Promotion of Reprogramming to Ground State Pluripotency by Signal Inhibition

Induced pluripotent stem (iPS) cells are generated from somatic cells by genetic manipulation. Reprogramming entails multiple transgene integrations and occurs apparently stochastically in rare cells over many days. Tissue stem cells may be subject to less-stringent epigenetic restrictions than othe...

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Bibliographic Details
Published in:	PLoS biology Vol. 6; no. 10; p. e253
Main Authors:	Silva, Jose, Barrandon, Ornella, Nichols, Jennifer, Kawaguchi, Jitsutaro, Theunissen, Thorold W, Smith, Austin
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01.10.2008 Public Library of Science (PLoS)
Subjects:	Animals Blotting, Northern Brain - cytology Brain - metabolism Brain research Cell Biology Cells, Cultured Cellular Reprogramming - genetics Cellular Reprogramming - physiology Councils Developmental Biology Efficiency Epigenetics Female Flow Cytometry Fluorescent Antibody Technique In Situ Hybridization, Fluorescence Kinases Kruppel-Like Factor 4 Leukemia Mice Neurons - cytology Neurons - metabolism Pluripotent Stem Cells - cytology Pluripotent Stem Cells - metabolism Proteins Reverse Transcriptase Polymerase Chain Reaction Signal Transduction - genetics Signal Transduction - physiology Stem cells Brain Nuclear Reprogramming Signal Transduction Neurons Cells, Cultured In Situ Hybridization, Fluorescence Reverse Transcriptase Polymerase Chain Reaction Blotting, Northern Animals Flow Cytometry Pluripotent Stem Cells Fluorescent Antibody Technique Female Mice
ISSN:	1545-7885, 1544-9173, 1545-7885
Online Access:	Get full text
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