Digital Health: Tracking Physiomes and Activity Using Wearable Biosensors Reveals Useful Health-Related Information

A new wave of portable biosensors allows frequent measurement of health-related physiology. We investigated the use of these devices to monitor human physiological changes during various activities and their role in managing health and diagnosing and analyzing disease. By recording over 250,000 dail...

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Vydáno v:	PLoS biology Ročník 15; číslo 1; s. e2001402
Hlavní autoři:	Li, Xiao, Dunn, Jessilyn, Salins, Denis, Zhou, Gao, Zhou, Wenyu, Schüssler-Fiorenza Rose, Sophia Miryam, Perelman, Dalia, Colbert, Elizabeth, Runge, Ryan, Rego, Shannon, Sonecha, Ria, Datta, Somalee, McLaughlin, Tracey, Snyder, Michael P.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Public Library of Science 12.01.2017 Public Library of Science (PLoS)
Témata:	Bands Biology and Life Sciences Biosensing Techniques Biosensors Borrelia Circadian Rhythm - physiology Disease detection Editing Electronics, Medical - instrumentation Endocrinology Engineering and Technology Equipment and supplies Fatigue Geography Health Health care access Humans Inflammation - diagnosis Insulin Insulin - metabolism Insulin Resistance Investigations Lyme disease Medicine Medicine and Health Sciences Methods Oxygen - metabolism Partial Pressure Patient monitoring Patient-Specific Modeling Physicians Physiology Precision Medicine R&D Radiation Reproducibility of Results Research & development Roles Sensors Skin Software Spinal cord injuries Vector-borne diseases Veterans Writing Xiao Li Palo Alto California United States > US California
ISSN:	1545-7885, 1544-9173, 1545-7885
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Shrnutí:	A new wave of portable biosensors allows frequent measurement of health-related physiology. We investigated the use of these devices to monitor human physiological changes during various activities and their role in managing health and diagnosing and analyzing disease. By recording over 250,000 daily measurements for up to 43 individuals, we found personalized circadian differences in physiological parameters, replicating previous physiological findings. Interestingly, we found striking changes in particular environments, such as airline flights (decreased peripheral capillary oxygen saturation [SpO2] and increased radiation exposure). These events are associated with physiological macro-phenotypes such as fatigue, providing a strong association between reduced pressure/oxygen and fatigue on high-altitude flights. Importantly, we combined biosensor information with frequent medical measurements and made two important observations: First, wearable devices were useful in identification of early signs of Lyme disease and inflammatory responses; we used this information to develop a personalized, activity-based normalization framework to identify abnormal physiological signals from longitudinal data for facile disease detection. Second, wearables distinguish physiological differences between insulin-sensitive and -resistant individuals. Overall, these results indicate that portable biosensors provide useful information for monitoring personal activities and physiology and are likely to play an important role in managing health and enabling affordable health care access to groups traditionally limited by socioeconomic class or remote geography.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 I have read the journal's policy and the authors of this manuscript have the following competing interests. A patent based on the disease detection work is in preparation.
ISSN:	1545-7885 1544-9173 1545-7885
DOI:	10.1371/journal.pbio.2001402