Neurobehavioral Deficits and Increased Blood Pressure in School-Age Children Prenatally Exposed to Pesticides

BACKGROUND: The long-term neurotoxicity risks caused by prenatal exposures to pesticides are unclear, but a previous pilot study of Ecuadorian school children suggested that blood pressure and visuospatial processing may be vulnerable. OBJECTIVES: In northern Ecuador, where floriculture is intensive...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Environmental health perspectives Ročník 118; číslo 6; s. 890 - 896
Hlavní autoři:	Harari, Raul, Julvez, Jordi, Murata, Katsuyuki, Barr, Dana, Bellinger, David C., Debes, Frodi, Grandjean, Philippe
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Research Triangle Park, NC National Institute of Environmental Health Sciences 01.06.2010 US Department of Health and Human Services
Témata:	Adult Agricultural Workers' Diseases - chemically induced Attention - drug effects Biological and medical sciences Blood pressure Blood Pressure - drug effects Body mass index Chemical hazards Child Children Children's Health Copying Cross-Sectional Studies Developmental Disabilities - chemically induced Ecuador Elementary school students Environment. Living conditions Environmental health Exposure Female Health Health aspects Humans Male Medical sciences Metabolites Neuropsychological Tests Neurotoxicity Occupational Exposure Organophosphates Organophosphates - toxicity Organophosphates - urine Pesticides Pesticides - toxicity Pesticides - urine Pesticides, fertilizers and other agrochemicals toxicology Phosphoric acid esters Pregnancy Pregnant women Prenatal drug exposure Prenatal Exposure Delayed Effects - chemically induced Psychomotor Performance - drug effects Public health. Hygiene Public health. Hygiene-occupational medicine Reproduction Risk factors School age children Stanford Binet test Toxicology Ecuador United States Toxicity Nervous system Esterases Acetylcholinesterase Occupational exposure Delay Prenatal Health and environment Mother Arterial pressure Blood pressure Behavior prenatal exposure delayed effects Child Human Nervous system diseases maternal exposure Enzyme Pesticides Syndrome Carboxylic ester hydrolases School age Hydrolases neurotoxicity syndromes Organophosphorus compounds Hemodynamics Occupational medicine
ISSN:	0091-6765, 1552-9924, 1552-9924
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Popis
Shrnutí:	BACKGROUND: The long-term neurotoxicity risks caused by prenatal exposures to pesticides are unclear, but a previous pilot study of Ecuadorian school children suggested that blood pressure and visuospatial processing may be vulnerable. OBJECTIVES: In northern Ecuador, where floriculture is intensive and relies on female employment, we carried out an intensive cross-sectional study to assess children's neurobehavioral functions at 6-8 years of age. METHODS: We examined all 87 children attending two grades in the local public school with an expanded battery of neurobehavioral tests. Information on pesticide exposure during the index pregnancy was obtained from maternal interview. The children's current pesticide exposure was assessed from the urinary excretion of organophosphate metabolites and erythrocyte acetylcholine esterase activity. RESULTS: Of 84 eligible participants, 35 were exposed to pesticides during pregnancy via maternal occupational exposure, and 23 had indirect exposure from paternal work. Twenty-two children had detectable current exposure irrespective of their prenatal exposure status. Only children with prenatal exposure from maternal greenhouse work showed consistent deficits after covariate adjustment, which included stunting and socioeconomic variables. Exposure-related deficits were the strongest for motor speed (Finger Tapping Task), motor coordination (Santa Ana Form Board), visuospatial performance (Stanford-Binet Copying Test), and visual memory (Stanford-Binet Copying Recall Test). These associations corresponded to a developmental delay of 1.5-2 years. Prenatal pesticide exposure was also significantly associated with an average increase of 3.6 mmHg in systolic blood pressure and a slight decrease in body mass index of 1.1 kg/m2. Inclusion of the pilot data strengthened these results. CONCLUSIONS: These findings support the notion that prenatal exposure to pesticides—at levels not producing adverse health outcomes in the mother—can cause lasting adverse effects on brain development in children. Pesticide exposure therefore may contribute to a "silent pandemic" of developmental neurotoxicity.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 R.H. is the managing director of a nonprofit foundation (Corporación para el Desarrollo de la Producción y el Medio Ambiente Laboral) that carries out research, training, and risk communication in occupational and environmental health. The author has no financial or personal relationship with people or organizations that could inappropriately influence the work submitted. The other authors declare they have no actual or potential competing financial interests.
ISSN:	0091-6765 1552-9924 1552-9924
DOI:	10.1289/ehp.0901582