Structural Basis of Transcriptional Gene Silencing Mediated by Arabidopsis MOM1

Shifts between epigenetic states of transcriptional activity are typically correlated with changes in epigenetic marks. However, exceptions to this rule suggest the existence of additional, as yet uncharacterized, layers of epigenetic regulation. MOM1, a protein of 2,001 amino acids that acts as a t...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	PLoS genetics Ročník 8; číslo 2; s. e1002484
Hlavní autoři:	Nishimura, Taisuke, Molinard, Guillaume, Petty, Tom J., Broger, Larissa, Gabus, Caroline, Halazonetis, Thanos D., Thore, Stéphane, Paszkowski, Jerzy
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Public Library of Science 01.02.2012 Public Library of Science (PLoS)
Témata:	Amino Acid Sequence Arabidopsis - chemistry Arabidopsis - genetics Arabidopsis Proteins - chemistry Arabidopsis Proteins - genetics Arabidopsis thaliana Biology Crystallography, X-Ray Deoxyribonucleic acid Derivatives DNA DNA methylation Efficiency Epigenesis, Genetic - genetics Epigenetics Experiments Gene Expression Regulation, Plant Gene Silencing Genes Genetic aspects Genetic engineering Genetic transcription Molecular Sequence Data Mutagenesis Nuclear Proteins - chemistry Nuclear Proteins - genetics Plants, Genetically Modified Protein Conformation Protein Folding Protein Multimerization Protein Structure, Tertiary - genetics Proteins RNA, Small Interfering - genetics Structure-Activity Relationship Transcription Factors - chemistry Transcription Factors - genetics Transcription, Genetic Japan
ISSN:	1553-7404, 1553-7390, 1553-7404
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Abstract	Shifts between epigenetic states of transcriptional activity are typically correlated with changes in epigenetic marks. However, exceptions to this rule suggest the existence of additional, as yet uncharacterized, layers of epigenetic regulation. MOM1, a protein of 2,001 amino acids that acts as a transcriptional silencer, represents such an exception. Here we define the 82 amino acid domain called CMM2 (Conserved MOM1 Motif 2) as a minimal MOM1 fragment capable of transcriptional regulation. As determined by X-ray crystallography, this motif folds into an unusual hendecad-based coiled-coil. Structure-based mutagenesis followed by transgenic complementation tests in plants demonstrate that CMM2 and its dimerization are effective for transcriptional suppression at chromosomal loci co-regulated by MOM1 and the siRNA pathway but not at loci controlled by MOM1 in an siRNA-independent fashion. These results reveal a surprising separation of epigenetic activities that enable the single, large MOM1 protein to coordinate cooperating mechanisms of epigenetic regulation.
AbstractList	Shifts between epigenetic states of transcriptional activity are typically correlated with changes in epigenetic marks. However, exceptions to this rule suggest the existence of additional, as yet uncharacterized, layers of epigenetic regulation. MOM1, a protein of 2,001 amino acids that acts as a transcriptional silencer, represents such an exception. Here we define the 82 amino acid domain called CMM2 (Conserved MOM1 Motif 2) as a minimal MOM1 fragment capable of transcriptional regulation. As determined by X-ray crystallography, this motif folds into an unusual hendecad-based coiled-coil. Structure-based mutagenesis followed by transgenic complementation tests in plants demonstrate that CMM2 and its dimerization are effective for transcriptional suppression at chromosomal loci co-regulated by MOM1 and the siRNA pathway but not at loci controlled by MOM1 in an siRNA-independent fashion. These results reveal a surprising separation of epigenetic activities that enable the single, large MOM1 protein to coordinate cooperating mechanisms of epigenetic regulation. Shifts between epigenetic states of transcriptional activity are typically correlated with changes in epigenetic marks. However, exceptions to this rule suggest the existence of additional, as yet uncharacterized, layers of epigenetic regulation. MOM1, a protein of 2,001 amino acids that acts as a transcriptional silencer, represents such an exception. Here we define the 82 amino acid domain called CMM2 (Conserved MOM1 Motif 2) as a minimal MOM1 fragment capable of transcriptional regulation. As determined by X-ray crystallography, this motif folds into an unusual hendecad-based coiled-coil. Structure-based mutagenesis followed by transgenic complementation tests in plants demonstrate that CMM2 and its dimerization are effective for transcriptional suppression at chromosomal loci co-regulated by MOM1 and the siRNA pathway but not at loci controlled by MOM1 in an siRNA-independent fashion. These results reveal a surprising separation of epigenetic activities that enable the single, large MOM1 protein to coordinate cooperating mechanisms of epigenetic regulation.Shifts between epigenetic states of transcriptional activity are typically correlated with changes in epigenetic marks. However, exceptions to this rule suggest the existence of additional, as yet uncharacterized, layers of epigenetic regulation. MOM1, a protein of 2,001 amino acids that acts as a transcriptional silencer, represents such an exception. Here we define the 82 amino acid domain called CMM2 (Conserved MOM1 Motif 2) as a minimal MOM1 fragment capable of transcriptional regulation. As determined by X-ray crystallography, this motif folds into an unusual hendecad-based coiled-coil. Structure-based mutagenesis followed by transgenic complementation tests in plants demonstrate that CMM2 and its dimerization are effective for transcriptional suppression at chromosomal loci co-regulated by MOM1 and the siRNA pathway but not at loci controlled by MOM1 in an siRNA-independent fashion. These results reveal a surprising separation of epigenetic activities that enable the single, large MOM1 protein to coordinate cooperating mechanisms of epigenetic regulation. Shifts between epigenetic states of transcriptional activity are typically correlated with changes in epigenetic marks. However, exceptions to this rule suggest the existence of additional, as yet uncharacterized, layers of epigenetic regulation. MOM1, a protein of 2,001 amino acids that acts as a transcriptional silencer, represents such an exception. Here we define the 82 amino acid domain called CMM2 (Conserved MOM1 Motif 2) as a minimal MOM1 fragment capable of transcriptional regulation. As determined by X-ray crystallography, this motif folds into an unusual hendecad-based coiled-coil. Structure-based mutagenesis followed by transgenic complementation tests in plants demonstrate that CMM2 and its dimerization are effective for transcriptional suppression at chromosomal loci co-regulated by MOM1 and the siRNA pathway but not at loci controlled by MOM1 in an siRNA–independent fashion. These results reveal a surprising separation of epigenetic activities that enable the single, large MOM1 protein to coordinate cooperating mechanisms of epigenetic regulation. Epigenetic shifts in transcriptional activities are usually correlated with changes in chromatin properties and covalent modification of DNA and/or histones. There are, however, exceptional regulators that are able to switch epigenetic states without the apparent involvement of changes in chromatin or DNA modifications. MOM1 protein, derived from CHD3 chromatin remodelers, belongs to this group. Here we defined a very small domain of MOM1 (less than 5% of its total sequence) that is sufficient for epigenetic regulation. We solved the structure of this domain and found that it forms a dimer with each monomer consisting of unusual consecutive 11 amino-acid hendecad repeats folding into an antiparallel coiled-coil. In vivo experiments demonstrated that the formation of this coiled-coil is essential for silencing activity; however, it is effective only at loci co-silenced by MOM1 and small RNAs. At loci not controlled by small RNAs, the entire MOM1 protein is required. Our results demonstrate that a single epigenetic regulator is able to differentially use its domains to control diverse chromosomal targets. The acquisition of the coiled-coil domain of MOM1 reflects a neofunctionalization of CHD3 proteins, which allowed MOM1 to broaden its activity and to provide input into multiple epigenetic pathways. Shifts between epigenetic states of transcriptional activity are typically correlated with changes in epigenetic marks. However, exceptions to this rule suggest the existence of additional, as yet uncharacterized, layers of epigenetic regulation. MOM1, a protein of 2,001 amino acids that acts as a transcriptional silencer, represents such an exception. Here we define the 82 amino acid domain called CMM2 (Conserved MOM1 Motif 2) as a minimal MOM1 fragment capable of transcriptional regulation. As determined by X-ray crystallography, this motif folds into an unusual hendecad-based coiled-coil. Structure-based mutagenesis followed by transgenic complementation tests in plants demonstrate that CMM2 and its dimerization are effective for transcriptional suppression at chromosomal loci co-regulated by MOM1 and the siRNA pathway but not at loci controlled by MOM1 in an siRNA-independent fashion. These results reveal a surprising separation of epigenetic activities that enable the single, large MOM1 protein to coordinate cooperating mechanisms of epigenetic regulation.
Audience	Academic
Author	Gabus, Caroline Broger, Larissa Petty, Tom J. Paszkowski, Jerzy Halazonetis, Thanos D. Molinard, Guillaume Nishimura, Taisuke Thore, Stéphane
AuthorAffiliation	2 Department of Molecular Biology, University of Geneva, Geneva, Switzerland University of Michigan, United States of America 1 Department of Plant Biology, University of Geneva, Geneva, Switzerland
AuthorAffiliation_xml	– name: 1 Department of Plant Biology, University of Geneva, Geneva, Switzerland – name: University of Michigan, United States of America – name: 2 Department of Molecular Biology, University of Geneva, Geneva, Switzerland
Author_xml	– sequence: 1 givenname: Taisuke surname: Nishimura fullname: Nishimura, Taisuke – sequence: 2 givenname: Guillaume surname: Molinard fullname: Molinard, Guillaume – sequence: 3 givenname: Tom J. surname: Petty fullname: Petty, Tom J. – sequence: 4 givenname: Larissa surname: Broger fullname: Broger, Larissa – sequence: 5 givenname: Caroline surname: Gabus fullname: Gabus, Caroline – sequence: 6 givenname: Thanos D. surname: Halazonetis fullname: Halazonetis, Thanos D. – sequence: 7 givenname: Stéphane surname: Thore fullname: Thore, Stéphane – sequence: 8 givenname: Jerzy surname: Paszkowski fullname: Paszkowski, Jerzy
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/22346760$$D View this record in MEDLINE/PubMed
BookMark	eNqVk1uL00AYhoOsuLvVfyAaEBQvWueYSbwQ6qJrYWvBrt4Okzmks6SZOpOI---d2FSaZRElkITked9vvtN5ctK4RifJUwhmEDP45sZ1vhH1bFfpZgYBQCQnD5IzSCmeMgLIydH7aXIewg0AmOYFe5ScIoRJxjJwlqzWre9k23lRp-9FsCF1Jr32ognS211rXQyRXupGp2tb60bapkqXWlnRapWWt-nci9Iqt-uVy9USPk4eGlEH_WR4TpKvHz9cX3yaXq0uFxfzq6lkBWynplDGsFKomArLsc4oYJnCSJWGGqQZJbqUomQaSgGxyBWVCmSSYgwBRIXEk-T53ndXu8CHWgQOMYw5ZqygkVjsCeXEDd95uxX-ljth-e8Pzldc-NbKWnNVUEYyzZigiJTaCEAKbADKAY4nifdJ8m6I1pVbraRu2liwken4T2M3vHI_OEYsowRHg1eDgXffOx1avrVB6roWjXZd4AVCjBYEZZF8cYe8P7mBqkQ8v22Mi2Fl78nnKEcgyxkkkZrdQ8VL6a2VcZxM7OlY8HokiEyrf7aV6ELgi_WX_2A__zu7-jZmXx6xGy3qdhNc3fWzGMbgs-Om_OnGYbgj8HYPSO9C8NpwaVvR-8Qy2JpDwPtNOhSY95vEh02KYnJHfPD_q-wXm90fiA
CitedBy_id	crossref_primary_10_1016_j_jsb_2012_10_006 crossref_primary_10_1016_j_mrfmmm_2016_04_003 crossref_primary_10_1111_nph_16752 crossref_primary_10_1007_s10722_020_00928_1 crossref_primary_10_3389_fpls_2023_1133327 crossref_primary_10_1038_s41467_023_39751_4 crossref_primary_10_3389_fpls_2015_00380 crossref_primary_10_1080_07352689_2014_852920 crossref_primary_10_1371_journal_pone_0202137 crossref_primary_10_1016_j_cell_2019_03_017 crossref_primary_10_1016_j_devcel_2018_11_031 crossref_primary_10_1111_tpj_14098 crossref_primary_10_1073_pnas_1402275111
Cites_doi	10.1038/nrg2719 10.1016/j.cub.2007.01.009 10.1038/sj.emboj.7600430 10.1093/emboj/cdf687 10.1038/emboj.2009.374 10.1038/79006 10.1104/pp.110.162131 10.1101/gad.905701 10.1046/j.1365-313X.2003.01667.x 10.1101/gad.1667808 10.1016/j.cub.2005.09.044 10.1271/bbb.100184 10.1107/S0907444903017694 10.1107/S0907444902011678 10.1016/S0960-9822(00)00862-9 10.1038/nsmb.1761 10.1111/j.1365-313X.2008.03631.x 10.1038/sj.embor.7400791 10.1016/j.cell.2007.07.007 10.1107/S0907444909052925 10.1038/nsb0497-269 10.1002/(SICI)1097-0134(199610)26:2<134::AID-PROT3>3.0.CO;2-G 10.1016/j.chom.2011.02.008 10.1093/emboj/cdf657 10.1105/tpc.12.7.1165 10.1016/j.cell.2009.12.023 10.1371/journal.pone.0003156 10.1107/S0365110X53001952 10.1038/emboj.2009.328 10.1073/pnas.1432939100 10.1107/S0907444909038360 10.1093/genetics/163.3.1109 10.1038/nature731 10.1107/S1744309110021068 10.1371/journal.pgen.1000156 10.1046/j.1365-313x.1998.00343.x 10.1107/S0907444904019158 10.1126/science.1059745 10.1016/j.ceb.2009.01.025 10.1016/S1359-0278(97)00021-7 10.1107/S0108767307043930 10.1038/sj.embor.7400835 10.1371/journal.pgen.1000165 10.1038/ng1138 10.1038/35012108
ContentType	Journal Article
Copyright	COPYRIGHT 2012 Public Library of Science 2012 Nishimura et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Nishimura T, Molinard G, Petty TJ, Broger L, Gabus C, et al. (2012) Structural Basis of Transcriptional Gene Silencing Mediated by Arabidopsis MOM1. PLoS Genet 8(2): e1002484. doi:10.1371/journal.pgen.1002484 Nishimura et al. 2012
Copyright_xml	– notice: COPYRIGHT 2012 Public Library of Science – notice: 2012 Nishimura et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Nishimura T, Molinard G, Petty TJ, Broger L, Gabus C, et al. (2012) Structural Basis of Transcriptional Gene Silencing Mediated by Arabidopsis MOM1. PLoS Genet 8(2): e1002484. doi:10.1371/journal.pgen.1002484 – notice: Nishimura et al. 2012
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM IOV ISN ISR 3V. 7QP 7QR 7SS 7TK 7TM 7TO 7X7 7XB 88E 8FD 8FE 8FH 8FI 8FJ 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. LK8 M0S M1P M7P P64 PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS RC3 7X8 5PM DOA
DOI	10.1371/journal.pgen.1002484
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Gale In Context: Opposing Viewpoints Gale In Context: Canada Gale In Context: Science ProQuest Central (Corporate) Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Entomology Abstracts (Full archive) Neurosciences Abstracts Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Technology Research Database ProQuest SciTech Collection ProQuest Natural Science Collection ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials - QC Biological Science Collection ProQuest Central Natural Science Collection ProQuest One Community College ProQuest Central Korea Engineering Research Database ProQuest Health & Medical Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences ProQuest Health & Medical Collection Medical Database Biological Science Database Biotechnology and BioEngineering Abstracts Proquest Central Premium ProQuest One Academic Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) Directory of Open Access Journals (DOAJ)
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Publicly Available Content Database ProQuest Central Student Oncogenes and Growth Factors Abstracts Technology Research Database ProQuest One Academic Middle East (New) ProQuest Central Essentials Nucleic Acids Abstracts ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Central China ProQuest Central ProQuest One Applied & Life Sciences ProQuest Health & Medical Research Collection Genetics Abstracts Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Health & Medical Research Collection Biological Science Collection AIDS and Cancer Research Abstracts Chemoreception Abstracts ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Entomology Abstracts ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	Publicly Available Content Database MEDLINE - Academic MEDLINE
Database_xml	– sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Biology
DocumentTitleAlternate	Structural Basis of MOM1 Function
EISSN	1553-7404
ExternalDocumentID	1313586795 oai_doaj_org_article_d95746e77a524befa0493f0280375480 PMC3276543 2904984861 A282068714 22346760 10_1371_journal_pgen_1002484
Genre	Research Support, Non-U.S. Gov't Journal Article
GeographicLocations	Japan
GeographicLocations_xml	– name: Japan
GroupedDBID	--- 123 29O 2WC 53G 5VS 7X7 88E 8FE 8FH 8FI 8FJ AAFWJ AAUCC AAWOE AAYXX ABDBF ABUWG ACCTH ACGFO ACIHN ACIWK ACPRK ACUHS ADBBV ADRAZ AEAQA AENEX AFFHD AFKRA AFPKN AHMBA ALMA_UNASSIGNED_HOLDINGS AOIJS B0M BAWUL BBNVY BCNDV BENPR BHPHI BPHCQ BVXVI BWKFM C1A CCPQU CITATION CS3 DIK DU5 E3Z EAP EAS EBD EBS EJD EMK EMOBN ESX F5P FPL FYUFA GROUPED_DOAJ GX1 HCIFZ HMCUK HYE IAO IGS IHR IHW INH INR IOV ISN ISR ITC KQ8 LK8 M1P M48 M7P O5R O5S OK1 OVT P2P PHGZM PHGZT PIMPY PJZUB PPXIY PQGLB PQQKQ PROAC PSQYO QF4 QN7 RNS RPM SV3 TR2 TUS UKHRP WOW XSB ~8M 3V. ALIPV CGR CUY CVF ECM EIF H13 IPNFZ M~E NPM PV9 RIG RZL WOQ 7QP 7QR 7SS 7TK 7TM 7TO 7XB 8FD 8FK AZQEC DWQXO FR3 GNUQQ H94 K9. P64 PKEHL PQEST PQUKI PRINS RC3 7X8 PUEGO 5PM AAPBV ABPTK
ID	FETCH-LOGICAL-c791t-f9dff7bad137783e65076d32dbf5f2e754ebcab7e1ca13a8d5cd06c53310129c3
IEDL.DBID	BENPR
ISICitedReferencesCount	18
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000300725500011&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	1553-7404 1553-7390
IngestDate	Sun Oct 01 00:20:32 EDT 2023 Mon Nov 10 04:34:10 EST 2025 Tue Nov 04 01:53:46 EST 2025 Fri Sep 05 06:10:07 EDT 2025 Sat Nov 29 14:59:41 EST 2025 Tue Nov 11 10:28:00 EST 2025 Tue Nov 04 18:07:27 EST 2025 Thu Nov 13 15:32:03 EST 2025 Thu Nov 13 15:28:35 EST 2025 Thu Nov 13 15:54:11 EST 2025 Thu May 22 21:21:10 EDT 2025 Wed Feb 19 01:55:00 EST 2025 Sat Nov 29 01:38:11 EST 2025 Tue Nov 18 21:57:45 EST 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	2
Language	English
License	This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. Creative Commons Attribution License
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c791t-f9dff7bad137783e65076d32dbf5f2e754ebcab7e1ca13a8d5cd06c53310129c3
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 a: Current address: PRESTO, Japan Science and Technology Agency, Honcho Kawaguchi, Japan b: Current address: Bioscience and Biotechnology Center, Nagoya University, Nagoya, Japan Conceived and designed the experiments: TN TDH ST JP. Performed the experiments: TN GM TJP LB CG TDH ST. Analyzed the data: TN TJP TDH ST JP. Contributed reagents/materials/analysis tools: TN TDH ST JP. Wrote the paper: TN ST JP.
OpenAccessLink	https://www.proquest.com/docview/1313586795?pq-origsite=%requestingapplication%
PMID	22346760
PQID	1313586795
PQPubID	1436339
ParticipantIDs	plos_journals_1313586795 doaj_primary_oai_doaj_org_article_d95746e77a524befa0493f0280375480 pubmedcentral_primary_oai_pubmedcentral_nih_gov_3276543 proquest_miscellaneous_922759426 proquest_journals_1313586795 gale_infotracmisc_A282068714 gale_infotracacademiconefile_A282068714 gale_incontextgauss_ISR_A282068714 gale_incontextgauss_ISN_A282068714 gale_incontextgauss_IOV_A282068714 gale_healthsolutions_A282068714 pubmed_primary_22346760 crossref_citationtrail_10_1371_journal_pgen_1002484 crossref_primary_10_1371_journal_pgen_1002484
PublicationCentury	2000
PublicationDate	2012-02-01
PublicationDateYYYYMMDD	2012-02-01
PublicationDate_xml	– month: 02 year: 2012 text: 2012-02-01 day: 01
PublicationDecade	2010
PublicationPlace	United States
PublicationPlace_xml	– name: United States – name: San Francisco – name: San Francisco, USA
PublicationTitle	PLoS genetics
PublicationTitleAlternate	PLoS Genet
PublicationYear	2012
Publisher	Public Library of Science Public Library of Science (PLoS)
Publisher_xml	– name: Public Library of Science – name: Public Library of Science (PLoS)
References	HR Woo (ref4) 2008; 4 L Bartee (ref6) 2001; 15 SJ Clough (ref38) 1998; 16 GM Sheldrick (ref40) 2008; 64 WJJ Soppe (ref14) 2002; 21 T Maekawa (ref34) 2011; 9 S Nakamura (ref37) 2010; 74 P Emsley (ref44) 2004; 60 AM Lindroth (ref8) 2004; 23 I Vaillant (ref21) 2006; 7 LM Johnson (ref13) 2007; 17 T Elmayen (ref31) 2005; 15 PD Adams (ref45) 2010; 66 IR Henderson (ref30) 2008; 22 LK Lee (ref33) 2010; 17 K Diederichs (ref46) 1997; 4 H Saze (ref3) 2003; 34 MR Hicks (ref29) 1997; 2 B Khraiwesh (ref35) 2010; 140 A Steimer (ref18) 2000; 12 P Amedeo (ref17) 2000; 405 AV Probst (ref19) 2003; 33 Y Habu (ref20) 2006; 7 M Čaikovski (ref24) 2008; 4 M Matzke (ref9) 2009; 21 JA Law (ref1) 2010; 11 C Yokthongwattana (ref23) 2010; 29 YV Bernatavichute (ref10) 2008; 3 K Cowtan (ref43) 1994; 31 MW Kankel (ref2) 2003; 163 FHC Crick (ref27) 1953; 6 H Numa (ref22) 2010; 29 JP Jackson (ref12) 2002; 416 G Bricogne (ref42) 2003; 59 JH Brown (ref28) 1996; 26 E Kraft (ref5) 2008; 56 AM Lindroth (ref7) 2001; 292 JB Morel (ref25) 2000; 10 M Tariq (ref15) 2003; 100 GM Sheldrick (ref41) 2010; 66 F Malagnac (ref11) 2002; 21 J Stetefeld (ref32) 2000; 7 TJ Petty (ref26) 2010; 66 O Mathieu (ref16) 2007; 130 TR Schneider (ref39) 2002; 58 Y Zhou (ref36) 2010; 154 11349138 - Science. 2001 Jun 15;292(5524):2077-80 20530878 - Biosci Biotechnol Biochem. 2010;74(6):1315-9 8916221 - Proteins. 1996 Oct;26(2):134-45 20010696 - EMBO J. 2010 Jan 20;29(2):352-62 12663548 - Genetics. 2003 Mar;163(3):1109-22 20693667 - Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Aug 1;66(Pt 8):916-8 15572765 - Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 1):2126-32 18156677 - Acta Crystallogr A. 2008 Jan;64(Pt 1):112-22 11137011 - Curr Biol. 2000 Dec 14-28;10(24):1591-4 12456661 - EMBO J. 2002 Dec 2;21(23):6549-59 20383001 - Acta Crystallogr D Biol Crystallogr. 2010 Apr;66(Pt 4):479-85 17082821 - EMBO Rep. 2006 Dec;7(12):1273-8 20085706 - Cell. 2010 Jan 8;140(1):111-22 12486005 - EMBO J. 2002 Dec 16;21(24):6842-52 15457214 - EMBO J. 2004 Oct 27;23(21):4286-96 12669067 - Nat Genet. 2003 May;34(1):65-9 12609046 - Plant J. 2003 Feb;33(4):743-9 10069079 - Plant J. 1998 Dec;16(6):735-43 10899982 - Plant Cell. 2000 Jul;12(7):1165-78 18643997 - Plant J. 2008 Dec;56(5):704-15 10821279 - Nature. 2000 May 11;405(6783):203-6 11898023 - Nature. 2002 Apr 4;416(6880):556-60 11459824 - Genes Dev. 2001 Jul 15;15(14):1753-8 17803908 - Cell. 2007 Sep 7;130(5):851-62 19243928 - Curr Opin Cell Biol. 2009 Jun;21(3):367-76 12351820 - Acta Crystallogr D Biol Crystallogr. 2002 Oct;58(Pt 10 Pt 2):1772-9 18559476 - Genes Dev. 2008 Jun 15;22(12):1597-606 20142834 - Nat Rev Genet. 2010 Mar;11(3):204-20 18704160 - PLoS Genet. 2008;4(8):e1000156 9218952 - Fold Des. 1997;2(3):149-58 18776934 - PLoS One. 2008;3(9):e3156 20124702 - Acta Crystallogr D Biol Crystallogr. 2010 Feb;66(Pt 2):213-21 19910926 - EMBO J. 2010 Jan 20;29(2):340-51 14573958 - Acta Crystallogr D Biol Crystallogr. 2003 Nov;59(Pt 11):2023-30 9095194 - Nat Struct Biol. 1997 Apr;4(4):269-75 17082818 - EMBO Rep. 2006 Dec;7(12):1279-84 16271868 - Curr Biol. 2005 Nov 8;15(21):1919-25 21402358 - Cell Host Microbe. 2011 Mar 17;9(3):187-99 18725928 - PLoS Genet. 2008;4(8):e1000165 17239600 - Curr Biol. 2007 Feb 20;17(4):379-84 12853574 - Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):8823-7 10966648 - Nat Struct Biol. 2000 Sep;7(9):772-6 20173764 - Nat Struct Mol Biol. 2010 Mar;17(3):373-8 20826701 - Plant Physiol. 2010 Nov;154(3):1272-80
References_xml	– volume: 11 start-page: 204 year: 2010 ident: ref1 article-title: Establishing, maintaining and modifying DNA methylation patterns in plants and animals. publication-title: Nat Rev Genet doi: 10.1038/nrg2719 – volume: 17 start-page: 379 year: 2007 ident: ref13 article-title: The SRA methyl-cytosine-binding domain links DNA and histone methylation. publication-title: Curr Biol doi: 10.1016/j.cub.2007.01.009 – volume: 23 start-page: 4146 year: 2004 ident: ref8 article-title: Dual histone H3 methylation marks at lysines 9 and 27 required for interaction with CHROMOMETHYLASE3. publication-title: EMBO J doi: 10.1038/sj.emboj.7600430 – volume: 21 start-page: 6842 year: 2002 ident: ref11 article-title: An Arabidopsis SET domain protein required for maintenance but not establishment of DNA methylation. publication-title: EMBO J doi: 10.1093/emboj/cdf687 – volume: 29 start-page: 352 year: 2010 ident: ref22 article-title: Transduction of RNA-directed DNA methylation signals to repressive histone marks in Arabidopsis thaliana. publication-title: EMBO J doi: 10.1038/emboj.2009.374 – volume: 7 start-page: 772 year: 2000 ident: ref32 article-title: Crystal structure of a naturally occurring parallel right-handed coiled coil tetramer. publication-title: Nat Struct Biol doi: 10.1038/79006 – volume: 154 start-page: 1272 year: 2010 ident: ref36 article-title: MORPHEUS' MOLECULE1 is required to prevent aberrant RNA transcriptional read-through in Arabidopsis. publication-title: Plant Physiol doi: 10.1104/pp.110.162131 – volume: 15 start-page: 1753 year: 2001 ident: ref6 article-title: Arabidopsis cmt3 chromomethylase mutations block non-CG methylation and silencing of an endogenous gene. publication-title: Gene Dev doi: 10.1101/gad.905701 – volume: 33 start-page: 743 year: 2003 ident: ref19 article-title: Two means of transcriptional reactivation within heterochromatin. publication-title: Plant J doi: 10.1046/j.1365-313X.2003.01667.x – volume: 22 start-page: 1597 year: 2008 ident: ref30 article-title: Tandem repeats upstream of the Arabidopsis endogene SDC recruit non-CG DNA methylation and initiate siRNA spreading. publication-title: Gene Dev doi: 10.1101/gad.1667808 – volume: 15 start-page: 1919 year: 2005 ident: ref31 article-title: Arabidopsis RPA2: a genetic link among transcriptional gene silencing, DNA repair, and DNA replication. publication-title: Curr Biol doi: 10.1016/j.cub.2005.09.044 – volume: 74 start-page: 1315 year: 2010 ident: ref37 article-title: Gateway binary vectors with the bialaphos resistance gene, bar, as a selection marker for plant transformation. publication-title: Biosci Biotech Bioch doi: 10.1271/bbb.100184 – volume: 59 start-page: 2023 year: 2003 ident: ref42 article-title: Generation, representation and flow of phase information in structure determination: recent developments in and around SHARP 2.0. publication-title: Acta Crystallogr D doi: 10.1107/S0907444903017694 – volume: 58 start-page: 1772 year: 2002 ident: ref39 article-title: Substructure solution with SHELXD. publication-title: Acta Crystallogr D doi: 10.1107/S0907444902011678 – volume: 10 start-page: 1591 year: 2000 ident: ref25 article-title: DNA methylation and chromatin structure affect transcriptional and post-transcriptional transgene silencing in Arabidopsis. publication-title: Curr Biol doi: 10.1016/S0960-9822(00)00862-9 – volume: 17 start-page: 373 year: 2010 ident: ref33 article-title: The structure of the peripheral stalk of Thermus thermophilus H+-ATPase/synthase. publication-title: Nat Struct Mol Biol doi: 10.1038/nsmb.1761 – volume: 31 start-page: 34 year: 1994 ident: ref43 article-title: ‘dm’: An automated procedure for phase improvement by density modification. publication-title: Joint CCP4 and ESF-EACBM Newsletter on Protein Crystallography – volume: 56 start-page: 704 year: 2008 ident: ref5 article-title: ORTH/VIM proteins that regulate DNA methylation are functional ubiquitin E3 ligases. publication-title: Plant J doi: 10.1111/j.1365-313X.2008.03631.x – volume: 7 start-page: 1273 year: 2006 ident: ref21 article-title: MOM1 mediates DNA-methylation-independent silencing of repetitive sequences in Arabidopsis. publication-title: EMBO Rep doi: 10.1038/sj.embor.7400791 – volume: 130 start-page: 851 year: 2007 ident: ref16 article-title: Transgenerational stability of the Arabidopsis epigenome is coordinated by CG methylation. publication-title: Cell doi: 10.1016/j.cell.2007.07.007 – volume: 66 start-page: 213 year: 2010 ident: ref45 article-title: PHENIX: a comprehensive Python-based system for macromolecular structure solution. publication-title: Acta Crystallogr D doi: 10.1107/S0907444909052925 – volume: 4 start-page: 269 year: 1997 ident: ref46 article-title: Improved R-factors for diffraction data analysis in macromolecular crystallography. publication-title: Nat Struct Biol doi: 10.1038/nsb0497-269 – volume: 26 start-page: 134 year: 1996 ident: ref28 article-title: Heptad breaks in alpha-helical coiled coils: Stutters and stammers. publication-title: Proteins doi: 10.1002/(SICI)1097-0134(199610)26:2<134::AID-PROT3>3.0.CO;2-G – volume: 9 start-page: 187 year: 2011 ident: ref34 article-title: Coiled-coil domain-dependent homodimerization of intracellular barley immune reseptors defines a minimal functional module for triggering cell death. publication-title: Cell Host Microbe doi: 10.1016/j.chom.2011.02.008 – volume: 21 start-page: 6549 year: 2002 ident: ref14 article-title: DNA methylation controls histone H3 lysine 9 methylation and heterochromatin assembly in Arabidopsis. publication-title: EMBO J doi: 10.1093/emboj/cdf657 – volume: 12 start-page: 1165 year: 2000 ident: ref18 article-title: Endogenous targets of transcriptional gene silencing in Arabidopsis. publication-title: Plant Cell doi: 10.1105/tpc.12.7.1165 – volume: 140 start-page: 111 year: 2010 ident: ref35 article-title: Transcriptional control of gene expression by microRNAs. publication-title: Cell doi: 10.1016/j.cell.2009.12.023 – volume: 3 start-page: e3156 year: 2008 ident: ref10 article-title: Genome-Wide Association of Histone H3 Lysine Nine Methylation with CHG DNA Methylation in Arabidopsis thaliana. publication-title: PLoS ONE doi: 10.1371/journal.pone.0003156 – volume: 6 start-page: 685 year: 1953 ident: ref27 article-title: The fourier transform of a coiled-coil. publication-title: Acta Crystallogr doi: 10.1107/S0365110X53001952 – volume: 29 start-page: 340 year: 2010 ident: ref23 article-title: MOM1 and Pol-IV/V interactions regulate the intensity and specificity of transcriptional gene silencing. publication-title: EMBO J doi: 10.1038/emboj.2009.328 – volume: 100 start-page: 8823 year: 2003 ident: ref15 article-title: Erasure of CpG methylation in Arabidopsis alters patterns of histone H3 methylation in heterochromatin. publication-title: Pros Natl Acad Sci U S A doi: 10.1073/pnas.1432939100 – volume: 66 start-page: 479 year: 2010 ident: ref41 article-title: Experimental phasing with SHELXC/D/E: combining chain tracing with density modification. publication-title: Acta Crystallogr D doi: 10.1107/S0907444909038360 – volume: 163 start-page: 1109 year: 2003 ident: ref2 article-title: Arabidopsis MET1 cytosine methyltransferase mutants. publication-title: Genetics doi: 10.1093/genetics/163.3.1109 – volume: 416 start-page: 556 year: 2002 ident: ref12 article-title: Control of CpNpG DNA methylation by the KRYPTONITE histone H3 methyltransferase. publication-title: Nature doi: 10.1038/nature731 – volume: 66 start-page: 916 year: 2010 ident: ref26 article-title: Expression, crystallization and preliminary X-ray diffraction analysis of the CMM2 region of the Arabidopsis thaliana Morpheus' molecule 1 protein. publication-title: Acta Crystallogr F doi: 10.1107/S1744309110021068 – volume: 4 start-page: e1000156 year: 2008 ident: ref4 article-title: Three SRA-Domain Methylcytosine-Binding Proteins Cooperate to Maintain Global CpG Methylation and Epigenetic Silencing in Arabidopsis. publication-title: PLoS Genet doi: 10.1371/journal.pgen.1000156 – volume: 16 start-page: 735 year: 1998 ident: ref38 article-title: Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana. publication-title: Plant J doi: 10.1046/j.1365-313x.1998.00343.x – volume: 60 start-page: 2126 year: 2004 ident: ref44 article-title: Coot: model-building tools for molecular graphics. publication-title: Acta Crystallogr D doi: 10.1107/S0907444904019158 – volume: 292 start-page: 2077 year: 2001 ident: ref7 article-title: Requirement of CHROMOMETHYLASE3 for maintenance of CpXpG methylation. publication-title: Science doi: 10.1126/science.1059745 – volume: 21 start-page: 367 year: 2009 ident: ref9 article-title: RNA-mediated chromatin-based silencing in plants. publication-title: Curr Opin Cell Biol doi: 10.1016/j.ceb.2009.01.025 – volume: 2 start-page: 149 year: 1997 ident: ref29 article-title: Coiled-coil assembly by peptides with non-heptad sequence motifs. publication-title: Fold Des doi: 10.1016/S1359-0278(97)00021-7 – volume: 64 start-page: 112 year: 2008 ident: ref40 article-title: A short history of SHELX. publication-title: Acta Crystallogr A doi: 10.1107/S0108767307043930 – volume: 7 start-page: 1279 year: 2006 ident: ref20 article-title: Epigenetic regulation of transcription in intermediate heterochromatin. publication-title: EMBO Rep doi: 10.1038/sj.embor.7400835 – volume: 4 start-page: e1000165 year: 2008 ident: ref24 article-title: Divergent evolution of CHD3 proteins resulted in MOM1 refining Epigenetic control in vascular plants. publication-title: PLoS Genet doi: 10.1371/journal.pgen.1000165 – volume: 34 start-page: 65 year: 2003 ident: ref3 article-title: Maintenance of CpG methylation is essential for epigenetic inheritance during plant gametogenesis. publication-title: Nat Genet doi: 10.1038/ng1138 – volume: 405 start-page: 203 year: 2000 ident: ref17 article-title: Disruption of the plant gene MOM releases transcriptional silencing of methylated genes. publication-title: Nature doi: 10.1038/35012108 – reference: 11459824 - Genes Dev. 2001 Jul 15;15(14):1753-8 – reference: 12351820 - Acta Crystallogr D Biol Crystallogr. 2002 Oct;58(Pt 10 Pt 2):1772-9 – reference: 21402358 - Cell Host Microbe. 2011 Mar 17;9(3):187-99 – reference: 17239600 - Curr Biol. 2007 Feb 20;17(4):379-84 – reference: 19910926 - EMBO J. 2010 Jan 20;29(2):340-51 – reference: 20010696 - EMBO J. 2010 Jan 20;29(2):352-62 – reference: 14573958 - Acta Crystallogr D Biol Crystallogr. 2003 Nov;59(Pt 11):2023-30 – reference: 12669067 - Nat Genet. 2003 May;34(1):65-9 – reference: 10899982 - Plant Cell. 2000 Jul;12(7):1165-78 – reference: 18156677 - Acta Crystallogr A. 2008 Jan;64(Pt 1):112-22 – reference: 12486005 - EMBO J. 2002 Dec 16;21(24):6842-52 – reference: 11137011 - Curr Biol. 2000 Dec 14-28;10(24):1591-4 – reference: 20530878 - Biosci Biotechnol Biochem. 2010;74(6):1315-9 – reference: 9095194 - Nat Struct Biol. 1997 Apr;4(4):269-75 – reference: 18704160 - PLoS Genet. 2008;4(8):e1000156 – reference: 12663548 - Genetics. 2003 Mar;163(3):1109-22 – reference: 10821279 - Nature. 2000 May 11;405(6783):203-6 – reference: 11898023 - Nature. 2002 Apr 4;416(6880):556-60 – reference: 12853574 - Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):8823-7 – reference: 11349138 - Science. 2001 Jun 15;292(5524):2077-80 – reference: 15572765 - Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 1):2126-32 – reference: 18725928 - PLoS Genet. 2008;4(8):e1000165 – reference: 17082818 - EMBO Rep. 2006 Dec;7(12):1279-84 – reference: 18559476 - Genes Dev. 2008 Jun 15;22(12):1597-606 – reference: 17082821 - EMBO Rep. 2006 Dec;7(12):1273-8 – reference: 16271868 - Curr Biol. 2005 Nov 8;15(21):1919-25 – reference: 12456661 - EMBO J. 2002 Dec 2;21(23):6549-59 – reference: 18643997 - Plant J. 2008 Dec;56(5):704-15 – reference: 18776934 - PLoS One. 2008;3(9):e3156 – reference: 20383001 - Acta Crystallogr D Biol Crystallogr. 2010 Apr;66(Pt 4):479-85 – reference: 20124702 - Acta Crystallogr D Biol Crystallogr. 2010 Feb;66(Pt 2):213-21 – reference: 8916221 - Proteins. 1996 Oct;26(2):134-45 – reference: 12609046 - Plant J. 2003 Feb;33(4):743-9 – reference: 20085706 - Cell. 2010 Jan 8;140(1):111-22 – reference: 20693667 - Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Aug 1;66(Pt 8):916-8 – reference: 20826701 - Plant Physiol. 2010 Nov;154(3):1272-80 – reference: 10966648 - Nat Struct Biol. 2000 Sep;7(9):772-6 – reference: 20142834 - Nat Rev Genet. 2010 Mar;11(3):204-20 – reference: 15457214 - EMBO J. 2004 Oct 27;23(21):4286-96 – reference: 19243928 - Curr Opin Cell Biol. 2009 Jun;21(3):367-76 – reference: 10069079 - Plant J. 1998 Dec;16(6):735-43 – reference: 20173764 - Nat Struct Mol Biol. 2010 Mar;17(3):373-8 – reference: 9218952 - Fold Des. 1997;2(3):149-58 – reference: 17803908 - Cell. 2007 Sep 7;130(5):851-62
SSID	ssj0035897
Score	2.1367176
Snippet	Shifts between epigenetic states of transcriptional activity are typically correlated with changes in epigenetic marks. However, exceptions to this rule... Shifts between epigenetic states of transcriptional activity are typically correlated with changes in epigenetic marks. However, exceptions to this rule...
SourceID	plos doaj pubmedcentral proquest gale pubmed crossref
SourceType	Open Website Open Access Repository Aggregation Database Index Database Enrichment Source
StartPage	e1002484
SubjectTerms	Amino Acid Sequence Arabidopsis - chemistry Arabidopsis - genetics Arabidopsis Proteins - chemistry Arabidopsis Proteins - genetics Arabidopsis thaliana Biology Crystallography, X-Ray Deoxyribonucleic acid Derivatives DNA DNA methylation Efficiency Epigenesis, Genetic - genetics Epigenetics Experiments Gene Expression Regulation, Plant Gene Silencing Genes Genetic aspects Genetic engineering Genetic transcription Molecular Sequence Data Mutagenesis Nuclear Proteins - chemistry Nuclear Proteins - genetics Plants, Genetically Modified Protein Conformation Protein Folding Protein Multimerization Protein Structure, Tertiary - genetics Proteins RNA, Small Interfering - genetics Structure-Activity Relationship Transcription Factors - chemistry Transcription Factors - genetics Transcription, Genetic
SummonAdditionalLinks	– databaseName: Directory of Open Access Journals (DOAJ) dbid: DOA link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3da9RAEF_kqOCL1M-erRpE8Cn2spvNZh9bsSjYO7EqfVs2-1EDJTmaa6H_vTO7SWik0D74ejubu_vN7MwsmfkNIe-tLassNzotDaghZ8ymUmtwhr6QQhq-0Dpo-ptYLsvTU_n9xqgvrAmL9MARuH0rucgLJ4TmNK-c15DSMo8vBHF4axlu65D1DJep6IMZL-NYFc5ZKuBa3zfNMZHt9zr6uAYFBQLSvMwnQSlw948eerY-b7vb0s9_qyhvhKWjbfK4zyeTg_g_npAHrnlKHsYJk9fPyOok8MMit0YCAavuktYnG4xPg7eABfiJLulqbD-CQJaEZhJIRJPqGp6rq9q2a9x5vDrOnpNfR59_fvqS9jMUUiNktkm9tN6LSltkFiyZg4RMFJZRW3nuqQMIsRqqEi4zOmO6tNzYRWEgCUTiL2nYCzJr2sbtkMQIowFKr73Mc2lLULJ3fmFYAQ-l0s8JG0BUpicYxzkX5yq8NRNw0YiYKIRe9dDPSTruWkeCjTvkD1E_oyzSY4cPwGhUbzTqLqOZk7eoXRV7TcdDrg4o0tnDHRK-5l2QQIqMBmtwzvRl16mvq9_3EDpZ3kfox0ToQy_kW8DM6L45ApBHfq6J5N5EEryBmSzvoMEO0HUAZAanoRCSw87BiG9fTsZlfCgW3zWuveyUpFRwCancnLyMJj-iD8klRNoCABWTwzBRz3Slqf8EFnNGBfY1v_of-twljyCRpbGafo_M4Gi512TLXG3q7uJNcA1_AaVUZa0 priority: 102 providerName: Directory of Open Access Journals – databaseName: Public Library of Science (PLoS) Journals Open Access dbid: FPL link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwELZgAYkLb-hCgQghcQokdhzHxxaxAqm7W7GAerMcPyBSlaxIi9R_z4zzgFStKNd4nETfeB6Wx98Q8traokwzo-PCgBoyxmwstQZn6HMppOGJ1kHTB2K1Ko6O5OGfjeK5E3wm0nc9pm-3AGggDM2K7Dq5QVmeYwnX4vBg8LyMF1L01-MumzkJP4Glf_TFs-1x016UaJ6vl_wrAC3u_u-v3yN3-lQz2uvWxn1yzdUPyK2u-eTZQ7LeBOpYpN2I9nVbtVHjoxC6BkcCA8hKHW0qvJkEMS5ahsYezkblGbxXl5VttjhzuV6mj8jXxYcv7z_GfXuF2AiZnsReWu9FqS2SDhbMQa4mcsuoLT331AmeYaFUKVxqdMp0YbmxSW4gP0ROMGnYYzKrm9rtkMgIo5lMvPYyy6QtQP_e-cSAjnhCpZ8TNqCuTM89ji0wjlU4UBOwB-kwUQiV6qGak3icte24N_4hv48KHWWROTs8AJ2o3hCVlVxkuRNCc5qVzmvYIjGPB8zYDLhI5uQlLgfVXUMd7V_tUWS6h-0lfOZVkED2jBrLc77r07ZVn9bfriC0WV1F6PNE6E0v5BvAzOj-3gQgj9RdE8ndiSQ4CjMZ3sEVPkDXApApmEwuJIeZw6q_eDgah_GlWJdXu-a0VZJSwSVkeXPypLOREX3IOyEI5wComFjPRD3Tkbr6EQjOGRV45fnp5T_8jNyGzJV25fO7ZAYG456Tm-bXSdX-fBG8wm-onmDb priority: 102 providerName: Public Library of Science
Title	Structural Basis of Transcriptional Gene Silencing Mediated by Arabidopsis MOM1
URI	https://www.ncbi.nlm.nih.gov/pubmed/22346760 https://www.proquest.com/docview/1313586795 https://www.proquest.com/docview/922759426 https://pubmed.ncbi.nlm.nih.gov/PMC3276543 https://doaj.org/article/d95746e77a524befa0493f0280375480 http://dx.doi.org/10.1371/journal.pgen.1002484
Volume	8
WOSCitedRecordID	wos000300725500011&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1553-7404 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0035897 issn: 1553-7404 databaseCode: DOA dateStart: 20050101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1553-7404 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0035897 issn: 1553-7404 databaseCode: M7P dateStart: 20050701 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1553-7404 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0035897 issn: 1553-7404 databaseCode: 7X7 dateStart: 20050701 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1553-7404 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0035897 issn: 1553-7404 databaseCode: BENPR dateStart: 20050701 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 1553-7404 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0035897 issn: 1553-7404 databaseCode: PIMPY dateStart: 20050701 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVATS databaseName: Public Library of Science (PLoS) Journals Open Access customDbUrl: eissn: 1553-7404 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0035897 issn: 1553-7404 databaseCode: FPL dateStart: 20050701 isFulltext: true titleUrlDefault: http://www.plos.org/publications/ providerName: Public Library of Science
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3db9MwELdYBxIv45sVRokQEk9hTRzH8RNa0SomrW20AipPkWPHo9KUdMuGtP-eO8cJBE0wiZc85M5Oe3c-n-3z7wh5q3WSB5GSfqJADRGl2hdSgjM0seBCsbGUVtPHfD5PViuRug232qVVtj7ROmpdKdwj3w9oQBmiw7EPm3Mfq0bh6aorobFFthGpLBqQ7cnhPD1pfTG0aMqrMEZ9Dst7d3mO8mDf6er9BhRlgUijJOpNThbDv_PUg81ZVd8Uhv6ZTfnb9DR98L9_7CHZcYGpd9BY0iNypygfk3tNqcrrJ2SxtECzCNLhTWS9rr3KeHaia90OEBDD2luu8R4TzIjezJYBKbSXX0O_Ml_raoMtZ4tZ8JR8mR5-_vjJd8UYfMVFcOkboY3hudQIUZjQAiI7Hmsa6twwExacRZhWlfMiUDKgMtFM6XGsIJpEBDGh6DMyKKuy2CWe4kqCLow0IoqETsBaTGHGisbQaSjMkNBWC5lySOVYMOMss8dvHFYsjUwy1F3mdDckftdq0yB1_IN_ggrueBFn276oLk4zN2wzLRiP4oJzycIoL4yEBRU1eByNpYOT8ZC8RvPImkurnbfIDkLExYfFKHzmjeVArI0Sk3lO5VVdZ0eLr7dgWs5vw3TSY3rnmEwFMlPS3bIAySPQV49zr8cJbkX1yLto8a3o6uyXnULL1pJvJnsdGTvFLL6yqK7qTIQhZwJiwiF53oyZTvoQpcKUHYNAeW809dTTp5Tr7xYOnYYcL0i_-PuveknuQ6wbNgn3e2QAg6Z4Re6qH5fr-mJEtviK22cycj5kZLdn4DlNj0eYEpwCJT2apd9-AtU-fEs
linkProvider	ProQuest
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwELbKAoILb-hCoRECcQrdxEkcHxBqgaqr7gOxBe3NOH6UlapkaVrQ_il-IzPOA4Iq6KUHrvHYyc7L4_XMN4Q80zrNgkhJP1UghohS7XMpwRnahDOu4oGUTtIjNpmk8zl_v0Z-NLUwmFbZ-ETnqHWh8D_yrYAGNEZ0uPj18quPXaPwdrVpoVGpxb5ZfYcjW_lq-Bbk-zwMd98dvNnz664CvmI8OPEt19ayTGrE2kupgRCFJZqGOrOxDQ2LI8wPypgJlAyoTHWs9CBREBYhFBZXFNa9RC6DH2eYQsbm7QEPvq9q5hLH1GeUD-pSPcqCrVozXi5BLRzsaZRGna3QdQxo94Xe8qgozwp6_8zd_G0z3L35v7HxFrlRh93edmUnt8maye-Qq1UjztVdMp05GF2EIPF2ZLkovcJ6bhtvnCoMIEK3N1tglRbs997YNTkx2stWsK7MFrpY4szxdBzcIx8v5NfcJ728yM068RRTEmRvpeVRxHUKtmCNHSiawKIht31CG6kLVeOwYzuQI-EuFxmcxyqeCNQVUetKn_jtrGWFQ_IP-h1UqJYWUcTdg-L4UNROSWgesygxjMk4jDJjJRwXqcXLdmyMnA76ZBPVUVQlua0vFNshov7DURte89RRIJJIjqlKh_K0LMVw-ukcRLPJeYg-dIhe1ES2AJ4pWdeQAOcRxqxDudGhBKepOsPraGEN60rxyy5gZmM5Zw977TAuijmKuSlOS8HDkMUcIt4-eVDZaMt9iMEhIEmAoaxjvR3xdEfyxRcH9k5DhuXfD__-VZvk2t7BeCRGw8n-I3IdovqwKi3YID0wIPOYXFHfThbl8RPnsTzy-aJt-yfEF9NU
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwELbKFhAX3tCFQiME4hR2EydxfECoS7ti1e5DXYp6M44fZaUqWZoWtH-NX8dMXhBUQS89cI3HTnY833i89nxDyEut48QLlHRjBdMQUKpdLiU4QxtxxlXYl7KY6X02mcRHR3y2Rn7UuTB4rbL2iYWj1pnC_8h7HvVoiOxwYc9W1yJmO8N3y68uVpDCk9a6nEZpIntm9R22b_nb0Q7M9SvfH-5-fP_BrSoMuIpx78y1XFvLEqmRdy-mBsIVFmnq68SG1jcsDPCuUMKMp6RHZaxDpfuRghAJabG4ojDuNbLOIMgAdK0Pdiezg3odgK8tS7uEIXVBol8l7lHm9So7ebMEIylIUIM4aC2MRf2AZpXoLE-y_KIQ-M-bnL8tjcM7_7NS75LbVUDubJcIukfWTHqf3ChLdK4ekOm8INhFchJnIPNF7mTWKRb42t1CA3J3O_MF5m9BJOCMi_InRjvJCsaVyUJnS-w5no69h-TwSn7NI9JJs9RsEEcxJcEOrLQ8CLiOASXW2L6iEQzqc9sltLYAoSqGdiwUciKKY0cGO7VSJwLtRlR20yVu02tZMpT8Q36AxtXIIr948SA7PRaVuxKahyyIDGMy9IPEWAkbSWrxGB5LJsf9LtlC0xRlsm7jJcW2j_UAYBMOr3lRSCDHSIqGdSzP81yMpp8uITSfXEbooCX0uhKyGehMySq7BDSPBGctyc2WJLhT1WreQLTVqsvFL4xAzxpFFzc7TTMOircXU5Od54L7Pgs5xMJd8rjEa6N9iM4hVIlAoayF5Nb0tFvSxZeCBp76DBPDn_z9q7bITYC02B9N9p6SWxDu-2XOwSbpAH7MM3JdfTtb5KfPK_flkM9XDe6fumrddQ
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Structural+basis+of+transcriptional+gene+silencing+mediated+by+Arabidopsis+MOM1&rft.jtitle=PLoS+genetics&rft.au=Nishimura%2C+Taisuke&rft.au=Molinard%2C+Guillaume&rft.au=Petty%2C+Tom+J&rft.au=Broger%2C+Larissa&rft.date=2012-02-01&rft.eissn=1553-7404&rft.volume=8&rft.issue=2&rft.spage=e1002484&rft_id=info:doi/10.1371%2Fjournal.pgen.1002484&rft_id=info%3Apmid%2F22346760&rft.externalDocID=22346760
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1553-7404&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1553-7404&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1553-7404&client=summon