Distinct evolutionary dynamics of horizontal gene transfer in drug resistant and virulent clones of Klebsiella pneumoniae

Klebsiella pneumoniae has emerged as an important cause of two distinct public health threats: multi-drug resistant (MDR) healthcare-associated infections and drug susceptible community-acquired invasive infections. These pathotypes are generally associated with two distinct subsets of K. pneumoniae...

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Bibliographic Details
Published in:	PLoS genetics Vol. 15; no. 4; p. e1008114
Main Authors:	Wyres, Kelly L., Wick, Ryan R., Judd, Louise M., Froumine, Roni, Tokolyi, Alex, Gorrie, Claire L., Lam, Margaret M. C., Duchêne, Sebastián, Jenney, Adam, Holt, Kathryn E.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 15.04.2019 Public Library of Science (PLoS)
Subjects:	Antimicrobial agents Biochemistry Bioinformatics Biotechnology Cloning CRISPR Disease susceptibility Drug resistance Epidemics Epidemiology Evolution Evolutionary genetics Gene transfer Genes Genetic aspects Genetic research Genetic transformation Genomes Genomics Hospitals Infection Infections Infectious diseases Klebsiella Klebsiella pneumoniae Molecular biology Multidrug resistance Natural history Phages Phylogenetics Plasmids Pneumonia Polysaccharides Public health Recombination Virulence Virulence (Microbiology) United Kingdom > UK Australia Victoria Australia
ISSN:	1553-7404, 1553-7390, 1553-7404
Online Access:	Get full text
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