Geographic Patterns of Genome Admixture in Latin American Mestizos
The large and diverse population of Latin America is potentially a powerful resource for elucidating the genetic basis of complex traits through admixture mapping. However, no genome-wide characterization of admixture across Latin America has yet been attempted. Here, we report an analysis of admixt...
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| Vydáno v: | PLoS genetics Ročník 4; číslo 3; s. e1000037 |
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| Hlavní autoři: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
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United States
Public Library of Science
01.03.2008
Public Library of Science (PLoS) |
| Témata: | |
| ISSN: | 1553-7404, 1553-7390, 1553-7404 |
| On-line přístup: | Získat plný text |
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| Abstract | The large and diverse population of Latin America is potentially a powerful resource for elucidating the genetic basis of complex traits through admixture mapping. However, no genome-wide characterization of admixture across Latin America has yet been attempted. Here, we report an analysis of admixture in thirteen Mestizo populations (i.e. in regions of mainly European and Native settlement) from seven countries in Latin America based on data for 678 autosomal and 29 X-chromosome microsatellites. We found extensive variation in Native American and European ancestry (and generally low levels of African ancestry) among populations and individuals, and evidence that admixture across Latin America has often involved predominantly European men and both Native and African women. An admixture analysis allowing for Native American population subdivision revealed a differentiation of the Native American ancestry amongst Mestizos. This observation is consistent with the genetic structure of pre-Columbian populations and with admixture having involved Natives from the area where the Mestizo examined are located. Our findings agree with available information on the demographic history of Latin America and have a number of implications for the design of association studies in population from the region. |
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| AbstractList |
The large and diverse population of Latin America is potentially a powerful resource for elucidating the genetic basis of complex traits through admixture mapping. However, no genome-wide characterization of admixture across Latin America has yet been attempted. Here, we report an analysis of admixture in thirteen Mestizo populations (i.e. in regions of mainly European and Native settlement) from seven countries in Latin America based on data for 678 autosomal and 29 X-chromosome microsatellites. We found extensive variation in Native American and European ancestry (and generally low levels of African ancestry) among populations and individuals, and evidence that admixture across Latin America has often involved predominantly European men and both Native and African women. An admixture analysis allowing for Native American population subdivision revealed a differentiation of the Native American ancestry amongst Mestizos. This observation is consistent with the genetic structure of pre-Columbian populations and with admixture having involved Natives from the area where the Mestizo examined are located. Our findings agree with available information on the demographic history of Latin America and have a number of implications for the design of association studies in population from the region. The large and diverse population of Latin America is potentially a powerful resource for elucidating the genetic basis of complex traits through admixture mapping. However, no genome-wide characterization of admixture across Latin America has yet been attempted. Here, we report an analysis of admixture in thirteen Mestizo populations (i.e. in regions of mainly European and Native settlement) from seven countries in Latin America based on data for 678 autosomal and 29 Xchromosome microsatellites. We found extensive variation in Native American and European ancestry (and generally low levels of African ancestry) among populations and individuals, and evidence that admixture across Latin America has often involved predominantly European men and both Native and African women. An admixture analysis allowing for Native American population subdivision revealed a differentiation of the Native American ancestry amongst Mestizos. This observation is consistent with the genetic structure of pre-Columbian populations and with admixture having involved Natives from the area where the Mestizo examined are located. Our findings agree with available information on the demographic history of Latin America and have a number of implications for the design of association studies in population from the region. The large and diverse population of Latin America is potentially a powerful resource for elucidating the genetic basis of complex traits through admixture mapping. However, no genome-wide characterization of admixture across Latin America has yet been attempted. Here, we report an analysis of admixture in thirteen Mestizo populations (i.e. in regions of mainly European and Native settlement) from seven countries in Latin America based on data for 678 autosomal and 29 X-chromosome microsatellites. We found extensive variation in Native American and European ancestry (and generally low levels of African ancestry) among populations and individuals, and evidence that admixture across Latin America has often involved predominantly European men and both Native and African women. An admixture analysis allowing for Native American population subdivision revealed a differentiation of the Native American ancestry amongst Mestizos. This observation is consistent with the genetic structure of pre-Columbian populations and with admixture having involved Natives from the area where the Mestizo examined are located. Our findings agree with available information on the demographic history of Latin America and have a number of implications for the design of association studies in population from the region. The large and diverse population of Latin America is potentially a powerful resource for elucidating the genetic basis of complex traits through admixture mapping. However, no genome-wide characterization of admixture across Latin America has yet been attempted. Here, we report an analysis of admixture in thirteen Mestizo populations (i.e. in regions of mainly European and Native settlement) from seven countries in Latin America based on data for 678 autosomal and 29 X-chromosome microsatellites. We found extensive variation in Native American and European ancestry (and generally low levels of African ancestry) among populations and individuals, and evidence that admixture across Latin America has often involved predominantly European men and both Native and African women. An admixture analysis allowing for Native American population subdivision revealed a differentiation of the Native American ancestry amongst Mestizos. This observation is consistent with the genetic structure of pre-Columbian populations and with admixture having involved Natives from the area where the Mestizo examined are located. Our findings agree with available information on the demographic history of Latin America and have a number of implications for the design of association studies in population from the region. Author Summary The history of Latin America has entailed a complex process of population mixture between Native and recent immigrants across a vast geographic region. Few details are known about this process or about how it has shaped the genetic makeup of contemporary Latin American populations. To perform a broad exploration of the genetic diversity of Latin America we carried out genome-wide analyses in 13 mestizo populations sampled from 7 countries across the region. We observe a marked variation in ancestry both within and between mestizo populations. This variation in ancestry correlates with pre-Columbian Native population density in the areas examined and with recent patterns of demographic growth of the sites sampled. We also find evidence that the mixture at the origin of these populations involved mainly immigrant European men and Native and African women. Finally, mestizo populations show a differentiated Amerindian genetic background, consistent with a predominantly local Native ancestry. Mestizos thus still reveal the genetic imprint of the pre-Columbian Native American population diversification. Our study helps delineate the genetic landscape of Latin America and has a number of implications for gene identification analyses in populations from the region. The large and diverse population of Latin America is potentially a powerful resource for elucidating the genetic basis of complex traits through admixture mapping. However, no genome-wide characterization of admixture across Latin America has yet been attempted. Here, we report an analysis of admixture in thirteen Mestizo populations (i.e. in regions of mainly European and Native settlement) from seven countries in Latin America based on data for 678 autosomal and 29 X-chromosome microsatellites. We found extensive variation in Native American and European ancestry (and generally low levels of African ancestry) among populations and individuals, and evidence that admixture across Latin America has often involved predominantly European men and both Native and African women. An admixture analysis allowing for Native American population subdivision revealed a differentiation of the Native American ancestry amongst Mestizos. This observation is consistent with the genetic structure of pre-Columbian populations and with admixture having involved Natives from the area where the Mestizo examined are located. Our findings agree with available information on the demographic history of Latin America and have a number of implications for the design of association studies in population from the region.The large and diverse population of Latin America is potentially a powerful resource for elucidating the genetic basis of complex traits through admixture mapping. However, no genome-wide characterization of admixture across Latin America has yet been attempted. Here, we report an analysis of admixture in thirteen Mestizo populations (i.e. in regions of mainly European and Native settlement) from seven countries in Latin America based on data for 678 autosomal and 29 X-chromosome microsatellites. We found extensive variation in Native American and European ancestry (and generally low levels of African ancestry) among populations and individuals, and evidence that admixture across Latin America has often involved predominantly European men and both Native and African women. An admixture analysis allowing for Native American population subdivision revealed a differentiation of the Native American ancestry amongst Mestizos. This observation is consistent with the genetic structure of pre-Columbian populations and with admixture having involved Natives from the area where the Mestizo examined are located. Our findings agree with available information on the demographic history of Latin America and have a number of implications for the design of association studies in population from the region. The large and diverse population of Latin America is potentially a powerful resource for elucidating the genetic basis of complex traits through admixture mapping. However, no genome-wide characterization of admixture across Latin America has yet been attempted. Here, we report an analysis of admixture in thirteen Mestizo populations (i.e. in regions of mainly European and Native settlement) from seven countries in Latin America based on data for 678 autosomal and 29 Xchromosome microsatellites. We found extensive variation in Native American and European ancestry (and generally low levels of African ancestry) among populations and individuals, and evidence that admixture across Latin America has often involved predominantly European men and both Native and African women. An admixture analysis allowing for Native American population subdivision revealed a differentiation of the Native American ancestry amongst Mestizos. This observation is consistent with the genetic structure of pre-Columbian populations and with admixture having involved Natives from the area where the Mestizo examined are located. Our findings agree with available information on the demographic history of Latin America and have a number of implications for the design of association studies in population from the region. doi:10.1371/journaLpgen.1000037 The large and diverse population of Latin America is potentially a powerful resource for elucidating the genetic basis of complex traits through admixture mapping. However, no genome-wide characterization of admixture across Latin America has yet been attempted. Here, we report an analysis of admixture in thirteen Mestizo populations (i.e. in regions of mainly European and Native settlement) from seven countries in Latin America based on data for 678 autosomal and 29 X-chromosome microsatellites. We found extensive variation in Native American and European ancestry (and generally low levels of African ancestry) among populations and individuals, and evidence that admixture across Latin America has often involved predominantly European men and both Native and African women. An admixture analysis allowing for Native American population subdivision revealed a differentiation of the Native American ancestry amongst Mestizos. This observation is consistent with the genetic structure of pre-Columbian populations and with admixture having involved Natives from the area where the Mestizo examined are located. Our findings agree with available information on the demographic history of Latin America and have a number of implications for the design of association studies in population from the region. The history of Latin America has entailed a complex process of population mixture between Native and recent immigrants across a vast geographic region. Few details are known about this process or about how it has shaped the genetic makeup of contemporary Latin American populations. To perform a broad exploration of the genetic diversity of Latin America we carried out genome-wide analyses in 13 mestizo populations sampled from 7 countries across the region. We observe a marked variation in ancestry both within and between mestizo populations. This variation in ancestry correlates with pre-Columbian Native population density in the areas examined and with recent patterns of demographic growth of the sites sampled. We also find evidence that the mixture at the origin of these populations involved mainly immigrant European men and Native and African women. Finally, mestizo populations show a differentiated Amerindian genetic background, consistent with a predominantly local Native ancestry. Mestizos thus still reveal the genetic imprint of the pre-Columbian Native American population diversification. Our study helps delineate the genetic landscape of Latin America and has a number of implications for gene identification analyses in populations from the region. |
| Audience | Academic |
| Author | Bedoya, Gabriel Parra, Maria V. Alfaro, Emma L. Gallo, Carla Dipierri, José E. Camrena, Beatriz Bailliet, Graciela Klitz, William Mazzotti, Guido Petzl-Erler, Maria L. Freimer, Nelson B. Ruiz-Linares, Andrés Ray, Nicolas Poletti, Giovanni Llop, Elena Excoffier, Laurent Bortolini, Maria Cátira Wang, Sijia Tsuneto, Luiza T. Bianchi, Nestor O. Rojas, Winston Hurtado, Ana M. Salzano, Francisco M. Rothhammer, Francisco Nicolini, Humberto Hill, Kim Barrantes, Ramiro Molina, Julio A. |
| AuthorAffiliation | 10 Escuela de Biología, Universidad de Costa Rica, San José, Costa Rica 13 Departamento de Genética, Universidade Federal do Paraná, Curitiba, Brazil 15 Laboratory of Human Molecular Population Genetics, IMBICE, La Plata, Argentina 9 Public Health Institute, Oakland, California, United States of America 6 Department of Anthropology, University of New Mexico, Albuquerque, New Mexico, United States of America 7 Departamento de Ciencias Genómicas, Universidad Autónoma de la Ciudad de México, México D.F., México 4 Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú 11 Center for Neurobehavioral Genetics, University of California Los Angeles, Los Angeles, California, United States of America 3 Laboratorio de Genética Molecular, Universidad de Antioquia, Medellín, Colombia 8 School of Public Health, University of California Berkeley, Berkeley, California, United States of America 14 Instituto de Biología de la Altura, Facultad |
| AuthorAffiliation_xml | – name: 16 Programa de Genética Humana, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile – name: 14 Instituto de Biología de la Altura, Facultad de Humanidades y Ciencias Sociales, Universidad Nacional de Jujuy, San Salvador de Jujuy, Argentina – name: 1 The Galton Laboratory, Department of Biology, University College London, London, United Kingdom – name: 15 Laboratory of Human Molecular Population Genetics, IMBICE, La Plata, Argentina – name: 3 Laboratorio de Genética Molecular, Universidad de Antioquia, Medellín, Colombia – name: 5 Facultad de Medicina, Universidad Peruana Cayetano Heredia, Lima, Perú – name: 10 Escuela de Biología, Universidad de Costa Rica, San José, Costa Rica – name: 2 Computational and Molecular Population Genetics Laboratory, University of Bern, Bern, Switzerland – name: 6 Department of Anthropology, University of New Mexico, Albuquerque, New Mexico, United States of America – name: 12 Departamento de Genética, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil – name: University of Oxford, United Kingdom – name: 17 Instituto de Alta Investigación, Universidad de Tarapacá, Arica, Chile – name: 7 Departamento de Ciencias Genómicas, Universidad Autónoma de la Ciudad de México, México D.F., México – name: 8 School of Public Health, University of California Berkeley, Berkeley, California, United States of America – name: 4 Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú – name: 9 Public Health Institute, Oakland, California, United States of America – name: 13 Departamento de Genética, Universidade Federal do Paraná, Curitiba, Brazil – name: 11 Center for Neurobehavioral Genetics, University of California Los Angeles, Los Angeles, California, United States of America |
| Author_xml | – sequence: 1 givenname: Sijia surname: Wang fullname: Wang, Sijia – sequence: 2 givenname: Nicolas surname: Ray fullname: Ray, Nicolas – sequence: 3 givenname: Winston surname: Rojas fullname: Rojas, Winston – sequence: 4 givenname: Maria V. surname: Parra fullname: Parra, Maria V. – sequence: 5 givenname: Gabriel surname: Bedoya fullname: Bedoya, Gabriel – sequence: 6 givenname: Carla surname: Gallo fullname: Gallo, Carla – sequence: 7 givenname: Giovanni surname: Poletti fullname: Poletti, Giovanni – sequence: 8 givenname: Guido surname: Mazzotti fullname: Mazzotti, Guido – sequence: 9 givenname: Kim surname: Hill fullname: Hill, Kim – sequence: 10 givenname: Ana M. surname: Hurtado fullname: Hurtado, Ana M. – sequence: 11 givenname: Beatriz surname: Camrena fullname: Camrena, Beatriz – sequence: 12 givenname: Humberto surname: Nicolini fullname: Nicolini, Humberto – sequence: 13 givenname: William surname: Klitz fullname: Klitz, William – sequence: 14 givenname: Ramiro surname: Barrantes fullname: Barrantes, Ramiro – sequence: 15 givenname: Julio A. surname: Molina fullname: Molina, Julio A. – sequence: 16 givenname: Nelson B. surname: Freimer fullname: Freimer, Nelson B. – sequence: 17 givenname: Maria Cátira surname: Bortolini fullname: Bortolini, Maria Cátira – sequence: 18 givenname: Francisco M. surname: Salzano fullname: Salzano, Francisco M. – sequence: 19 givenname: Maria L. surname: Petzl-Erler fullname: Petzl-Erler, Maria L. – sequence: 20 givenname: Luiza T. surname: Tsuneto fullname: Tsuneto, Luiza T. – sequence: 21 givenname: José E. surname: Dipierri fullname: Dipierri, José E. – sequence: 22 givenname: Emma L. surname: Alfaro fullname: Alfaro, Emma L. – sequence: 23 givenname: Graciela surname: Bailliet fullname: Bailliet, Graciela – sequence: 24 givenname: Nestor O. surname: Bianchi fullname: Bianchi, Nestor O. – sequence: 25 givenname: Elena surname: Llop fullname: Llop, Elena – sequence: 26 givenname: Francisco surname: Rothhammer fullname: Rothhammer, Francisco – sequence: 27 givenname: Laurent surname: Excoffier fullname: Excoffier, Laurent – sequence: 28 givenname: Andrés surname: Ruiz-Linares fullname: Ruiz-Linares, Andrés |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/18369456$$D View this record in MEDLINE/PubMed |
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| Title | Geographic Patterns of Genome Admixture in Latin American Mestizos |
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