Treating Viral Exacerbations of Chronic Obstructive Pulmonary Disease: Insights from a Mouse Model of Cigarette Smoke and H1N1 Influenza Infection

Chronic obstructive pulmonary disease is a progressive lung disease that is punctuated by periods of exacerbations (worsening of symptoms) that are attributable to viral infections. While rhinoviruses are most commonly isolated viruses during episodes of exacerbation, influenza viruses have the pote...

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Bibliographic Details
Published in:	PloS one Vol. 5; no. 10; p. e13251
Main Authors:	Bauer, Carla M. T., Zavitz, Caleb C. J., Botelho, Fernando M., Lambert, Kristen N., Brown, Earl G., Mossman, Karen L., Taylor, John D., Stämpfli, Martin R.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 12.10.2010 Public Library of Science (PLoS)
Subjects:	Alveoli Animal models Animals Anti-inflammatory agents Avian flu Bacterial infections Biochemistry CC chemokine receptors CCR2 protein Chemokines Chemokines - metabolism Chronic infection Chronic obstructive lung disease Chronic obstructive pulmonary disease Cigarette smoke Cigarettes Corticoids Corticosteroids Cytokines Dexamethasone Disease Models, Animal Drugs Epidemics Exposure Genomes Health aspects House mouse Humans Immunization Infection Infections Infectious Diseases/Respiratory Infections Inflammation Inflammatory response Influenza Influenza A Influenza A virus Influenza A Virus, H1N1 Subtype - isolation & purification Influenza viruses Influenza, Human - complications Influenza, Human - drug therapy Influenza, Human - metabolism Influenza, Human - virology Lung diseases Medicine Mice Mice, Inbred C57BL Monocyte chemoattractant protein 1 Mutation Neutrophilia Obstructive lung disease Pathology Peroxisome proliferator-activated receptors Pharmacology Pioglitazone PPAR gamma - agonists Pseudomonas aeruginosa Pulmonary Disease, Chronic Obstructive - metabolism Pulmonary Disease, Chronic Obstructive - physiopathology Pulmonary Disease, Chronic Obstructive - virology Respiratory distress syndrome Respiratory Medicine/COPD and Allied Disorders Respiratory Medicine/Respiratory Infections Rhinovirus Rodents Smoke Smoking Smooth muscle Steroids Studies Swine flu Swine influenza Thiazolidinediones - pharmacology Thiazolidinediones - therapeutic use Viral infections Viruses Canada
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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