Reduced Field-of-View Diffusion-Weighted Imaging of the Lumbosacral Enlargement: A Pilot In Vivo Study of the Healthy Spinal Cord at 3T

Diffusion tensor imaging (DTI) has recently started to be adopted into clinical investigations of spinal cord (SC) diseases. However, DTI applications to the lower SC are limited due to a number of technical challenges, related mainly to the even smaller size of the SC structure at this level, its p...

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Vydáno v:	PloS one Ročník 11; číslo 10; s. e0164890
Hlavní autoři:	Yiannakas, Marios C., Grussu, Francesco, Louka, Polymnia, Prados, Ferran, Samson, Rebecca S., Battiston, Marco, Altmann, Daniel R., Ourselin, Sebastien, Miller, David H., Gandini Wheeler-Kingshott, Claudia A. M.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Public Library of Science 14.10.2016 Public Library of Science (PLoS)
Témata:	Adult Anisotropy Biology and Life Sciences Biomedical engineering Biomedical research Bladder Brain research Coefficient of variation Coils Data acquisition Diffusion Echo surveys Enlargement Feasibility studies Female Field of view Gray Matter - diagnostic imaging Health physics Healthy Volunteers Hospitals Humans Image Processing, Computer-Assisted Imaging In vivo methods and tests Magnetic Resonance Imaging Male Mathematical analysis Medical research Medicine and Health Sciences Middle Aged Multiple sclerosis Neurology NMR Nuclear magnetic resonance Physical Sciences Pilot Projects Reproducibility Reproducibility of Results Research and Analysis Methods Sexual behavior Sexual disorders Signal-To-Noise Ratio Spinal cord Spinal Cord - diagnostic imaging Spinal cord injuries Substantia alba Urinary bladder White Matter - diagnostic imaging Young Adult
ISSN:	1932-6203, 1932-6203
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Popis
Shrnutí:	Diffusion tensor imaging (DTI) has recently started to be adopted into clinical investigations of spinal cord (SC) diseases. However, DTI applications to the lower SC are limited due to a number of technical challenges, related mainly to the even smaller size of the SC structure at this level, its position relative to the receiver coil elements and the effects of motion during data acquisition. Developing methods to overcome these problems would offer new means to gain further insights into microstructural changes of neurological conditions involving the lower SC, and in turn could help explain symptoms such as bladder and sexual dysfunction. In this work, the feasibility of obtaining grey and white matter (GM/WM) DTI indices such as axial/radial/mean diffusivity (AD/RD/MD) and fractional anisotropy (FA) within the lumbosacral enlargement (LSE) was investigated using a reduced field-of-view (rFOV) single-shot echo-planar imaging (ss-EPI) acquisition in 14 healthy participants using a clinical 3T MR system. The scan-rescan reproducibility of the measurements was assessed by calculating the percentage coefficient of variation (%COV). Mean FA was higher in WM compared to GM (0.58 and 0.4 in WM and GM respectively), AD and MD were higher in WM compared to GM (1.66 μm2ms-1 and 0.94 μm2ms-1 in WM and 1.2 μm2ms-1 and 0.82 μm2ms-1 in GM for AD and MD respectively) and RD was lower in WM compared to GM (0.58 μm2ms-1 and 0.63 μm2ms-1 respectively). The scan-rescan %COV was lower than 10% in all cases with the highest values observed for FA and the lowest for MD. This pilot study demonstrates that it is possible to obtain reliable tissue-specific estimation of DTI indices within the LSE using a rFOV ss-EPI acquisition. The DTI acquisition and analysis protocol presented here is clinically feasible and may be used in future investigations of neurological conditions implicating the lower SC.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Competing Interests: The authors have declared that no competing interests exist. Conceptualization: MCY FG PL FP RSS MB DRA SO DHM CAMGW. Data curation: SO DHM CAMGW. Formal analysis: MCY FG PL DRA. Funding acquisition: SO DHM CAMGW. Investigation: MCY FG PL FP RSS MB. Methodology: MCY FG PL FP RSS MB DRA CAMGW. Project administration: SO DHM CAMGW. Resources: SO DHM CAMGW. Software: MCY FG PL FP RSS MB DRA SO DHM CAMGW. Supervision: SO DHM CAMGW. Validation: SO DHM CAMGW. Visualization: MCY FG. Writing – original draft: MCY FG PL FP RSS MB DRA SO DHM CAMGW. Writing – review & editing: MCY FG PL FP RSS MB DRA SO DHM CAMGW.
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0164890