (CR9) 1922; 56 Aulchenko, de Koning, Haley (CR42) 2007; 177 Purcell (CR31) 2007; 81 Kirin (CR12) 2010; 5 Wright, Charlesworth, Rudan, Carothers, Campbell (CR26) 2003; 19 Wright (CR8) 1977 Darwin (CR2) 1868 Campbell (CR6) 2007; 16 Marioni (CR43) 2014; 44 Charlesworth, Willis (CR7) 2009; 10 Najmabadi (CR21) 2011; 478 Rietveld (CR39) 2013; 340 Rudan (CR5) 2003; 163 Keller, Visscher, Goddard (CR13) 2011; 189 Aulchenko, Ripke, Isaacs, van Duijn (CR32) 2007; 23 Soler Artigas (CR38) 2011; 43 Willer (CR37) 2013; 45 Garrod (CR1) 1902; 160 Flynn (CR23) 1987; 101 Hedges, Olkin (CR44) 1985 Broman, Weber (CR10) 1999; 65 Powell (CR28) 2013; 9 Hoffman (CR25) 2014; 111 Stefansson (CR40) 2014; 505 Abdellaoui (CR15) 2015; 10 Scott (CR36) 2012; 44 Ronnegard, Shen, Alam (CR33) 2010; 2 Pemberton, Rosenberg (CR14) 2014; 77 Marioni (CR17) 2014; 44 Ehret (CR35) 2011; 478 Wood (CR18) 2014; 46 CR41 Deary (CR19) 2012; 482 Keller (CR29) 2012; 8 McQuillan (CR4) 2012; 8 Neel (CR16) 1970; 22 Darwin (CR30) 1876 Galton (CR24) 1889 Weiss, Pan, Abney, Ober (CR27) 2006; 38 Morton (CR20) 1978; 75 M Kirin (BFnature14618_CR12) 2010; 5 H Najmabadi (BFnature14618_CR21) 2011; 478 JI Hoffman (BFnature14618_CR25) 2014; 111 L Ronnegard (BFnature14618_CR33) 2010; 2 J Gibson (BFnature14618_CR11) 2006; 15 D Charlesworth (BFnature14618_CR7) 2009; 10 JV Neel (BFnature14618_CR16) 1970; 22 MC Keller (BFnature14618_CR13) 2011; 189 H Campbell (BFnature14618_CR6) 2007; 16 S Purcell (BFnature14618_CR31) 2007; 81 C Darwin (BFnature14618_CR2) 1868 S Wright (BFnature14618_CR8) 1977 A Abdellaoui (BFnature14618_CR15) 2015; 10 YS Aulchenko (BFnature14618_CR42) 2007; 177 RE Marioni (BFnature14618_CR17) 2014; 44 C Darwin (BFnature14618_CR30) 1876 GB Ehret (BFnature14618_CR35) 2011; 478 R McQuillan (BFnature14618_CR4) 2012; 8 RA Scott (BFnature14618_CR36) 2012; 44 CA Rietveld (BFnature14618_CR39) 2013; 340 BFnature14618_CR41 A Garrod (BFnature14618_CR1) 1902; 160 H Stefansson (BFnature14618_CR40) 2014; 505 M Soler Artigas (BFnature14618_CR38) 2011; 43 JR Flynn (BFnature14618_CR23) 1987; 101 MC Keller (BFnature14618_CR29) 2012; 8 H Lango Allen (BFnature14618_CR34) 2010; 467 LA Weiss (BFnature14618_CR27) 2006; 38 AR Wood (BFnature14618_CR18) 2014; 46 F Galton (BFnature14618_CR24) 1889 CJ Willer (BFnature14618_CR37) 2013; 45 KW Broman (BFnature14618_CR10) 1999; 65 TJ Pemberton (BFnature14618_CR14) 2014; 77 NE Morton (BFnature14618_CR20) 1978; 75 IJ Deary (BFnature14618_CR19) 2012; 482 MA Nalls (BFnature14618_CR22) 2009; 5 A Wright (BFnature14618_CR26) 2003; 19 RE Marioni (BFnature14618_CR43) 2014; 44 R McQuillan (BFnature14618_CR3) 2008; 83 LV Hedges (BFnature14618_CR44) 1985 YS Aulchenko (BFnature14618_CR32) 2007; 23 I Rudan (BFnature14618_CR5) 2003; 163 S Wright (BFnature14618_CR9) 1922; 56 JE Powell (BFnature14618_CR28) 2013; 9 |
| References_xml | – volume: 340 start-page: 1467 year: 2013 end-page: 1471 ident: CR39 article-title: GWAS of 126,559 individuals identified genetic variants associated with educational attainment publication-title: Science doi: 10.1126/science.1235488 – year: 1977 ident: CR8 publication-title: Evolution and the Genetics of Populations, Vol. 3: Experimental Results and Evolutionary Deductions – volume: 75 start-page: 3906 year: 1978 end-page: 3908 ident: CR20 article-title: Effect of inbreeding on IQ and mental retardation publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.75.8.3906 – year: 1868 ident: CR2 publication-title: The Variation of Animals and Plants Under Domestication – volume: 8 start-page: e1002656 year: 2012 ident: CR29 article-title: Runs of homozygosity implicate autozygosity as a schizophrenia risk factor publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1002656 – volume: 163 start-page: 1011 year: 2003 end-page: 1021 ident: CR5 article-title: Inbreeding and the genetic complexity of human hypertension publication-title: Genetics – volume: 43 start-page: 1082 year: 2011 end-page: 1090 ident: CR38 article-title: Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function publication-title: Nature Genet. doi: 10.1038/ng.941 – volume: 10 start-page: 783 year: 2009 end-page: 796 ident: CR7 article-title: The genetics of inbreeding depression publication-title: Nature Rev. Genet. doi: 10.1038/nrg2664 – volume: 482 start-page: 212 year: 2012 end-page: 215 ident: CR19 article-title: Genetic contributions to stability and change in intelligence from childhood to old age publication-title: Nature doi: 10.1038/nature10781 – volume: 160 start-page: 1616 year: 1902 end-page: 1620 ident: CR1 article-title: The incidence of alkaptonuria: a study of chemical individuality publication-title: Lancet doi: 10.1016/S0140-6736(01)41972-6 – volume: 81 start-page: 559 year: 2007 end-page: 575 ident: CR31 article-title: PLINK: a tool set for whole-genome association and population-based linkage analyses publication-title: Am. J. Hum. Genet. doi: 10.1086/519795 – volume: 38 start-page: 218 year: 2006 end-page: 222 ident: CR27 article-title: The sex-specific genetic architecture of quantitative traits in humans publication-title: Nature Genet. doi: 10.1038/ng1726 – volume: 23 start-page: 1294 year: 2007 end-page: 1296 ident: CR32 article-title: GenABEL: an R library for genome-wide association analysis publication-title: Bioinformatics doi: 10.1093/bioinformatics/btm108 – volume: 5 start-page: e1000415 year: 2009 ident: CR22 article-title: Measures of autozygosity in decline: globalization, urbanization, and its implications for medical genetics publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1000415 – volume: 2 start-page: 20 year: 2010 end-page: 28 ident: CR33 article-title: hglm: a package for fitting hierarchical generalized linear models publication-title: R Journal doi: 10.32614/RJ-2010-009 – volume: 22 start-page: 263 year: 1970 end-page: 286 ident: CR16 article-title: The effects of parental consanguinity and inbreeding in Hirado, Japan. II. Physical development, tapping rate, blood pressure, intelligence quotient, and school performance publication-title: Am. J. Hum. Genet. – volume: 44 start-page: 991 year: 2012 end-page: 1005 ident: CR36 article-title: Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways publication-title: Nature Genet. doi: 10.1038/ng.2385 – year: 1985 ident: CR44 publication-title: Statistical Methods for Meta-Analysis – volume: 65 start-page: 1493 year: 1999 end-page: 1500 ident: CR10 article-title: Long homozygous chromosomal segments in reference families from the Centre d’Étude du Polymorphisme Humain publication-title: Am. J. Hum. Genet. doi: 10.1086/302661 – volume: 10 start-page: e0118935 year: 2015 ident: CR15 article-title: Educational attainment influences levels of homozygosity through migration and assortative mating publication-title: PLoS ONE doi: 10.1371/journal.pone.0118935 – volume: 56 start-page: 330 year: 1922 end-page: 339 ident: CR9 article-title: Coefficients of inbreeding and relationships publication-title: Am. Nat. doi: 10.1086/279872 – volume: 16 start-page: 233 year: 2007 end-page: 241 ident: CR6 article-title: Effects of genome-wide heterozygosity on a range of biomedically relevant human quantitative traits publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddl473 – year: 1876 ident: CR30 publication-title: The Effects of Crossing and Self Fertilization in the Vegetable Kingdom doi: 10.5962/bhl.title.110800 – volume: 478 start-page: 57 year: 2011 end-page: 63 ident: CR21 article-title: Deep sequencing reveals 50 novel genes for recessive cognitive disorders publication-title: Nature doi: 10.1038/nature10423 – year: 1889 ident: CR24 publication-title: Natural inheritance doi: 10.5962/bhl.title.32181 – volume: 505 start-page: 361 year: 2014 end-page: 366 ident: CR40 article-title: CNVs conferring risk of autism or schizophrenia affect cognition in controls publication-title: Nature doi: 10.1038/nature12818 – volume: 44 start-page: 26 year: 2014 end-page: 32 ident: CR43 article-title: Molecular genetic contributions to socioeconomic status and intelligence publication-title: Intelligence doi: 10.1016/j.intell.2014.02.006 – volume: 46 start-page: 1173 year: 2014 end-page: 1186 ident: CR18 article-title: Defining the role of common variation in the genomic and biological architecture of adult human height publication-title: Nature Genet. doi: 10.1038/ng.3097 – volume: 8 start-page: e1002655 year: 2012 ident: CR4 article-title: Evidence of inbreeding depression on human height publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1002655 – volume: 189 start-page: 237 year: 2011 end-page: 249 ident: CR13 article-title: Quantification of inbreeding due to distant ancestors and its detection using dense single nucleotide polymorphism data publication-title: Genetics doi: 10.1534/genetics.111.130922 – volume: 44 start-page: 91 year: 2014 end-page: 96 ident: CR17 article-title: Common genetic variants explain the majority of the correlation between height and intelligence: the generation Scotland study publication-title: Behav. Genet. doi: 10.1007/s10519-014-9644-z – volume: 101 start-page: 171 year: 1987 end-page: 191 ident: CR23 article-title: Massive IQ gains in 14 nations: what IQ tests really measure publication-title: Psychol. Bull. doi: 10.1037/0033-2909.101.2.171 – volume: 9 start-page: e1003502 year: 2013 ident: CR28 article-title: Congruence of additive and non-additive effects on gene expression estimated from pedigree and SNP data publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1003502 – volume: 177 start-page: 577 year: 2007 end-page: 585 ident: CR42 article-title: Genomewide rapid association using mixed model and regression: a fast and simple method for genome-wide pedigree-based quantitative trait loci association analysis publication-title: Genetics doi: 10.1534/genetics.107.075614 – volume: 77 start-page: 37 year: 2014 end-page: 48 ident: CR14 article-title: Population-genetic influences on genomic estimates of the inbreeding coefficient: a global perspective publication-title: Hum. Hered. doi: 10.1159/000362878 – volume: 467 start-page: 832 year: 2010 end-page: 838 ident: CR34 article-title: Hundreds of variants clustered in genomic loci and biological pathways affect human height publication-title: Nature doi: 10.1038/nature09410 – volume: 19 start-page: 97 year: 2003 end-page: 106 ident: CR26 article-title: A polygenic basis for late-onset disease publication-title: Trends Genet. doi: 10.1016/S0168-9525(02)00033-1 – volume: 15 start-page: 789 year: 2006 end-page: 795 ident: CR11 article-title: Extended tracts of homozygosity in outbred human populations publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddi493 – ident: CR41 – volume: 111 start-page: 3775 year: 2014 end-page: 3780 ident: CR25 article-title: High-throughput sequencing reveals inbreeding depression in a natural population publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1318945111 – volume: 45 start-page: 1274 year: 2013 end-page: 1283 ident: CR37 article-title: Discovery and refinement of loci associated with lipid levels publication-title: Nature Genet. doi: 10.1038/ng.2797 – volume: 83 start-page: 359 year: 2008 end-page: 372 ident: CR3 article-title: Runs of homozygosity in European populations publication-title: Am. J. Hum. Genet. doi: 10.1016/j.ajhg.2008.08.007 – volume: 5 start-page: e13996 year: 2010 ident: CR12 article-title: Genomic runs of homozygosity record population history and consanguinity publication-title: PLoS ONE doi: 10.1371/journal.pone.0013996 – volume: 478 start-page: 103 year: 2011 end-page: 109 ident: CR35 article-title: Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk publication-title: Nature doi: 10.1038/nature10405 – volume: 189 start-page: 237 year: 2011 ident: BFnature14618_CR13 publication-title: Genetics doi: 10.1534/genetics.111.130922 – volume: 22 start-page: 263 year: 1970 ident: BFnature14618_CR16 publication-title: Am. J. Hum. Genet. – volume: 23 start-page: 1294 year: 2007 ident: BFnature14618_CR32 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btm108 – volume: 65 start-page: 1493 year: 1999 ident: BFnature14618_CR10 publication-title: Am. J. Hum. Genet. doi: 10.1086/302661 – volume: 5 start-page: e13996 year: 2010 ident: BFnature14618_CR12 publication-title: PLoS ONE doi: 10.1371/journal.pone.0013996 – volume-title: Evolution and the Genetics of Populations, Vol. 3: Experimental Results and Evolutionary Deductions year: 1977 ident: BFnature14618_CR8 – volume: 5 start-page: e1000415 year: 2009 ident: BFnature14618_CR22 publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1000415 – volume-title: Statistical Methods for Meta-Analysis year: 1985 ident: BFnature14618_CR44 – volume: 44 start-page: 26 year: 2014 ident: BFnature14618_CR43 publication-title: Intelligence doi: 10.1016/j.intell.2014.02.006 – volume: 8 start-page: e1002656 year: 2012 ident: BFnature14618_CR29 publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1002656 – volume: 75 start-page: 3906 year: 1978 ident: BFnature14618_CR20 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.75.8.3906 – volume: 10 start-page: 783 year: 2009 ident: BFnature14618_CR7 publication-title: Nature Rev. Genet. doi: 10.1038/nrg2664 – volume: 467 start-page: 832 year: 2010 ident: BFnature14618_CR34 publication-title: Nature doi: 10.1038/nature09410 – volume: 478 start-page: 103 year: 2011 ident: BFnature14618_CR35 publication-title: Nature doi: 10.1038/nature10405 – volume: 81 start-page: 559 year: 2007 ident: BFnature14618_CR31 publication-title: Am. J. Hum. Genet. doi: 10.1086/519795 – volume: 15 start-page: 789 year: 2006 ident: BFnature14618_CR11 publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddi493 – volume: 505 start-page: 361 year: 2014 ident: BFnature14618_CR40 publication-title: Nature doi: 10.1038/nature12818 – volume: 83 start-page: 359 year: 2008 ident: BFnature14618_CR3 publication-title: Am. J. Hum. Genet. doi: 10.1016/j.ajhg.2008.08.007 – volume: 10 start-page: e0118935 year: 2015 ident: BFnature14618_CR15 publication-title: PLoS ONE doi: 10.1371/journal.pone.0118935 – volume: 43 start-page: 1082 year: 2011 ident: BFnature14618_CR38 publication-title: Nature Genet. doi: 10.1038/ng.941 – volume: 45 start-page: 1274 year: 2013 ident: BFnature14618_CR37 publication-title: Nature Genet. doi: 10.1038/ng.2797 – volume: 19 start-page: 97 year: 2003 ident: BFnature14618_CR26 publication-title: Trends Genet. doi: 10.1016/S0168-9525(02)00033-1 – volume-title: The Variation of Animals and Plants Under Domestication year: 1868 ident: BFnature14618_CR2 – volume: 2 start-page: 20 year: 2010 ident: BFnature14618_CR33 publication-title: R Journal doi: 10.32614/RJ-2010-009 – volume-title: Natural inheritance year: 1889 ident: BFnature14618_CR24 doi: 10.5962/bhl.title.32181 – volume: 38 start-page: 218 year: 2006 ident: BFnature14618_CR27 publication-title: Nature Genet. doi: 10.1038/ng1726 – volume: 482 start-page: 212 year: 2012 ident: BFnature14618_CR19 publication-title: Nature doi: 10.1038/nature10781 – volume: 16 start-page: 233 year: 2007 ident: BFnature14618_CR6 publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddl473 – volume: 8 start-page: e1002655 year: 2012 ident: BFnature14618_CR4 publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1002655 – volume: 101 start-page: 171 year: 1987 ident: BFnature14618_CR23 publication-title: Psychol. Bull. doi: 10.1037/0033-2909.101.2.171 – volume: 56 start-page: 330 year: 1922 ident: BFnature14618_CR9 publication-title: Am. Nat. doi: 10.1086/279872 – volume: 46 start-page: 1173 year: 2014 ident: BFnature14618_CR18 publication-title: Nature Genet. doi: 10.1038/ng.3097 – volume: 111 start-page: 3775 year: 2014 ident: BFnature14618_CR25 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1318945111 – volume: 478 start-page: 57 year: 2011 ident: BFnature14618_CR21 publication-title: Nature doi: 10.1038/nature10423 – volume: 44 start-page: 991 year: 2012 ident: BFnature14618_CR36 publication-title: Nature Genet. doi: 10.1038/ng.2385 – volume: 340 start-page: 1467 year: 2013 ident: BFnature14618_CR39 publication-title: Science doi: 10.1126/science.1235488 – ident: BFnature14618_CR41 doi: 10.1038/nature11632 – volume: 77 start-page: 37 year: 2014 ident: BFnature14618_CR14 publication-title: Hum. Hered. doi: 10.1159/000362878 – volume: 163 start-page: 1011 year: 2003 ident: BFnature14618_CR5 publication-title: Genetics doi: 10.1093/genetics/163.3.1011 – volume: 9 start-page: e1003502 year: 2013 ident: BFnature14618_CR28 publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1003502 – volume-title: The Effects of Crossing and Self Fertilization in the Vegetable Kingdom year: 1876 ident: BFnature14618_CR30 doi: 10.5962/bhl.title.110800 – volume: 160 start-page: 1616 year: 1902 ident: BFnature14618_CR1 publication-title: Lancet doi: 10.1016/S0140-6736(01)41972-6 – volume: 177 start-page: 577 year: 2007 ident: BFnature14618_CR42 publication-title: Genetics doi: 10.1534/genetics.107.075614 – volume: 44 start-page: 91 year: 2014 ident: BFnature14618_CR17 publication-title: Behav. Genet. doi: 10.1007/s10519-014-9644-z |
| SSID | ssj0005174 |
| Score | 2.5388122 |
| SecondaryResourceType | review_article |
| Snippet | An analysis of 16 health-related quantitative traits in approximately 350,000 individuals reveals statistically significant associations between genome-wide... Homozygosity has long been associated with rare, often devastating, Mendelian disorders, and Darwin was one of the first to recognize that inbreeding reduces... Homozygosity has long been associated with rare, often devastating, Mendelian disorders (1), and Darwin was one of the first to recognize that inbreeding... Homozygosity has long been associated with rare, often devastating, Mendelian disorders1 and Darwin was one of the first to recognise that inbreeding reduces... Homozygosity has long been associated with rare, often devastating, Mendelian disorders(1), and Darwin was one of the first to recognize that inbreeding... |
| SourceID | swepub pubmedcentral proquest gale pubmed crossref springer |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 459 |
| SubjectTerms | 45 45/43 631/181/2474 631/208/729/743 631/208/730 Biological Evolution Blood pressure Blood Pressure - genetics Body Height - genetics Cholesterol, LDL - genetics Cognition Cognition & reasoning Cognitive ability Cohort Studies Disease Educational attainment Educational Status Female Forced Expiratory Volume - genetics Genetic research Genome, Human - genetics Genomes Genomics Homozygosity Homozygote Human populations Humanities and Social Sciences Humans Inbreeding letter Lung Volume Measurements Male multidisciplinary Offspring Phenotype Public health Risk factors Science Studies |
| Title | Directional dominance on stature and cognition in diverse human populations |
| URI | https://link.springer.com/article/10.1038/nature14618 https://www.ncbi.nlm.nih.gov/pubmed/26131930 https://www.proquest.com/docview/1698979697 https://www.proquest.com/docview/1698961376 https://pubmed.ncbi.nlm.nih.gov/PMC4516141 https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-258904 https://research.hhs.se/esploro/outputs/journalArticle/Directional-dominance-on-stature-and-cognition/991001480975506056 http://kipublications.ki.se/Default.aspx?queryparsed=id:131711856 |
| Volume | 523 |
| WOSCitedRecordID | wos000358378900036&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAQT databaseName: Nature Journals Online customDbUrl: eissn: 1476-4687 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: RNT dateStart: 19970101 isFulltext: true titleUrlDefault: https://www.nature.com providerName: Nature Publishing – providerCode: PRVPQU databaseName: Advanced Technologies & Aerospace Database customDbUrl: eissn: 1476-4687 dateEnd: 20241213 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: P5Z dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/hightechjournals providerName: ProQuest – providerCode: PRVPQU databaseName: Agricultural Science Database customDbUrl: eissn: 1476-4687 dateEnd: 20241213 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: M0K dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/agriculturejournals providerName: ProQuest – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1476-4687 dateEnd: 20241213 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: M7P dateStart: 19880107 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Earth, Atmospheric & Aquatic Science Database customDbUrl: eissn: 1476-4687 dateEnd: 20241213 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: PCBAR dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/eaasdb providerName: ProQuest – providerCode: PRVPQU databaseName: Engineering Database customDbUrl: eissn: 1476-4687 dateEnd: 20241213 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: M7S dateStart: 19880107 isFulltext: true titleUrlDefault: http://search.proquest.com providerName: ProQuest – providerCode: PRVPQU databaseName: Environmental Science Database customDbUrl: eissn: 1476-4687 dateEnd: 20241213 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: PATMY dateStart: 19880107 isFulltext: true titleUrlDefault: http://search.proquest.com/environmentalscience providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1476-4687 dateEnd: 20241213 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: 7X7 dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Materials Science Database customDbUrl: eissn: 1476-4687 dateEnd: 20241213 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: KB. dateStart: 19880107 isFulltext: true titleUrlDefault: http://search.proquest.com/materialsscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Nursing & Allied Health Database customDbUrl: eissn: 1476-4687 dateEnd: 20241213 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: 7RV dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/nahs providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1476-4687 dateEnd: 20241213 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: BENPR dateStart: 19880107 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Psychology Database customDbUrl: eissn: 1476-4687 dateEnd: 20241213 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: M2M dateStart: 19880107 isFulltext: true titleUrlDefault: https://www.proquest.com/psychology providerName: ProQuest – providerCode: PRVPQU databaseName: Public Health Database customDbUrl: eissn: 1476-4687 dateEnd: 20241213 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: 8C1 dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest – providerCode: PRVPQU databaseName: Research Library customDbUrl: eissn: 1476-4687 dateEnd: 20241213 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: M2O dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/pqrl providerName: ProQuest – providerCode: PRVPQU databaseName: Science Database (subscription) customDbUrl: eissn: 1476-4687 dateEnd: 20241213 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: M2P dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/sciencejournals providerName: ProQuest |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3db9MwELfYBhISAla-wkYV0DY-pLB8ubafUDc2gaqWqoOp4sVKHKeNQEnXtPz9nB03a6qKF15Oau6SJj77fGeff4fQUZJEvi8T6aS0kzph6MdOLEgCoQohsRtKBT2pi02QwYCOx2xoFtxKk1a5sonaUCeFUGvkp56qdEhYh5FPsxtHVY1Su6umhMYO2gNHmaqB2ff7tykeGyjM5nyeG9DTCjZTFbWmjRlp0y6vTUybSZP1zukGyqiemS4f_e83PUYPjU9qd6tOtI_uyLyF7uncUFG20INqac-uTiy10L6xB6X9zoBWv3-CesZ2KsfeTgqdYCOkXeS2OrIEjWBHeWKbZCW4muV2olNCpK3LBNqzupJY-RT9uLz4fv7FMYUaHEEYXjgiDaMEZsMgDXDsQshISeIRGYE36bkiFmkSA4cwqYLRkMUpjkTMXJ-l4D1J0MwztJsXuXyB7AjcPQzzNvESGUKwwyShKcMsTQMW4pha6MNKWVwYFHNVTOM317vpAeVrmrXQUS08q8A7tou9UVrnCg4jV_k2k2hZlvzr1Yh3Q70P6TNsobdGKC3gD0Vkji_AaysErYbkQUNSzLIbvsY9aXAnlaK2PeawIQjDXjTZqz7Fjdkp-W2HstDrmq3uVKl0uSyWRgacONKx0POqS9eNA-E0mOTAtRBpdPZaQIGRNzl5NtWg5Krgsxd6FjpeDYu119rW5sfVmGk8-nN23eXFfMKXS-5jytwQ9L1FbjoteSkhetX-PmUaVgjDB51sETaXfmXqFqzOhuOX_268A3Qf_GKslvD94BDtLuZL-QrdFX8WWTlvox0yulZ0TDSlQOm510Z7ZxeD4Qh-9c4-Au27vba2R5p-03SoKKnoFdAh_vkX8AiSrg |
| linkProvider | ProQuest |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V3db9MwED-NAQIJAStfYQMMWseHFC2fdfyAUMWYVnUUBAPtzSSO00agpGtaEP8UfyNnx-2aquJtD7zmLk5in-8jvvsdwG6axp4nU2lnUSezg8BL7ETQFEMVShMnkAp6UjeboINBdHrKPm7An3ktjEqrnOtErajTUqh_5Puu6nRIWYfRN-MzW3WNUqer8xYatVj05e9fGLJVr3sHuL5tzzt8d_L2yDZdBWxBWTi1RRbEKapuP_PDxMH4JqKpS2WMro_riERkaYIUyqSKnAKWZGEsEuZ4LENTL9FjwXEvweVARUIqVdD7cJ5SsoL6bOoBHT_ar2E6VRPtqGEBV-3AkiFcTdJcnNSuoJpqS3h463-bw9tw0_jcpFtvki3YkEULrurcV1G14Eb965LUFVkt2DL6riIvDCj3yzvQN7ZBBS4kLXUCkZCkLIgqycJJJ3GREpOMhVfzgqQ65UUS3QaRjBed0qq78OVCPvcebBZlIR8AidGdDdEvoW4qAwzmmKRRxkKWZT4LwiSy4NVcOLgwKO2qWcgPrrMF_IgvSZIFuwvmcQ1Osp7tmZIyruA-CpVPNIxnVcV7nz_xbqDPWT0WWvDcMGUlPlDEpjwDX1shhDU4txucYpyf8SXqXoM6rBdq3TA7DUZUa6JJnsswN2q14ucCbMHTBVndqVIFC1nODA86qbRjwf16Cy0mx8PrGLE4FtDG5lowKLD1JqXIRxp0XTW0dgPXgvZ8Gy691ro5b9d7tDH0Qf61y8vJkM9m3Asj5gS43mv4RqOKVxKjcx3PREzDJoX4QXtrmM2l77m6JVS17-HDf0_eE7h2dPL-mB_3Bv1tuI4xQKiOKzx_Bzank5l8BFfEz2leTR5r_Ubg20Urg790ZOOx |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V3db9MwED-N8SEkBGx8hQ0waB0fUtQ0jev4AaGKUlEVVRUDNPFiEsdpK1DSNS2If42_jrPjdk1V8bYHXnMXJ7HP9xHf_Q7gKEki31eJctOwlbpB4MduLFmCoQpjsRcoDT1pmk2wwSA8PeXDHfizrIXRaZVLnWgUdZJL_Y-83tCdDhlvcVZPbVrEsNN9Mz1zdQcpfdK6bKdRikhf_f6F4VvxutfBta75fvfdp7fvXdthwJWM07kr0yBKUI030yaNPYx1QpY0mIrQDWp4MpZpEiOFcaWjqIDHKY1kzD2fp2j2FXovOO4luMwwxtTphEP69Ty9ZAMB2tYGes2wXkJ26obaYcUabtqENaO4mbC5OrXdQDg1VrF763-ez9tw0_ripF1unj3YUdk-XDU5sbLYhxvlL01SVmrtw57VgwV5YcG6X96BvrUZOqAhSW4Si6QieUZ0qRYuAImyhNgkLbw6yUhiUmEUMe0RyXTVQa24C58v5HPvwW6WZ-oBkAjdXIr-CmskKsAgjysWppzyNG3ygMahA6-WgiKkRW_XTUR-CJNF0AzFmlQ5cLRinpagJdvZnmmJExoGJNMCMIoWRSF6Jx9FOzDnrz6nDjy3TGmOD5SRLdvA19bIYRXOgwqnnE7OxBr1uEIdlQu1bZjDCiOqO1klL-VZWHVbiHNhduDpiqzv1CmEmcoXlgedV9Zy4H65nVaT4-N1jGQ8B1hlo60YNAh7lZJNxgaMXTe6bgQNB2rLLbn2WtvmvFbu18rQncmXtshnI7FYCJ-G3AtwvbfwjceFKBRG7SbOCbmBU6L4QcdbmO2l7xN9C9U18fThvyfvCVxDHSA-9Ab9A7iOoQHVpxh-8xB257OFegRX5M_5pJg9NqqOwLeL1gV_Ac4y7KA |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Directional+dominance+on+stature+and+cognition+in%C2%A0diverse+human+populations&rft.jtitle=Nature+%28London%29&rft.au=Joshi%2C+Peter+K.&rft.au=Esko%2C+Tonu&rft.au=Mattsson%2C+Hannele&rft.au=Eklund%2C+Niina&rft.date=2015-07-23&rft.issn=0028-0836&rft.eissn=1476-4687&rft.volume=523&rft.issue=7561&rft.spage=459&rft.epage=462&rft_id=info:doi/10.1038%2Fnature14618&rft.externalDBID=n%2Fa&rft.externalDocID=10_1038_nature14618 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0028-0836&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0028-0836&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0028-0836&client=summon |