Digital Health: Tracking Physiomes and Activity Using Wearable Biosensors Reveals Useful Health-Related Information
A new wave of portable biosensors allows frequent measurement of health-related physiology. We investigated the use of these devices to monitor human physiological changes during various activities and their role in managing health and diagnosing and analyzing disease. By recording over 250,000 dail...
Saved in:
| Published in: | PLoS biology Vol. 15; no. 1; p. e2001402 |
|---|---|
| Main Authors: | , , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
Public Library of Science
12.01.2017
Public Library of Science (PLoS) |
| Subjects: | |
| ISSN: | 1545-7885, 1544-9173, 1545-7885 |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | A new wave of portable biosensors allows frequent measurement of health-related physiology. We investigated the use of these devices to monitor human physiological changes during various activities and their role in managing health and diagnosing and analyzing disease. By recording over 250,000 daily measurements for up to 43 individuals, we found personalized circadian differences in physiological parameters, replicating previous physiological findings. Interestingly, we found striking changes in particular environments, such as airline flights (decreased peripheral capillary oxygen saturation [SpO2] and increased radiation exposure). These events are associated with physiological macro-phenotypes such as fatigue, providing a strong association between reduced pressure/oxygen and fatigue on high-altitude flights. Importantly, we combined biosensor information with frequent medical measurements and made two important observations: First, wearable devices were useful in identification of early signs of Lyme disease and inflammatory responses; we used this information to develop a personalized, activity-based normalization framework to identify abnormal physiological signals from longitudinal data for facile disease detection. Second, wearables distinguish physiological differences between insulin-sensitive and -resistant individuals. Overall, these results indicate that portable biosensors provide useful information for monitoring personal activities and physiology and are likely to play an important role in managing health and enabling affordable health care access to groups traditionally limited by socioeconomic class or remote geography. |
|---|---|
| AbstractList | A new wave of portable biosensors allows frequent measurement of health-related physiology. We investigated the use of these devices to monitor human physiological changes during various activities and their role in managing health and diagnosing and analyzing disease. By recording over 250,000 daily measurements for up to 43 individuals, we found personalized circadian differences in physiological parameters, replicating previous physiological findings. Interestingly, we found striking changes in particular environments, such as airline flights (decreased peripheral capillary oxygen saturation [SpO2] and increased radiation exposure). These events are associated with physiological macro-phenotypes such as fatigue, providing a strong association between reduced pressure/oxygen and fatigue on high-altitude flights. Importantly, we combined biosensor information with frequent medical measurements and made two important observations: First, wearable devices were useful in identification of early signs of Lyme disease and inflammatory responses; we used this information to develop a personalized, activity-based normalization framework to identify abnormal physiological signals from longitudinal data for facile disease detection. Second, wearables distinguish physiological differences between insulin-sensitive and -resistant individuals. Overall, these results indicate that portable biosensors provide useful information for monitoring personal activities and physiology and are likely to play an important role in managing health and enabling affordable health care access to groups traditionally limited by socioeconomic class or remote geography. A new wave of portable biosensors allows frequent measurement of health-related physiology. We investigated the use of these devices to monitor human physiological changes during various activities and their role in managing health and diagnosing and analyzing disease. By recording over 250,000 daily measurements for up to 43 individuals, we found personalized circadian differences in physiological parameters, replicating previous physiological findings. Interestingly, we found striking changes in particular environments, such as airline flights (decreased peripheral capillary oxygen saturation [SpO2] and increased radiation exposure). These events are associated with physiological macro-phenotypes such as fatigue, providing a strong association between reduced pressure/oxygen and fatigue on high-altitude flights. Importantly, we combined biosensor information with frequent medical measurements and made two important observations: First, wearable devices were useful in identification of early signs of Lyme disease and inflammatory responses; we used this information to develop a personalized, activity-based normalization framework to identify abnormal physiological signals from longitudinal data for facile disease detection. Second, wearables distinguish physiological differences between insulin-sensitive and -resistant individuals. Overall, these results indicate that portable biosensors provide useful information for monitoring personal activities and physiology and are likely to play an important role in managing health and enabling affordable health care access to groups traditionally limited by socioeconomic class or remote geography. A new wave of portable biosensors allows frequent measurement of health-related physiology. We investigated the use of these devices to monitor human physiological changes during various activities and their role in managing health and diagnosing and analyzing disease. By recording over 250,000 daily measurements for up to 43 individuals, we found personalized circadian differences in physiological parameters, replicating previous physiological findings. Interestingly, we found striking changes in particular environments, such as airline flights (decreased peripheral capillary oxygen saturation [SpO2] and increased radiation exposure). These events are associated with physiological macro-phenotypes such as fatigue, providing a strong association between reduced pressure/oxygen and fatigue on high-altitude flights. Importantly, we combined biosensor information with frequent medical measurements and made two important observations: First, wearable devices were useful in identification of early signs of Lyme disease and inflammatory responses; we used this information to develop a personalized, activity-based normalization framework to identify abnormal physiological signals from longitudinal data for facile disease detection. Second, wearables distinguish physiological differences between insulin-sensitive and -resistant individuals. Overall, these results indicate that portable biosensors provide useful information for monitoring personal activities and physiology and are likely to play an important role in managing health and enabling affordable health care access to groups traditionally limited by socioeconomic class or remote geography. A new wave of wearable sensors allows frequent and continuous measurements of body functions (physiology), including heart rate, skin temperature, blood oxygen levels, and physical activity. We investigated the ability of wearable sensors to follow physiological changes that occur over the course of a day, during illness and other activities. Data from these sensors revealed personalized differences in daily patterns of activities. Interestingly, we discovered striking changes in particular environments such as airline flights. Blood oxygen levels decreased during high-altitude flights, and this decrease was associated with fatigue. By combining sensor information with frequent medical measurements, we made two important health-related observations. First, wearable sensors were useful in identifying the onset of Lyme disease and inflammation. From this observation, we then developed a computational algorithm for personalized disease detection using such sensors. Second, we found that wearable sensors can reveal physiological differences between insulin-sensitive and insulin-resistant individuals, raising the possibility that these sensors could help detect risk for type 2 diabetes. Overall, these results indicate that the information provided by wearable sensors is physiologically meaningful and actionable. Wearable sensors are likely to play an important role in managing health. A new wave of portable biosensors allows frequent measurement of health-related physiology. We investigated the use of these devices to monitor human physiological changes during various activities and their role in managing health and diagnosing and analyzing disease. By recording over 250,000 daily measurements for up to 43 individuals, we found personalized circadian differences in physiological parameters, replicating previous physiological findings. Interestingly, we found striking changes in particular environments, such as airline flights (decreased peripheral capillary oxygen saturation [SpO.sub.2 ] and increased radiation exposure). These events are associated with physiological macro-phenotypes such as fatigue, providing a strong association between reduced pressure/oxygen and fatigue on high-altitude flights. Importantly, we combined biosensor information with frequent medical measurements and made two important observations: First, wearable devices were useful in identification of early signs of Lyme disease and inflammatory responses; we used this information to develop a personalized, activity-based normalization framework to identify abnormal physiological signals from longitudinal data for facile disease detection. Second, wearables distinguish physiological differences between insulin-sensitive and -resistant individuals. Overall, these results indicate that portable biosensors provide useful information for monitoring personal activities and physiology and are likely to play an important role in managing health and enabling affordable health care access to groups traditionally limited by socioeconomic class or remote geography. |
| Audience | Academic |
| Author | Colbert, Elizabeth Sonecha, Ria McLaughlin, Tracey Rego, Shannon Snyder, Michael P. Datta, Somalee Zhou, Wenyu Zhou, Gao Schüssler-Fiorenza Rose, Sophia Miryam Runge, Ryan Perelman, Dalia Li, Xiao Dunn, Jessilyn Salins, Denis |
| AuthorAffiliation | 1 Department of Genetics, Stanford University School of Medicine, Stanford, California, United States of America 4 Department of Neurosurgery, Stanford University School of Medicine, Stanford, California, United States of America 3 Spinal Cord Injury Service, Veterans Affairs Palo Alto Health Care System, Palo Alto, California, United States of America 2 Mobilize Center, Stanford University, Palo Alto, California, United States of America 5 Division of Endocrinology, Stanford University School of Medicine, Stanford, California, United States of America Newcastle University, United Kingdom of Great Britain and Northern Ireland |
| AuthorAffiliation_xml | – name: 1 Department of Genetics, Stanford University School of Medicine, Stanford, California, United States of America – name: 3 Spinal Cord Injury Service, Veterans Affairs Palo Alto Health Care System, Palo Alto, California, United States of America – name: 4 Department of Neurosurgery, Stanford University School of Medicine, Stanford, California, United States of America – name: 5 Division of Endocrinology, Stanford University School of Medicine, Stanford, California, United States of America – name: 2 Mobilize Center, Stanford University, Palo Alto, California, United States of America – name: Newcastle University, United Kingdom of Great Britain and Northern Ireland |
| Author_xml | – sequence: 1 givenname: Xiao surname: Li fullname: Li, Xiao – sequence: 2 givenname: Jessilyn surname: Dunn fullname: Dunn, Jessilyn – sequence: 3 givenname: Denis surname: Salins fullname: Salins, Denis – sequence: 4 givenname: Gao surname: Zhou fullname: Zhou, Gao – sequence: 5 givenname: Wenyu surname: Zhou fullname: Zhou, Wenyu – sequence: 6 givenname: Sophia Miryam surname: Schüssler-Fiorenza Rose fullname: Schüssler-Fiorenza Rose, Sophia Miryam – sequence: 7 givenname: Dalia surname: Perelman fullname: Perelman, Dalia – sequence: 8 givenname: Elizabeth surname: Colbert fullname: Colbert, Elizabeth – sequence: 9 givenname: Ryan surname: Runge fullname: Runge, Ryan – sequence: 10 givenname: Shannon surname: Rego fullname: Rego, Shannon – sequence: 11 givenname: Ria surname: Sonecha fullname: Sonecha, Ria – sequence: 12 givenname: Somalee surname: Datta fullname: Datta, Somalee – sequence: 13 givenname: Tracey surname: McLaughlin fullname: McLaughlin, Tracey – sequence: 14 givenname: Michael P. surname: Snyder fullname: Snyder, Michael P. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28081144$$D View this record in MEDLINE/PubMed |
| BookMark | eNqVk11v0zAUhiM0xD7gHyCIxA1ctNiOkzi7QCrjY5UmhsoGl5brnKTukrjYSUX_PSc0Res0oZFISWQ_75vj83EcHDS2gSB4TsmYRil9u7Sda1Q1Xs2NHTNCKCfsUXBEYx6PUiHig1vfh8Gx90tCGMuYeBIcMkEEpZwfBf6DKU2rqvAcVNUuTsMrp_SNacrw62Ljja3Bh6rJw4luzdq0m_Da95s_QDk1ryB8b6yHxlvnwxms0cMjAUW3MxzNoFIt5OG0KayrVWts8zR4XCAIz4b3SXD96ePV2fno4vLz9GxyMdJpxttRzhQRBAjPcpGKPBKgk4xEScFjIIqyXCUiLpK5nseEpTzJFGMaQEMaxSle0Unwcuu7qqyXQ768pAJtCD4FEtMtkVu1lCtnauU20ioj_yxYV0rlWqMrkFmsOYaQxVTHnDIqCsYFS6DIspxyrdHr3fC3bl5DrqFpnar2TPd3GrOQpV3LmEUkTSI0eD0YOPuzA9_K2ngNVaUasF0fd8pEH3b2ADShPEkywRB9dQe9PxEDVSo8q8FaYYi6N5UTnmG7YXclSI3vofDOoTYa27MwuL4neLMnQKaFX22pOu_l9NvsP9gvD2cvv--zL27X5W9BdjOAwOkW0M5676CQGieib1Q8nakkJbIfuF3eZD9wchg4FPM74p3_P2W_ASKALZU |
| CitedBy_id | crossref_primary_10_1016_j_cobme_2019_01_001 crossref_primary_10_1371_journal_pone_0227709 crossref_primary_10_1186_s40504_020_00108_0 crossref_primary_10_3390_diagnostics12092110 crossref_primary_10_1016_j_coisb_2020_07_012 crossref_primary_10_3390_bios15060384 crossref_primary_10_3389_fpubh_2018_00376 crossref_primary_10_1111_cts_12910 crossref_primary_10_1371_journal_pbio_2004285 crossref_primary_10_1109_ACCESS_2018_2861711 crossref_primary_10_1007_s42979_022_01015_1 crossref_primary_10_1016_j_yebeh_2021_107928 crossref_primary_10_3390_electronics11091380 crossref_primary_10_1007_s10111_021_00671_2 crossref_primary_10_1115_1_4068927 crossref_primary_10_1007_s13167_022_00284_3 crossref_primary_10_1109_ACCESS_2022_3231446 crossref_primary_10_1016_j_coisb_2020_07_003 crossref_primary_10_1093_hmg_ddy114 crossref_primary_10_1016_j_coisb_2020_07_001 crossref_primary_10_1038_s41551_022_00999_8 crossref_primary_10_3390_jcm13113134 crossref_primary_10_1016_j_cjca_2018_04_021 crossref_primary_10_1371_journal_pcbi_1009303 crossref_primary_10_3389_fphys_2023_1219221 crossref_primary_10_4103_digm_digm_4_18 crossref_primary_10_3390_s21227693 crossref_primary_10_1038_s41598_023_36062_y crossref_primary_10_1109_TNSRE_2023_3243257 crossref_primary_10_1001_jamanetworkopen_2021_28534 crossref_primary_10_1016_j_nanoen_2021_106783 crossref_primary_10_1093_biostatistics_kxaf013 crossref_primary_10_1186_s13756_020_00825_3 crossref_primary_10_3414_ME17_03_0001 crossref_primary_10_3390_s23125752 crossref_primary_10_1016_j_engappai_2020_104122 crossref_primary_10_3390_biomimetics10080483 crossref_primary_10_1097_SLA_0000000000006263 crossref_primary_10_1038_s41598_021_84838_x crossref_primary_10_1016_j_mcna_2023_06_003 crossref_primary_10_1038_s41467_021_26040_1 crossref_primary_10_3390_brainsci8060098 crossref_primary_10_1007_s43657_022_00071_0 crossref_primary_10_1038_s41551_018_0305_z crossref_primary_10_32628_IJSRST23113269 crossref_primary_10_1109_ACCESS_2018_2854966 crossref_primary_10_1371_journal_pone_0306393 crossref_primary_10_1057_s41292_020_00202_8 crossref_primary_10_1136_bmjopen_2018_025939 crossref_primary_10_1016_j_jcjd_2021_09_126 crossref_primary_10_1038_s41598_020_80605_6 crossref_primary_10_1007_s12152_018_9371_x crossref_primary_10_1111_tri_13860 crossref_primary_10_2196_60284 crossref_primary_10_3390_jpm14030277 crossref_primary_10_1093_jamiaopen_ooy014 crossref_primary_10_1038_s41746_022_00591_z crossref_primary_10_3389_fdgth_2020_614670 crossref_primary_10_1007_s11936_021_00942_1 crossref_primary_10_21693_1933_088X_17_4_141 crossref_primary_10_1111_epi_16492 crossref_primary_10_1007_s11882_020_00927_3 crossref_primary_10_1097_CIN_0000000000001060 crossref_primary_10_1016_j_talanta_2024_126709 crossref_primary_10_1155_2020_6152041 crossref_primary_10_1093_ndt_gfaa015 crossref_primary_10_1016_j_maturitas_2025_108254 crossref_primary_10_3389_fphys_2019_01396 crossref_primary_10_2337_dci21_0051 crossref_primary_10_1177_1535370217744775 crossref_primary_10_3390_jcm11237019 crossref_primary_10_1177_20552076221132127 crossref_primary_10_1146_annurev_med_052422_020437 crossref_primary_10_1016_j_ijmedinf_2024_105376 crossref_primary_10_1038_s41551_023_01005_5 crossref_primary_10_1177_23328584211052055 crossref_primary_10_3390_metabo9060117 crossref_primary_10_1038_s41928_020_00533_1 crossref_primary_10_1007_s11042_018_6514_3 crossref_primary_10_3414_ME16_02_0047 crossref_primary_10_1002_adhm_202202629 crossref_primary_10_1038_s41551_020_00640_6 crossref_primary_10_1038_s41598_024_57830_4 crossref_primary_10_1007_s42452_024_06156_x crossref_primary_10_1097_CU9_0000000000000030 crossref_primary_10_1152_japplphysiol_00236_2021 crossref_primary_10_1016_j_inffus_2018_09_012 crossref_primary_10_3390_s22103834 crossref_primary_10_3390_asi6050079 crossref_primary_10_1016_j_compenvurbsys_2021_101650 crossref_primary_10_1111_ajt_16339 crossref_primary_10_1016_j_microc_2023_109774 crossref_primary_10_3390_s23115027 crossref_primary_10_1007_s00411_025_01115_5 crossref_primary_10_1093_her_cyad047 crossref_primary_10_3389_fonc_2024_1420888 crossref_primary_10_3390_s22145226 crossref_primary_10_1038_s41598_022_24118_4 crossref_primary_10_1007_s10441_018_9330_2 crossref_primary_10_1177_20552076221120725 crossref_primary_10_1056_NEJMcibr1806952 crossref_primary_10_1038_s41551_020_00659_9 crossref_primary_10_1016_j_cct_2023_107103 crossref_primary_10_1016_j_soncn_2020_151087 crossref_primary_10_1038_s41591_021_01339_0 crossref_primary_10_3389_fphys_2021_691074 crossref_primary_10_1016_S2215_0366_19_30096_3 crossref_primary_10_1371_journal_pone_0274472 crossref_primary_10_1186_s13054_019_2485_7 crossref_primary_10_1109_TBME_2021_3137756 crossref_primary_10_3390_s18020623 crossref_primary_10_1177_20552076221129096 crossref_primary_10_1038_s41746_019_0150_9 crossref_primary_10_1002_adma_201902133 crossref_primary_10_1038_s41591_021_01593_2 crossref_primary_10_1002_adom_201801109 crossref_primary_10_1111_cts_12874 crossref_primary_10_1007_s00253_022_11930_1 crossref_primary_10_1038_s41591_019_0414_6 crossref_primary_10_1161_CIRCRESAHA_117_310909 crossref_primary_10_1111_bph_15822 crossref_primary_10_1038_s41598_024_73557_8 crossref_primary_10_1038_s41746_025_01728_6 crossref_primary_10_1146_annurev_biodatasci_012721_122807 crossref_primary_10_1016_j_arbr_2020_04_006 crossref_primary_10_1016_j_cels_2022_02_001 crossref_primary_10_3390_app14083208 crossref_primary_10_1002_aelm_202201343 crossref_primary_10_1038_nrg_2018_4 crossref_primary_10_3233_ADR_200273 crossref_primary_10_1145_3564276 crossref_primary_10_1016_j_colsurfa_2024_134198 crossref_primary_10_1016_j_coisb_2017_10_003 crossref_primary_10_2196_49320 crossref_primary_10_1016_j_cell_2019_03_004 crossref_primary_10_1371_journal_pdig_0000100 crossref_primary_10_2196_11181 crossref_primary_10_1146_annurev_bioeng_103020_040136 crossref_primary_10_1038_s41746_019_0185_y crossref_primary_10_1038_s42255_023_00778_y crossref_primary_10_1109_JBHI_2019_2963048 crossref_primary_10_1038_s41746_024_01030_x crossref_primary_10_2337_db21_0777 crossref_primary_10_1109_MNET_001_1800162 crossref_primary_10_2196_64018 crossref_primary_10_1002_adfm_202008087 crossref_primary_10_1016_j_procs_2021_05_030 crossref_primary_10_3390_bios11080245 crossref_primary_10_1080_02701367_2020_1759768 crossref_primary_10_2196_14599 crossref_primary_10_1038_nbt_3934 crossref_primary_10_3389_fdgth_2020_00008 crossref_primary_10_1017_S0022215119001531 crossref_primary_10_1093_bib_bbz119 crossref_primary_10_1108_IJIEOM_02_2023_0021 crossref_primary_10_2196_16409 crossref_primary_10_1137_22M1509680 crossref_primary_10_1109_JTEHM_2021_3058841 crossref_primary_10_1016_j_fertnstert_2018_05_006 crossref_primary_10_2337_db18_0537 crossref_primary_10_2196_jmir_9732 crossref_primary_10_1016_j_landig_2025_100886 crossref_primary_10_1159_000479951 crossref_primary_10_3390_s22030756 crossref_primary_10_1016_j_smhl_2022_100370 crossref_primary_10_1038_s41598_022_11329_y crossref_primary_10_1136_bmjdrc_2020_002027 crossref_primary_10_1038_s41598_018_23044_8 crossref_primary_10_3390_healthcare9030343 crossref_primary_10_1515_pac_2018_0908 crossref_primary_10_1016_j_bios_2022_114264 crossref_primary_10_1080_00330124_2018_1547978 crossref_primary_10_1016_j_jaip_2022_06_026 crossref_primary_10_2196_34669 crossref_primary_10_1016_j_cej_2025_159478 crossref_primary_10_1016_j_aei_2023_101901 crossref_primary_10_3390_s23063004 crossref_primary_10_1007_s00421_022_04951_1 crossref_primary_10_1007_s11814_025_00436_x crossref_primary_10_1007_s12170_023_00731_4 crossref_primary_10_3390_bios14110560 crossref_primary_10_1186_s12889_019_7920_9 crossref_primary_10_3390_diagnostics13193071 crossref_primary_10_1016_j_apmt_2023_101874 crossref_primary_10_1038_s41598_022_16326_9 crossref_primary_10_1016_j_jgo_2017_08_008 crossref_primary_10_1002_adma_201901994 crossref_primary_10_2217_pme_2018_0044 crossref_primary_10_3389_fdgth_2021_595704 crossref_primary_10_1016_j_arbres_2020_04_022 crossref_primary_10_3390_s24196394 crossref_primary_10_1038_s41587_022_01350_x crossref_primary_10_1146_annurev_genet_021920_102037 crossref_primary_10_3389_fnins_2020_00769 crossref_primary_10_1007_s11936_019_0729_0 crossref_primary_10_1016_j_mcpro_2023_100561 crossref_primary_10_1002_aelm_202400884 crossref_primary_10_1017_cts_2018_4 crossref_primary_10_2196_12190 crossref_primary_10_1002_jgc4_1509 crossref_primary_10_1109_ACCESS_2024_3456904 crossref_primary_10_1016_j_bios_2020_112362 crossref_primary_10_1002_bies_201700148 crossref_primary_10_1038_s41598_023_37301_y crossref_primary_10_3389_fdgth_2024_1422929 crossref_primary_10_1038_s41746_020_0250_6 crossref_primary_10_1002_cpt_966 crossref_primary_10_1186_s12859_021_04463_3 crossref_primary_10_1523_ENEURO_0349_17_2017 crossref_primary_10_1001_jama_2018_16558 crossref_primary_10_1016_j_nantod_2021_101127 crossref_primary_10_1007_s12541_021_00503_3 crossref_primary_10_2196_29884 crossref_primary_10_3390_mi14091792 crossref_primary_10_1017_S0029665120006977 crossref_primary_10_1089_ipm_09_04_12 crossref_primary_10_1016_j_sna_2024_115139 crossref_primary_10_3390_fi13050127 crossref_primary_10_3390_s23063032 crossref_primary_10_1136_bmjopen_2018_028284 crossref_primary_10_1016_j_neubiorev_2018_09_027 crossref_primary_10_1038_s41467_024_47237_0 crossref_primary_10_3389_fphys_2017_00277 crossref_primary_10_1016_j_apergo_2025_104507 crossref_primary_10_1159_000512166 crossref_primary_10_3390_healthcare11223003 crossref_primary_10_2196_48020 crossref_primary_10_1038_s42256_023_00617_5 crossref_primary_10_1159_000518024 crossref_primary_10_1016_j_fnutr_2025_100032 crossref_primary_10_3389_fdigh_2018_00013 crossref_primary_10_1371_journal_pdig_0000161 crossref_primary_10_2196_jmir_9410 crossref_primary_10_1038_s41746_022_00672_z crossref_primary_10_1093_infdis_jiac262 crossref_primary_10_3390_ijms26115179 crossref_primary_10_2196_29510 crossref_primary_10_1038_s41928_018_0043_y crossref_primary_10_2196_29875 crossref_primary_10_1080_0144929X_2019_1685597 crossref_primary_10_1007_s12221_020_1017_z |
| Cites_doi | 10.1378/chest.11-2016 10.1080/07420520701800702 10.2337/diacare.23.5.624 10.1056/NEJMoa062770 10.1210/jc.2012-3104 10.1161/01.ATV.19.11.2818 10.1590/S0100-879X2002000800018 10.3357/ASEM.3438.2013 10.1097/00006565-200204000-00004 10.2337/db12-1463 10.1136/bmj.317.7165.1063 10.1097/00005768-200106001-00013 10.2337/dc09-S301 10.1152/jappl.1964.19.3.417 10.1080/07853890.2016.1226512 10.1016/j.numecd.2015.02.008 10.1503/cmaj.150535 10.1093/annhyg/mer024 10.1093/ndt/gfp057 10.1007/s11906-012-0306-3 10.1007/BF00404344 10.2337/db12-0138 10.2337/diab.30.5.387 10.2337/diab.30.3.219 10.1016/j.pcad.2009.05.003 10.1136/jnnp.2008.143610 10.1093/brain/awm315 10.1111/j.1365-2044.2005.04124.x 10.1081/CEH-48925 10.1081/CNV-200032767 10.1111/j.1365-2044.2004.03673.x 10.1136/bjsm.26.1.29 10.1016/j.fss.2015.05.001 10.1056/NEJMoa1212052 10.1093/wentk/9780190234775.001.0001 10.2337/db15-1213 10.1159/000362714 10.1093/ije/dyv079 10.7717/peerj.1554 10.2170/jjphysiol.27.423 10.1046/j.1440-1819.1999.00503.x 10.1088/0952-4746/36/1/93 10.1191/096228099673819272 10.1126/science.7434029 |
| ContentType | Journal Article |
| Copyright | COPYRIGHT 2017 Public Library of Science 2017 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Li X, Dunn J, Salins D, Zhou G, Zhou W, Schüssler-Fiorenza Rose SM, et al. (2017) Digital Health: Tracking Physiomes and Activity Using Wearable Biosensors Reveals Useful Health-Related Information. PLoS Biol 15(1): e2001402. doi:10.1371/journal.pbio.2001402 2017 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Li X, Dunn J, Salins D, Zhou G, Zhou W, Schüssler-Fiorenza Rose SM, et al. (2017) Digital Health: Tracking Physiomes and Activity Using Wearable Biosensors Reveals Useful Health-Related Information. PLoS Biol 15(1): e2001402. doi:10.1371/journal.pbio.2001402 |
| Copyright_xml | – notice: COPYRIGHT 2017 Public Library of Science – notice: 2017 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Li X, Dunn J, Salins D, Zhou G, Zhou W, Schüssler-Fiorenza Rose SM, et al. (2017) Digital Health: Tracking Physiomes and Activity Using Wearable Biosensors Reveals Useful Health-Related Information. PLoS Biol 15(1): e2001402. doi:10.1371/journal.pbio.2001402 – notice: 2017 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Li X, Dunn J, Salins D, Zhou G, Zhou W, Schüssler-Fiorenza Rose SM, et al. (2017) Digital Health: Tracking Physiomes and Activity Using Wearable Biosensors Reveals Useful Health-Related Information. PLoS Biol 15(1): e2001402. doi:10.1371/journal.pbio.2001402 |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM IOV ISN ISR 3V. 7QG 7QL 7SN 7SS 7T5 7TK 7TM 7X7 7XB 88E 8FD 8FE 8FH 8FI 8FJ 8FK ABUWG AEUYN AFKRA ATCPS AZQEC BBNVY BENPR BHPHI C1K CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. LK8 M0S M1P M7N M7P P64 PATMY PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS PYCSY RC3 7U8 7X8 JXQ 5PM DOA CZG |
| DOI | 10.1371/journal.pbio.2001402 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Gale In Context: Opposing Viewpoints Gale In Context: Canada Gale In Context: Science ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Ecology Abstracts Entomology Abstracts (Full archive) Immunology Abstracts Neurosciences Abstracts Nucleic Acids Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Technology Research Database ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central ProQuest One Sustainability ProQuest Central UK/Ireland Agricultural & Environmental Science Collection ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Central Korea Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) ProQuest Biological Science Collection Health & Medical Collection (Alumni Edition) Medical Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Biotechnology and BioEngineering Abstracts Environmental Science Database ProQuest Central Premium ProQuest One Academic (New) ProQuest Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China Environmental Science Collection Genetics Abstracts TOXLINE MEDLINE - Academic Toxline PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals PLoS Biology |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Publicly Available Content Database ProQuest Central Student ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Natural Science Collection Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database Engineering Research Database ProQuest One Academic ProQuest One Academic (New) Technology Research Database ProQuest One Academic Middle East (New) ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts ProQuest SciTech Collection ProQuest Medical Library Animal Behavior Abstracts Immunology Abstracts ProQuest Central (Alumni) TOXLINE MEDLINE - Academic |
| DatabaseTitleList | Publicly Available Content Database TOXLINE MEDLINE Genetics Abstracts |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology Medicine Geography |
| DocumentTitleAlternate | Wearables Reveal Useful Health-Related Information |
| EISSN | 1545-7885 |
| EndPage | e2001402 |
| ExternalDocumentID | 1869001868 oai_doaj_org_article_95c438e951c541218f24826ef99d14cc PMC5230763 4314738311 A493711406 28081144 10_1371_journal_pbio_2001402 |
| Genre | Research Support, U.S. Gov't, Non-P.H.S Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GeographicLocations | Palo Alto California United States--US California |
| GeographicLocations_xml | – name: Palo Alto California – name: United States--US – name: California |
| GrantInformation_xml | – fundername: NIDDK NIH HHS grantid: U54 DK102556 – fundername: NIBIB NIH HHS grantid: U54 EB020405 – fundername: NCATS NIH HHS grantid: UL1 TR001085 |
| GroupedDBID | --- 123 29O 2WC 36B 53G 5VS 7X7 7XC 88E 8FE 8FH 8FI 8FJ AAFWJ AAUCC AAWOE AAYXX ABDBF ABIVO ABUFD ABUWG ACCTH ACGFO ACIHN ACPRK ACUHS ADBBV ADRAZ AEAQA AENEX AEUYN AFFHD AFKRA AFPKN AFRAH AFXKF AHMBA AKRSQ ALMA_UNASSIGNED_HOLDINGS AOIJS ATCPS B0M BAIFH BAWUL BBNVY BBTPI BCNDV BENPR BHPHI BPHCQ BVXVI BWKFM CCPQU CITATION CS3 DIK DU5 E3Z EAD EAP EAS EBD EBS EJD EMB EMK EMOBN EPL ESX F5P FPL FYUFA GROUPED_DOAJ GX1 HCIFZ HMCUK HYE IAG IAO IGS IHR IOV ISE ISN ISR ITC KQ8 LK8 M1P M48 M7P O5R O5S OK1 OVT P2P PATMY PHGZM PHGZT PIMPY PJZUB PPXIY PQGLB PQQKQ PROAC PSQYO PV9 PYCSY QF4 QN7 RNS RPM RZL SJN SV3 TR2 TUS UKHRP WOW XSB YZZ ~8M .GJ 3V. AGJBV ALIPV C1A CGR CUY CVF ECM EIF IPNFZ M~E NPM RIG WOQ YIN 7QG 7QL 7SN 7SS 7T5 7TK 7TM 7XB 8FD 8FK AZQEC C1K DWQXO FR3 GNUQQ H94 K9. M7N P64 PKEHL PQEST PQUKI PRINS RC3 7U8 7X8 JXQ PUEGO 5PM - AAPBV ABFLS ABPTK ADACO BBAFP CZG ZA5 |
| ID | FETCH-LOGICAL-c794t-d2a080e049d878d38ec69036f45e0a12da685f6bcb5027469a22ceece73577773 |
| IEDL.DBID | FPL |
| ISICitedReferencesCount | 272 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000393787500010&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1545-7885 1544-9173 |
| IngestDate | Fri Nov 26 17:11:53 EST 2021 Tue Oct 14 15:11:21 EDT 2025 Tue Nov 04 01:50:59 EST 2025 Tue Oct 07 08:15:56 EDT 2025 Thu Oct 02 06:14:40 EDT 2025 Sat Nov 29 14:45:10 EST 2025 Tue Nov 11 10:54:11 EST 2025 Tue Nov 04 18:13:56 EST 2025 Thu Nov 13 16:12:20 EST 2025 Thu Nov 13 16:11:49 EST 2025 Thu Nov 13 16:12:24 EST 2025 Wed Feb 19 02:08:35 EST 2025 Sat Nov 29 06:29:10 EST 2025 Tue Nov 18 22:09:41 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Language | English |
| License | This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. Creative Commons Attribution License |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c794t-d2a080e049d878d38ec69036f45e0a12da685f6bcb5027469a22ceece73577773 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 I have read the journal's policy and the authors of this manuscript have the following competing interests. A patent based on the disease detection work is in preparation. |
| OpenAccessLink | http://dx.doi.org/10.1371/journal.pbio.2001402 |
| PMID | 28081144 |
| PQID | 1869001868 |
| PQPubID | 1436341 |
| ParticipantIDs | plos_journals_1869001868 doaj_primary_oai_doaj_org_article_95c438e951c541218f24826ef99d14cc pubmedcentral_primary_oai_pubmedcentral_nih_gov_5230763 proquest_miscellaneous_1872818689 proquest_miscellaneous_1861466982 proquest_journals_1869001868 gale_infotracmisc_A493711406 gale_infotracacademiconefile_A493711406 gale_incontextgauss_ISR_A493711406 gale_incontextgauss_ISN_A493711406 gale_incontextgauss_IOV_A493711406 pubmed_primary_28081144 crossref_citationtrail_10_1371_journal_pbio_2001402 crossref_primary_10_1371_journal_pbio_2001402 |
| PublicationCentury | 2000 |
| PublicationDate | 2017-01-12 |
| PublicationDateYYYYMMDD | 2017-01-12 |
| PublicationDate_xml | – month: 01 year: 2017 text: 2017-01-12 day: 12 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: San Francisco – name: San Francisco, CA USA |
| PublicationTitle | PLoS biology |
| PublicationTitleAlternate | PLoS Biol |
| PublicationYear | 2017 |
| Publisher | Public Library of Science Public Library of Science (PLoS) |
| Publisher_xml | – name: Public Library of Science – name: Public Library of Science (PLoS) |
| References | CS Bloss (ref11) 2016; 4 O Coste (ref41) 2007; 24 R Fronczek (ref6) 2008; 79 AP Lee (ref28) 2002; 18 NB Hampson (ref25) 2013; 84 MJ Kluger (ref2) 2015; xxi ref55 ref10 D Martins (ref35) 2003; 49 Y Ostchega (ref23) 2011 DC Peterson (ref42) 2013; 368 BD Kent (ref5) 2011; 6 B Grajewski (ref36) 2011; 55 HJ Lowe (ref58) 2009; 2009 MK Lim (ref37) 2001; 30 MB Ferraro (ref57) 2015; 279 NG Chen (ref15) 1999; 84 M Javorka (ref19) 2002; 35 M Torii (ref22) 1992; 26 H Kubo (ref24) 1999; 53 A Festa (ref46) 2000; 23 JJ Cottrell (ref27) 1995; 66 A Kishimoto (ref31) 2005; 27 T Nakayama (ref21) 1977; 27 PT Kelly (ref30) 2006; 77 DG Altman (ref16) 1983; 32 AJ Sigurdson (ref38) 2004; 22 C Bouchard (ref8) 2001; 33 N Roubinian (ref29) 2012; 142 F Abbasi (ref14) 1999; 19 MJ Ribeiro (ref49) 2013; 62 D Aune (ref44) 2015; 25 CM Licht (ref52) 2013; 98 LE Alvarez (ref39) 2016; 36 VA Fonseca (ref33) 2009; 32 CJ Magri (ref34) 2014; 129 C Perret-Guillaume (ref3) 2009; 52 AJ Peacock (ref26) 1998; 317 S Humphreys (ref32) 2005; 60 L Wang (ref47) 2015; 44 DA Lewis (ref9) 1986; 3 RJ Raymann (ref7) 2008; 131 CA Czeisler (ref18) 1980; 210 MJ Kluger (ref1) 1979; 20 M Nuhr (ref56) 2004; 59 D Pei (ref13) 1994; 37 JM Muhm (ref40) 2007; 357 S Reule (ref4) 2012; 14 MS Greenfield (ref12) 1981; 30 E Topol (ref54) 2015 NE Straznicky (ref51) 2012; 61 T McLaughlin (ref59) 2016; 65 JM Bland (ref17) 1999; 8 F Snyder (ref20) 1964; 19 S Beddhu (ref45) 2009; 24 JW Rowe (ref50) 1981; 30 M Snyder (ref53) 2016 D Zhang (ref48) 2016; 188 S Aeschbacher (ref43) 2016 28682357 - Nature. 2017 Jul 4;547(7661):13-14 |
| References_xml | – volume: 142 start-page: 885 issue: 4 year: 2012 ident: ref29 article-title: Effects of commercial air travel on patients with pulmonary hypertension air travel and pulmonary hypertension publication-title: Chest doi: 10.1378/chest.11-2016 – volume: 24 start-page: 1139 issue: 6 year: 2007 ident: ref41 article-title: Impact of hypobaric hypoxia in pressurized cabins of simulated long-distance flights on the 24 h patterns of biological variables, fatigue, and clinical status publication-title: Chronobiol Int doi: 10.1080/07420520701800702 – volume: 23 start-page: 624 issue: 5 year: 2000 ident: ref46 article-title: Heart rate in relation to insulin sensitivity and insulin secretion in nondiabetic subjects publication-title: Diabetes Care doi: 10.2337/diacare.23.5.624 – volume: 3 start-page: 357 issue: 5 year: 1986 ident: ref9 article-title: Physiological differences between genders publication-title: Implications for sports conditioning. Sports medicine – volume: 357 start-page: 18 issue: 1 year: 2007 ident: ref40 article-title: Effect of aircraft-cabin altitude on passenger discomfort publication-title: N Engl J Med doi: 10.1056/NEJMoa062770 – volume: 98 start-page: 2484 issue: 6 year: 2013 ident: ref52 article-title: Dysregulation of the autonomic nervous system predicts the development of the metabolic syndrome publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2012-3104 – volume: 20 start-page: 209 year: 1979 ident: ref1 article-title: Temperature regulation, fever, and disease publication-title: Int Rev Physiol – volume: 19 start-page: 2818 issue: 11 year: 1999 ident: ref14 article-title: Comparison of plasminogen activator inhibitor-1 concentration in insulin-resistant versus insulin-sensitive healthy women publication-title: Arterioscler Thromb Vasc Biol doi: 10.1161/01.ATV.19.11.2818 – start-page: 1 issue: 41 year: 2011 ident: ref23 article-title: Resting pulse rate reference data for children, adolescents, and adults: United States, 1999–2008 publication-title: Natl Health Stat Report – volume: 35 start-page: 991 issue: 8 year: 2002 ident: ref19 article-title: Heart rate recovery after exercise: relations to heart rate variability and complexity publication-title: Braz J Med Biol Res doi: 10.1590/S0100-879X2002000800018 – volume: 49 start-page: 1305 issue: 8 year: 2003 ident: ref35 article-title: The relationship between body mass index, blood pressure and pulse rate among normotensive and hypertensive participants in the third National Health and Nutrition Examination Survey (NHANES) publication-title: Cell Mol Biol – volume: 84 start-page: 27 issue: 1 year: 2013 ident: ref25 article-title: Altitude exposures during commercial flight: a reappraisal publication-title: Aviat Space Environ Med doi: 10.3357/ASEM.3438.2013 – volume: 18 start-page: 78 issue: 2 year: 2002 ident: ref28 article-title: Commercial airline travel decreases oxygen saturation in children publication-title: Pediatr Emerg Care doi: 10.1097/00006565-200204000-00004 – volume: 62 start-page: 2905 issue: 8 year: 2013 ident: ref49 article-title: Carotid body denervation prevents the development of insulin resistance and hypertension induced by hypercaloric diets publication-title: Diabetes doi: 10.2337/db12-1463 – volume: 317 start-page: 1063 issue: 7165 year: 1998 ident: ref26 article-title: ABC of oxygen: oxygen at high altitude publication-title: BMJ doi: 10.1136/bmj.317.7165.1063 – volume: 33 start-page: S446 issue: 6 Suppl year: 2001 ident: ref8 article-title: Individual differences in response to regular physical activity publication-title: Medicine and science in sports and exercise doi: 10.1097/00005768-200106001-00013 – volume: 32 start-page: S151 issue: Suppl 2 year: 2009 ident: ref33 article-title: Defining and characterizing the progression of type 2 diabetes publication-title: Diabetes Care doi: 10.2337/dc09-S301 – volume: 19 start-page: 417 year: 1964 ident: ref20 article-title: Changes in Respiration, Heart Rate, and Systolic Blood Pressure in Human Sleep publication-title: J Appl Physiol doi: 10.1152/jappl.1964.19.3.417 – start-page: 1 year: 2016 ident: ref43 article-title: Heart rate, heart rate variability and inflammatory biomarkers among young and healthy adults publication-title: Ann Med doi: 10.1080/07853890.2016.1226512 – volume: 25 start-page: 526 issue: 6 year: 2015 ident: ref44 article-title: Resting heart rate and the risk of type 2 diabetes: A systematic review and dose—response meta-analysis of cohort studies publication-title: Nutr Metab Cardiovasc Dis doi: 10.1016/j.numecd.2015.02.008 – volume: 188 start-page: E53 issue: 3 year: 2016 ident: ref48 article-title: Resting heart rate and all-cause and cardiovascular mortality in the general population: a meta-analysis publication-title: CMAJ: Canadian Medical Association journal = journal de l'Association medicale canadienne doi: 10.1503/cmaj.150535 – volume: 55 start-page: 465 issue: 5 year: 2011 ident: ref36 article-title: Airline pilot cosmic radiation and circadian disruption exposure assessment from logbooks and company records publication-title: Ann Occup Hyg doi: 10.1093/annhyg/mer024 – volume: 24 start-page: 2482 issue: 8 year: 2009 ident: ref45 article-title: Associations of resting heart rate with insulin resistance, cardiovascular events and mortality in chronic kidney disease publication-title: Nephrol Dial Transplant doi: 10.1093/ndt/gfp057 – volume: 6 start-page: 199 year: 2011 ident: ref5 article-title: Hypoxemia in patients with COPD: cause, effects, and disease progression publication-title: Int J Chron Obstruct Pulmon Dis – volume: 14 start-page: 478 issue: 6 year: 2012 ident: ref4 article-title: Heart rate and blood pressure: any possible implications for management of hypertension? publication-title: Curr Hypertens Rep doi: 10.1007/s11906-012-0306-3 – volume: 37 start-page: 843 issue: 8 year: 1994 ident: ref13 article-title: Evaluation of octreotide to assess insulin-mediated glucose disposal by the insulin suppression test publication-title: Diabetologia doi: 10.1007/BF00404344 – volume: 61 start-page: 2506 issue: 10 year: 2012 ident: ref51 article-title: Neuroadrenergic dysfunction along the diabetes continuum: a comparative study in obese metabolic syndrome subjects publication-title: Diabetes doi: 10.2337/db12-0138 – volume: 30 start-page: 387 issue: 5 year: 1981 ident: ref12 article-title: Assessment of insulin resistance with the insulin suppression test and the euglycemic clamp publication-title: Diabetes doi: 10.2337/diab.30.5.387 – volume: 30 start-page: 219 issue: 3 year: 1981 ident: ref50 article-title: Effect of insulin and glucose infusions on sympathetic nervous system activity in normal man publication-title: Diabetes doi: 10.2337/diab.30.3.219 – volume: 52 start-page: 6 issue: 1 year: 2009 ident: ref3 article-title: Heart rate as a risk factor for cardiovascular disease publication-title: Prog Cardiovasc Dis doi: 10.1016/j.pcad.2009.05.003 – volume: 79 start-page: 1354 issue: 12 year: 2008 ident: ref6 article-title: Manipulation of skin temperature improves nocturnal sleep in narcolepsy publication-title: J Neurol Neurosurg Psychiatry doi: 10.1136/jnnp.2008.143610 – volume: 131 start-page: 500 issue: Pt 2 year: 2008 ident: ref7 article-title: Skin deep: enhanced sleep depth by cutaneous temperature manipulation publication-title: Brain doi: 10.1093/brain/awm315 – volume: 66 start-page: 126 issue: 2 year: 1995 ident: ref27 article-title: Inflight arterial saturation: continuous monitoring by pulse oximetry publication-title: Aviat Space Environ Med – volume: xxi start-page: 195 year: 2015 ident: ref2 article-title: Fever, its biology, evolution, and function – year: 2015 ident: ref54 article-title: The patient will see you now: the future of medicine is in your hands – volume: 60 start-page: 458 issue: 5 year: 2005 ident: ref32 article-title: The effect of high altitude commercial air travel on oxygen saturation publication-title: Anaesthesia doi: 10.1111/j.1365-2044.2005.04124.x – volume: 27 start-page: 279 issue: 2–3 year: 2005 ident: ref31 article-title: Ring-shaped pulse oximeter and its application: measurement of SpO2 and blood pressure during sleep and during flight publication-title: Clin Exp Hypertens doi: 10.1081/CEH-48925 – volume: 22 start-page: 743 issue: 5 year: 2004 ident: ref38 article-title: Cosmic radiation exposure and cancer risk among flight crew publication-title: Cancer Invest doi: 10.1081/CNV-200032767 – volume: 59 start-page: 390 issue: 4 year: 2004 ident: ref56 article-title: Forehead SpO2 monitoring compared to finger SpO2 recording in emergency transport publication-title: Anaesthesia doi: 10.1111/j.1365-2044.2004.03673.x – volume: 26 start-page: 29 issue: 1 year: 1992 ident: ref22 article-title: Fall in skin temperature of exercising man publication-title: Br J Sports Med doi: 10.1136/bjsm.26.1.29 – volume: 279 start-page: 1 year: 2015 ident: ref57 article-title: A toolbox for fuzzy clustering using the R programming language publication-title: Fuzzy Sets and Systems doi: 10.1016/j.fss.2015.05.001 – ident: ref55 – volume: 368 start-page: 2075 issue: 22 year: 2013 ident: ref42 article-title: Outcomes of medical emergencies on commercial airline flights publication-title: N Engl J Med doi: 10.1056/NEJMoa1212052 – volume: 77 start-page: 1143 issue: 11 year: 2006 ident: ref30 article-title: Normobaric hypoxia inhalation test vs. response to airline flight in healthy passengers publication-title: Aviat Space Environ Med – volume: 30 start-page: 494 issue: 5 year: 2001 ident: ref37 article-title: Exposure of airline pilots and cabin crew to cosmic radiation during flight—what's the fuss? publication-title: Ann Acad Med Singapore – year: 2016 ident: ref53 article-title: Genomics and Personalized Medicine: What Everyone Needs to Know doi: 10.1093/wentk/9780190234775.001.0001 – volume: 2009 start-page: 391 year: 2009 ident: ref58 article-title: STRIDE—An integrated standards-based translational research informatics platform publication-title: AMIA Annu Symp Proc – volume: 84 start-page: 3485 issue: 10 year: 1999 ident: ref15 article-title: Relationship between insulin resistance, soluble adhesion molecules, and mononuclear cell binding in healthy volunteers publication-title: J Clin Endocrinol Metab – volume: 65 start-page: 1245 issue: 5 year: 2016 ident: ref59 article-title: Adipose Cell Size and Regional Fat Deposition as Predictors of Metabolic Response to Overfeeding in Insulin-Resistant and Insulin-Sensitive Humans publication-title: Diabetes doi: 10.2337/db15-1213 – volume: 129 start-page: 28 issue: 1 year: 2014 ident: ref34 article-title: Non-dipping heart rate and microalbuminuria in type 2 diabetes mellitus publication-title: Cardiology doi: 10.1159/000362714 – volume: 44 start-page: 689 issue: 2 year: 2015 ident: ref47 article-title: Resting heart rate and the risk of developing impaired fasting glucose and diabetes: the Kailuan prospective study publication-title: Int J Epidemiol doi: 10.1093/ije/dyv079 – volume: 4 start-page: e1554 year: 2016 ident: ref11 article-title: A prospective randomized trial examining health care utilization in individuals using multiple smartphone-enabled biosensors publication-title: PeerJ doi: 10.7717/peerj.1554 – volume: 32 start-page: 307 issue: 3 year: 1983 ident: ref16 article-title: Measurement in Medicine: The Analysis of Method Comparison Studies publication-title: Journal of the Royal Statistical Society Series D (The Statistician) – volume: 27 start-page: 423 issue: 4 year: 1977 ident: ref21 article-title: Fall in skin temperature during exercise publication-title: Jpn J Physiol doi: 10.2170/jjphysiol.27.423 – volume: 53 start-page: 121 issue: 2 year: 1999 ident: ref24 article-title: Sleep stage and skin temperature regulation during night-sleep in winter publication-title: Psychiatry Clin Neurosci doi: 10.1046/j.1440-1819.1999.00503.x – volume: 36 start-page: 93 issue: 1 year: 2016 ident: ref39 article-title: Radiation dose to the global flying population publication-title: J Radiol Prot doi: 10.1088/0952-4746/36/1/93 – volume: 8 start-page: 135 issue: 2 year: 1999 ident: ref17 article-title: Measuring agreement in method comparison studies publication-title: Stat Methods Med Res doi: 10.1191/096228099673819272 – ident: ref10 – volume: 210 start-page: 1264 issue: 4475 year: 1980 ident: ref18 article-title: Human sleep: its duration and organization depend on its circadian phase publication-title: Science doi: 10.1126/science.7434029 – reference: 28682357 - Nature. 2017 Jul 4;547(7661):13-14 |
| RelatedPersons | Xiao Li |
| RelatedPersons_xml | – fullname: Xiao Li |
| SSID | ssj0022928 |
| Score | 2.644788 |
| Snippet | A new wave of portable biosensors allows frequent measurement of health-related physiology. We investigated the use of these devices to monitor human... A new wave of portable biosensors allows frequent measurement of health-related physiology. We investigated the use of these devices to monitor human... |
| SourceID | plos doaj pubmedcentral proquest gale pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | e2001402 |
| SubjectTerms | Bands Biology and Life Sciences Biosensing Techniques Biosensors Borrelia Circadian Rhythm - physiology Disease detection Editing Electronics, Medical - instrumentation Endocrinology Engineering and Technology Equipment and supplies Fatigue Geography Health Health care access Humans Inflammation - diagnosis Insulin Insulin - metabolism Insulin Resistance Investigations Lyme disease Medicine Medicine and Health Sciences Methods Oxygen - metabolism Partial Pressure Patient monitoring Patient-Specific Modeling Physicians Physiology Precision Medicine R&D Radiation Reproducibility of Results Research & development Roles Sensors Skin Software Spinal cord injuries Vector-borne diseases Veterans Writing Xiao Li |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lj9QwDI7QCCQuiPcWFhQQEqewbfpIw214rOAyoOW1t6hN0mWkpR1NZlbi32Mn6WiLFpYDPU5cV2M7sd3a_gh5VtV51bbaMMymWQE-hEkjLMPoIS8KraUIYBNisaiPj-XHc1BfWBMWxgMHwR3IUhd5bSEQ0GWRgUPqeAEhse2kNBnwwtMXop4xmYqpFpceVRVHzcB2FnlsmstFdhB19GLVLn3zH2QYfOKU_Oz-3Qk9W50O7qLw8_cqynNu6fAmuRHjSToP_-MWuWL72-RaQJj8eYe4N8sThAWhod3oJQXfpPHtOPWln8MP62jTGzrXAUWC-hIC-g3sH3uqKDBykOgOa0eP7BnwcEBhu-3IkPliOmtobGtCNd8lXw7ffn79jkWcBaZhN26Y4Q1I0EKuYGpRG5C2hpw5r7qitGmTcdNUddlVrW5LTGIr2XAOvlVbkZcCrvwemfVDb_cIrXEXp9JIiLKKuilam7U5N2kFbG2qdULyUdBKxyHkiIVxqvyXNQHJSJCbQvWoqJ6EsN1dqzCE4xL6V6jDHS2O0PY_gGGpaFjqMsNKyFO0AIVDMnqswjlpts6p9x--qnmBUwThSdWfiD4t_oXoaEL0PBJ1A0hEN7E9AuSKE7omlPsTSjgP9GR5D012FIxTHnQsRVgEuHM044uXn-yWkSmW3_V22Hoa8KiVrPnfaAROFqtqmZD7YWfsFMAR3wVS94SIyZ6ZaGi60i-_-2Hn-NUCfOCD_6HSh-Q6x6gszVjG98lss97aR-SqPtss3fqxP0F-AWsfcfg priority: 102 providerName: Directory of Open Access Journals – databaseName: Biological Science Database dbid: M7P link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpR1Zb9Mw2IJyvnCMY4WBDELiySxxnMTmBZVjggfGNI7tLUpsp6s0klK3k_j3fJ_jBoLGQKJPVf3Fjf3d9ncQ8iSTSVZV2jD0ppkAHcKUyS1D6yERQmuVd80m8t1deXio9sKBmwthlWuZ6AW1aTWekW_71kkRFnd_Mf_GsGsU3q6GFhrnyQWskpD40L293uHiyvdWxYIzwNR5ElLnkjzeDph6Nq9mPgUQ_Aw-UE2-gn8vp0fz49adZoT-Hkv5i3Lauf6_y7pBrgWzlE46OrpJztlmg1zqGlV-3yBXQq_0I_h--X24jr9F3OvZFJuO0C6Z6TkFzafx7J36wNL2q3W0bAyd6K5HBfUBCvQAuAsztijM78CNbheO7tsTmMMBhK1X6wmZD9WzhoakKSSi2-TzzptPr96y0MWBaeD1JTO8BKvUgidiZC5NIq2GJSdZLVIblTE3ZSbTOqt0laKLnKmSc9Dc2uZJmsMnuUNGTdvYTUIlyohIGQU2nJClqGxcJdxEGUxrI63HJFkjsNChxDl22jgu_L1dDq5Ot50For0IaB8T1j8170p8_AX-JdJGD4sFuv0P7WJaBH4vVKoFLBXsV50KoE1ZcwGenK2VMrHAV32MlFVgCY4GY3ym5cq54t2HL8VEYI1C-KfsT0Afd_8FaH8A9DQA1S3siC5D8gXsK9b_GkBuDSBB2ujB8CaywnpjXPGTgOHJNYmfPvyoH8ZJMbivse3Kw4C-zpTkZ8HkWLcsk2pM7nYc1yOAY_eYWIgxyQe8OMDQcKSZHflS6ngnAhr23tmvfp9c5WjNRTGL-RYZLRcr-4Bc1CfLmVs89DLnB29xh_8 priority: 102 providerName: ProQuest |
| Title | Digital Health: Tracking Physiomes and Activity Using Wearable Biosensors Reveals Useful Health-Related Information |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/28081144 https://www.proquest.com/docview/1869001868 https://www.proquest.com/docview/1861466982 https://www.proquest.com/docview/1872818689 https://pubmed.ncbi.nlm.nih.gov/PMC5230763 https://doaj.org/article/95c438e951c541218f24826ef99d14cc http://dx.doi.org/10.1371/journal.pbio.2001402 |
| Volume | 15 |
| WOSCitedRecordID | wos000393787500010&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1545-7885 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0022928 issn: 1545-7885 databaseCode: DOA dateStart: 20030101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1545-7885 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0022928 issn: 1545-7885 databaseCode: M7P dateStart: 20031001 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Environmental Science Database customDbUrl: eissn: 1545-7885 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0022928 issn: 1545-7885 databaseCode: PATMY dateStart: 20031001 isFulltext: true titleUrlDefault: http://search.proquest.com/environmentalscience providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1545-7885 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0022928 issn: 1545-7885 databaseCode: 7X7 dateStart: 20031001 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1545-7885 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0022928 issn: 1545-7885 databaseCode: BENPR dateStart: 20031001 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 1545-7885 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0022928 issn: 1545-7885 databaseCode: PIMPY dateStart: 20031001 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVATS databaseName: Public Library of Science (PLoS) Journals Open Access customDbUrl: eissn: 1545-7885 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0022928 issn: 1545-7885 databaseCode: FPL dateStart: 20030101 isFulltext: true titleUrlDefault: http://www.plos.org/publications/ providerName: Public Library of Science |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Zj9MwELagC4gXjuXYwhIZhMRTIHESH7x1YStWYktUru5TlDjOUmlJqqZdiX_PjJMGstpy5KEP8Wc3GXs8M_EchDznMuBZpnMXrWk3BBniqlwYF7WHIAy1VqIpNiEmEzmbqfiXoXjhBD8Q_quWpi8X2dwG64FFAFvuDgs4Rxeucfy-M7CYYrINj9vWsyd-bJb-bi8eLM6q-jJF86K_5G8CaHz7fx_9DrnVqpp01KyNu-SKKXfJ9ab45I9dcuO4PVa_R-q381MsHkKboKTXFCSYxm_o1DqIVt9NTdMypyPd1Jqg1tGAfgUuwcgrCmPWYA5Xy5pOzTmMUQPCFOvNgK51uTM5bYOfcDHcJ5_Hh5_evHPbagyuBp5duTlLQbs0YFHkUsg8kEaDZR3wIoyMl_osT7mMCp7pLEJTl6uUMZDA2oggEnAFD8igrEqzR6hEXvdUrkAXC2UaZsbPApZ7HIY1ntZDEmwmKdFtqnKsmHGW2PM3ASZLQ8IEKZu0lB0St-u1aFJ1_AV_gPPfYTHRtr0BU5i0fJuoSIfwqqCH6ij0QR8qWAgWmSmUyv0QH_UZrp4EU2mU6Ktzmq7rOjn68CUZhZhrEP6JbwN9nPwLaNoDvWhBRQUU0WkbRAF0xTxePeR-Dwm7hu417-Fy3xCmTmxpMg-LJ0DPDQtc3vy0a8ZB0UmvNNXaYkDuciXZnzAC849xqYbkYcNV3QQwrAIDBv6QiB6_9Wao31LOv9mU6Hi2AZLy0fa3ekxuMtTIPN_12T4ZrJZr84Rc0-ereb10yFUxE_ZXOmTn4HASTx37ecaxO4yDLsExtMRHx_HJT2kEd3w |
| linkProvider | Public Library of Science |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V3db9MwELdG-RgvfIyPFQYYBOIpLHG-HCSECmNata1M24C9hcR2u0ojKXU7tH-Kv5E7xwkEjcHLHuhTVV8uiX13vqvv7kfI04j7UZ4L6WA07QSwhziJjJWD3oMfBEIkcQU2EQ8G_OAg2Vkg3-taGEyrrG2iMdSyFPgf-aqBTnKxufvryVcHUaPwdLWG0KjEYlOdfIOQTb_qr8H6PmNs_d3-2w3Hogo4AmRv5kiWgZekwDOWPObS50oAZz8aBqFyM4_JLOLhMMpFHmLIFiUZY7CTCBX7YQwfH_heIBfBjWDcpAruNAEeSwyWKza4ASMS-7ZUz4-9VSsZLyb52JQcQlzDWluhQQxo9oXO5KjUpzm9v-du_rIZrl__36bxBrlm3W7aq_TkJllQxRK5XAFxniyRRYsFfwjfr2zbdINbRK-NRwiqQqtirZcUdnaBZwvUJM6WX5SmWSFpT1QYHNQkYNBP8H5YkUaBv1aFLqea7qpj4KGBQg3nNUPHpCIqSW1RGCrJbfLhXCbiDukUZaGWCeVoA91EJiBcAc-CXHm5z6QbAVvlCtElfi0wqbAt3BFJ5Cg155IxhHLVdKYoZqkVsy5xmqsmVQuTv9C_QVlsaLEBufmhnI5Sa8_SJBQBvCr45yIETfD4kAUQqaphkkgvwEd9gpKcYouRAnOYRtlc67T__mPaC7AHI9wp-hPR3uBfiHZbRM8t0bCEGRGZLS6BecX-Zi3KlRYlWFPRGl5G1asnRqc_FQaurFXq9OHHzTAyxeTFQpVzQwP-SJRwdhZNjH3ZIp50yd1Kw5sFYIiO4wVBl8Qt3W-tUHukGB-aVvF45gMexL2zH_0RWdzY395Kt_qDzfvkKkPP1fUcj62Qzmw6Vw_IJXE8G-vpQ2PvKPl83pbhB2Uo48Q |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9NAEF6VAIULj_JooMCCQJxM7PX6sUgIBUJEVAhRy6M3Y6_XaaRihzgp6l_j1zGzXhuMSuHSAzlF2fHanp2dR3ZmPkIe-qHrJ4lMLYymLQ42xBJpoCz0HlzOpRRBBTYRjMfh3p6YrJHvdS0MplXWOlEr6rSQ-B95T0Mn2djcvZeZtIjJYPh8_tVCBCk8aa3hNCoR2VZH3yB8K5-NBrDWjxgbvnr_8rVlEAYsCXK4tFIWg8ekwEtOwyBM3VBJuIvrZ9xTduywNPZDL_MTmXgYvvkiZgysilSB6wXwcWHeM-RsgE3LddrgpAn2mNC4rtjsBhRK4JqyPTdwekZKnsyTmS4_hBiHtcyiRg9obERnflCUxznAv-dx_mIYh5f_Z5ZeIZeMO0771f65StZUvkHOVwCdRxvkgsGI34fv629NGsI1Ug5mUwRboVUR11MKFl_imQPVCbXFF1XSOE9pX1bYHFQnZtBP8H5YqUZh_lLlZbEo6Y46hDlKoFDAHTOhpVMUVUpNsRhunuvkw6kw4gbp5EWuNgkNUTfaIhXgu_Iw5olyEpeltg_TKlvKLnFr4Ymkae2OCCMHkT6vDCDEq9gZochFRuS6xGqumletTf5C_wLlsqHFxuT6h2IxjYyei4QnObwq-O3S4w74jxnjEMGqTIjU4fioD1CqI2w9kqPETeNVWUajdx-jPsfejHAn_09Eu-N_IdppET02RFkBHJGxKToBvmLfsxblVosStKxsDW_iNqwZU0Y_Nw9cWW-v44fvN8M4KSY15qpYaRrwU3wRspNoAuzX5oeiS25Wu71ZAIaoOQ7nXRK09EBrhdoj-Wxft5DHsyDwLG6d_Oj3yDoohOjNaLx9m1xk6NDajuWwLdJZLlbqDjknD5ezcnFXqz5KPp-2YvgBbLXsgQ |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Digital+Health%3A+Tracking+Physiomes+and+Activity+Using+Wearable+Biosensors+Reveals+Useful+Health-Related+Information&rft.jtitle=PLoS+biology&rft.au=Li%2C+Xiao&rft.au=Dunn%2C+Jessilyn&rft.au=Salins%2C+Denis&rft.au=Zhou%2C+Gao&rft.date=2017-01-12&rft.pub=Public+Library+of+Science&rft.issn=1544-9173&rft.eissn=1545-7885&rft.volume=15&rft.issue=1&rft_id=info:doi/10.1371%2Fjournal.pbio.2001402&rft_id=info%3Apmid%2F28081144&rft.externalDocID=PMC5230763 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1545-7885&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1545-7885&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1545-7885&client=summon |