Genetic compensation: A phenomenon in search of mechanisms

Several recent studies in a number of model systems including zebrafish, Arabidopsis, and mouse have revealed phenotypic differences between knockouts (i.e., mutants) and knockdowns (e.g., antisense-treated animals). These differences have been attributed to a number of reasons including off-target...

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Vydáno v:	PLoS genetics Ročník 13; číslo 7; s. e1006780
Hlavní autoři:	El-Brolosy, Mohamed A., Stainier, Didier Y. R.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Public Library of Science 13.07.2017 Public Library of Science (PLoS)
Témata:	Animals Antisense Antisense RNA Arabidopsis Arabidopsis - genetics Biology and life sciences Compensation Danio rerio Defects Dosage compensation Dosage Compensation, Genetic Drosophila Drosophila - genetics Eukaryotes Fruit flies Gene expression Gene Knockdown Techniques Gene Knockout Techniques Gene mutation Genetic research Genetics Insects Medical research Mice MicroRNAs Models, Animal Molecular modelling Mutant Proteins - biosynthesis Mutant Proteins - genetics Organisms Post-transcription Proteins Research and Analysis Methods Review Studies Transcription Transcription, Genetic Yeast Zebrafish - genetics Zebrafish Proteins - genetics
ISSN:	1553-7404, 1553-7390, 1553-7404
On-line přístup:	Získat plný text
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