A more accurate method for colocalisation analysis allowing for multiple causal variants

In genome-wide association studies (GWAS) it is now common to search for, and find, multiple causal variants located in close proximity. It has also become standard to ask whether different traits share the same causal variants, but one of the popular methods to answer this question, coloc, makes th...

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Veröffentlicht in:	PLoS genetics Jg. 17; H. 9; S. e1009440
1. Verfasser:	Wallace, Chris
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Public Library of Science 29.09.2021 Public Library of Science (PLoS)
Schlagworte:	Adaptation Analysis Bayes Theorem Bayesian statistical decision theory Biology and Life Sciences Causality Computational biology Datasets Gene mapping Genetic Predisposition to Disease Genetic variation Genome-wide association studies Genome-Wide Association Study Genomes Genomics Haplotypes Humans Hypotheses Linkage Disequilibrium Medicine and Health Sciences Methods Research and Analysis Methods Statistics United Kingdom
ISSN:	1553-7404, 1553-7390, 1553-7404
Online-Zugang:	Volltext
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