The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias

Anna Andersson, Tanja Gruber, James Downing and colleagues report a genomic analysis of infant acute lymphoblastic leukemias with MLL rearrangements. They identify recurrent activating mutations in tyrosine kinase, phosphatidylinositol 3-kinase and RAS pathway genes but find that these mutations wer...

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Bibliographic Details
Published in:	Nature genetics Vol. 47; no. 4; pp. 330 - 337
Main Authors:	Andersson, Anna K, Ma, Jing, Wang, Jianmin, Chen, Xiang, Gedman, Amanda Larson, Dang, Jinjun, Nakitandwe, Joy, Holmfeldt, Linda, Parker, Matthew, Easton, John, Huether, Robert, Kriwacki, Richard, Rusch, Michael, Wu, Gang, Li, Yongjin, Mulder, Heather, Raimondi, Susana, Pounds, Stanley, Kang, Guolian, Shi, Lei, Becksfort, Jared, Gupta, Pankaj, Payne-Turner, Debbie, Vadodaria, Bhavin, Boggs, Kristy, Yergeau, Donald, Manne, Jayanthi, Song, Guangchun, Edmonson, Michael, Nagahawatte, Panduka, Wei, Lei, Cheng, Cheng, Pei, Deqing, Sutton, Rosemary, Venn, Nicola C, Chetcuti, Albert, Rush, Amanda, Catchpoole, Daniel, Heldrup, Jesper, Fioretos, Thoas, Lu, Charles, Ding, Li, Pui, Ching-Hon, Shurtleff, Sheila, Mullighan, Charles G, Mardis, Elaine R, Wilson, Richard K, Gruber, Tanja A, Zhang, Jinghui, Downing, James R
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.04.2015 Nature Publishing Group
Subjects:	38 38/23 38/47 38/90 38/91 45 45/22 45/23 631/208/212 692/308/575 692/699/67/1990/283/2125 Acute lymphocytic leukemia Agriculture Allelic Imbalance - genetics Animal Genetics and Genomics Babies Basic Medicine Bioinformatics Biomedicine Cancer Cancer Research Children & youth Cohort Studies Development and progression DNA Mutational Analysis Gene Frequency Gene Function Gene mutations Genes Genetic aspects Genetic engineering Genomes Health aspects Histone-Lysine N-Methyltransferase Hospitals Human Genetics Humans Hypotheses Identification and classification Infant Infants Laboratories Leukemia Medical and Health Sciences Medical Genetics and Genomics (including Gene Therapy) Medicin och hälsovetenskap Medicinsk genetik och genomik (Här ingår: Genterapi) Medicinska och farmaceutiska grundvetenskaper Mutation Myeloid-Lymphoid Leukemia Protein - genetics Oncogene Proteins, Fusion - genetics Pediatrics Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - metabolism Precursor Cell Lymphoblastic Leukemia-Lymphoma - epidemiology Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Protein-Tyrosine Kinases - genetics Protein-Tyrosine Kinases - metabolism Proteins ras Proteins - genetics ras Proteins - metabolism Signal Transduction - genetics
ISSN:	1061-4036, 1546-1718, 1546-1718
Online Access:	Get full text
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