Genetic compensation: A phenomenon in search of mechanisms

Several recent studies in a number of model systems including zebrafish, Arabidopsis, and mouse have revealed phenotypic differences between knockouts (i.e., mutants) and knockdowns (e.g., antisense-treated animals). These differences have been attributed to a number of reasons including off-target...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PLoS genetics Jg. 13; H. 7; S. e1006780
Hauptverfasser:	El-Brolosy, Mohamed A., Stainier, Didier Y. R.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Public Library of Science 13.07.2017 Public Library of Science (PLoS)
Schlagworte:	Animals Antisense Antisense RNA Arabidopsis Arabidopsis - genetics Biology and life sciences Compensation Danio rerio Defects Dosage compensation Dosage Compensation, Genetic Drosophila Drosophila - genetics Eukaryotes Fruit flies Gene expression Gene Knockdown Techniques Gene Knockout Techniques Gene mutation Genetic research Genetics Insects Medical research Mice MicroRNAs Models, Animal Molecular modelling Mutant Proteins - biosynthesis Mutant Proteins - genetics Organisms Post-transcription Proteins Research and Analysis Methods Review Studies Transcription Transcription, Genetic Yeast Zebrafish - genetics Zebrafish Proteins - genetics
ISSN:	1553-7404, 1553-7390, 1553-7404
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!