The Circular RNA Cdr1as Act as an Oncogene in Hepatocellular Carcinoma through Targeting miR-7 Expression

CircRNAs are a class of endogenous RNA that regulates gene expression at the post-transcriptional or transcriptionallevel through interacting with other molecules or microRNAs. Increasing studies have demonstrated that circRNAs play a crucial role in biology processes. CircRNAs are proved as potenti...

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Vydáno v:	PloS one Ročník 11; číslo 7; s. e0158347
Hlavní autoři:	Yu, Lei, Gong, Xuejun, Sun, Lei, Zhou, Qiying, Lu, Baoling, Zhu, Liying
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Public Library of Science 08.07.2016 Public Library of Science (PLoS)
Témata:	Alzheimer's disease Alzheimers disease Biology Biology and Life Sciences Biosynthesis Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell cycle Cell growth Cell proliferation Cell Proliferation - genetics Circular RNA Class I Phosphatidylinositol 3-Kinases - biosynthesis Class I Phosphatidylinositol 3-Kinases - genetics Female Gene expression Gene Expression Regulation, Neoplastic Genetic aspects Genomes Hepatocellular carcinoma Hospitals Humans Infectious diseases Kinases Liver cancer Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - pathology Male Medicine and Health Sciences Metastasis MicroRNAs MicroRNAs - biosynthesis MicroRNAs - genetics miRNA Neoplasm Invasiveness Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics Oncogenes Physiological aspects Post-transcription Research and Analysis Methods Ribonucleic acid Risk factors RNA RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism RNA, Neoplasm - genetics RNA, Neoplasm - metabolism Surgery Tissues Tumor Cells, Cultured Tumors China United States > US
ISSN:	1932-6203, 1932-6203
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Abstract	CircRNAs are a class of endogenous RNA that regulates gene expression at the post-transcriptional or transcriptionallevel through interacting with other molecules or microRNAs. Increasing studies have demonstrated that circRNAs play a crucial role in biology processes. CircRNAs are proved as potentialbiomarkers in many diseases including cancers. However, the role of Cdr1as in Hepatocellular carcinoma (HCC) remains to be elucidated. We demonstrated that Cdr1as expression was upregulated in HCC tissues compared with the adjacent non-tumor tissues. In addtion, miR-7 expression was downregulated in HCC tissues compared with the adjacent non-tumor tissues. Moreover, the expression level of miR-7 was inversely correlated with that in HCC tissues. Knockdown of Cdr1as suppressed the HCC cell proliferation and invasion. Overexpression of miR-7 inhibited the HCC cell proliferation and invasion. Overexpression of miR-7 could suppress the direct target gene CCNE1 and PIK3CD expression. Knockdown of Cdr1as suppressed the expression of miR-7 and also inhibited the CCNE1 and PIK3CD expression. Furthermore, knockdown of Cdr1as suppressed the HCC cell proliferation and invasion through targeting miR-7. These data suggested that Cdr1as acted as an oncogene partly through targeting miR-7 in HCC.
AbstractList	CircRNAs are a class of endogenous RNA that regulates gene expression at the post-transcriptional or transcriptionallevel through interacting with other molecules or microRNAs. Increasing studies have demonstrated that circRNAs play a crucial role in biology processes. CircRNAs are proved as potentialbiomarkers in many diseases including cancers. However, the role of Cdr1as in Hepatocellular carcinoma (HCC) remains to be elucidated. We demonstrated that Cdr1as expression was upregulated in HCC tissues compared with the adjacent non-tumor tissues. In addtion, miR-7 expression was downregulated in HCC tissues compared with the adjacent non-tumor tissues. Moreover, the expression level of miR-7 was inversely correlated with that in HCC tissues. Knockdown of Cdr1as suppressed the HCC cell proliferation and invasion. Overexpression of miR-7 inhibited the HCC cell proliferation and invasion. Overexpression of miR-7 could suppress the direct target gene CCNE1 and PIK3CD expression. Knockdown of Cdr1as suppressed the expression of miR-7 and also inhibited the CCNE1 and PIK3CD expression. Furthermore, knockdown of Cdr1as suppressed the HCC cell proliferation and invasion through targeting miR-7. These data suggested that Cdr1as acted as an oncogene partly through targeting miR-7 in HCC.
Audience	Academic
Author	Gong, Xuejun Sun, Lei Yu, Lei Zhou, Qiying Zhu, Liying Lu, Baoling
AuthorAffiliation	2 Department of Biliary and Pancreatic Surgery, Xiangya Hospital of Central South University, Changsha, 410008, Hunan, China 1 Department of Infectious Disease,The Fourth Hospital of Harbin Medical University, Harbin 150001, Heilongjiang, China 3 Department of Ophthalmology,The Fourth Hospital of Harbin Medical University, Harbin 150001, Heilongjiang, China University of Saarland Medical School, GERMANY 4 College of Computer Science and Technology (Network and Information Security), JiLin University, Changchun, 130001, Jilin, China
AuthorAffiliation_xml	– name: 2 Department of Biliary and Pancreatic Surgery, Xiangya Hospital of Central South University, Changsha, 410008, Hunan, China – name: University of Saarland Medical School, GERMANY – name: 4 College of Computer Science and Technology (Network and Information Security), JiLin University, Changchun, 130001, Jilin, China – name: 3 Department of Ophthalmology,The Fourth Hospital of Harbin Medical University, Harbin 150001, Heilongjiang, China – name: 1 Department of Infectious Disease,The Fourth Hospital of Harbin Medical University, Harbin 150001, Heilongjiang, China
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BackLink	https://www.ncbi.nlm.nih.gov/pubmed/27391479$$D View this record in MEDLINE/PubMed
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DocumentTitleAlternate	The Circular RNA Cdr1as Act as an Oncogene in Hepatocellular Carcinoma
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Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 ObjectType-Correction/Retraction-3 Conceived and designed the experiments: LY XG LS QZ BL LZ. Performed the experiments: LY XG LS QZ BL LZ. Analyzed the data: LY XG LS QZ BL LZ. Contributed reagents/materials/analysis tools: LY XG LS QZ BL LZ. Wrote the paper: LY XG LS QZ BL LZ. Competing Interests: The authors have declared that no competing interests exist. These authors are joint first authors on this work.
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SubjectTerms	Alzheimer's disease Alzheimers disease Biology Biology and Life Sciences Biosynthesis Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell cycle Cell growth Cell proliferation Cell Proliferation - genetics Circular RNA Class I Phosphatidylinositol 3-Kinases - biosynthesis Class I Phosphatidylinositol 3-Kinases - genetics Female Gene expression Gene Expression Regulation, Neoplastic Genetic aspects Genomes Hepatocellular carcinoma Hospitals Humans Infectious diseases Kinases Liver cancer Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - pathology Male Medicine and Health Sciences Metastasis MicroRNAs MicroRNAs - biosynthesis MicroRNAs - genetics miRNA Neoplasm Invasiveness Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics Oncogenes Physiological aspects Post-transcription Research and Analysis Methods Ribonucleic acid Risk factors RNA RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism RNA, Neoplasm - genetics RNA, Neoplasm - metabolism Surgery Tissues Tumor Cells, Cultured Tumors
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Title	The Circular RNA Cdr1as Act as an Oncogene in Hepatocellular Carcinoma through Targeting miR-7 Expression
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