Genetic compensation: A phenomenon in search of mechanisms

Several recent studies in a number of model systems including zebrafish, Arabidopsis, and mouse have revealed phenotypic differences between knockouts (i.e., mutants) and knockdowns (e.g., antisense-treated animals). These differences have been attributed to a number of reasons including off-target...

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Bibliographic Details
Published in:	PLoS genetics Vol. 13; no. 7; p. e1006780
Main Authors:	El-Brolosy, Mohamed A., Stainier, Didier Y. R.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 13.07.2017 Public Library of Science (PLoS)
Subjects:	Animals Antisense Antisense RNA Arabidopsis Arabidopsis - genetics Biology and life sciences Compensation Danio rerio Defects Dosage compensation Dosage Compensation, Genetic Drosophila Drosophila - genetics Eukaryotes Fruit flies Gene expression Gene Knockdown Techniques Gene Knockout Techniques Gene mutation Genetic research Genetics Insects Medical research Mice MicroRNAs Models, Animal Molecular modelling Mutant Proteins - biosynthesis Mutant Proteins - genetics Organisms Post-transcription Proteins Research and Analysis Methods Review Studies Transcription Transcription, Genetic Yeast Zebrafish - genetics Zebrafish Proteins - genetics
ISSN:	1553-7404, 1553-7390, 1553-7404
Online Access:	Get full text
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